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Published in: Head and Neck Pathology 1/2012

01-03-2012 | North American Society of Head and Neck Pathology Companion Meeting, March 18, 2012, Vancouver, British Colombia

My Journey into the World of Salivary Gland Sebaceous Neoplasms

Author: Douglas R. Gnepp

Published in: Head and Neck Pathology | Issue 1/2012

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Abstract

As part of this symposium honoring Leon Barnes, the authors were asked to present the case from which they learned the most. I chose a cystic sebaceous lymphadenoma (SL) as my case presentation. This paper presents this unusual case, as well as several additional sebaceous tumors that came across my desk the first few years I was in practice. These interesting cases led me to thoroughly review the literature on sebaceous tumors of the salivary glands, resulting in several publications, the largest series of sebaceous tumors published at this time as well as a careful review of all cases in the literature. The author will also review the current and previous literature on the five types of salivary gland sebaceous tumors: sebaceous adenoma, SL (and non-sebaceous lymphadenoma), sebaceous carcinoma, sebaceous lymphadenocarcinoma, and sebaceous differentiation in other types of salivary gland lesions.
Literature
1.
go back to reference Gnepp DR, Sporck FT. Lymphoepithelial cyst with sebaceous differentiation (cystic sebaceous lymphadenoma). Am J Clin Pathol. 1980;74:683–7.PubMed Gnepp DR, Sporck FT. Lymphoepithelial cyst with sebaceous differentiation (cystic sebaceous lymphadenoma). Am J Clin Pathol. 1980;74:683–7.PubMed
2.
go back to reference Gnepp DR. Warthin tumor exhibiting sebaceous differentiation and necrotizing sialometaplasia. A pathological anatomy and histology. Virchows Arch A Pathol Anat Histol. 1981;391(3):267–73.PubMedCrossRef Gnepp DR. Warthin tumor exhibiting sebaceous differentiation and necrotizing sialometaplasia. A pathological anatomy and histology. Virchows Arch A Pathol Anat Histol. 1981;391(3):267–73.PubMedCrossRef
3.
go back to reference Cramer S, Gnepp DR. Sebaceous differentiation in an adenoid cystic carcinoma of the parotid gland. Cancer. 1980;46:1405–10.PubMedCrossRef Cramer S, Gnepp DR. Sebaceous differentiation in an adenoid cystic carcinoma of the parotid gland. Cancer. 1980;46:1405–10.PubMedCrossRef
4.
go back to reference Gnepp DR, Brannon R. Sebaceous neoplasms of salivary gland origin, report of 21 cases. Cancer. 1984;53:2155–70.PubMedCrossRef Gnepp DR, Brannon R. Sebaceous neoplasms of salivary gland origin, report of 21 cases. Cancer. 1984;53:2155–70.PubMedCrossRef
5.
go back to reference Gnepp DR. Sebaceous neoplasms of salivary gland origin: a review. Pathol Annu. 1983;18(Part 1):71–102.PubMed Gnepp DR. Sebaceous neoplasms of salivary gland origin: a review. Pathol Annu. 1983;18(Part 1):71–102.PubMed
6.
go back to reference Linhartova A. Sebaceous glands in salivary gland tissue. Arch Pathol. 1974;98:320–4.PubMed Linhartova A. Sebaceous glands in salivary gland tissue. Arch Pathol. 1974;98:320–4.PubMed
7.
go back to reference Auclair PL, Ellis GL, Gnepp DR. Other benign epithelial neoplasms. In: Ellis GL, Auclair PL, Gnepp DR, editors. Surgical pathology of the salivary glands. Philadelphia: W.B. Saunders; 1991. p. 252–67. Auclair PL, Ellis GL, Gnepp DR. Other benign epithelial neoplasms. In: Ellis GL, Auclair PL, Gnepp DR, editors. Surgical pathology of the salivary glands. Philadelphia: W.B. Saunders; 1991. p. 252–67.
