Skip to main content
Top
Published in: Clinical Orthopaedics and Related Research® 11/2009

01-11-2009 | Symposium: Selected Papers Presented at the 2008 Meeting of the Musculoskeletal Tumor Society

Joint Preservation after Extensive Curettage of Knee Giant Cell Tumors

Authors: Miguel A. Ayerza, MD, Luis A. Aponte-Tinao, MD, German L. Farfalli, MD, Carlos A. Lores Restrepo, MD, D. Luis Muscolo, MD

Published in: Clinical Orthopaedics and Related Research® | Issue 11/2009

Login to get access

Abstract

Curettage is the most attractive procedure for surgically treating a giant cell tumor because it preserves joint function. However, since many giant cell tumors compromise subchondral bone this technique can jeopardize the articular surface with subsequent fractures or collapse. We asked whether intralesional curettage of a giant cell tumor close to the knee that combined morselized bone and cortical structural allograft would preserve joint function. We retrospectively reviewed 22 patients treated with that approach. The minimum followup was 2 years (average, 48 months; range, 24–80 months). The distal femur was involved in 12 patients and proximal tibia in 10. Complications and failures were recorded and functional results evaluated with Musculoskeletal Tumor Society score. We determined survivorship using the Kaplan-Meier technique using removal of the implant as the endpoint. The survival was 85% and the average functional score 28 points. Three of the 22 patients had a local tumor recurrence and one had a partial subchondral collapse not requiring further treatment. Among the remaining patients, none had fracture, infection, or knee instability. The combination of fragmented and cortical allograft allows reconstructing the bone defect and ligaments created after extensive curettage of a knee giant cell tumor obtaining normal joint function and a high survival rate with minimal complications in a high percentage of the patients.
Level of Evidence: Level IV, therapeutic study. See the Guidelines for Authors for a complete description of levels of evidence.
Literature
1.
go back to reference Arbeitsgemeinschaft Knochentumoren, Becker WT, Dohle J, Bernd L, Braun A, Cserhati M, Enderle A, Hovy L, Matejovsky Z, Szendroi M, Trieb K, Tunn PU. Local recurrence of giant cell tumor of bone after intralesional treatment with and without adjuvant therapy. J Bone Joint Surg Am. 2008;90:1060–1067.CrossRef Arbeitsgemeinschaft Knochentumoren, Becker WT, Dohle J, Bernd L, Braun A, Cserhati M, Enderle A, Hovy L, Matejovsky Z, Szendroi M, Trieb K, Tunn PU. Local recurrence of giant cell tumor of bone after intralesional treatment with and without adjuvant therapy. J Bone Joint Surg Am. 2008;90:1060–1067.CrossRef
2.
go back to reference Ayerza MA, Aponte-Tinao LA, Muscolo DL, Abalo ED. Morsellized and structural cortical allograft reconstruction after intralesional curettage of a distal femoral giant-cell tumor. Orthopedics. 2006;29:679–682.PubMed Ayerza MA, Aponte-Tinao LA, Muscolo DL, Abalo ED. Morsellized and structural cortical allograft reconstruction after intralesional curettage of a distal femoral giant-cell tumor. Orthopedics. 2006;29:679–682.PubMed
3.
go back to reference Balke M, Schremper L, Gebert C, Ahrens H, Streitbuerger A, Koehler G, Hardes J, Gosheger G. Giant cell tumor of bone: treatment and outcome of 214 cases. J Cancer Res Clin Oncol. 2008;134:969–978.PubMedCrossRef Balke M, Schremper L, Gebert C, Ahrens H, Streitbuerger A, Koehler G, Hardes J, Gosheger G. Giant cell tumor of bone: treatment and outcome of 214 cases. J Cancer Res Clin Oncol. 2008;134:969–978.PubMedCrossRef
4.
go back to reference Blackley HR, Wunder JS, Davis AM, White LM, Kandel R, Bell RS. Treatment of giant-cell tumors of long bones with curettage and bone-grafting. J Bone Joint Surg Am. 1999;81:811–820.PubMedCrossRef Blackley HR, Wunder JS, Davis AM, White LM, Kandel R, Bell RS. Treatment of giant-cell tumors of long bones with curettage and bone-grafting. J Bone Joint Surg Am. 1999;81:811–820.PubMedCrossRef
5.
