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Published in: Indian Journal of Otolaryngology and Head & Neck Surgery 2/2022

19-10-2020 | Metastasis | Original Article

Utilization of PET/CT Scan in Head and Neck Carcinoma: A Tertiary Care Hospital Experience

Authors: Rajeev Chugh, D. K. Gupta, Bhaumik Patel, Arun Ravi John, Rekha Vashisth, Sunil Goyal

Published in: Indian Journal of Otolaryngology and Head & Neck Surgery | Special Issue 2/2022

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Abstract

Objective

PET/CT scan has been increasingly used in assessment of Head and Neck cancer prior to treatment for evaluation and for surveillance. In this study we aim to assess the utilization of PET/CT scan at a tertiary care hospital.

Methods

Retrospectively data was reviewed of all patients of Head and Neck cancer who underwent PET/CT scan for workup or for follow-up between July 2018 and December 2019. PET/CT scan done in the pre-treatment assessment and post-treatment surveillance were analyzed for its utility.

Results

A total of 145 patients were included. The main indication for pre-treatment PET/CT scan was loco-regionally advanced disease (62 of 90 patients, 68.8%). No specific indication was noted in 19 patients (21%). A significant change in treatment decision was seen in pre-treatment patients based on M stage following a PET/CT scan. However, no change was noted on the basis of T or N stage. In the post-treatment surveillance there was a significant correlation of type of recurrence with clinical assessment and indication for PET/CT scan. 37 out of 87 patients (42.5%) underwent PET/CT scan for no specific reason, of which, 07 patients (18.9%) were detected to have distant metastasis.

