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Neurocritical Care

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01-02-2008 | Original Paper

Effectiveness of Factor IX Complex Concentrate in Reversing Warfarin Associated Coagulopathy for Intracerebral Hemorrhage

Authors: Farhan Siddiq, Abdul Jalil, Cara McDaniel, David G. Brock, Carissa C. Pineda, Rodney D. Bell, Kiwon Lee

Published in: Neurocritical Care | Issue 1/2008

Abstract

Introduction

The objective of this study is to show the effectiveness of Factor IX complex concentrate (FIXCC) for rapid reversal of an elevated International Normalized Ratio (INR) in patients with anticoagulation-associated intracerebral hemorrhage (AAICH).

Methods

We, retrospectively, analyzed the clinical data of 19 patients with the diagnosis of AAICH from January 2005 to May 2006. A comparison was made among patients treated with FFP and Vit.K [FFP-group (n = 9)] and patients treated with FIXCC in addition to FFP and Vit.K [FIXCC-group (n = 10)]. INR of 1.4 or less was taken as target.

Results

Mean INR on admission for FFP and FIXCC group was 1.84 ± 0.31 and 2.44 ± 1.48, respectively (P = 0.315). After administration of therapy, the INR was reduced from 1.84 ± 0.31 to 1.34 ± 0.08 (P < 0.05) in FFP group and 2.44 ± 1.48 to 1.34 ± 0.07 (P < 0.005) in FIXCC group. Three patients in FFP group (33%) and 8 patients in FIXCC group (80%) reached their target INR in 3–4 h after initiation of therapy (P = 0.012). Mean time taken by both FFP and FIXCC groups to reach the target INR was 8.52 ± 5.60 h and 4.25 ± 2.12 h, respectively (P < 0.05). The mean rate of INR correction was 0.06 ± 0.03 and 0.27 ± 0.25 per hour for the FFP and FIXCC group, respectively (P < 0.005). There was one death in FIX group and two in FFP group and no thrombotic complications.

Conclusion

Our data suggests that FIXCC in combination with FFP and Vit.K may result in decreased time required when compared to FFP and Vit.K alone for correction of warfarin associated coagulopathy in neurosurgical emergencies.

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Title: Effectiveness of Factor IX Complex Concentrate in Reversing Warfarin Associated Coagulopathy for Intracerebral Hemorrhage
Authors: Farhan Siddiq
Abdul Jalil
Cara McDaniel
David G. Brock
Carissa C. Pineda
Rodney D. Bell
Kiwon Lee
Publication date: 01-02-2008
Publisher: Humana Press Inc
Published in: Neurocritical Care / Issue 1/2008
Print ISSN: 1541-6933
Electronic ISSN: 1556-0961
DOI: https://doi.org/10.1007/s12028-007-9011-5

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Effectiveness of Factor IX Complex Concentrate in Reversing Warfarin Associated Coagulopathy for Intracerebral Hemorrhage

Abstract

Introduction

Methods

Results

Conclusion

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Introduction

Methods

Results

Conclusion

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