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09-04-2024 | Iron Deficiency Anemia | Scientific Letter

Coexistence of Severe Iron Deficiency Anemia in Adolescent Girls with Exonic Variants Linked to Membranopathies

Authors: Subrahamanyam Dantham, Indraja Gaddam

Published in: Indian Journal of Pediatrics | Issue 6/2024

Excerpt

To the Editor: Iron deficiency remains a major contributor to anemia in Indian children and adolescents. Despite iron supplementation, many with iron deficiency anemia (IDA) show limited improvement [1, 2]. This suggests that IDA may be compounded by other factors, possibly mutation in genes related to erythrocyte structure and function [3]. Most of these coding (exonic) variants are dominant, causing moderate to severe phenotypes with varying degrees of hemolytic episodes when triggered by external factors, further exacerbating the existing nutritional deficiency [4]. …

Chakrabarty M, Singh A, Singh S, Chowdhury S. Is the burden of anaemia among Indian adolescent women increasing? Evidence from Indian demographic and health surveys (2015–21). PLOS Glob Public Health. 2023;3:e0002117.CrossRefPubMedPubMedCentral

Rai RK, Fawzi WW, Barik A, Chowdhury A. The burden of iron-deficiency anaemia among women in India: how have iron and folic acid interventions fared? WHO South East Asia. J Public Health. 2018;7:18–23.

Beaton G, McCabe G. Efficacy of intermittent iron supplementation in the control of iron deficiency anaemia in developing countries. An analysis of experience: final report to the Micronutrient Initiative. 1999. Available at: https://www.semanticscholar.org/paper/Efficacy-of-intermittent-iron-supplementation-in-of-Beaton-McCabe/e519f9ce280b6eeb9bfe1c81f98a2395c9f5c26b. Accessed on 11 Sept 2023.

Aggarwal A, Jamwal M, Sharma P, et al. Deciphering molecular heterogeneity of Indian families with hereditary spherocytosis using targeted next-generation sequencing: first south Asian study. Br J Haematol. 2020;188:784–95.CrossRefPubMed

Title: Coexistence of Severe Iron Deficiency Anemia in Adolescent Girls with Exonic Variants Linked to Membranopathies
Authors: Subrahamanyam Dantham
Indraja Gaddam
Publication date: 09-04-2024
Publisher: Springer India
Keywords: Iron Deficiency Anemia
Anemia
Published in: Indian Journal of Pediatrics / Issue 6/2024
Print ISSN: 0019-5456
Electronic ISSN: 0973-7693
DOI: https://doi.org/10.1007/s12098-024-05117-x

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Coexistence of Severe Iron Deficiency Anemia in Adolescent Girls with Exonic Variants Linked to Membranopathies

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