Conclusion

Role of PET/CT in the pre-treatment assessment is very limited and maybe confined to advanced local or regional disease. Post-treatment surveillance with PET/CT scan has a promising role and must be done as a baseline during 1st follow up at 03 months in all patients who have advanced disease and have undergone multi-modality treatment for the same.
Literature
1.
go back to reference National Comprehensive Cancer Network. NCCN guidelines insights: head and neck cancers, version 2.2017 National Comprehensive Cancer Network. NCCN guidelines insights: head and neck cancers, version 2.2017
2.
go back to reference Kitagawa Y, Nishizawa S, Sano K, Ogasawara T, Nakamura M, Sadato N, Yoshida M, Yonekura Y (2003) Prospective comparison of 18F-FDG PET with conventional imaging modalities (MRI, CT, and 67Ga scintigraphy) in assessment of combined intraarterial chemotherapy and radiotherapy for head and neck carcinoma. J Nucl Med 44(2):198–206PubMed Kitagawa Y, Nishizawa S, Sano K, Ogasawara T, Nakamura M, Sadato N, Yoshida M, Yonekura Y (2003) Prospective comparison of 18F-FDG PET with conventional imaging modalities (MRI, CT, and 67Ga scintigraphy) in assessment of combined intraarterial chemotherapy and radiotherapy for head and neck carcinoma. J Nucl Med 44(2):198–206PubMed
3.
go back to reference Shintani SA, Foote RL, Lowe VJ, Brown PD, Garces YI, Kasperbauer JL (2008) Utility of PET/CT imaging performed early after surgical resection in the adjuvant treatment planning for head and neck cancer. Int J Radiat Oncol Biol Phys 70(2):322–329CrossRefPubMed Shintani SA, Foote RL, Lowe VJ, Brown PD, Garces YI, Kasperbauer JL (2008) Utility of PET/CT imaging performed early after surgical resection in the adjuvant treatment planning for head and neck cancer. Int J Radiat Oncol Biol Phys 70(2):322–329CrossRefPubMed
4.
go back to reference Jorgensen JB, Smith RB, Coughlin A, Spanos WC, Lohr MM, Sperry SM, Militsakh O, Zitsch RP III, Yueh B, Dooley LM, Panwar A (2019) Impact of PET/CT on staging and treatment of advanced head and neck squamous cell carcinoma. Otolaryngol Head Neck Surg 160(2):261–266CrossRefPubMed Jorgensen JB, Smith RB, Coughlin A, Spanos WC, Lohr MM, Sperry SM, Militsakh O, Zitsch RP III, Yueh B, Dooley LM, Panwar A (2019) Impact of PET/CT on staging and treatment of advanced head and neck squamous cell carcinoma. Otolaryngol Head Neck Surg 160(2):261–266CrossRefPubMed
5.
go back to reference Regelink G, Brouwer J, de Bree R, Pruim J, van der Laan BF, Vaalburg W, Hoekstra OS, Comans EF, Vissink A, Leemans RC, Roodenburg JL (2002) Detection of unknown primary tumours and distant metastases in patients with cervical metastases: value of FDG-PET versus conventional modalities. Eur J Nucl Med Mol Imaging 29(8):1024–1030CrossRefPubMed Regelink G, Brouwer J, de Bree R, Pruim J, van der Laan BF, Vaalburg W, Hoekstra OS, Comans EF, Vissink A, Leemans RC, Roodenburg JL (2002) Detection of unknown primary tumours and distant metastases in patients with cervical metastases: value of FDG-PET versus conventional modalities. Eur J Nucl Med Mol Imaging 29(8):1024–1030CrossRefPubMed
6.
go back to reference Stoeckli SJ, Mosna-Firlejczyk K, Goerres GW (2003) Lymph node metastasis of squamous cell carcinoma from an unknown primary: impact of positron emission tomography. Eur J Nucl Med Mol Imaging 30(3):411–416CrossRefPubMed Stoeckli SJ, Mosna-Firlejczyk K, Goerres GW (2003) Lymph node metastasis of squamous cell carcinoma from an unknown primary: impact of positron emission tomography. Eur J Nucl Med Mol Imaging 30(3):411–416CrossRefPubMed
7.
go back to reference Zhu L, Wang N (2013) 18F-fluorodeoxyglucose positron emission tomography-computed tomography as a diagnostic tool in patients with cervical nodal metastases of unknown primary site: a meta-analysis. Surg Oncol 22(3):190–194CrossRefPubMed Zhu L, Wang N (2013) 18F-fluorodeoxyglucose positron emission tomography-computed tomography as a diagnostic tool in patients with cervical nodal metastases of unknown primary site: a meta-analysis. Surg Oncol 22(3):190–194CrossRefPubMed
8.
go back to reference Strobel K, Haerle SK, Stoeckli SJ, Schrank M, Soyka JD, Veit-Haibach P, Hany TF (2009) Head and neck squamous cell carcinoma (HNSCC)–detection of synchronous primaries with 18 F-FDG-PET/CT. Eur J Nucl Med Mol Imaging 36(6):919–927CrossRefPubMed Strobel K, Haerle SK, Stoeckli SJ, Schrank M, Soyka JD, Veit-Haibach P, Hany TF (2009) Head and neck squamous cell carcinoma (HNSCC)–detection of synchronous primaries with 18 F-FDG-PET/CT. Eur J Nucl Med Mol Imaging 36(6):919–927CrossRefPubMed
9.
go back to reference Kyzas PA, Evangelou E, Denaxa-Kyza D, Ioannidis JP (2008) 18F-fluorodeoxyglucose positron emission tomography to evaluate cervical node metastases in patients with head and neck squamous cell carcinoma: a meta-analysis. J Natl Cancer Inst 100(10):712–720CrossRefPubMed Kyzas PA, Evangelou E, Denaxa-Kyza D, Ioannidis JP (2008) 18F-fluorodeoxyglucose positron emission tomography to evaluate cervical node metastases in patients with head and neck squamous cell carcinoma: a meta-analysis. J Natl Cancer Inst 100(10):712–720CrossRefPubMed
10.
go back to reference Deurvorst SE, Hoekstra OS, Castelijns JA, Witte BI, Leemans CR, de Bree R (2018) Clinical value of 18 FDG PET/CT in screening for distant metastases in head and neck squamous cell carcinoma. Clin Otolaryngol 43(3):875–881CrossRefPubMed Deurvorst SE, Hoekstra OS, Castelijns JA, Witte BI, Leemans CR, de Bree R (2018) Clinical value of 18 FDG PET/CT in screening for distant metastases in head and neck squamous cell carcinoma. Clin Otolaryngol 43(3):875–881CrossRefPubMed
12.
