Skip to main content
Top
Published in: Clinical Orthopaedics and Related Research® 3/2011

01-03-2011 | Symposium: Current Concepts in Cervical Spine Surgery

Does Smoking Influence Fusion Rates in Posterior Cervical Arthrodesis With Lateral Mass Instrumentation?

Authors: Jason David Eubanks, MD, Steven W. Thorpe, MD, Vinay K. Cheruvu, MSc, MS, Brett A. Braly, MD, James D. Kang, MD

Published in: Clinical Orthopaedics and Related Research® | Issue 3/2011

Login to get access

Abstract

Background

Smoking is associated with reduced fusion rates after anterior cervical decompression and arthrodesis procedures. Posterior cervical arthrodesis procedures are believed to have a higher fusion rate than anterior procedures.

Questions/purposes

We asked whether smoking (1) would reduce the fusion rate in posterior cervical procedures; and (2) be associated with increased pain, decreased activity level, and a decreased rate of return of work as compared with nonsmokers.

Methods

We retrospectively reviewed 158 patients who had a posterior cervical fusion with lateral mass instrumentation and iliac crest bone grafting between 2003 and 2008. Fusion rates and Odom Criteria grades were compared among smokers and nonsmokers. The minimum followup was 3 months (average, 14.5 months; range, 3–72 months).

Results

Smokers and nonsmokers had similar fusion rates (100%). Although 80% of patients had Odom Criteria Grade I or II, smokers were five times more likely to have Grade III or IV with considerable limitation of physical activity. Age, gender, and diagnosis did not influence fusion rates or the Odom Criteria grade.

Conclusions

In contrast to the effect of smoking on anterior cervical fusion, we found smoking did not decrease posterior cervical fusion with lateral mass instrumentation and iliac crest bone grafting. Posterior cervical fusion with lateral mass instrumentation should be considered over anterior procedures in smokers if the abnormality can appropriately be addressed from a posterior approach.

