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01-06-2015 | Original Paper

Circulating MicroRNA Let-7d in Attention-Deficit/Hyperactivity Disorder

Authors: Li Hui Wu, Min Peng, Mei Yu, Qian Lei Zhao, Chao Li, Yu Tong Jin, Yong Jiang, Zhong Yi Chen, Nian Hui Deng, Hui Sun, Xing Zhong Wu

Published in: NeuroMolecular Medicine | Issue 2/2015

Abstract

Up to date, there has been no molecular signature available in the clinical practice for attention-deficit/hyperactivity disorder (ADHD). To investigate circulating miRNA let-7d significance in ADHD, we investigated serum miRNA let-7d in 35 newly diagnosed ADHD subjects who were randomly selected from 406 patients out of 7450 children, paired with gender- and age-matched control through case–control study. We observed that circulating miRNA let-7d was significantly higher in ADHD subjects than in control (p < 0.05). Higher circulation level of miRNA let-7d was significantly associated with ADHD (odds ratio 16.7; 95 % confidence, p < 0.05). Meanwhile, serum galectin-3 level was down-regulated in ADHD subjects and the subjects with low galectin-3 expression accounted for 66 % in ADHD. The difference of the serum galectin-3 levels between ADHD and non-ADHD groups reached significance (p < 0.05). In 1-year follow-up, a significantly higher rate of clinical improvement was noted in subjects with low level of circulating miRNA let-7d (p < 0.05) than those with high level of circulating miRNA let-7d. Our data demonstrated that miRNA let-7d was elevated in the serum of ADHD subjects, which might be a novel, useful molecule signature for ADHD.

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Title: Circulating MicroRNA Let-7d in Attention-Deficit/Hyperactivity Disorder
Authors: Li Hui Wu
Min Peng
Mei Yu
Qian Lei Zhao
Chao Li
Yu Tong Jin
Yong Jiang
Zhong Yi Chen
Nian Hui Deng
Hui Sun
Xing Zhong Wu
Publication date: 01-06-2015
Publisher: Springer US
Published in: NeuroMolecular Medicine / Issue 2/2015
Print ISSN: 1535-1084
Electronic ISSN: 1559-1174
DOI: https://doi.org/10.1007/s12017-015-8345-y

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Circulating MicroRNA Let-7d in Attention-Deficit/Hyperactivity Disorder

Abstract

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

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