8.
go back to reference Martinez-Madrigal F, Bosq J, et al. Major salivary glands. In: Sternberg SS, editor. Histology for pathologists. 2nd ed. Philadelphia: Lippincott-Raven; 1997. p. 405–29. Martinez-Madrigal F, Bosq J, et al. Major salivary glands. In: Sternberg SS, editor. Histology for pathologists. 2nd ed. Philadelphia: Lippincott-Raven; 1997. p. 405–29.
9.
go back to reference Neville BW, Damm DD, Allen CM, et al. Oral and maxillofacial pathology. 2nd ed. Philadelphia: W.B. Saunders; 2002. p. 6–7. Neville BW, Damm DD, Allen CM, et al. Oral and maxillofacial pathology. 2nd ed. Philadelphia: W.B. Saunders; 2002. p. 6–7.
10.
go back to reference Felice CD, Parrini S, Chitano G, et al. Fordyce granules and hereditary non-polyposis colorectal cancer syndrome. Gut. 2005;54:1279–82.PubMedCrossRef Felice CD, Parrini S, Chitano G, et al. Fordyce granules and hereditary non-polyposis colorectal cancer syndrome. Gut. 2005;54:1279–82.PubMedCrossRef
11.
go back to reference Daley TD. Intraoral sebaceous hyperplasia. Diagnostic criteria. Oral Surg Oral Med Oral Pathol. 1992;74:343–7.CrossRef Daley TD. Intraoral sebaceous hyperplasia. Diagnostic criteria. Oral Surg Oral Med Oral Pathol. 1992;74:343–7.CrossRef
12.
go back to reference Gnepp DR, Henley JD, Simpson RHW, Eveson J. Salivary and lacrimal glands. In: Gnepp DR, editor. Diagnostic surgical pathology of the head and neck. 2nd ed. Philadelphia: W.B. Saunders; 2009. p. 508–12. Gnepp DR, Henley JD, Simpson RHW, Eveson J. Salivary and lacrimal glands. In: Gnepp DR, editor. Diagnostic surgical pathology of the head and neck. 2nd ed. Philadelphia: W.B. Saunders; 2009. p. 508–12.
13.
go back to reference Rulon DB, Helwig EB. Multiple sebaceous neoplasms of the skin: an association with multiple visceral carcinomas, especially of the colon. Am J Clin Pathol. 1973;60:745–53.PubMed Rulon DB, Helwig EB. Multiple sebaceous neoplasms of the skin: an association with multiple visceral carcinomas, especially of the colon. Am J Clin Pathol. 1973;60:745–53.PubMed
14.
go back to reference Housholder MS, Zeligman I. Sebaceous neoplasms with visceral carcinomas. Arch Dermatol. 1980;116:61–4.PubMedCrossRef Housholder MS, Zeligman I. Sebaceous neoplasms with visceral carcinomas. Arch Dermatol. 1980;116:61–4.PubMedCrossRef
15.
go back to reference de Vicente Rodríguez JC, Fresno Forcelledo MF, González García M, Aguilar Andrea C. Sebaceous adenoma of the parotid gland. Med Oral Patol Oral Cir Bucal. 2006;11:E446–8.PubMed de Vicente Rodríguez JC, Fresno Forcelledo MF, González García M, Aguilar Andrea C. Sebaceous adenoma of the parotid gland. Med Oral Patol Oral Cir Bucal. 2006;11:E446–8.PubMed
16.
go back to reference Apple SK, Moatamed NA, Lai CK, Bhuta S. Sebaceous adenoma of the parotid gland: a case report with fine needle aspiration findings and histologic correlation. Acta Cytol. 2009;53(4):419–22.PubMedCrossRef Apple SK, Moatamed NA, Lai CK, Bhuta S. Sebaceous adenoma of the parotid gland: a case report with fine needle aspiration findings and histologic correlation. Acta Cytol. 2009;53(4):419–22.PubMedCrossRef
17.