Level of Evidence

Level III, therapeutic study. See Guidelines for Authors for a complete description of levels of evidence.
Literature
1.
go back to reference An HS, Simpson JM, Glover JM, Stephany J. Comparison between allograft plus demineralized bone matrix versus autograft in anterior cervical fusion. A prospective multicenter study. Spine. 1995;20:2211–3326.CrossRefPubMed An HS, Simpson JM, Glover JM, Stephany J. Comparison between allograft plus demineralized bone matrix versus autograft in anterior cervical fusion. A prospective multicenter study. Spine. 1995;20:2211–3326.CrossRefPubMed
2.
go back to reference Bishop RC, Moore KA, Hadley MN. Anterior cervical interbody fusion using autogenic and allogeneic bone graft substrate: a prospective comparative analysis. J Neurosurg. 1996;85:206–210.CrossRefPubMed Bishop RC, Moore KA, Hadley MN. Anterior cervical interbody fusion using autogenic and allogeneic bone graft substrate: a prospective comparative analysis. J Neurosurg. 1996;85:206–210.CrossRefPubMed
3.
go back to reference Boden SD, Sumner DR. Biologic factors affecting spinal fusion and bone regeneration. Spine (Phila Pa 1976). 1995;20(Suppl):102S–112S. Boden SD, Sumner DR. Biologic factors affecting spinal fusion and bone regeneration. Spine (Phila Pa 1976). 1995;20(Suppl):102S–112S.
4.
go back to reference Bohlman HH, Emery SE, Goodfellow DB, Jones PK. Robinson anterior cervical discectomy and arthrodesis for cervical radiculopathy. Long-term follow-up of one hundred and twenty-two patients. J Bone Joint Surg Am. 1993;75:1298–1307.PubMed Bohlman HH, Emery SE, Goodfellow DB, Jones PK. Robinson anterior cervical discectomy and arthrodesis for cervical radiculopathy. Long-term follow-up of one hundred and twenty-two patients. J Bone Joint Surg Am. 1993;75:1298–1307.PubMed
5.
go back to reference Bose B. Anterior cervical instrumentation enhances fusion rates in multilevel reconstruction in smokers. J Spinal Disord. 2001;14:3–9.CrossRefPubMed Bose B. Anterior cervical instrumentation enhances fusion rates in multilevel reconstruction in smokers. J Spinal Disord. 2001;14:3–9.CrossRefPubMed
6.
go back to reference Brodsky AE, Khalil MA, Sassard WR, Newman BP. Repair of symptomatic pseudoarthrosis of anterior cervical fusion. Spine. 1992;17:1137–1143.CrossRefPubMed Brodsky AE, Khalil MA, Sassard WR, Newman BP. Repair of symptomatic pseudoarthrosis of anterior cervical fusion. Spine. 1992;17:1137–1143.CrossRefPubMed
7.
go back to reference Brown CW, Orme TJ, Richardson HD. The rate of pseudoarthrosis (surgical nonunion) in patients who are smokers and patients who are nonsmokers: a comparison study. Spine. 1986;11:942–943.CrossRefPubMed Brown CW, Orme TJ, Richardson HD. The rate of pseudoarthrosis (surgical nonunion) in patients who are smokers and patients who are nonsmokers: a comparison study. Spine. 1986;11:942–943.CrossRefPubMed
8.
go back to reference Cannada LK, Scherping SC, Yoo JU. Pseudoarthrosis of the cervical spine: a comparison of radiographic diagnostic measures. Spine. 2003;28:46–51.CrossRefPubMed Cannada LK, Scherping SC, Yoo JU. Pseudoarthrosis of the cervical spine: a comparison of radiographic diagnostic measures. Spine. 2003;28:46–51.CrossRefPubMed
9.
go back to reference Carreon L, Glassman SD, Campbell MJ. Treatment of anterior cervical pseudoarthrosis: posterior fusion versus anterior revision. Spine J. 2006;6:154–156.CrossRefPubMed Carreon L, Glassman SD, Campbell MJ. Treatment of anterior cervical pseudoarthrosis: posterior fusion versus anterior revision. Spine J. 2006;6:154–156.CrossRefPubMed
10.
go back to reference Cuathen JC, Kinard RE, Vogler JB, Jackson DE, DePaz OB, Hunter OL, Wasserburger LB, Williams VM. Outcome analysis of noninstrumented anterior discectomy and interbody fusion in 348 patients. Spine. 1998;23:188–192.CrossRef Cuathen JC, Kinard RE, Vogler JB, Jackson DE, DePaz OB, Hunter OL, Wasserburger LB, Williams VM. Outcome analysis of noninstrumented anterior discectomy and interbody fusion in 348 patients. Spine. 1998;23:188–192.CrossRef
11.
go back to reference Dafarti TK, Whitesides TE, Heller JG, Goodrich AC, McCarey, Hutton WC. Nicotine on the revascularization of bone graft. An experimental study in rabbits. Spine. 1994;19:904–911.CrossRef Dafarti TK, Whitesides TE, Heller JG, Goodrich AC, McCarey, Hutton WC. Nicotine on the revascularization of bone graft. An experimental study in rabbits. Spine. 1994;19:904–911.CrossRef
12.
go back to reference Deen HG, Birch BD, Wharen RE, Reimer R. Lateral mass screw-rod fixation of the cervical spine: a prospective clinical series with a 1-year follow-up. Spine J. 2003;3:489–495.PubMed Deen HG, Birch BD, Wharen RE, Reimer R. Lateral mass screw-rod fixation of the cervical spine: a prospective clinical series with a 1-year follow-up. Spine J. 2003;3:489–495.PubMed
