Skip to main content
Top
Published in: Current Urology Reports 11/2018

01-11-2018 | Lower Urinary Tract Symptoms & Voiding Dysfunction (J Sandhu, Section Editor)

Management of Overactive Bladder in Older Women

Authors: Toya S. Pratt, Anne M. Suskind

Published in: Current Urology Reports | Issue 11/2018

Login to get access

Abstract

Purpose of review:

This review will highlight our current understanding of age-related changes in bladder function and propose important clinical considerations in the management of overactive bladder (OAB) specific to older women.

Recent findings:

Frailty, functional and cognitive impairment, multimorbidity, polypharmacy, estrogen deficiency, and remaining life expectancy are important clinical factors to consider and may impact OAB symptom management in older women. Third-line therapies, particularly PTNS, may be preferable over second-line therapy in some cases.

Summary:

Due to the complexity within this population, the standard treatment algorithms may not be applicable, thus a broader, more holistic focus is recommended when managing OAB in older women.
Literature
1.
go back to reference Sexton C, Coyne K, Thompson C, et al. Prevalence and effect on health-related quality of life of overactive bladder in older Americans: results from the epidemiology of lower urinary tract symptoms study. J Am Geriatr Soc. 2011;59:1465–70.CrossRefPubMed Sexton C, Coyne K, Thompson C, et al. Prevalence and effect on health-related quality of life of overactive bladder in older Americans: results from the epidemiology of lower urinary tract symptoms study. J Am Geriatr Soc. 2011;59:1465–70.CrossRefPubMed
2.
go back to reference Brown JS, Vittinghoff E, Wyman J, et al. Urinary incontinence: does it increase risk for fall and fracture? J Am Geriatr Soc. 2000;48:721–5.CrossRefPubMed Brown JS, Vittinghoff E, Wyman J, et al. Urinary incontinence: does it increase risk for fall and fracture? J Am Geriatr Soc. 2000;48:721–5.CrossRefPubMed
3.
go back to reference Coyne KS, Sexton CC, Kopp Z, et al. Assessing patients’ descriptions of lower urinary tract symptoms (LUTS) and perspectives on treatment outcomes: results of qualitative research. IJCP. 2010:1–37. Coyne KS, Sexton CC, Kopp Z, et al. Assessing patients’ descriptions of lower urinary tract symptoms (LUTS) and perspectives on treatment outcomes: results of qualitative research. IJCP. 2010:1–37.
4.
go back to reference Ganz ML, Smalarz AM, Krupski TL, Anger JT, Hu JC, Wittrup-Jensen KU, et al. Economic costs of overactive bladder in the United States. Urology. 2010;75(3):526–32.CrossRefPubMed Ganz ML, Smalarz AM, Krupski TL, Anger JT, Hu JC, Wittrup-Jensen KU, et al. Economic costs of overactive bladder in the United States. Urology. 2010;75(3):526–32.CrossRefPubMed
5.
go back to reference Gormley EA, Lightner DJ, Burgio KL, Chai TC, Clemens JQ, Culkin DJ, Das AK, Foster Jr HE, Scarpero HM, Tessier CD, Vasavada SP American Urological Association; Society of Urodynamics, Female Pelvic Medicine & Urogenital Reconstruction. Diagnosis and treatment of overactive bladder (non-neurogenic) in adults: AUA/SUFU guideline J Urol 2012;188(6 Suppl):2455–2463. Gormley EA, Lightner DJ, Burgio KL, Chai TC, Clemens JQ, Culkin DJ, Das AK, Foster Jr HE, Scarpero HM, Tessier CD, Vasavada SP American Urological Association; Society of Urodynamics, Female Pelvic Medicine & Urogenital Reconstruction. Diagnosis and treatment of overactive bladder (non-neurogenic) in adults: AUA/SUFU guideline J Urol 2012;188(6 Suppl):2455–2463.
6.