go back to reference Zare-Mahmoodabadi R, Salehinejad J, Saghafi S, et al. Sebaceous adenoma of the submandibular gland: a case report. J Oral Sci. 2009;51:641–4.PubMedCrossRef Zare-Mahmoodabadi R, Salehinejad J, Saghafi S, et al. Sebaceous adenoma of the submandibular gland: a case report. J Oral Sci. 2009;51:641–4.PubMedCrossRef
18.
go back to reference Ellis GL, Auclair PL. Atlas of tumor pathology. Tumors of the salivary gland, 3rd series, fascicle 17. Washington, DC: Armed Forces Institute of Pathology; 1996. p. 130–6, 333–6. Ellis GL, Auclair PL. Atlas of tumor pathology. Tumors of the salivary gland, 3rd series, fascicle 17. Washington, DC: Armed Forces Institute of Pathology; 1996. p. 130–6, 333–6.
19.
go back to reference Chang JY, Hsiao CH. Lymphadenoma lacking sebaceous differentiation in the parotid gland. J Formos Med Assoc. 2004;103:459–62.PubMed Chang JY, Hsiao CH. Lymphadenoma lacking sebaceous differentiation in the parotid gland. J Formos Med Assoc. 2004;103:459–62.PubMed
20.
go back to reference Ma J, Chan JKC, Chow CW, et al. Lymphadenoma: a report of three cases of an uncommon salivary gland neoplasm. Histopathology. 2002;41:342–50.PubMedCrossRef Ma J, Chan JKC, Chow CW, et al. Lymphadenoma: a report of three cases of an uncommon salivary gland neoplasm. Histopathology. 2002;41:342–50.PubMedCrossRef
21.
go back to reference Seethala RR, Thompson LD, Gnepp DR, Barnes EL, Skalova A, Montone K, Kane S, Lewis JS Jr, Solomon LW, Simpson RH, Khan A, Prasad ML. Lymphadenoma of the salivary gland: clinicopathological and immunohistochemical analysis of 33 tumors. Mod Pathol. 2012;25(1):26–35.PubMedCrossRef Seethala RR, Thompson LD, Gnepp DR, Barnes EL, Skalova A, Montone K, Kane S, Lewis JS Jr, Solomon LW, Simpson RH, Khan A, Prasad ML. Lymphadenoma of the salivary gland: clinicopathological and immunohistochemical analysis of 33 tumors. Mod Pathol. 2012;25(1):26–35.PubMedCrossRef
22.
go back to reference Squillaci S, Marchione R, Piccolomini M. Cystic sebaceous lymphadenoma of the parotid gland: case report and review of the literature. Pathologica. 2011;103(2):32–9.PubMed Squillaci S, Marchione R, Piccolomini M. Cystic sebaceous lymphadenoma of the parotid gland: case report and review of the literature. Pathologica. 2011;103(2):32–9.PubMed
23.
go back to reference Mishra A, Tripathi K, Mohanty L, Nayak M. Sebaceous lymphadenoma of the parotid gland. Indian J Pathol Microbiol. 2011;54(1):131–2.PubMedCrossRef Mishra A, Tripathi K, Mohanty L, Nayak M. Sebaceous lymphadenoma of the parotid gland. Indian J Pathol Microbiol. 2011;54(1):131–2.PubMedCrossRef
24.
go back to reference Maffini F, Fasani R, Petrella D, Maiorano E, Bruschini R, Pelosi G, Viale G. Sebaceous lymphadenoma of salivary gland: a case report and a review of the literature. Acta Otorhinolaryngol Ital. 2007;27(3):147–50.PubMed Maffini F, Fasani R, Petrella D, Maiorano E, Bruschini R, Pelosi G, Viale G. Sebaceous lymphadenoma of salivary gland: a case report and a review of the literature. Acta Otorhinolaryngol Ital. 2007;27(3):147–50.PubMed
25.
