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Journal of Gastrointestinal Cancer
Published in: Journal of Gastrointestinal Cancer 1/2014

01-03-2014 | Original Research

Prognostic Value of Tumor-Infiltrating Mast Cells in Outcome of Patients with Esophagus Squamous Cell Carcinoma

Authors: Ashraf Fakhrjou, Seid Mahdi Niroumand-Oscoei, Mohamad Hosein Somi, Morteza Ghojazadeh, Shahnaz Naghashi, Shabnam Samankan

Published in: Journal of Gastrointestinal Cancer | Issue 1/2014

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Abstract

Background

Squamous cell carcinoma (SCC) of the esophagus is one of the most common malignancies of the gastrointestinal tract and carries poor prognosis. The role of mast cell density (MCD) in the prognosis of most human tumors is partly known, and there is a growing body of studies addressing it. However, the prognostic value of MCD has not been investigated in esophageal SCC, and thus, it was the subject during this study.

Methods

In this study, 78 patients with esophageal SCC in pT = 3 were selected, their MCD was evaluated with toluidine blue staining, and the relationship with survival rate was analyzed. Patients were compared in identical groups of lymph node involvement and post-surgery complementary therapy.

Results

Survival rate was significantly decreased in patients with high MCD based on Kaplan–Meier analysis (P < 0.001). This relationship was also found in groups with similar lymph node involvement and post-surgery therapies.

Conclusions

The results of the current study showed that high MCD in the invasive edge of tumor is related to tumor progression and decreased survival rate following surgery.
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Metadata
Title
Prognostic Value of Tumor-Infiltrating Mast Cells in Outcome of Patients with Esophagus Squamous Cell Carcinoma
Authors
Ashraf Fakhrjou
Seid Mahdi Niroumand-Oscoei
Mohamad Hosein Somi
Morteza Ghojazadeh
Shahnaz Naghashi
Shabnam Samankan
Publication date
01-03-2014
Publisher
Springer US
Published in
Journal of Gastrointestinal Cancer / Issue 1/2014
Print ISSN: 1941-6628
Electronic ISSN: 1941-6636
DOI
https://doi.org/10.1007/s12029-013-9550-2

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