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01-08-2011 | Original Article

Vasopressor Use and Effect on Blood Pressure After Severe Adult Traumatic Brain Injury

Authors: Pimwan Sookplung, Arunotai Siriussawakul, Amin Malakouti, Deepak Sharma, Jin Wang, Michael J. Souter, Randall M. Chesnut, Monica S. Vavilala

Published in: Neurocritical Care | Issue 1/2011

Abstract

Background

We describe institutional vasopressor usage, and examine the effect of vasopressors on hemodynamics: heart rate (HR), mean arterial blood pressure (MAP), intracranial pressure (ICP), cerebral perfusion pressure (CPP), brain tissue oxygenation (PbtO₂), and jugular venous oximetry (SjVO₂) in adults with severe traumatic brain injury (TBI).

Methods

We performed a retrospective analysis of 114 severely head injured patients who were admitted to the neurocritical care unit of Level 1 trauma center and who received vasopressors (phenylephrine, norepinephrine, dopamine, vasopressin or epinephrine) to increase blood pressure

Results

Phenylephrine was the most commonly used vasopressor (43%), followed by norepinephrine (30%), dopamine (22%), and vasopressin (5%). Adjusted for age, gender, injury severity score, vasopressor dose, baseline blood pressure, fluid administration, propofol sedation, and hypertonic saline infusion, phenylephrine use was associated with 8 mmHg higher mean arterial pressure (MAP) than dopamine (P = 0.03), and 12 mmHg higher cerebral perfusion pressure (CPP) than norepinephrine (P = 0.02) during the 3 h after vasopressor start. There was no difference in ICP between the drug groups, either at baseline or after vasopressor treatment.

Conclusions

Most severe TBI patients received phenylephrine. Patients who received phenylephrine had higher MAP and CPP than patients who received dopamine and norepinephrine, respectively.

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Title: Vasopressor Use and Effect on Blood Pressure After Severe Adult Traumatic Brain Injury
Authors: Pimwan Sookplung
Arunotai Siriussawakul
Amin Malakouti
Deepak Sharma
Jin Wang
Michael J. Souter
Randall M. Chesnut
Monica S. Vavilala
Publication date: 01-08-2011
Publisher: Humana Press Inc
Published in: Neurocritical Care / Issue 1/2011
Print ISSN: 1541-6933
Electronic ISSN: 1556-0961
DOI: https://doi.org/10.1007/s12028-010-9448-9

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Vasopressor Use and Effect on Blood Pressure After Severe Adult Traumatic Brain Injury

Abstract

Background

Methods

Results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background

Methods

Results

Conclusions

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