go back to reference Majeed M, Murray B, Hume W, Makura Z. Sebaceous lymphadenoma of the parotid gland. Dentomaxillofac Radiol. 2008;37(5):300–4.PubMedCrossRef Majeed M, Murray B, Hume W, Makura Z. Sebaceous lymphadenoma of the parotid gland. Dentomaxillofac Radiol. 2008;37(5):300–4.PubMedCrossRef
26.
go back to reference Auclair PL. Tumor-associated lymphoid proliferation in the parotid gland. A potential diagnostic pitfall. Oral Surg Oral Med Oral Pathol. 1994;77:19–26.PubMedCrossRef Auclair PL. Tumor-associated lymphoid proliferation in the parotid gland. A potential diagnostic pitfall. Oral Surg Oral Med Oral Pathol. 1994;77:19–26.PubMedCrossRef
27.
go back to reference Bos I, Meyer S, Merz H. Lymphadenoma of the parotid gland without sebaceous differentiation, immmunohistochemical investigations. Pathologe. 2003;25:73–8.CrossRef Bos I, Meyer S, Merz H. Lymphadenoma of the parotid gland without sebaceous differentiation, immmunohistochemical investigations. Pathologe. 2003;25:73–8.CrossRef
28.
go back to reference Musthyala NB, Low SE, Seneviratne RH. Lymphadenoma of the salivary gland: a rare tumour. J Clin Pathol. 2004;57:1007.PubMedCrossRef Musthyala NB, Low SE, Seneviratne RH. Lymphadenoma of the salivary gland: a rare tumour. J Clin Pathol. 2004;57:1007.PubMedCrossRef
29.
go back to reference Ide F, Shimoyama T, Horie N, et al. Benign lymphoepithelial lesion of the parotid gland with sebaceous differentiation. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 1999;87:721–4.PubMedCrossRef Ide F, Shimoyama T, Horie N, et al. Benign lymphoepithelial lesion of the parotid gland with sebaceous differentiation. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 1999;87:721–4.PubMedCrossRef
30.
go back to reference Persichetti P, Langella M, Cogliandro A, et al. Cutaneous lymphadenoma: a rare clinicopathological entity. J Exp Clin Cancer Res. 2005;24:497–9.PubMed Persichetti P, Langella M, Cogliandro A, et al. Cutaneous lymphadenoma: a rare clinicopathological entity. J Exp Clin Cancer Res. 2005;24:497–9.PubMed
31.
go back to reference Wang H, Yao J, Solomon M, Axiotis CA. Sebaceous carcinoma of the oral cavity: a case report and review of the literature. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2010;110:e37–40.PubMedCrossRef Wang H, Yao J, Solomon M, Axiotis CA. Sebaceous carcinoma of the oral cavity: a case report and review of the literature. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2010;110:e37–40.PubMedCrossRef
32.
go back to reference Siriwardena BS, Tilakaratne WM, Rajapakshe RM. A case of sebaceous carcinoma of the parotid gland. J Oral Pathol Med. 2003;32:121–3.PubMedCrossRef Siriwardena BS, Tilakaratne WM, Rajapakshe RM. A case of sebaceous carcinoma of the parotid gland. J Oral Pathol Med. 2003;32:121–3.PubMedCrossRef
33.
go back to reference Mighell AJ, Stassen LFA, Soames JV. Sebaceous carcinoma of the parotid gland. Dentomaxillofac Radiol. 1996;25:51–4.PubMed Mighell AJ, Stassen LFA, Soames JV. Sebaceous carcinoma of the parotid gland. Dentomaxillofac Radiol. 1996;25:51–4.PubMed
34.
