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Indian Journal of Pediatrics
Published in: Indian Journal of Pediatrics 10/2015

01-10-2015 | Review Article

Sleep Disordered Breathing in Children

Authors: Christopher Grime, Hui-leng Tan

Published in: Indian Journal of Pediatrics | Issue 10/2015

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Abstract

Sleep-disordered breathing (SDB) refers to a group of disorders characterized by abnormalities of respiration or ventilation during sleep. It encompasses obstructive sleep apnea (OSA), central sleep apnea (CSA) syndromes, sleep-related hypoventilation and sleep-related hypoxemia disorders. This review will concentrate on the disorder most prevalent in pediatrics, i.e., OSA, highlighting the most recent developments in our understanding of the etiology, pathophysiology and treatment options of this condition. OSA morbidities primarily involve the neurocognitive, cardiovascular and metabolic systems. However, there can be significant phenotypic variation in terms of end organ morbidity for the same OSA severity. This is likely due to the interplay between genetic and environmental factors; recent developments in the fields of genomics and proteomics have the potential to shed light on these complex pathological cascades. As we enter the era of personalized medicine, phenotyping patients to enable clinicians to tailor bespoke clinical management plans will be of crucial importance.
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Metadata
Title
Sleep Disordered Breathing in Children
Authors
Christopher Grime
Hui-leng Tan
Publication date
01-10-2015
Publisher
Springer India
Published in
Indian Journal of Pediatrics / Issue 10/2015
Print ISSN: 0019-5456
Electronic ISSN: 0973-7693
DOI
https://doi.org/10.1007/s12098-015-1857-5

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