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Immunologic Research
Published in: Immunologic Research 3/2015

Open Access 01-03-2015

Roles of retinoic acid-inducible gene-I-like receptors (RLRs), Toll-like receptor (TLR) 3 and 2′-5′ oligoadenylate synthetase as viral recognition receptors on human mast cells in response to viral infection

Authors: Mizuho Tsutsui-Takeuchi, Hiroko Ushio, Minoru Fukuda, Takahiko Yamada, François Niyonsaba, Ko Okumura, Hideoki Ogawa, Shigaku Ikeda

Published in: Immunologic Research | Issue 3/2015

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Abstract

To investigate the anti-viral responses of human mast cells, we performed PCR array analysis of these cells after infection with vesicular stomatitis virus (VSV). PCR array analysis revealed that human mast cells up-regulated several anti-viral genes, including melanoma differentiation-associated gene 5, retinoic acid-inducible gene-I, and Toll-like receptor 3, together with type I interferons and chemokines, upon VSV infection. Additionally, we found that 2′-5′ oligoadenylate synthetase, which also works as a virus recognition receptor by activating the latent form of RNase L, leading to viral RNA degradation, was up-regulated in human mast cells upon VSV infection. Moreover, small interfering RNA analysis to identify the receptors responsible for mast cell activation by VSV revealed that these receptors reciprocally cooperate to produce anti-viral cytokines and chemokines, inhibiting VSV replication. Our findings suggest that human mast cells produce cytokines and chemokines using several viral recognition receptors, leading to the inhibition of viral replication. These data provide novel information that improves our understanding of the roles of human mast cells in immune responses against viruses.
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Metadata
Title
Roles of retinoic acid-inducible gene-I-like receptors (RLRs), Toll-like receptor (TLR) 3 and 2′-5′ oligoadenylate synthetase as viral recognition receptors on human mast cells in response to viral infection
Authors
Mizuho Tsutsui-Takeuchi
Hiroko Ushio
Minoru Fukuda
Takahiko Yamada
François Niyonsaba
Ko Okumura
Hideoki Ogawa
Shigaku Ikeda
Publication date
01-03-2015
Publisher
Springer US
Published in
Immunologic Research / Issue 3/2015
Print ISSN: 0257-277X
Electronic ISSN: 1559-0755
DOI
https://doi.org/10.1007/s12026-014-8617-x

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