go back to reference Baiocco R, Palma O, Locatelli G. Squamous carcinoma of the epiglottis with sebaceous differentiation. Report of a case. Pathologica. 1995;87:531–3.PubMed Baiocco R, Palma O, Locatelli G. Squamous carcinoma of the epiglottis with sebaceous differentiation. Report of a case. Pathologica. 1995;87:531–3.PubMed
35.
go back to reference Alawi F, Siddiqui A. Sebaceous carcinoma of the oral mucosa: case report and review of the literature. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2005;99:79–84.PubMedCrossRef Alawi F, Siddiqui A. Sebaceous carcinoma of the oral mucosa: case report and review of the literature. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2005;99:79–84.PubMedCrossRef
36.
go back to reference Cohn ML, Callender DL, El-Naggar AK. Sebaceous carcinoma ex-pleomorphic adenoma: a rare phenotypic occurrence. Ann Diagn Pathol. 2004;8:224–6.PubMedCrossRef Cohn ML, Callender DL, El-Naggar AK. Sebaceous carcinoma ex-pleomorphic adenoma: a rare phenotypic occurrence. Ann Diagn Pathol. 2004;8:224–6.PubMedCrossRef
37.
go back to reference Boniuk M, Zimmerman LE. Sebaceous carcinoma of the eyelid, eyebrow, caruncle, and orbit. Trans Am Acad Ophthal Otolaryngol. 1968;72:619–42. Boniuk M, Zimmerman LE. Sebaceous carcinoma of the eyelid, eyebrow, caruncle, and orbit. Trans Am Acad Ophthal Otolaryngol. 1968;72:619–42.
38.
go back to reference Claudius K, Ginzkey C, Gattenlöhner S, Müller J, Demmer P, Bröcker E. A red cheek as first clinical sign of a sebaceous lymphadenocarcinoma of the parotid gland with lymphangiosis carcinomatosa and lymph node metastases. Am J Dermatopathol. 2011;33:e50–3.PubMedCrossRef Claudius K, Ginzkey C, Gattenlöhner S, Müller J, Demmer P, Bröcker E. A red cheek as first clinical sign of a sebaceous lymphadenocarcinoma of the parotid gland with lymphangiosis carcinomatosa and lymph node metastases. Am J Dermatopathol. 2011;33:e50–3.PubMedCrossRef
39.
go back to reference Croitoru CM, Mooney JE, Luna MA. Sebaceous lymphadenocarcinoma of salivary glands. Ann Diagn Pathol. 2003;7:236–9.PubMedCrossRef Croitoru CM, Mooney JE, Luna MA. Sebaceous lymphadenocarcinoma of salivary glands. Ann Diagn Pathol. 2003;7:236–9.PubMedCrossRef
40.
go back to reference Shukla M, Panicker S. Synchronous sebaceous lymphadenoma with squamous cell carcinoma—case report. World J Surg Oncol. 2003;1:30–3.PubMedCrossRef Shukla M, Panicker S. Synchronous sebaceous lymphadenoma with squamous cell carcinoma—case report. World J Surg Oncol. 2003;1:30–3.PubMedCrossRef
41.
go back to reference Ahn SH, Park SY. Sebaceous lymphadenocarcinoma of parotid gland. Eur Arch Otorhinolaryngol. 2006;263:940–2.PubMedCrossRef Ahn SH, Park SY. Sebaceous lymphadenocarcinoma of parotid gland. Eur Arch Otorhinolaryngol. 2006;263:940–2.PubMedCrossRef
42.
go back to reference Seethala RR, Barnes L, Hunt JL. Epithelial-myoepithelial carcinoma: a review of clinicopathologic spectrum and immunophenotypic characteristics in 61 tumors of the salivary glands and upper aerodigestive tract. Am J Surg Pathol. 2007;31:44–57.PubMedCrossRef Seethala RR, Barnes L, Hunt JL. Epithelial-myoepithelial carcinoma: a review of clinicopathologic spectrum and immunophenotypic characteristics in 61 tumors of the salivary glands and upper aerodigestive tract. Am J Surg Pathol. 2007;31:44–57.PubMedCrossRef
43.
