Skip to main content
Top
Published in: Indian Journal of Pediatrics 7/2014

01-07-2014 | Original Article

Serum 25 Hydroxy Vitamin D Insufficiency Associated with Bronchial Asthma in Lucknow, India

Authors: Shally Awasthi, Kumar Vikram

Published in: Indian Journal of Pediatrics | Issue 7/2014

Login to get access

Abstract

Objectives

To assess the association between serum 25 hydroxy vitamin D levels and asthma and its control in Indian children.

Methods

This was a prospective case–control study conducted in tertiary care hospital. Cases of asthma and healthy age-matched controls were included, aged 1–15 y, who had not received any vitamin D supplementation in the last year and had no other co-morbidity, after obtaining written informed parental consent. 25 hydroxy vitamin D insufficiency was taken below level of ≤ 30 ng/mL.

Results

Fifty asthmatics and 25 age-matched controls were recruited from August 2011–July 2012. 25 hydroxy vitamin D insufficiency was associated with occurrence of asthma (OR = 13.5; 95 % CI = 4.25–42.85: p = 0.000). With decreasing level of asthma control there was increasing strength of association with 25 hydroxy vitamin D insufficiency [χ 2 for trend = 24.96 (p = 0.000)].

Conclusions

25 hydroxy vitamin D insufficiency is associated with bronchial asthma as well as its level of control.
Literature
1.
go back to reference Bisgaard H, Szefler S. Prevalence of asthma-like symptoms in young children. Pediatr Pulmonol. 2007;42:723–8.PubMedCrossRef Bisgaard H, Szefler S. Prevalence of asthma-like symptoms in young children. Pediatr Pulmonol. 2007;42:723–8.PubMedCrossRef
3.
go back to reference Awasthi S, Kalra E, Roy S, Awasthi S. Prevalence and risk factors of asthma and wheeze in school going children in Lucknow, North India. Indian Pediatr. 2004;41:1205–10.PubMed Awasthi S, Kalra E, Roy S, Awasthi S. Prevalence and risk factors of asthma and wheeze in school going children in Lucknow, North India. Indian Pediatr. 2004;41:1205–10.PubMed
4.
go back to reference Singh M, Singh SP, Singh K, Bhatia AS, Kajal NC, Aggarwal D, et al. Prevalence of bronchial asthma among school children in urban and rural areas. Chest. 2004;126:762S. Singh M, Singh SP, Singh K, Bhatia AS, Kajal NC, Aggarwal D, et al. Prevalence of bronchial asthma among school children in urban and rural areas. Chest. 2004;126:762S.
5.
6.
go back to reference Busse WW, Lemanske RF Jr. Asthma. N Engl J Med. 2001;344:350–62. Busse WW, Lemanske RF Jr. Asthma. N Engl J Med. 2001;344:350–62.
7.
go back to reference Sandhu MS, Casale TB. The role of vitamin D in asthma. Ann Allergy Asthma Immunol. 2010;105:191–9.PubMedCrossRef Sandhu MS, Casale TB. The role of vitamin D in asthma. Ann Allergy Asthma Immunol. 2010;105:191–9.PubMedCrossRef
9.
go back to reference Bischoff-Ferrari HA, Giovannucci E, Willett WC, Dietrich T, Dawson-Hughes B. Estimation of optimal serum concentrations of 25-hydroxyvitamin D for multiple health outcomes. Am J Clin Nutr. 2006;84:18–28.PubMed Bischoff-Ferrari HA, Giovannucci E, Willett WC, Dietrich T, Dawson-Hughes B. Estimation of optimal serum concentrations of 25-hydroxyvitamin D for multiple health outcomes. Am J Clin Nutr. 2006;84:18–28.PubMed
10.
go back to reference Smith HG Jr, Bauer PJ. Light-induced permeability changes in sonicated bovine disks: Arsenazo III and flow system measurements. Biochemistry. 1979;18:5067–73. Smith HG Jr, Bauer PJ. Light-induced permeability changes in sonicated bovine disks: Arsenazo III and flow system measurements. Biochemistry. 1979;18:5067–73.
11.
go back to reference Daly JA, Ertingshausen G. Direct method for determining inorganic phosphate in serum with the “CentrifiChem”. Clin Chem. 1972;18:263–5.PubMed Daly JA, Ertingshausen G. Direct method for determining inorganic phosphate in serum with the “CentrifiChem”. Clin Chem. 1972;18:263–5.PubMed
12.
