Skip to main content
Top
Published in: Indian Journal of Pediatrics 11/2011

01-11-2011 | Original Article

Health Consequences of Childhood Obesity

Authors: Anindya Kumar Saha, Neille Sarkar, Tapabrata Chatterjee

Published in: Indian Journal of Pediatrics | Issue 11/2011

Login to get access

Abstract

Objectives

To evaluate the cardiovascular and endocrine effects of childhood obesity as well as prevalence of metabolic syndrome associated with it.

Methods

49 obese and overweight children aged between 6 and 11 years as study group and 45 healthy non-obese controls of same age were selected for the study. Both the groups were evaluated for height, weight, BMI, waist circumference, blood pressure, fasting serum lipid fractions, insulin level, fasting and post-prandial blood glucose and C-reactive protein. Screening for metabolic syndrome was performed following most acceptable criteria.

Results

The study group children had significantly higher blood pressure, altered lipid fractions and high C-reactive Protein. Criteria-wise insulin resistance, hypertriglyceridemia and low high density lipoprotein also were found at significantly higher rate among obese children. The metabolic syndrome existed at a high prevalence of 14.1% in the study group.

Conclusions

Obesity in childhood causes cardiovascular and endocrine dysregulation with onset of insulin resistance and metabolic syndrome even in absence of significant evidence of hypertension and type 2 diabetes mellitus in this age group.
Literature
1.
go back to reference Marwaha RK, Tandon N, Singh Y, Aggarwal R, Grewal K, Mani K. A study of growth parameters and prevalence of overweight and obesity in school children from Delhi. Indian Pediatr. 2006;43:943–52.PubMed Marwaha RK, Tandon N, Singh Y, Aggarwal R, Grewal K, Mani K. A study of growth parameters and prevalence of overweight and obesity in school children from Delhi. Indian Pediatr. 2006;43:943–52.PubMed
2.
go back to reference Srinivasan SR, Myers L, Berenson GS. Predictability of childhood adiposity and insulin for developing insulin resistance syndrome (syndrome X) in young adulthood. The Bogalusa Heart Study. Diabetes. 2002;51:204–9.PubMedCrossRef Srinivasan SR, Myers L, Berenson GS. Predictability of childhood adiposity and insulin for developing insulin resistance syndrome (syndrome X) in young adulthood. The Bogalusa Heart Study. Diabetes. 2002;51:204–9.PubMedCrossRef
4.
go back to reference Cole TJ, Bellizzi MC, Flegal KM, Dietz WH. Establishing a standard definition for child overweight and obesity worldwide: International Survey. BMJ. 2000;320:1240–3.PubMedCrossRef Cole TJ, Bellizzi MC, Flegal KM, Dietz WH. Establishing a standard definition for child overweight and obesity worldwide: International Survey. BMJ. 2000;320:1240–3.PubMedCrossRef
5.
go back to reference Fernandez JR, Redden DT, Pietrobelli A, Allison DB. Waist circumference percentiles in nationally representative sample of African-American, European-American and Mexican-American children and adolescents. J Pediatr. 2004;145:439–44.PubMedCrossRef Fernandez JR, Redden DT, Pietrobelli A, Allison DB. Waist circumference percentiles in nationally representative sample of African-American, European-American and Mexican-American children and adolescents. J Pediatr. 2004;145:439–44.PubMedCrossRef
6.
go back to reference Executive Summary of the Third Report of the National Cholesterol Education Program(NCEP) Expert Panel on Detection, Education & Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III). JAMA 2001;285:2485–97. Executive Summary of the Third Report of the National Cholesterol Education Program(NCEP) Expert Panel on Detection, Education & Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III). JAMA 2001;285:2485–97.
7.
go back to reference Weiss R, Dziura J, Burgert T, et al. Obesity and the metabolic syndrome in children and adolescents. New Engl J Med. 2004;350:2362–74.PubMedCrossRef Weiss R, Dziura J, Burgert T, et al. Obesity and the metabolic syndrome in children and adolescents. New Engl J Med. 2004;350:2362–74.PubMedCrossRef
8.
go back to reference Matthews DR, Hosker JP, Rudenski AS, Naylor BA, Treacher DF, Turner RC. Homeostasis model assessment: insulin resistance and beta cell function from fasting plasma glucose and insulin concentration in man. Diabetologia. 1985;28:412–9.PubMedCrossRef Matthews DR, Hosker JP, Rudenski AS, Naylor BA, Treacher DF, Turner RC. Homeostasis model assessment: insulin resistance and beta cell function from fasting plasma glucose and insulin concentration in man. Diabetologia. 1985;28:412–9.PubMedCrossRef
9.
go back to reference De Ferranti SD, Gauvreau K, Ludwig DS, Neufeld EJ, Newburger JW, Rifai N. Prevalence of the metabolic syndrome in American adolescents: findings from the Third National Health and Nutrition Examination Survey. Circulation. 2004;110:2494–7.PubMedCrossRef De Ferranti SD, Gauvreau K, Ludwig DS, Neufeld EJ, Newburger JW, Rifai N. Prevalence of the metabolic syndrome in American adolescents: findings from the Third National Health and Nutrition Examination Survey. Circulation. 2004;110:2494–7.PubMedCrossRef
