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Immunologic Research
Published in: Immunologic Research 3/2016

01-06-2016 | Review

The role of complement system in adipose tissue-related inflammation

Authors: Sonia I. Vlaicu, Alexandru Tatomir, Dallas Boodhoo, Stefan Vesa, Petru A. Mircea, Horea Rus

Published in: Immunologic Research | Issue 3/2016

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Abstract

As the common factor linking adipose tissue to the metabolic context of obesity, insulin resistance and atherosclerosis are associated with a low-grade chronic inflammatory status, to which the complement system is an important contributor. Adipose tissue synthesizes complement proteins and is a target of complement activation. C3a-desArg/acylation-stimulating protein stimulates lipogenesis and affects lipid metabolism. The C3a receptor and C5aR are involved in the development of adipocytes’ insulin resistance through macrophage infiltration and the activation of adipose tissue. The terminal complement pathway has been found to be instrumental in promoting hyperglycemia-associated tissue damage, which is characteristic of the major vascular complications of diabetes mellitus and diabetic ketoacidosis. As a mediator of the effects of the terminal complement complex C5b-9, RGC-32 has an impact on energy expenditure as well as lipid and glucose metabolic homeostasis. All of this evidence, taken together, indicates an important role for complement activation in metabolic diseases.
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Metadata
Title
The role of complement system in adipose tissue-related inflammation
Authors
Sonia I. Vlaicu
Alexandru Tatomir
Dallas Boodhoo
Stefan Vesa
Petru A. Mircea
Horea Rus
Publication date
01-06-2016
Publisher
Springer US
Published in
Immunologic Research / Issue 3/2016
Print ISSN: 0257-277X
Electronic ISSN: 1559-0755
DOI
https://doi.org/10.1007/s12026-015-8783-5

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