Skip to main content
Top
Published in: Clinical Orthopaedics and Related Research® 10/2013

01-10-2013 | Clinical Research

Complications of Cemented Long-stem Hip Arthroplasty in Metastatic Bone Disease Revisited

Authors: Shawn L. Price, MD, M. Aabid Farukhi, BA, Kevin B. Jones, MD, Stephen K. Aoki, MD, R. Lor Randall, MD, FACS

Published in: Clinical Orthopaedics and Related Research® | Issue 10/2013

Login to get access

Abstract

Background

The literature suggests that a cemented long-stem femoral arthroplasty is associated with increased intraoperative and perioperative risks. Embolic events may precipitate cardiopulmonary complications and even death; by contrast, others have reported that the use of a cemented long-stem femoral arthroplasty in patients with metastatic bone disease is a safe procedure.

Questions/purposes

Specifically, in this study, we sought to identify (1) intraoperative complications potentially attributable to the use of cemented long-stem femoral components, and (2) early postoperative complications potentially attributable to the use of cemented long-stem femoral components in patients having an arthroplasty for metastatic bone disease.

Methods

In this study, we performed a retrospective chart review of 42 patients (44 arthroplasties), in which the same surgical technique was used. The primary outcome measure was perioperative complications, including intraoperative cement-associated desaturation, cement-associated hypotension, sympathomimetic administration, postoperative hypotension/desaturation, and death.

Results

In this series, 19% of the patients had cement-associated hypotension and sympathomimetics were administered to 48%. Two patients required prolonged intubation. One death occurred during hospitalization but there were no cardiopulmonary events.

Conclusions

This study showed that some patients experienced postoperative desaturation, prolonged intubation, and increased use of sympathomimetics, however, these events were short-lived and did not result in patient mortality. Although there are significant risks to cemented long-stem femoral arthroplasty, it can be performed with a low risk of fatal cardiopulmonary complications and remains a surgical option when treating patients with metastatic bone disease.

