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Published in:

01-11-2007

The regulation of dendritic cell function by calcium-signaling and its inhibition by microbial pathogens

Authors: S. F. Connolly, D. J. Kusner

Published in: Immunologic Research | Issue 1-3/2007

Abstract

Dendritic cells (DC) are the sentinels of the immune system, linking innate with adaptive responses. The functional responses of DC are subject to complex regulation and serve as targets for pathogens. Ca²⁺-mediated signal transduction pathways serve a central regulatory role in DC responses to diverse antigens, including TLR ligands, intact bacteria, and microbial toxins. This review summarizes the major mechanisms of Ca²⁺-signaling that DC utilize to regulate maturation and antigen presentation, including a Ca²⁺-calmodulin (CaM)-CaM kinase II pathway that is localized to phagosomes and is targeted by the human intracellular pathogen, Mycobacterium tuberculosis. Restoration of functional Ca²⁺ signaling in DC may provide a novel mechanism to enhance therapy and promote vaccine efficacy to infectious diseases, including tuberculosis.

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Title: The regulation of dendritic cell function by calcium-signaling and its inhibition by microbial pathogens
Authors: S. F. Connolly
D. J. Kusner
Publication date: 01-11-2007
Publisher: Humana Press Inc
Published in: Immunologic Research / Issue 1-3/2007
Print ISSN: 0257-277X
Electronic ISSN: 1559-0755
DOI: https://doi.org/10.1007/s12026-007-0076-1

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The regulation of dendritic cell function by calcium-signaling and its inhibition by microbial pathogens

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