go back to reference Uchibori N, Yoshizaki S, Shamoto M, et al. Epidermoid carcinoma arising in parotid adenolymphomatous lesion with microdeposit of amyloid substance. Acta Pathol Jpn. 1983;33:141–6.PubMed Uchibori N, Yoshizaki S, Shamoto M, et al. Epidermoid carcinoma arising in parotid adenolymphomatous lesion with microdeposit of amyloid substance. Acta Pathol Jpn. 1983;33:141–6.PubMed
44.
go back to reference Li J, Wang BY, Nelson M, et al. Salivary adenocarcinoma, not otherwise specified: a collection of orphans. Arch Pathol Lab Med. 2004;128:1385–94.PubMed Li J, Wang BY, Nelson M, et al. Salivary adenocarcinoma, not otherwise specified: a collection of orphans. Arch Pathol Lab Med. 2004;128:1385–94.PubMed
45.
go back to reference Klieb HBE, Peerez-Ordonez B. Oncocytic lipoadenoma of the parotid gland with sebaceous differentiation. Study of its keratin profile. Virchows Arch. 2006;449:722–5.PubMedCrossRef Klieb HBE, Peerez-Ordonez B. Oncocytic lipoadenoma of the parotid gland with sebaceous differentiation. Study of its keratin profile. Virchows Arch. 2006;449:722–5.PubMedCrossRef
46.
go back to reference Nagao T, Sugano I, Ishida Y, et al. Sialolipoma: a report of seven cases of a new variant of salivary gland lipoma. Histopathology. 2001;38:30–6.PubMedCrossRef Nagao T, Sugano I, Ishida Y, et al. Sialolipoma: a report of seven cases of a new variant of salivary gland lipoma. Histopathology. 2001;38:30–6.PubMedCrossRef
47.
go back to reference Siddiqui NH, Wu S-J. Fine-needle aspiration biopsy of cystic pleomorphic adenoma with adnexal-like differentiation mimicking mucoepidermoid carcinoma: a case report. Diagn Cytopathol. 2005;32:229–32.PubMedCrossRef Siddiqui NH, Wu S-J. Fine-needle aspiration biopsy of cystic pleomorphic adenoma with adnexal-like differentiation mimicking mucoepidermoid carcinoma: a case report. Diagn Cytopathol. 2005;32:229–32.PubMedCrossRef
48.
go back to reference Kadivar M, Shahzadi SZ, Javadi M. Sialolipoma of the parotid gland with diffuse sebaceous differentiation in a female child. Pediatr Dev Pathol. 2007;10(2):138–41.PubMedCrossRef Kadivar M, Shahzadi SZ, Javadi M. Sialolipoma of the parotid gland with diffuse sebaceous differentiation in a female child. Pediatr Dev Pathol. 2007;10(2):138–41.PubMedCrossRef
49.
go back to reference Pusiol T, Franceschetti I, Scialpi M, Piscioli I. Oncocytic sialolipoma of the submandibular gland with sebaceous differentiation: a new pathological entity. Indian J Pathol Microbiol. 2009;52:379–82.PubMedCrossRef Pusiol T, Franceschetti I, Scialpi M, Piscioli I. Oncocytic sialolipoma of the submandibular gland with sebaceous differentiation: a new pathological entity. Indian J Pathol Microbiol. 2009;52:379–82.PubMedCrossRef
50.
go back to reference Ilie M, Hofman V, Pedeutour F, Attias R, Santini J, Hofman P. Oncocytic lipoadenoma of the parotid gland: immunohistochemical and cytogenetic analysis. Pathol Res Pract. 2010;206(1):66–72.PubMedCrossRef Ilie M, Hofman V, Pedeutour F, Attias R, Santini J, Hofman P. Oncocytic lipoadenoma of the parotid gland: immunohistochemical and cytogenetic analysis. Pathol Res Pract. 2010;206(1):66–72.PubMedCrossRef
51.