Level of Evidence

Level IV, therapeutic study. See Instructions for Authors for a complete description of levels of evidence.
Literature
1.
go back to reference Alvi HM, Damron TA. Prophylactic stabilization for bone metastases, myeloma, or lymphoma: do we need to protect the entire none? Clin Orthop Relat Res. 2013;471:706–714.PubMedCrossRef Alvi HM, Damron TA. Prophylactic stabilization for bone metastases, myeloma, or lymphoma: do we need to protect the entire none? Clin Orthop Relat Res. 2013;471:706–714.PubMedCrossRef
2.
go back to reference Bickels J, Dadia S, Lidar Z. Surgical management of metastatic bone disease. J Bone Joint Surg Am. 2009;91;1503–1516.PubMedCrossRef Bickels J, Dadia S, Lidar Z. Surgical management of metastatic bone disease. J Bone Joint Surg Am. 2009;91;1503–1516.PubMedCrossRef
3.
go back to reference Biermann JS, Holt GE, Lewis VO, Schwartz HS, Yaszemski MJ. Metastatic bone disease: diagnosis, evaluation and treatment. J Bone Joint Surg Am. 2009;91:1518–1530.PubMed Biermann JS, Holt GE, Lewis VO, Schwartz HS, Yaszemski MJ. Metastatic bone disease: diagnosis, evaluation and treatment. J Bone Joint Surg Am. 2009;91:1518–1530.PubMed
4.
go back to reference Chia SK, Speers CH, D’yachikova Y, Kang A, Malfair-Taylor S, Barnett J, Coldman A, Gelmon KA, O’reilly SE, Olivotta IA. The impact of new chemotherapeutic and hormone agents on survival in a population-based cohort of women with metastatic breast cancer. Cancer. 2007;110:973–979.PubMedCrossRef Chia SK, Speers CH, D’yachikova Y, Kang A, Malfair-Taylor S, Barnett J, Coldman A, Gelmon KA, O’reilly SE, Olivotta IA. The impact of new chemotherapeutic and hormone agents on survival in a population-based cohort of women with metastatic breast cancer. Cancer. 2007;110:973–979.PubMedCrossRef
5.
go back to reference Coleman R, Gnant M, Morgan G, Clezardin P. Effects of bone-targeted agents on cancer progression and mortality. J Natl Cancer Inst. 2012;104:1059–1067.PubMedCrossRef Coleman R, Gnant M, Morgan G, Clezardin P. Effects of bone-targeted agents on cancer progression and mortality. J Natl Cancer Inst. 2012;104:1059–1067.PubMedCrossRef
6.
go back to reference Donaldson AJ, Thomson HE, Harper NJ, Kenny NW. Bone cement implantation syndrome. Br J Anaesth. 2009;102:12–22.PubMedCrossRef Donaldson AJ, Thomson HE, Harper NJ, Kenny NW. Bone cement implantation syndrome. Br J Anaesth. 2009;102:12–22.PubMedCrossRef
7.
go back to reference Fallon KM, Fuller JG, Morley-Forster P. Fat embolization and fatal cardiac arrest during hip arthroplasty with methylmethacrylate. Can J Anaesth. 2001;48:626–629.PubMedCrossRef Fallon KM, Fuller JG, Morley-Forster P. Fat embolization and fatal cardiac arrest during hip arthroplasty with methylmethacrylate. Can J Anaesth. 2001;48:626–629.PubMedCrossRef
8.
go back to reference Herrenbruck T, Erickson EW, Damron TA, Heiner J. Adverse clinical events during cemented long-stem femoral arthroplasty. Clin Orthop Relat Res. 2002;395:154–163.PubMedCrossRef Herrenbruck T, Erickson EW, Damron TA, Heiner J. Adverse clinical events during cemented long-stem femoral arthroplasty. Clin Orthop Relat Res. 2002;395:154–163.PubMedCrossRef
9.
go back to reference Mirels H. Metastatic disease in longs bones: a proposed scoring system for diagnosing impending pathologic fractures. Clin Orthop Relat Res. 1989;249:256–264.PubMed Mirels H. Metastatic disease in longs bones: a proposed scoring system for diagnosing impending pathologic fractures. Clin Orthop Relat Res. 1989;249:256–264.PubMed
10.
go back to reference Paulson OB, Strandsgaard S, Edvinsson L. Cerebral autoregulation. Cerebrovasc Brain Metab Rev. 1990;2:161–192.PubMed Paulson OB, Strandsgaard S, Edvinsson L. Cerebral autoregulation. Cerebrovasc Brain Metab Rev. 1990;2:161–192.PubMed
11.
go back to reference Randall RL, Aoki SK, Olson PR, Bott SI. Complications of cemented long-stem hip arthroplasties in metastatic bone disease. Clin Orthop Relat Res. 2006;443:287–295.PubMedCrossRef Randall RL, Aoki SK, Olson PR, Bott SI. Complications of cemented long-stem hip arthroplasties in metastatic bone disease. Clin Orthop Relat Res. 2006;443:287–295.PubMedCrossRef
12.
go back to reference Ryan CJ, Elkin EP, Cowan J, Carroll PR. Initial treatment patterns and outcome of contemporary prostate cancer patients with bone metastases at initial presentation: data from CaPSURE. Cancer. 2007;110:81–86.PubMedCrossRef Ryan CJ, Elkin EP, Cowan J, Carroll PR. Initial treatment patterns and outcome of contemporary prostate cancer patients with bone metastases at initial presentation: data from CaPSURE. Cancer. 2007;110:81–86.PubMedCrossRef
13.
go back to reference Schulman KL, Kohles J. Economic burden of metastatic bone disease in the U.S. Cancer. 2007;109:2334–2342.PubMedCrossRef Schulman KL, Kohles J. Economic burden of metastatic bone disease in the U.S. Cancer. 2007;109:2334–2342.PubMedCrossRef
14.
go back to reference Selek H, Basarir K, Yildiz Y, Saglik Y. Cement endoprosthetic replacement for metastatic bone disease in the proximal femur. J Arthroplasty. 2008;23:112–117.PubMedCrossRef Selek H, Basarir K, Yildiz Y, Saglik Y. Cement endoprosthetic replacement for metastatic bone disease in the proximal femur. J Arthroplasty. 2008;23:112–117.PubMedCrossRef
15.
go back to reference Thein R, Herman A, Chechik A, Liberman B. Uncemented arthroplasty for metastatic disease of the hip: preliminary clinical experience. J Arthroplasty. 2012;27:1658–1662.PubMedCrossRef Thein R, Herman A, Chechik A, Liberman B. Uncemented arthroplasty for metastatic disease of the hip: preliminary clinical experience. J Arthroplasty. 2012;27:1658–1662.PubMedCrossRef
16.
go back to reference Weber KL, Randall RL, Grossman S, Parvizi J. Management of lower-extremity bone metastasis. J Bone Joint Surg Am. 2006;88(suppl 4):11–19.PubMedCrossRef Weber KL, Randall RL, Grossman S, Parvizi J. Management of lower-extremity bone metastasis. J Bone Joint Surg Am. 2006;88(suppl 4):11–19.PubMedCrossRef
Metadata
Title
Complications of Cemented Long-stem Hip Arthroplasty in Metastatic Bone Disease Revisited
Authors
Shawn L. Price, MD
M. Aabid Farukhi, BA
Kevin B. Jones, MD
Stephen K. Aoki, MD
R. Lor Randall, MD, FACS
Publication date
01-10-2013
Publisher
Springer US
Published in
Clinical Orthopaedics and Related Research® / Issue 10/2013
Print ISSN: 0009-921X
Electronic ISSN: 1528-1132
DOI
https://doi.org/10.1007/s11999-013-3113-5

Other articles of this Issue 10/2013

Clinical Orthopaedics and Related Research® 10/2013 Go to the issue