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Published in:

01-04-2011

AID expression during B-cell development: searching for answers

Authors: Masayuki Kuraoka, Laurie McWilliams, Garnett Kelsoe

Published in: Immunologic Research | Issue 1-3/2011

Abstract

Expression of activation-induced cytidine deaminase (AID) by germinal center (GC) B cells drives the processes of immunoglobulin (Ig) somatic hypermutation (SHM) and class switch recombination (CSR) necessary for the generation of high affinity IgG serum antibody and the memory B-cell compartment. Increasing evidence indicates that AID is also expressed at low levels in developing B cells but to date, this early, developmentally regulated AID expression has no known function. Does the timing and extent of AID expression in developmentally immature, non-GC B cells provide clues to reveal its physiologic role?

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Title: AID expression during B-cell development: searching for answers
Authors: Masayuki Kuraoka
Laurie McWilliams
Garnett Kelsoe
Publication date: 01-04-2011
Publisher: Humana Press Inc
Published in: Immunologic Research / Issue 1-3/2011
Print ISSN: 0257-277X
Electronic ISSN: 1559-0755
DOI: https://doi.org/10.1007/s12026-010-8185-7

Keynote webinar | Spotlight on medication adherence

Springer Medicine

AID expression during B-cell development: searching for answers

Abstract

Keynote webinar | Spotlight on medication adherence

Springer Medicine

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