go back to reference McNeil ML, Bullock MJ, Trites JR, Hart RD, Taylor SM. Oncocytic lipoadenoma of the parotid gland with sebaceous differentiation in a 73-year-old male. J Otolaryngol Head Neck Surg. 2010;39(5):E48–50.PubMed McNeil ML, Bullock MJ, Trites JR, Hart RD, Taylor SM. Oncocytic lipoadenoma of the parotid gland with sebaceous differentiation in a 73-year-old male. J Otolaryngol Head Neck Surg. 2010;39(5):E48–50.PubMed
52.
go back to reference Laury AR, Perets R, Piao H, et al. A comprehensive analysis of PAX8 expression in human epithelial tumors. Am J Surg Pathol. 2011;35:816–26.PubMedCrossRef Laury AR, Perets R, Piao H, et al. A comprehensive analysis of PAX8 expression in human epithelial tumors. Am J Surg Pathol. 2011;35:816–26.PubMedCrossRef
53.
go back to reference Ozcan A, Shen SS, Hamilton C, et al. Pax 8 expression in non-neoplastic tissues, primary tumors, and metastatic tumors: a comprehensive immunohistochemical study. Mod Pathol. 2011;24:751–64.PubMedCrossRef Ozcan A, Shen SS, Hamilton C, et al. Pax 8 expression in non-neoplastic tissues, primary tumors, and metastatic tumors: a comprehensive immunohistochemical study. Mod Pathol. 2011;24:751–64.PubMedCrossRef
54.
go back to reference Ivan D, Nash JW, Prieto VG, et al. Use of p63 expression in distinguishing primary and metastatic cutaneous adnexal neoplasms from metastatic adenocarcinoma to skin. J Cutan Pathol. 2007;34:474–80.PubMedCrossRef Ivan D, Nash JW, Prieto VG, et al. Use of p63 expression in distinguishing primary and metastatic cutaneous adnexal neoplasms from metastatic adenocarcinoma to skin. J Cutan Pathol. 2007;34:474–80.PubMedCrossRef
55.
go back to reference McHugh JB, Hoschar AP, Dvorakova M, et al. p63 immunohistochemistry differentiates salivary gland oncocytoma and oncocytic carcinoma from metastatic renal cell carcinoma. Head Neck Pathol. 2007;1:123–31.PubMedCrossRef McHugh JB, Hoschar AP, Dvorakova M, et al. p63 immunohistochemistry differentiates salivary gland oncocytoma and oncocytic carcinoma from metastatic renal cell carcinoma. Head Neck Pathol. 2007;1:123–31.PubMedCrossRef
56.
go back to reference Qureshi HS, Ormsby AH, Lee MW, Zarbo RJ, Ma CK. The diagnostic utility of p63, CK5/6, CK 7, and CK 20 in distinguishing primary cutaneous adnexal neoplasms from metastatic carcinomas. J Cutan Pathol. 2004;31:145–52.PubMedCrossRef Qureshi HS, Ormsby AH, Lee MW, Zarbo RJ, Ma CK. The diagnostic utility of p63, CK5/6, CK 7, and CK 20 in distinguishing primary cutaneous adnexal neoplasms from metastatic carcinomas. J Cutan Pathol. 2004;31:145–52.PubMedCrossRef
57.
go back to reference Plaza JA, Ortega PF, Stockman DL, Suster S. Value of p63 and podoplanin (D2-40) immunoreactivity in the distinction between primary cutaneous tumors and adenocarcinomas metastatic to the skin: a clinicopathologic and immunohistochemical study of 79 cases. J Cutan Pathol. 2010;37:403–10.PubMedCrossRef Plaza JA, Ortega PF, Stockman DL, Suster S. Value of p63 and podoplanin (D2-40) immunoreactivity in the distinction between primary cutaneous tumors and adenocarcinomas metastatic to the skin: a clinicopathologic and immunohistochemical study of 79 cases. J Cutan Pathol. 2010;37:403–10.PubMedCrossRef
58.
