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Clinical Orthopaedics and Related Research®

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01-08-2011 | Symposium: UHMWPE for Arthroplasty: From Powder to Debris

Cartilage-mimicking, High-density Brush Structure Improves Wear Resistance of Crosslinked Polyethylene: A Pilot Study

Authors: Masayuki Kyomoto, PhD, Toru Moro, MD, Yoshio Takatori, MD, Hiroshi Kawaguchi, MD, Kazuhiko Ishihara, PhD

Published in: Clinical Orthopaedics and Related Research® | Issue 8/2011

Abstract

Background

In natural synovial joints under physiologic conditions, fluid thin-film lubrication by a hydrated layer of the cartilage is essential for the smooth motion of the joints. The considerably less efficient lubrication of artificial joints of polyethylene is prone to wear, leading to osteolysis and aseptic loosening and limiting the longevity of THA. A nanometer-scale layer of poly(2-methacryloyloxyethyl phosphorylcholine) (PMPC) with cartilage-mimicking brushlike structures on a crosslinked polyethylene (CLPE) surface may provide hydrophilicity and lubricity resembling the physiologic joint surface.

Questions/purposes

We asked whether the photoirradiation time during graft polymerization would affect the density and stability of the PMPC layer and the PMPC-grafted surface would enhance the durability of artificial joints. We investigated the effect of photoirradiation time and the resultant characteristics of the PMPC layer on the durability of the CLPE.

Methods

For each of the PMPC-grafted CLPE surfaces with various photoirradiation times (six groups: 0 [untreated CLPE], 11, 23, 45, 90, and 180 minutes), 18 sample pieces (total of 108 samples) were evaluated in surface analyses, and four cups (total of 24 samples) were evaluated in a hip simulator test.

Results

The density of the PMPC layer increased with an increase in the photoirradiation time. The hip simulator test confirmed the PMPC-grafted CLPE with a high density of the PMPC layer exhibited minimal wear as compared with the untreated CLPE. High-density PMPC grafting appears essential for maintaining the high wear resistance of the PMPC-grafted CLPE. To obtain a high-density PMPC layer, the photoirradiation time must be greater than 45 minutes.

Conclusions

The cartilage-mimicking, density brushlike structure of the PMPC-grafted CLPE could extend high durability to acetabular cups in THA.

Clinical Relevance

Our in vitro findings suggest the wear performance of CLPE acetabular cups in THA can be improved by this approach.

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Title: Cartilage-mimicking, High-density Brush Structure Improves Wear Resistance of Crosslinked Polyethylene: A Pilot Study
Authors: Masayuki Kyomoto, PhD
Toru Moro, MD
Yoshio Takatori, MD
Hiroshi Kawaguchi, MD
Kazuhiko Ishihara, PhD
Publication date: 01-08-2011
Publisher: Springer-Verlag
Published in: Clinical Orthopaedics and Related Research® / Issue 8/2011
Print ISSN: 0009-921X
Electronic ISSN: 1528-1132
DOI: https://doi.org/10.1007/s11999-010-1718-5

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Cartilage-mimicking, High-density Brush Structure Improves Wear Resistance of Crosslinked Polyethylene: A Pilot Study

Abstract

Background

Questions/purposes

Methods

Results

Conclusions

Clinical Relevance

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background

Questions/purposes

Methods

Results

Conclusions

Clinical Relevance

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