10.
go back to reference He Q, Ding ZY, Fong DY, Karlberg J. Blood pressure is associated with body mass index in both normal and obese children. Hypertension. 2000;36:165–70.PubMed He Q, Ding ZY, Fong DY, Karlberg J. Blood pressure is associated with body mass index in both normal and obese children. Hypertension. 2000;36:165–70.PubMed
11.
go back to reference Gupta AK, Ahmed AJ. Childhood obesity and hypertension. Indian Pediatr. 1990;27:333–7.PubMed Gupta AK, Ahmed AJ. Childhood obesity and hypertension. Indian Pediatr. 1990;27:333–7.PubMed
12.
go back to reference Viner RM, Segal TY, Lichtarowicz-Krynska E, Hindmarsh P. Prevalence of insulin resistance syndrome in obesity. Arch Dis Child. 2005;90:10–4.PubMedCrossRef Viner RM, Segal TY, Lichtarowicz-Krynska E, Hindmarsh P. Prevalence of insulin resistance syndrome in obesity. Arch Dis Child. 2005;90:10–4.PubMedCrossRef
13.
go back to reference Garcés C, Gutierrez-Guisado J, Benavente M, et al. Obesity in Spanish school children: relationship with lipid profile and insulin resistance. Obes Res. 2005;13:959–63.PubMedCrossRef Garcés C, Gutierrez-Guisado J, Benavente M, et al. Obesity in Spanish school children: relationship with lipid profile and insulin resistance. Obes Res. 2005;13:959–63.PubMedCrossRef
14.
go back to reference Stensel DJ, Lin FP, Ho TF, Aw TC. Serum lipids, serum insulin, plasma fibrinogen and aerobic capacity in obese & non-obese Singaporean boys. Int J Obes Relat Metab Disord. 2001;25:984–9.PubMedCrossRef Stensel DJ, Lin FP, Ho TF, Aw TC. Serum lipids, serum insulin, plasma fibrinogen and aerobic capacity in obese & non-obese Singaporean boys. Int J Obes Relat Metab Disord. 2001;25:984–9.PubMedCrossRef
15.
go back to reference Horri M, Vakili R. Evaluation of cardiovascular and lipid profile abnormalities in obese children and adolescents. Iran J Med Sci. 2006;31:87–90. Horri M, Vakili R. Evaluation of cardiovascular and lipid profile abnormalities in obese children and adolescents. Iran J Med Sci. 2006;31:87–90.
16.
go back to reference Shea S, Aymong E, Zybert P, et al. Obesity, fasting plasma insulin and C-reactive protein levels in healthy children. Obes Res. 2003;11:95–103.PubMedCrossRef Shea S, Aymong E, Zybert P, et al. Obesity, fasting plasma insulin and C-reactive protein levels in healthy children. Obes Res. 2003;11:95–103.PubMedCrossRef
17.
go back to reference Misra A, Vikram NK, Arya S, et al. High prevalence of insulin resistance in postpubertal Asian Indian children is associated with adverse truncal body fat patterning, abdominal adiposity and excess body fat. Int J Obes Relat Metab Disord. 2004;28:1217–26.PubMedCrossRef Misra A, Vikram NK, Arya S, et al. High prevalence of insulin resistance in postpubertal Asian Indian children is associated with adverse truncal body fat patterning, abdominal adiposity and excess body fat. Int J Obes Relat Metab Disord. 2004;28:1217–26.PubMedCrossRef
18.
go back to reference Hiura M, Kikuchi T, Nagasaki K, Uchiyama M. Elevation of C-reactive protein levels is associated with obesity in boys. Hypertens Res. 2003;26:541–6.PubMedCrossRef Hiura M, Kikuchi T, Nagasaki K, Uchiyama M. Elevation of C-reactive protein levels is associated with obesity in boys. Hypertens Res. 2003;26:541–6.PubMedCrossRef
19.
go back to reference Cook DG, Mendall MA, Whincup PH, et al. C-reactive protein concentration in children: relationship of adiposity and other cardiovascular risk factors. Atherosclerosis. 2000;149:139–50.PubMedCrossRef Cook DG, Mendall MA, Whincup PH, et al. C-reactive protein concentration in children: relationship of adiposity and other cardiovascular risk factors. Atherosclerosis. 2000;149:139–50.PubMedCrossRef
20.
go back to reference Moran A, Steffen LM, Jacobs Jr DR, et al. Relation of C-reactive protein to insulin resistance and cardiovascular risk factors in youth. Diabetes Care. 2005;28:1763–8.PubMedCrossRef Moran A, Steffen LM, Jacobs Jr DR, et al. Relation of C-reactive protein to insulin resistance and cardiovascular risk factors in youth. Diabetes Care. 2005;28:1763–8.PubMedCrossRef
21.
go back to reference Mehta M, Bhasin SK, Agrawal K, Dwivedi S. Obesity amongst affluent adolescent girls. Indian J Pediatr. 2007;74:619–22.PubMedCrossRef Mehta M, Bhasin SK, Agrawal K, Dwivedi S. Obesity amongst affluent adolescent girls. Indian J Pediatr. 2007;74:619–22.PubMedCrossRef
22.
Metadata
Title
Health Consequences of Childhood Obesity
Authors
Anindya Kumar Saha
Neille Sarkar
Tapabrata Chatterjee
Publication date
01-11-2011
Publisher
Springer-Verlag
Published in
Indian Journal of Pediatrics / Issue 11/2011
Print ISSN: 0019-5456
Electronic ISSN: 0973-7693
DOI
https://doi.org/10.1007/s12098-011-0489-7

Other articles of this Issue 11/2011

Indian Journal of Pediatrics 11/2011 Go to the issue

Picture of the Month

Cystic Bone Tuberculosis