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Neurocritical Care
Published in: Neurocritical Care 1/2016

01-08-2016 | Original Article

Bedside Xenon-CT Shows Lower CBF in SAH Patients with Impaired CBF Pressure Autoregulation as Defined by Pressure Reactivity Index (PRx)

Authors: Ulf Johnson, Henrik Engquist, Tim Howells, Pelle Nilsson, Elisabeth Ronne-Engström, Anders Lewén, Elham Rostami, Per Enblad

Published in: Neurocritical Care | Issue 1/2016

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Abstract

Background

Subarachnoid hemorrhage (SAH) is a disease with a high rate of unfavorable outcome, often related to delayed cerebral ischemia (DCI), i.e., ischemic injury that develops days–weeks after onset, with a multifactorial etiology. Disturbances in cerebral pressure autoregulation, the ability to maintain a steady cerebral blood flow (CBF), despite fluctuations in systemic blood pressure, have been suggested to play a role in the development of DCI. Pressure reactivity index (PRx) is a well-established measure of cerebral pressure autoregulation that has been used to study traumatic brain injury, but not extensively in SAH.

Objective

To study the relation between PRx and CBF in SAH patients, and to examine if PRx can be used to predict DCI.

Methods

Retrospective analysis of prospectively collected data. PRx was calculated as the correlation coefficient between mean arterial blood pressure (MABP) and intracranial pressure (ICP) in a 5 min moving window. CBF was measured using bedside Xenon-CT (Xe-CT). DCI was diagnosed clinically.

Results

47 poor-grade mechanically ventilated patients were studied. Patients with disturbed pressure autoregulation (high PRx values) had lower CBF, as measured by bedside Xe-CT; both in the early (day 0–3) and late (day 4–14) acute phase of the disease. PRx did not differ significantly between patients who developed DCI or not.

Conclusion

In mechanically ventilated and sedated SAH patients, high PRx (more disturbed CBF pressure autoregulation) is associated with low CBF, both day 0–3 and day 4–14 after onset. The role of PRx as a monitoring tool in SAH patients needs further studying.
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Metadata
Title
Bedside Xenon-CT Shows Lower CBF in SAH Patients with Impaired CBF Pressure Autoregulation as Defined by Pressure Reactivity Index (PRx)
Authors
Ulf Johnson
Henrik Engquist
Tim Howells
Pelle Nilsson
Elisabeth Ronne-Engström
Anders Lewén
Elham Rostami
Per Enblad
Publication date
01-08-2016
Publisher
Springer US
Published in
Neurocritical Care / Issue 1/2016
Print ISSN: 1541-6933
Electronic ISSN: 1556-0961
DOI
https://doi.org/10.1007/s12028-016-0240-3

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