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Endocrine
Published in: Endocrine 3/2011

01-12-2011 | Original Article

Genetic variants in ADIPOQ gene and the risk of type 2 diabetes: a case–control study of Chinese Han population

Authors: Wencong Du, Qian Li, Ying Lu, Xiaofang Yu, Xinhua Ye, Yanqin Gao, Jianhua Ma, Jinluo Cheng, Yuanyuan Cao, Juan Du, Hui Shi, Ling Zhou

Published in: Endocrine | Issue 3/2011

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Abstract

This study was to evaluate the association between ADIPOQ gene variants and type 2 diabetes mellitus (T2DM). TaqMan® assay was performed to test the genotypes in T2DM patients (n = 1,105) and normal control subjects (n = 1,107). Serum adiponectin concentration was measured by ELISA kit. The variant genotypes rs7649121AT and rs7649121AT/TT, compared with the AA genotype, were associated with a significantly decreased risk of T2DM [Adjusted OR (95% CI) = 0.79(0.66–0.95), 0.80(0.67–0.96), respectively]. In stratified analysis, rs2241767AG genotype increased the risk of T2DM in obesity group [Adjusted OR (95% CI) = 1.32(1.03–1.69)]. Patients with genotype AG/GG of rs2241767 had lower levels of serum adiponectin than those with the genotype AA (P = 0.044). Haplotype analyses were not significant. Crossover analysis of rs7649121 and environmental risk factor (obesity) indicated that the protect effect of rs7649121AT/TT maybe offset by the environmental risk. Those who exposed to environmental risk factor (obesity) had a chance to attack T2DM compared with those who did not expose to the two factors [Adjusted OR (95% CI) = 1.64(1.30–2.06)]. This study suggested that the ADIPOQ gene polymorphisms were associated with the risk of T2DM in a Chinese Han population.
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Metadata
Title
Genetic variants in ADIPOQ gene and the risk of type 2 diabetes: a case–control study of Chinese Han population
Authors
Wencong Du
Qian Li
Ying Lu
Xiaofang Yu
Xinhua Ye
Yanqin Gao
Jianhua Ma
Jinluo Cheng
Yuanyuan Cao
Juan Du
Hui Shi
Ling Zhou
Publication date
01-12-2011
Publisher
Springer US
Published in
Endocrine / Issue 3/2011
Print ISSN: 1355-008X
Electronic ISSN: 1559-0100
DOI
https://doi.org/10.1007/s12020-011-9488-8

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