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Open Access 01-12-2021 | SARS-CoV-2 | Original Paper

Specific Susceptibility to COVID-19 in Adults with Down Syndrome

Authors: Tomer Illouz, Arya Biragyn, Milana Frenkel-Morgenstern, Orly Weissberg, Alessandro Gorohovski, Eugene Merzon, Ilan Green, Florencia Iulita, Lisi Flores-Aguilar, Mara Dierssen, Ilario De Toma, Hefziba Lifshitz, Stylianos E. Antonarakis, Eugene Yu, Yann Herault, Marie-Claude Potier, Alexandra Botté, Randall Roper, Benjamin Sredni, Ronit Sarid, Jacqueline London, William Mobley, Andre Strydom, Eitan Okun

Published in: NeuroMolecular Medicine | Issue 4/2021

Abstract

The current SARS-CoV-2 outbreak, which causes COVID-19, is particularly devastating for individuals with chronic medical conditions, in particular those with Down Syndrome (DS) who often exhibit a higher prevalence of respiratory tract infections, immune dysregulation and potential complications. The incidence of Alzheimer’s disease (AD) is much higher in DS than in the general population, possibly increasing further the risk of COVID-19 infection and its complications. Here we provide a biological overview with regard to specific susceptibility of individuals with DS to SARS-CoV-2 infection as well as data from a recent survey on the prevalence of COVID-19 among them. We see an urgent need to protect people with DS, especially those with AD, from COVID-19 and future pandemics and focus on developing protective measures, which also include interventions by health systems worldwide for reducing the negative social effects of long-term isolation and increased periods of hospitalization.

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Title: Specific Susceptibility to COVID-19 in Adults with Down Syndrome
Authors: Tomer Illouz
Arya Biragyn
Milana Frenkel-Morgenstern
Orly Weissberg
Alessandro Gorohovski
Eugene Merzon
Ilan Green
Florencia Iulita
Lisi Flores-Aguilar
Mara Dierssen
Ilario De Toma
Hefziba Lifshitz
Stylianos E. Antonarakis
Eugene Yu
Yann Herault
Marie-Claude Potier
Alexandra Botté
Randall Roper
Benjamin Sredni
Ronit Sarid
Jacqueline London
William Mobley
Andre Strydom
Eitan Okun
Publication date: 01-12-2021
Publisher: Springer US
Keywords: SARS-CoV-2
Trisomy 21
COVID-19
Published in: NeuroMolecular Medicine / Issue 4/2021
Print ISSN: 1535-1084
Electronic ISSN: 1559-1174
DOI: https://doi.org/10.1007/s12017-021-08651-5

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Specific Susceptibility to COVID-19 in Adults with Down Syndrome

Abstract

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

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