go back to reference Ostler DA, Prieto VG, Reed JA, et al. Adipophilin expression in sebaceous tumors and other cutaneous lesions with clear cell histology: an immunohistochemical study of 117 cases. Mod Pathol. 2010;23:567–73.PubMedCrossRef Ostler DA, Prieto VG, Reed JA, et al. Adipophilin expression in sebaceous tumors and other cutaneous lesions with clear cell histology: an immunohistochemical study of 117 cases. Mod Pathol. 2010;23:567–73.PubMedCrossRef
59.
go back to reference Muthusamy K, Halbert G, Roberts F, et al. Immunohistochemical staining for adipophilin, perilipin and TIP47. J Clin Pathol. 2006;59:1166–70.PubMedCrossRef Muthusamy K, Halbert G, Roberts F, et al. Immunohistochemical staining for adipophilin, perilipin and TIP47. J Clin Pathol. 2006;59:1166–70.PubMedCrossRef
60.
go back to reference Ansai S, Takeichi H, Arase S, et al. Sebaceous carcinoma: an immunohistochemical reappraisal. Am J Dermatopathol. 2011;33(6):579–87.PubMedCrossRef Ansai S, Takeichi H, Arase S, et al. Sebaceous carcinoma: an immunohistochemical reappraisal. Am J Dermatopathol. 2011;33(6):579–87.PubMedCrossRef
61.
go back to reference Izumi M, Mukai K, Nagai T, et al. Sebaceous carcinoma of the eyelids: thirty cases from Japan. Pathol Int. 2008;58:483–8.PubMedCrossRef Izumi M, Mukai K, Nagai T, et al. Sebaceous carcinoma of the eyelids: thirty cases from Japan. Pathol Int. 2008;58:483–8.PubMedCrossRef
62.
go back to reference Shinozaki A, Nagao T, Endo H, et al. Sebaceous epithelial-myoepithelial carcinoma of the salivary gland: clinicopathologic and immunohistochemical analysis of 6 cases of a new histologic variant. Am J Surg Pathol. 2008;32(6):913–23.PubMedCrossRef Shinozaki A, Nagao T, Endo H, et al. Sebaceous epithelial-myoepithelial carcinoma of the salivary gland: clinicopathologic and immunohistochemical analysis of 6 cases of a new histologic variant. Am J Surg Pathol. 2008;32(6):913–23.PubMedCrossRef
63.
go back to reference Oshiro H, Iwai T, Hirota M, et al. Primary sebaceous carcinoma of the tongue. Med Mol Morphol. 2010;43:246–52.PubMedCrossRef Oshiro H, Iwai T, Hirota M, et al. Primary sebaceous carcinoma of the tongue. Med Mol Morphol. 2010;43:246–52.PubMedCrossRef
64.
go back to reference Rangel J, McCalmont T. Intracytoplasmic adipophilin immunopositivity: A pitfall in the distinction of metastatic renal carcinoma from sebaceous carcinoma. J Cutan Pathol. 2010;37:1194–5.CrossRef Rangel J, McCalmont T. Intracytoplasmic adipophilin immunopositivity: A pitfall in the distinction of metastatic renal carcinoma from sebaceous carcinoma. J Cutan Pathol. 2010;37:1194–5.CrossRef
Metadata
Title
My Journey into the World of Salivary Gland Sebaceous Neoplasms
Author
Douglas R. Gnepp
Publication date
01-03-2012
Publisher
Springer US
Published in
Head and Neck Pathology / Issue 1/2012
Electronic ISSN: 1936-0568
DOI
https://doi.org/10.1007/s12105-012-0343-x

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