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Immunologic Research
Published in: Immunologic Research 1/2011

01-10-2011

Immunologically restricted patients exhibit a pronounced inflammation and inadequate response to hypoxia in fracture hematomas

Authors: Paula Hoff, T. Gaber, K. Schmidt-Bleek, U. Sentürk, C. L. Tran, K. Blankenstein, S. Lütkecosmann, J. Bredahl, H. J. Schüler, P. Simon, G. Wassilew, F. Unterhauser, G. R. Burmester, G. Schmidmaier, C. Perka, G. N. Duda, F. Buttgereit

Published in: Immunologic Research | Issue 1/2011

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Abstract

For patients who are known to have an impaired immune system, bone healing is often impaired. Therefore, it has been suggested that an effectively functioning immune system will have an influence on the quality of bone healing. Here, we demonstrate that cells within the fracture hematoma of immunologically restricted patients (1) exhibit a disturbed osteogenic differentiation (normal SPP1 but diminished RUNX2 expression), (2) show a strong inflammatory reaction (high IL8 and CXCR4), and (3) react on local hypoxia (high expression of HIF1A) but with inadequate target gene responses (diminished LDHA and PGK1 expression). Thus, it is already within the early inflammatory phase of fracture healing that the local gene expression in fracture hematomas of immunologically restricted patients points toward a critical regeneration.
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Metadata
Title
Immunologically restricted patients exhibit a pronounced inflammation and inadequate response to hypoxia in fracture hematomas
Authors
Paula Hoff
T. Gaber
K. Schmidt-Bleek
U. Sentürk
C. L. Tran
K. Blankenstein
S. Lütkecosmann
J. Bredahl
H. J. Schüler
P. Simon
G. Wassilew
F. Unterhauser
G. R. Burmester
G. Schmidmaier
C. Perka
G. N. Duda
F. Buttgereit
Publication date
01-10-2011
Publisher
Humana Press Inc
Published in
Immunologic Research / Issue 1/2011
Print ISSN: 0257-277X
Electronic ISSN: 1559-0755
DOI
https://doi.org/10.1007/s12026-011-8235-9

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