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Published in:

01-11-2007

Monoclonal antibody mechanisms of action in cancer

Author: George J. Weiner

Published in: Immunologic Research | Issue 1-3/2007

Abstract

Monoclonal antibodies (mAbs) are used extensively as treatment for cancer. A variety of mechanisms are thought to play important roles in mediating the observed anti-tumor effects of mAb. These include signaling mediated by cross-linking of surface antigen that leads to cell death, blocking an activation signal that is necessary for continued cell growth, antibody-dependent cellular cytotoxicity (ADCC), complement mediated cytotoxicity (CMC) and the ability of mAb to alter the cytokine milieu or enhance development of an active anti-tumor immune response. In this review the in vitro, animal model and clinical results supporting each of these varied mechanisms is summarized as is the potential for these mechanisms to interact with each other.

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Title: Monoclonal antibody mechanisms of action in cancer
Author: George J. Weiner
Publication date: 01-11-2007
Publisher: Humana Press Inc
Published in: Immunologic Research / Issue 1-3/2007
Print ISSN: 0257-277X
Electronic ISSN: 1559-0755
DOI: https://doi.org/10.1007/s12026-007-0073-4

2024 ASCO Annual Meeting

Springer Medicine

Monoclonal antibody mechanisms of action in cancer

Abstract

2024 ASCO Annual Meeting

Springer Medicine

Abstract

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