go back to reference Buecker PJ, Gebhardt MC. Are fibula strut allografts a reliable alternative for periarticular reconstruction after curettage for bone tumors? Clin Orthop Relat Res. 2007;461:170–174.PubMed Buecker PJ, Gebhardt MC. Are fibula strut allografts a reliable alternative for periarticular reconstruction after curettage for bone tumors? Clin Orthop Relat Res. 2007;461:170–174.PubMed
6.
go back to reference Campanacci M, Baldini N, Boriani S, Sudanese A. Giant-cell tumor of bone. J Bone Joint Surg Am. 1987;69:106–114.PubMed Campanacci M, Baldini N, Boriani S, Sudanese A. Giant-cell tumor of bone. J Bone Joint Surg Am. 1987;69:106–114.PubMed
7.
go back to reference Eckardt JJ, Grogan TJ. Giant cell tumor of bone. Clin Orthop Relat Res. 1986;204:45–58.PubMed Eckardt JJ, Grogan TJ. Giant cell tumor of bone. Clin Orthop Relat Res. 1986;204:45–58.PubMed
8.
go back to reference Enneking WF, Dunham W, Gebhardt MC, Malawer M, Prichard DJ. A system for the functional evaluation of reconstructive procedures after surgical treatment of tumors of the musculoskeletal system. Clin Orthop Relat Res. 1993;286:241–246.PubMed Enneking WF, Dunham W, Gebhardt MC, Malawer M, Prichard DJ. A system for the functional evaluation of reconstructive procedures after surgical treatment of tumors of the musculoskeletal system. Clin Orthop Relat Res. 1993;286:241–246.PubMed
9.
go back to reference Gitelis S, Mallin BA, Piasecki P, Turner F. Intralesional excision compared with en bloc resection for giant-cell tumor of bone. J Bone Joint Surg Am. 1993;75:1648–1655.PubMed Gitelis S, Mallin BA, Piasecki P, Turner F. Intralesional excision compared with en bloc resection for giant-cell tumor of bone. J Bone Joint Surg Am. 1993;75:1648–1655.PubMed
10.
go back to reference Glasser D, Langlais F. The ISOLS radiological implant evaluation system. In: Langlais F, Tomeno B, eds. Limb Salvage: Major Reconstructions in Oncologic and Nontumoral Conditions. Heidelberg, Germany: Springer-Verlag; 1991. Glasser D, Langlais F. The ISOLS radiological implant evaluation system. In: Langlais F, Tomeno B, eds. Limb Salvage: Major Reconstructions in Oncologic and Nontumoral Conditions. Heidelberg, Germany: Springer-Verlag; 1991.
11.
go back to reference Kivioja AH, Blomqvist C, Hietaniemi K, Trovik C, Walloe A, Bauer HC, Jorgensen PH, Bergh P, Follerås G. Cement is recommended in intralesional surgery of giant cell tumors: a Scandinavian Sarcoma Group study of 294 patients followed for a median time of 5 years. Acta Orthop. 2008;79:86–93.PubMedCrossRef Kivioja AH, Blomqvist C, Hietaniemi K, Trovik C, Walloe A, Bauer HC, Jorgensen PH, Bergh P, Follerås G. Cement is recommended in intralesional surgery of giant cell tumors: a Scandinavian Sarcoma Group study of 294 patients followed for a median time of 5 years. Acta Orthop. 2008;79:86–93.PubMedCrossRef
12.
go back to reference Li JM, Yang ZP, Li ZF, Li X, Carter SR. Knee reconstruction with preservation of the meniscus in tibial giant cell tumor. Clin Orthop Relat Res. 2008;466:3101–3107.PubMedCrossRef Li JM, Yang ZP, Li ZF, Li X, Carter SR. Knee reconstruction with preservation of the meniscus in tibial giant cell tumor. Clin Orthop Relat Res. 2008;466:3101–3107.PubMedCrossRef
13.
go back to reference Malawer MM, Bickels J, Meller I, Buch RG, Henshaw RM, Kollender Y. Cryosurgery in the treatment of giant cell tumor: a long-term followup study. Clin Orthop Relat Res. 1999;359:176–188.PubMedCrossRef Malawer MM, Bickels J, Meller I, Buch RG, Henshaw RM, Kollender Y. Cryosurgery in the treatment of giant cell tumor: a long-term followup study. Clin Orthop Relat Res. 1999;359:176–188.PubMedCrossRef
14.
go back to reference McDonald DJ, Sim FH, McLeod RA, Dahlin DC. Giant-cell tumor of bone. J Bone Joint Surg Am. 1986;68:235–242.PubMed McDonald DJ, Sim FH, McLeod RA, Dahlin DC. Giant-cell tumor of bone. J Bone Joint Surg Am. 1986;68:235–242.PubMed
15.
go back to reference Muscolo DL, Ayerza MA, Aponte-Tinao LA. Massive allograft use in orthopedic oncology. Orthop Clin North Am. 2006;37:65–74.PubMedCrossRef Muscolo DL, Ayerza MA, Aponte-Tinao LA. Massive allograft use in orthopedic oncology. Orthop Clin North Am. 2006;37:65–74.PubMedCrossRef
