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Head and Neck Pathology
Published in: Head and Neck Pathology 1/2013

01-03-2013 | Case Report

Lacrimal Gland Adenoid Cystic Carcinoma with High-Grade Transformation to Myoepithelial Carcinoma: Report of a Case and Review of Literature

Authors: Prokopios P. Argyris, Stefan E. Pambuccian, Zuzan Cayci, Charanjeet Singh, Konstantinos I. Tosios, Ioannis G. Koutlas

Published in: Head and Neck Pathology | Issue 1/2013

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Abstract

Adenoid cystic carcinoma (AdCC) is the most frequent malignant neoplasm of the lacrimal glands. Like its salivary gland counterpart, lacrimal AdCC can rarely undergo high-grade transformation (“dedifferentiation”). We herein report the clinical, radiographic and microscopic findings of a lacrimal gland AdCC with high grade transformation, occurring in a 39-year-old female patient. In contrast to salivary gland AdCC with high-grade transformation, which usually shows a high grade component with “ductal” differentiation, in the case presented, the “dedifferentiated” component showed morphologic and immunohistochemical features of myoepithelial differentiation.
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Metadata
Title
Lacrimal Gland Adenoid Cystic Carcinoma with High-Grade Transformation to Myoepithelial Carcinoma: Report of a Case and Review of Literature
Authors
Prokopios P. Argyris
Stefan E. Pambuccian
Zuzan Cayci
Charanjeet Singh
Konstantinos I. Tosios
Ioannis G. Koutlas
Publication date
01-03-2013
Publisher
Springer US
Published in
Head and Neck Pathology / Issue 1/2013
Electronic ISSN: 1936-0568
DOI
https://doi.org/10.1007/s12105-012-0383-2

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