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01-09-2012 | Original Paper

Comparison of Myofibroblasts Expression in Oral Squamous Cell Carcinoma, Verrucous Carcinoma, High Risk Epithelial Dysplasia, Low Risk Epithelial Dysplasia and Normal Oral Mucosa

Authors: Minal Chaudhary, Amol Ramchandra Gadbail, Gaurav Vidhale, Mugdha P. Mankar (Gadbail), Shailesh M. Gondivkar, Madhuri Gawande, Swati Patil

Published in: Head and Neck Pathology | Issue 3/2012

Abstract

The aim was to evaluate and compare the presence of myofibroblasts in oral squamous cell carcinoma (OSCC), verrucous carcinoma (VC), high-risk epithelial dysplasia (HRED), low-risk epithelial dysplasia (LRED), and normal oral mucosa (NOM). The study consisted of 37 OSCC, 15 VC, 15 HRED, 15 LRED and 15 NOM. α-smooth muscle actin (α-SMA) antibody was used to identify myofibroblasts. The α-SMA expression was not observed in NOM and LRED. The α-SMA was expressed in 97.29% of OSCC, 86.66% of VC, 46.66 % of HRED. The α-SMA expression was significantly higher in OSCC than VC (p = 0.023) and HRED (p < 0.000). The α-SMA expression was significantly higher in VC than HRED (p = 0.043). Myofibroblastic expression, as highlighted by α-SMA, is undetectable in NOM and LRED but increases as the disease progresses from potentially malignant disorders, as HRED to VC to invasive OSCC. Thus, proliferation of myofibroblasts may be used as a stromal marker of oral premalignancy and malignancy.

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Title: Comparison of Myofibroblasts Expression in Oral Squamous Cell Carcinoma, Verrucous Carcinoma, High Risk Epithelial Dysplasia, Low Risk Epithelial Dysplasia and Normal Oral Mucosa
Authors: Minal Chaudhary
Amol Ramchandra Gadbail
Gaurav Vidhale
Mugdha P. Mankar (Gadbail)
Shailesh M. Gondivkar
Madhuri Gawande
Swati Patil
Publication date: 01-09-2012
Publisher: Springer US
Published in: Head and Neck Pathology / Issue 3/2012
Electronic ISSN: 1936-0568
DOI: https://doi.org/10.1007/s12105-012-0335-x

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Comparison of Myofibroblasts Expression in Oral Squamous Cell Carcinoma, Verrucous Carcinoma, High Risk Epithelial Dysplasia, Low Risk Epithelial Dysplasia and Normal Oral Mucosa

Abstract

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