go back to reference Rosalki SB, Foo AY, Burlina A, Prellwitz W, Stieber P, Neumeier D, et al. Multicenter evaluation of Iso-ALP test kit for measurement of bone alkaline phosphatase activity in serum and plasma. Clin Chem. 1993;39:648–52.PubMed Rosalki SB, Foo AY, Burlina A, Prellwitz W, Stieber P, Neumeier D, et al. Multicenter evaluation of Iso-ALP test kit for measurement of bone alkaline phosphatase activity in serum and plasma. Clin Chem. 1993;39:648–52.PubMed
13.
go back to reference Alyasin S, Momen T, Kashef S, Alipour A, Amin R. The relationship between serum 25-hydroxy vitamin D levels and asthma in children. Allergy Asthma Immunol Res. 2011;3:251–5.PubMedCentralPubMedCrossRef Alyasin S, Momen T, Kashef S, Alipour A, Amin R. The relationship between serum 25-hydroxy vitamin D levels and asthma in children. Allergy Asthma Immunol Res. 2011;3:251–5.PubMedCentralPubMedCrossRef
14.
go back to reference Maalmi H, Berraïes A, Tangour E, Ammar J, Abid H, Hamzaoui K, et al. The impact of vitamin D deficiency on immune T cells on asthmatic children: A case–control study. J Asthma Allergy. 2012;5:11–9. Maalmi H, Berraïes A, Tangour E, Ammar J, Abid H, Hamzaoui K, et al. The impact of vitamin D deficiency on immune T cells on asthmatic children: A case–control study. J Asthma Allergy. 2012;5:11–9.
15.
go back to reference Camargo CA Jr, Ingham T, Wickens K, Thadhani R, Silvers KM, Epton MJ, et al; New Zealand Asthma and Allergy Cohort Study Group. Cord-blood 25-hydroxyvitamin D levels and risk of respiratory infection, wheezing, and asthma. Pediatrics. 2011;127:e180–7. Camargo CA Jr, Ingham T, Wickens K, Thadhani R, Silvers KM, Epton MJ, et al; New Zealand Asthma and Allergy Cohort Study Group. Cord-blood 25-hydroxyvitamin D levels and risk of respiratory infection, wheezing, and asthma. Pediatrics. 2011;127:e180–7.
16.
go back to reference Menon J, Maranda L, Noose BU. Serum 25-hydroxyvitamin D levels do not correlate with asthma severity in a case-controlled study of children and adolescents. J Pediatr Endocrinol Metab. 2012;25:673–9.PubMed Menon J, Maranda L, Noose BU. Serum 25-hydroxyvitamin D levels do not correlate with asthma severity in a case-controlled study of children and adolescents. J Pediatr Endocrinol Metab. 2012;25:673–9.PubMed
17.
go back to reference Tiwari S, Kumar R, Singla S, Dudeja A, Nangia S, Sailli A. Congenital rickets presenting as refractory respiratory distress at birth. Indian J Pediatr. 2013. [Epub ahead of print]. Tiwari S, Kumar R, Singla S, Dudeja A, Nangia S, Sailli A. Congenital rickets presenting as refractory respiratory distress at birth. Indian J Pediatr. 2013. [Epub ahead of print].
18.
go back to reference Ozaydin E, Butun MF, Kakir BC, Kose G. The association between vitamin D status and recurrent wheezing. Indian J Pediatr. 2013;80:907–10.PubMedCrossRef Ozaydin E, Butun MF, Kakir BC, Kose G. The association between vitamin D status and recurrent wheezing. Indian J Pediatr. 2013;80:907–10.PubMedCrossRef
19.
go back to reference Chinellato I, Piazza M, Sandri M, Peroni D, Piacentini G, Boner AL. Vitamin D serum levels and markers of asthma control in Italian children. J Pediatr. 2011;158:437–41.PubMedCrossRef Chinellato I, Piazza M, Sandri M, Peroni D, Piacentini G, Boner AL. Vitamin D serum levels and markers of asthma control in Italian children. J Pediatr. 2011;158:437–41.PubMedCrossRef
20.
go back to reference Gupta A, Sjoukes A, Richards D, Banya W, Hawrylowicz C, Bush A, et al. Relationship between srerum vitamin D, disease severity, and airway remodelling in children with asthma. Am J Respir Crit Care Med. 2011;184:1342–9.PubMedCentralPubMedCrossRef Gupta A, Sjoukes A, Richards D, Banya W, Hawrylowicz C, Bush A, et al. Relationship between srerum vitamin D, disease severity, and airway remodelling in children with asthma. Am J Respir Crit Care Med. 2011;184:1342–9.PubMedCentralPubMedCrossRef
21.