13.
go back to reference Emery SE, Bohlman HH, Bolesta MJ, Jones PK. Anterior cervical decompression and arthrodesis for the treatment of cervical spondylotic myelopathy. J Bone Joint Surg Am. 1998;80:941–951.CrossRefPubMed Emery SE, Bohlman HH, Bolesta MJ, Jones PK. Anterior cervical decompression and arthrodesis for the treatment of cervical spondylotic myelopathy. J Bone Joint Surg Am. 1998;80:941–951.CrossRefPubMed
14.
go back to reference Emery SE, Fisher JR, Bohlman HH. Three level anterior cervical discectomy and fusion: radiographic and clinical results. Spine. 1997;22:2622–2624.CrossRefPubMed Emery SE, Fisher JR, Bohlman HH. Three level anterior cervical discectomy and fusion: radiographic and clinical results. Spine. 1997;22:2622–2624.CrossRefPubMed
15.
go back to reference Farey ID, McAffee PC, Davis RF, Long DM. Pseudoarthrosis of the cervical spine after anterior arthrodesis. J Bone Joint Surg Am. 1990;72:1171–1177.PubMed Farey ID, McAffee PC, Davis RF, Long DM. Pseudoarthrosis of the cervical spine after anterior arthrodesis. J Bone Joint Surg Am. 1990;72:1171–1177.PubMed
16.
go back to reference Hadley MN, Reddy SV. Smoking and the human vertebral column: a review of the impact of cigarette use on vertebral bone metabolism and spinal fusion. Neurosurgery. 1997;41:116–124.CrossRefPubMed Hadley MN, Reddy SV. Smoking and the human vertebral column: a review of the impact of cigarette use on vertebral bone metabolism and spinal fusion. Neurosurgery. 1997;41:116–124.CrossRefPubMed
17.
go back to reference Hanley EN, Levy JA. Surgical treatment of isthmic lumbosacral spondylolisthesis. Analysis of variables influencing results. Spine. 1989;14:48–50.CrossRefPubMed Hanley EN, Levy JA. Surgical treatment of isthmic lumbosacral spondylolisthesis. Analysis of variables influencing results. Spine. 1989;14:48–50.CrossRefPubMed
18.
go back to reference Hilibrand AS, Fye MA, Emery SE, Palumbo MA, Bohlman HH. Impact of smoking on the outcome of anterior cervical arthrodesis with interbody strut grafting. J Bone Joint Surg Am. 2001;83:668–673.CrossRefPubMed Hilibrand AS, Fye MA, Emery SE, Palumbo MA, Bohlman HH. Impact of smoking on the outcome of anterior cervical arthrodesis with interbody strut grafting. J Bone Joint Surg Am. 2001;83:668–673.CrossRefPubMed
19.
go back to reference Huang RC, Girardi FP, Poynton AR, Cammisa FP Jr. Treatment of multilevel cervical spondylotic myeloradiculopathy with posterior decompression and fusion with lateral mass plate fixation and local bone graft. J Spinal Disord Tech. 2003;16:123–129.CrossRefPubMed Huang RC, Girardi FP, Poynton AR, Cammisa FP Jr. Treatment of multilevel cervical spondylotic myeloradiculopathy with posterior decompression and fusion with lateral mass plate fixation and local bone graft. J Spinal Disord Tech. 2003;16:123–129.CrossRefPubMed
20.
go back to reference Korinth MC, Kruger A, Oertel MF, Gilsbach JM. Posterior foraminotomy or anterior discectomy with polymethyl methacrylate interbody stabilization for cervical soft disc disease: results in 292 patients with monoradiculopathy. Spine. 2006;31:1207–1214.CrossRefPubMed Korinth MC, Kruger A, Oertel MF, Gilsbach JM. Posterior foraminotomy or anterior discectomy with polymethyl methacrylate interbody stabilization for cervical soft disc disease: results in 292 patients with monoradiculopathy. Spine. 2006;31:1207–1214.CrossRefPubMed
21.
go back to reference Kuhns CA, Geck MJ, Wang JC, Delemarter RB. An outcomes analysis of the treatment of cervical pseudoarthrosis with posterior fusion. Spine. 2005;30:2424–2429.CrossRefPubMed Kuhns CA, Geck MJ, Wang JC, Delemarter RB. An outcomes analysis of the treatment of cervical pseudoarthrosis with posterior fusion. Spine. 2005;30:2424–2429.CrossRefPubMed
22.
go back to reference Lovely T, Carl A. Posterior cervical spine fusion with tension-band wiring. J Neurosurg. 1995;83:631–635.CrossRefPubMed Lovely T, Carl A. Posterior cervical spine fusion with tension-band wiring. J Neurosurg. 1995;83:631–635.CrossRefPubMed
23.
go back to reference Mutoh N, Shinomiya K, Furuya K, Yamaura I, Satoh H. Pseudoarthrosis and delayed union after anterior cervical fusion. Int Orthop. 1993;17:286–289.CrossRefPubMed Mutoh N, Shinomiya K, Furuya K, Yamaura I, Satoh H. Pseudoarthrosis and delayed union after anterior cervical fusion. Int Orthop. 1993;17:286–289.CrossRefPubMed
24.
