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01-06-2013 | Original Paper

PICALM Gene rs3851179 Polymorphism Contributes to Alzheimer’s Disease in an Asian Population

Authors: Guiyou Liu, Shuyan Zhang, Zhiyou Cai, Guoda Ma, Liangcai Zhang, Yongshuai Jiang, Rennan Feng, Mingzhi Liao, Zugen Chen, Bin Zhao, Keshen Li

Published in: NeuroMolecular Medicine | Issue 2/2013

Abstract

PICALM gene rs3851179 polymorphism was reported to an Alzheimer’s disease (AD) susceptibility locus in a Caucasian population. However, recent studies reported consistent and inconsistent results in an Asian population. Four studies indicated no association between rs3851179 and AD in a Chinese population and one study reported weak association in a Japanese population. We consider that the failure to replicate the significant association between rs3851179 and AD may be caused by at least two reasons. The first reason may be the genetic heterogeneity in AD among different populations, and the second may be the relatively small sample size compared with large-scale GWAS in Caucasian ancestry. In order to confirm this view, in this research, we first evaluated the genetic heterogeneity of rs3851179 polymorphism in Caucasian and Asian populations. We then investigated rs3851179 polymorphism in an Asian population by a pooled analysis method and a meta-analysis method. We did not observe significant genetic heterogeneity of rs3851179 in the Caucasian and Asian populations. Our results indicate that rs3851179 polymorphism is significantly associated with AD in the Asian population by both pooled analysis and meta-analysis methods. We believe that our findings will be very useful for future genetic studies in AD.

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Title: PICALM Gene rs3851179 Polymorphism Contributes to Alzheimer’s Disease in an Asian Population
Authors: Guiyou Liu
Shuyan Zhang
Zhiyou Cai
Guoda Ma
Liangcai Zhang
Yongshuai Jiang
Rennan Feng
Mingzhi Liao
Zugen Chen
Bin Zhao
Keshen Li
Publication date: 01-06-2013
Publisher: Humana Press Inc
Published in: NeuroMolecular Medicine / Issue 2/2013
Print ISSN: 1535-1084
Electronic ISSN: 1559-1174
DOI: https://doi.org/10.1007/s12017-013-8225-2

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PICALM Gene rs3851179 Polymorphism Contributes to Alzheimer’s Disease in an Asian Population

Abstract

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Abstract

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