go back to reference Kuperman DI, Auethavekiat V, Adkins DR, Nussenbaum B, Collins S, Boonchalermvichian C, Trinkaus K, Chen L, Morgensztern D (2011) Squamous cell cancer of the head and neck with distant metastasis at presentation. Head Neck 33(5):714–718CrossRefPubMed Kuperman DI, Auethavekiat V, Adkins DR, Nussenbaum B, Collins S, Boonchalermvichian C, Trinkaus K, Chen L, Morgensztern D (2011) Squamous cell cancer of the head and neck with distant metastasis at presentation. Head Neck 33(5):714–718CrossRefPubMed
13.
go back to reference Senft A, de Bree R, Hoekstra OS, Kuik DJ, Golding RP, Oyen WJ, Pruim J, van den Hoogen FJ, Roodenburg JL, Leemans CR (2008) Screening for distant metastases in head and neck cancer patients by chest CT or whole body FDG-PET: a prospective multicenter trial. Radiother Oncol 87(2):221–229CrossRefPubMed Senft A, de Bree R, Hoekstra OS, Kuik DJ, Golding RP, Oyen WJ, Pruim J, van den Hoogen FJ, Roodenburg JL, Leemans CR (2008) Screening for distant metastases in head and neck cancer patients by chest CT or whole body FDG-PET: a prospective multicenter trial. Radiother Oncol 87(2):221–229CrossRefPubMed
14.
go back to reference Rohde M, Nielsen AL, Johansen J, Sørensen JA, Diaz A, Asmussen JT, Gerke O, Thomassen A, Gyldenkerne N, Døssing H, Bjørndal K (2018) Up-front PET/CT changes treatment intent in patients with head and neck squamous cell carcinoma. Eur J Nucl Medi Mol Imaging 45(4):613–621CrossRef Rohde M, Nielsen AL, Johansen J, Sørensen JA, Diaz A, Asmussen JT, Gerke O, Thomassen A, Gyldenkerne N, Døssing H, Bjørndal K (2018) Up-front PET/CT changes treatment intent in patients with head and neck squamous cell carcinoma. Eur J Nucl Medi Mol Imaging 45(4):613–621CrossRef
15.
go back to reference Ryu IS, Roh JL, Kim JS, Lee JH, Cho KJ, Choi SH, Nam SY, Kim SY (2016) Impact of 18F-FDG PET/CT staging on management and prognostic stratification in head and neck squamous cell carcinoma: a prospective observational study. Eur J Cancer 1(63):88–96CrossRef Ryu IS, Roh JL, Kim JS, Lee JH, Cho KJ, Choi SH, Nam SY, Kim SY (2016) Impact of 18F-FDG PET/CT staging on management and prognostic stratification in head and neck squamous cell carcinoma: a prospective observational study. Eur J Cancer 1(63):88–96CrossRef
16.
go back to reference Gupta T, Master Z, Kannan S, Agarwal JP, Ghsoh-Laskar S, Rangarajan V, Murthy V, Budrukkar A (2011) Diagnostic performance of post-treatment FDG PET or FDG PET/CT imaging in head and neck cancer: a systematic review and meta-analysis. Eur J Nucl Medi Mol Imaging 38(11):2083CrossRef Gupta T, Master Z, Kannan S, Agarwal JP, Ghsoh-Laskar S, Rangarajan V, Murthy V, Budrukkar A (2011) Diagnostic performance of post-treatment FDG PET or FDG PET/CT imaging in head and neck cancer: a systematic review and meta-analysis. Eur J Nucl Medi Mol Imaging 38(11):2083CrossRef
17.
go back to reference Leung AS, Rath TJ, Hughes MA, Kim S, Branstetter BF IV (2016) Optimal timing of first posttreatment FDG PET/CT in head and neck squamous cell carcinoma. Head Neck 38(S1):E853–E858CrossRefPubMed Leung AS, Rath TJ, Hughes MA, Kim S, Branstetter BF IV (2016) Optimal timing of first posttreatment FDG PET/CT in head and neck squamous cell carcinoma. Head Neck 38(S1):E853–E858CrossRefPubMed
18.
go back to reference Moeller BJ, Rana V, Cannon BA, Williams MD, Sturgis EM, Ginsberg LE, Macapinlac HA, Lee JJ, Ang KK, Chao KC, Chronowski GM (2009) Prospective risk-adjusted [18F] fluorodeoxyglucose positron emission tomography and computed tomography assessment of radiation response in head and neck cancer. J Clin Oncol 27(15):2509CrossRefPubMedPubMedCentral Moeller BJ, Rana V, Cannon BA, Williams MD, Sturgis EM, Ginsberg LE, Macapinlac HA, Lee JJ, Ang KK, Chao KC, Chronowski GM (2009) Prospective risk-adjusted [18F] fluorodeoxyglucose positron emission tomography and computed tomography assessment of radiation response in head and neck cancer. J Clin Oncol 27(15):2509CrossRefPubMedPubMedCentral
19.
go back to reference Nelissen C, Sherriff J, Jones T, Guest P, Colley S, Sanghera P, Hartley A (2017) The role of positron emission tomography/computed tomography imaging in head and neck cancer after radical chemoradiotherapy: a single institution experience. Clin Oncol 29(11):753–759CrossRef Nelissen C, Sherriff J, Jones T, Guest P, Colley S, Sanghera P, Hartley A (2017) The role of positron emission tomography/computed tomography imaging in head and neck cancer after radical chemoradiotherapy: a single institution experience. Clin Oncol 29(11):753–759CrossRef
20.
go back to reference Ho AS, Tsao GJ, Chen FW, Shen T, Kaplan MJ, Colevas AD, Fischbein NJ, Quon A, Le QT, Pinto HA, Fee WE Jr (2013) Impact of positron emission tomography/computed tomography surveillance at 12 and 24 months for detecting head and neck cancer recurrence. Cancer 119(7):1349–1356CrossRefPubMed Ho AS, Tsao GJ, Chen FW, Shen T, Kaplan MJ, Colevas AD, Fischbein NJ, Quon A, Le QT, Pinto HA, Fee WE Jr (2013) Impact of positron emission tomography/computed tomography surveillance at 12 and 24 months for detecting head and neck cancer recurrence. Cancer 119(7):1349–1356CrossRefPubMed
Metadata
Title
Utilization of PET/CT Scan in Head and Neck Carcinoma: A Tertiary Care Hospital Experience
Authors
Rajeev Chugh
D. K. Gupta
Bhaumik Patel
Arun Ravi John
Rekha Vashisth
Sunil Goyal
Publication date
19-10-2020
Publisher
Springer India
Keywords
Metastasis
Care
Published in
Indian Journal of Otolaryngology and Head & Neck Surgery / Issue Special Issue 2/2022
Print ISSN: 2231-3796
Electronic ISSN: 0973-7707
DOI
https://doi.org/10.1007/s12070-020-02228-7

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