go back to reference Newman M. The outcome of pseudoarthrosis after cervical anterior fusion. Spine. 1993;18:2380–2382.CrossRefPubMed Newman M. The outcome of pseudoarthrosis after cervical anterior fusion. Spine. 1993;18:2380–2382.CrossRefPubMed
25.
go back to reference Odom GL, Finney W, Woodhall B. Cervical disk lesions. JAMA. 1958;166:23–28. Odom GL, Finney W, Woodhall B. Cervical disk lesions. JAMA. 1958;166:23–28.
26.
go back to reference Papagelopoulos PJ, Currier BL, Neale PG, Hokari Y, Berglund LJ, Larson DR, Fisher DR, An KN. Biomechanical evaluation of posterior screw fixation in cadaveric cervical spines. Clin Orthop Relat Res. 2003;411:13–24.CrossRefPubMed Papagelopoulos PJ, Currier BL, Neale PG, Hokari Y, Berglund LJ, Larson DR, Fisher DR, An KN. Biomechanical evaluation of posterior screw fixation in cadaveric cervical spines. Clin Orthop Relat Res. 2003;411:13–24.CrossRefPubMed
27.
go back to reference Pateder DB, Carbone JJ. Lateral mass screw fixation for cervical spine trauma: associated complications and efficacy in maintaining alignment. Spine J. 2006;6:40–43.CrossRefPubMed Pateder DB, Carbone JJ. Lateral mass screw fixation for cervical spine trauma: associated complications and efficacy in maintaining alignment. Spine J. 2006;6:40–43.CrossRefPubMed
28.
go back to reference Samartzis D, Shen FH, Goldberg EJ, An HS. Is autograft the gold standard in achieving radiographic fusion in one-level anterior cervical discectomy and fusion with rigid anterior plate fixation? Spine. 2005;30:1756–1761.CrossRefPubMed Samartzis D, Shen FH, Goldberg EJ, An HS. Is autograft the gold standard in achieving radiographic fusion in one-level anterior cervical discectomy and fusion with rigid anterior plate fixation? Spine. 2005;30:1756–1761.CrossRefPubMed
29.
go back to reference Sawin PD, Traynelis VC, Menezes MD. A comparative analysis of fusion rates and donor-site morbidity for autogeneic rib and iliac crest bone grafts in posterior cervical fusions. J Neurosurg. 1998;88:255–265.CrossRefPubMed Sawin PD, Traynelis VC, Menezes MD. A comparative analysis of fusion rates and donor-site morbidity for autogeneic rib and iliac crest bone grafts in posterior cervical fusions. J Neurosurg. 1998;88:255–265.CrossRefPubMed
30.
go back to reference Schultz KD, McLaughlin MR, Haid RW, Comey CH, Rodts GE Jr, Alexander J. Single-stage anterior-posterior decompression and stabilization for complex cervical spine disorders. J Neurosurg. 2000;93(Suppl):214–221.PubMed Schultz KD, McLaughlin MR, Haid RW, Comey CH, Rodts GE Jr, Alexander J. Single-stage anterior-posterior decompression and stabilization for complex cervical spine disorders. J Neurosurg. 2000;93(Suppl):214–221.PubMed
31.
go back to reference Sembrano JN, Mehbod AA, Garvey TA, Denis F, Perra JH, Schwender JD, Transfeldt EE, Winter RB, Wroblewski JM. A concomitant posterior approach improves fusion rates but not overall reoperation rates in multilevel cervical fusion for spondylosis. J Spinal Disord Tech. 2009;22:162–169.CrossRefPubMed Sembrano JN, Mehbod AA, Garvey TA, Denis F, Perra JH, Schwender JD, Transfeldt EE, Winter RB, Wroblewski JM. A concomitant posterior approach improves fusion rates but not overall reoperation rates in multilevel cervical fusion for spondylosis. J Spinal Disord Tech. 2009;22:162–169.CrossRefPubMed
32.
go back to reference Silcox DH, Dafarti T, Boden SD, Schimadle JH, Hutton WC, Whitesides TE. The effect of nicotine on spinal fusion. Spine. 1995;20:1549–1553.CrossRefPubMed Silcox DH, Dafarti T, Boden SD, Schimadle JH, Hutton WC, Whitesides TE. The effect of nicotine on spinal fusion. Spine. 1995;20:1549–1553.CrossRefPubMed
33.
go back to reference Zdeblick TA, Hughes SS, Riew D, Bohlman HH. Failed anterior cervical discetomy and arthrodesis. Analysis and treatment of thirty-five patients. J Bone Joint Surg Am. 1997;79:523–532.CrossRefPubMed Zdeblick TA, Hughes SS, Riew D, Bohlman HH. Failed anterior cervical discetomy and arthrodesis. Analysis and treatment of thirty-five patients. J Bone Joint Surg Am. 1997;79:523–532.CrossRefPubMed
Metadata
Title
Does Smoking Influence Fusion Rates in Posterior Cervical Arthrodesis With Lateral Mass Instrumentation?
Authors
Jason David Eubanks, MD
Steven W. Thorpe, MD
Vinay K. Cheruvu, MSc, MS
Brett A. Braly, MD
James D. Kang, MD
Publication date
01-03-2011
Publisher
Springer-Verlag
Published in
Clinical Orthopaedics and Related Research® / Issue 3/2011
Print ISSN: 0009-921X
Electronic ISSN: 1528-1132
DOI
https://doi.org/10.1007/s11999-010-1575-2

Other articles of this Issue 3/2011

Clinical Orthopaedics and Related Research® 3/2011 Go to the issue

Symposium: Current Concepts in Cervical Spine Surgery

Cervical Spine Surgery: An Historical Perspective