16.
go back to reference Muscolo DL, Ayerza MA, Calabrese ME, Gruenberg M. The use of a bone allograft for reconstruction after resection of giant-cell tumor close to the knee. J Bone Joint Surg Am. 1993;75:1656–1662.PubMed Muscolo DL, Ayerza MA, Calabrese ME, Gruenberg M. The use of a bone allograft for reconstruction after resection of giant-cell tumor close to the knee. J Bone Joint Surg Am. 1993;75:1656–1662.PubMed
17.
go back to reference Persson BM, Ekelund L, Lövdahl R, Gunterberg B. Favourable results of acrylic cementation for giant cell tumors. Acta Orthop Scand. 1984;55:209–214.PubMedCrossRef Persson BM, Ekelund L, Lövdahl R, Gunterberg B. Favourable results of acrylic cementation for giant cell tumors. Acta Orthop Scand. 1984;55:209–214.PubMedCrossRef
18.
go back to reference Prosser GH, Baloch KG, Tillman RM, Carter SR, Grimer RJ. Does curettage without adjuvant therapy provide low recurrence rates in giant-cell tumors of bone? Clin Orthop Relat Res. 2005;435:211–218.PubMedCrossRef Prosser GH, Baloch KG, Tillman RM, Carter SR, Grimer RJ. Does curettage without adjuvant therapy provide low recurrence rates in giant-cell tumors of bone? Clin Orthop Relat Res. 2005;435:211–218.PubMedCrossRef
19.
go back to reference Schindler OS, Cannon SR, Briggs TW, Blunn GW. Use of a novel bone graft substitute in peri-articular bone tumours of the knee. Knee. 2007;14:458–464.PubMedCrossRef Schindler OS, Cannon SR, Briggs TW, Blunn GW. Use of a novel bone graft substitute in peri-articular bone tumours of the knee. Knee. 2007;14:458–464.PubMedCrossRef
20.
go back to reference Sung HW, Kuo DP, Shu WP, Chai YB, Liu CC, Li SM. Giant cell tumor of bone: analysis of two hundred and eight cases in Chinese patients. J Bone Joint Surg Am. 1982;64:755–761.PubMed Sung HW, Kuo DP, Shu WP, Chai YB, Liu CC, Li SM. Giant cell tumor of bone: analysis of two hundred and eight cases in Chinese patients. J Bone Joint Surg Am. 1982;64:755–761.PubMed
21.
go back to reference Turcotte RE, Wunder JS, Isler MH, Bell RS, Schachar N, Masri BA, Moreau G, Davis AM, Canadian Sarcoma Group. Giant cell tumor of long bone: a Canadian Sarcoma Group study. Clin Orthop Relat Res. 2002;397:248–258.PubMedCrossRef Turcotte RE, Wunder JS, Isler MH, Bell RS, Schachar N, Masri BA, Moreau G, Davis AM, Canadian Sarcoma Group. Giant cell tumor of long bone: a Canadian Sarcoma Group study. Clin Orthop Relat Res. 2002;397:248–258.PubMedCrossRef
22.
go back to reference Ward WG Sr, Li G 3rd. Customized treatment algorithm for giant cell tumor of bone: report of a series. Clin Orthop Relat Res. 2002;397:259–270.PubMedCrossRef Ward WG Sr, Li G 3rd. Customized treatment algorithm for giant cell tumor of bone: report of a series. Clin Orthop Relat Res. 2002;397:259–270.PubMedCrossRef
23.
go back to reference Zhen W, Yaotian H, Songjian L, Ge L, Qingliang W. Giant-cell tumour of bone: the long-term results of treatment by curettage and bone graft. J Bone Joint Surg Br. 2004;86:212–216.PubMedCrossRef Zhen W, Yaotian H, Songjian L, Ge L, Qingliang W. Giant-cell tumour of bone: the long-term results of treatment by curettage and bone graft. J Bone Joint Surg Br. 2004;86:212–216.PubMedCrossRef
Metadata
Title
Joint Preservation after Extensive Curettage of Knee Giant Cell Tumors
Authors
Miguel A. Ayerza, MD
Luis A. Aponte-Tinao, MD
German L. Farfalli, MD
Carlos A. Lores Restrepo, MD
D. Luis Muscolo, MD
Publication date
01-11-2009
Publisher
Springer-Verlag
Published in
Clinical Orthopaedics and Related Research® / Issue 11/2009
Print ISSN: 0009-921X
Electronic ISSN: 1528-1132
DOI
https://doi.org/10.1007/s11999-009-0913-8

Other articles of this Issue 11/2009

Clinical Orthopaedics and Related Research® 11/2009 Go to the issue

Symposium: Selected Papers Presented at the 2008 Meeting of the Musculoskeletal Tumor Society

The Classic: The Registry of Bone Sarcomas as an Example of the End-Result Idea in Hospital Organization