go back to reference Hansdottir S, Monick MM, Lovan N, Powers L, Gerke A, Hunninghake GW. Vitamin D decreases respiratory syncytial virus induction of NF-kappaB-linked chemokines and cytokines in airway epithelium while maintaining the antiviral state. J Immunol. 2010;184:965–74.PubMedCentralPubMedCrossRef Hansdottir S, Monick MM, Lovan N, Powers L, Gerke A, Hunninghake GW. Vitamin D decreases respiratory syncytial virus induction of NF-kappaB-linked chemokines and cytokines in airway epithelium while maintaining the antiviral state. J Immunol. 2010;184:965–74.PubMedCentralPubMedCrossRef
22.
go back to reference Adams JS, Hewison M. Unexpected actions of vitamin D: New perspectives on the regulation of innate and adaptive immunity. Nat Clin Pract Endocrinol Metab. 2008;4:80–90. Adams JS, Hewison M. Unexpected actions of vitamin D: New perspectives on the regulation of innate and adaptive immunity. Nat Clin Pract Endocrinol Metab. 2008;4:80–90.
23.
go back to reference Khadilkar VV, Khadilkar AV. Use of vitamin D in various disorders. Indian J Pediatr. 2013;80:215–8. Khadilkar VV, Khadilkar AV. Use of vitamin D in various disorders. Indian J Pediatr. 2013;80:215–8.
24.
go back to reference Wayse V, Yousafzai A, Mogale K, Filteau S. Association of subclinical vitamin D deficiency with severe acute lower respiratory infection in Indian children under 5 y. Eur J Clin Nutr. 2004;58:563–7.PubMedCrossRef Wayse V, Yousafzai A, Mogale K, Filteau S. Association of subclinical vitamin D deficiency with severe acute lower respiratory infection in Indian children under 5 y. Eur J Clin Nutr. 2004;58:563–7.PubMedCrossRef
25.
go back to reference Ginde AA, Mansbach JM, Camargo CA Jr. Association between serum 25-dydroxyvitamin D level and upper respiratory tract infection in the Third National Health and Nutrition Examination Survey. Arch Intern Med. 2009;169:384–90. Ginde AA, Mansbach JM, Camargo CA Jr. Association between serum 25-dydroxyvitamin D level and upper respiratory tract infection in the Third National Health and Nutrition Examination Survey. Arch Intern Med. 2009;169:384–90.
26.
go back to reference Searing DA, Zhang Y, Murphy JR, Hauk PJ, Goleva E, Leung DY. Decreased serum vitamin D levels in children with asthma are associated with increased corticosteroid use. J Allergy Clin Immunol. 2010;125:995–1000.PubMedCentralPubMedCrossRef Searing DA, Zhang Y, Murphy JR, Hauk PJ, Goleva E, Leung DY. Decreased serum vitamin D levels in children with asthma are associated with increased corticosteroid use. J Allergy Clin Immunol. 2010;125:995–1000.PubMedCentralPubMedCrossRef
27.
go back to reference Song Y, Qi H, Wu C. Effect of 1,25-(OH)2D3 (a vitamin D analogue) on passively sensitized human airway smooth muscle cells. Respirology. 2007;12:486–94.PubMedCrossRef Song Y, Qi H, Wu C. Effect of 1,25-(OH)2D3 (a vitamin D analogue) on passively sensitized human airway smooth muscle cells. Respirology. 2007;12:486–94.PubMedCrossRef
28.
go back to reference Awasthi S, Tripathi P, Ganesh S, Husain N. Associaton of ADAM33 gene polymorphisms with asthma in Indian children. J Hum Genet. 2011;56:188–95.PubMedCrossRef Awasthi S, Tripathi P, Ganesh S, Husain N. Associaton of ADAM33 gene polymorphisms with asthma in Indian children. J Hum Genet. 2011;56:188–95.PubMedCrossRef
29.
go back to reference Brehm JM, Celedón JC, Soto-Quiros ME, Avila L, Hunninghake GM, Forno E, et al. Serum vitamin D levels and markers of severity of childhood asthma in Costa Rica. Am J Respir Crit Care Med. 2009;179:765–71.PubMedCentralPubMedCrossRef Brehm JM, Celedón JC, Soto-Quiros ME, Avila L, Hunninghake GM, Forno E, et al. Serum vitamin D levels and markers of severity of childhood asthma in Costa Rica. Am J Respir Crit Care Med. 2009;179:765–71.PubMedCentralPubMedCrossRef
Metadata
Title
Serum 25 Hydroxy Vitamin D Insufficiency Associated with Bronchial Asthma in Lucknow, India
Authors
Shally Awasthi
Kumar Vikram
Publication date
01-07-2014
Publisher
Springer India
Published in
Indian Journal of Pediatrics / Issue 7/2014
Print ISSN: 0019-5456
Electronic ISSN: 0973-7693
DOI
https://doi.org/10.1007/s12098-013-1310-6

Other articles of this Issue 7/2014

Indian Journal of Pediatrics 7/2014 Go to the issue