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Indian Journal of Thoracic and Cardiovascular Surgery
Published in: Indian Journal of Thoracic and Cardiovascular Surgery 2/2023

Open Access 25-05-2023 | Aortic Aneurysm | Review Article

The role of transforming growth factor beta in bicuspid aortic valve aortopathy

Authors: Nimrat Grewal, Onur Dolmaci, Arthur Klautz, Juno Legue, Antoine Driessen, Robert Klautz, Robert Poelmann

Published in: Indian Journal of Thoracic and Cardiovascular Surgery | Special Issue 2/2023

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Abstract

A bicuspid aortic valve (BAV) is the most prevalent congenital cardiac deformity, which is associated with an increased risk to develop a thoracic aortic aneurysm and/or an aortic dissection as compared to persons with a tricuspid aortic valve. Due to the high prevalence of a BAV in the general population and the associated life-long increased risk for adverse vascular events, BAV disease places a considerable burden on the public health. The aim of the present review is to discuss the role of transforming growth factor beta (TGF-β) signaling in the development of the vascular wall and on how this complex signaling pathway may be involved in thoracic aortic aneurysm formation in tricuspid and BAV patients.
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Metadata
Title
The role of transforming growth factor beta in bicuspid aortic valve aortopathy
Authors
Nimrat Grewal
Onur Dolmaci
Arthur Klautz
Juno Legue
Antoine Driessen
Robert Klautz
Robert Poelmann
Publication date
25-05-2023
Publisher
Springer Nature Singapore
Published in
Indian Journal of Thoracic and Cardiovascular Surgery / Issue Special Issue 2/2023
Print ISSN: 0970-9134
Electronic ISSN: 0973-7723
DOI
https://doi.org/10.1007/s12055-023-01513-8

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