go back to reference • Gormely E, Lightner D, Faraday M, et al. Diagnosis and treatment of overactive bladder (non-neurogenic) in adults: AUA/SUFU guideline amendment. J Urol. 2015;193:1572–80. An important update including relevant newly published literature for the diagnosis and treatment of patients with non-neurogenic overactive bladder. CrossRef • Gormely E, Lightner D, Faraday M, et al. Diagnosis and treatment of overactive bladder (non-neurogenic) in adults: AUA/SUFU guideline amendment. J Urol. 2015;193:1572–80. An important update including relevant newly published literature for the diagnosis and treatment of patients with non-neurogenic overactive bladder. CrossRef
7.
go back to reference Tadic SD, Griffiths D, Schaefer W, Murrin A, Clarkson B, Resnick NM. Brain activity underlying impaired continence control in older women with overactive bladder. Neurourol Urodyn. 2012 Jun;31(5):652–658.CrossRefPubMedPubMedCentral Tadic SD, Griffiths D, Schaefer W, Murrin A, Clarkson B, Resnick NM. Brain activity underlying impaired continence control in older women with overactive bladder. Neurourol Urodyn. 2012 Jun;31(5):652–658.CrossRefPubMedPubMedCentral
8.
go back to reference Ketai LH, Komesu YM, Dodd AB et al. Urgency urinary incontinence and the interoceptive network: a functional magnetic resonance imaging study. Am J Obstet Gynecol. 2016;215(4):449.e1–449.e17.CrossRefPubMedPubMedCentral Ketai LH, Komesu YM, Dodd AB et al. Urgency urinary incontinence and the interoceptive network: a functional magnetic resonance imaging study. Am J Obstet Gynecol. 2016;215(4):449.e1–449.e17.CrossRefPubMedPubMedCentral
9.
go back to reference Brading A, Symes S. Ischemia as an etiological factor in bladder instability: implications for therapy. Adv Exp Med Biol. 2003;503:255–69. Brading A, Symes S. Ischemia as an etiological factor in bladder instability: implications for therapy. Adv Exp Med Biol. 2003;503:255–69.
10.
go back to reference Yoshida M, Miyamae K, Iwashita H, Otani M, Inadome A. Management of detrusor dysfunction in the elderly: changes in acetylcholine and adenosine triphosphate release during aging. Urology. 2004;63(3 Suppl 1):17–23. Review CrossRef Yoshida M, Miyamae K, Iwashita H, Otani M, Inadome A. Management of detrusor dysfunction in the elderly: changes in acetylcholine and adenosine triphosphate release during aging. Urology. 2004;63(3 Suppl 1):17–23. Review CrossRef
11.
go back to reference Tincello D, Taylor A, Spurling S, et al. Receptor isoforms that mediate estrogen and progesterone action in the female lower urinary tract. J Urol. 2009;181:1474–82.CrossRefPubMed Tincello D, Taylor A, Spurling S, et al. Receptor isoforms that mediate estrogen and progesterone action in the female lower urinary tract. J Urol. 2009;181:1474–82.CrossRefPubMed
12.
go back to reference Iosif S, Batra S, Ek A, et al. Estrogens receptors in the human female lower urinary tract. Am J Obstet Gynaecol. 1981;141:817–20.CrossRef Iosif S, Batra S, Ek A, et al. Estrogens receptors in the human female lower urinary tract. Am J Obstet Gynaecol. 1981;141:817–20.CrossRef
13.
go back to reference Batra SC, Iosif LS. Progesterone receptors in the female urinary tract. J Urol. 1987;138:130–4.CrossRef Batra SC, Iosif LS. Progesterone receptors in the female urinary tract. J Urol. 1987;138:130–4.CrossRef
14.
go back to reference • Robinson D, Cardoza L, Milsom I et al. Oestrogens and overactive bladder. Neurourol Urodynam.2014.33:1086-1091 Interesting review article on the evidence for the role of estrogen therapy in the management of OAB. • Robinson D, Cardoza L, Milsom I et al. Oestrogens and overactive bladder. Neurourol Urodynam.2014.33:1086-1091 Interesting review article on the evidence for the role of estrogen therapy in the management of OAB.
16.
go back to reference Fried LP, Tangen CM, Walston J, Newman AB, Hirsch C, Gottdiener J, et al. Frailty in older adults: evidence for a phenotype. J Gerontol A Biol Sci Med Sci. 2001;56(3):M146–56.CrossRef Fried LP, Tangen CM, Walston J, Newman AB, Hirsch C, Gottdiener J, et al. Frailty in older adults: evidence for a phenotype. J Gerontol A Biol Sci Med Sci. 2001;56(3):M146–56.CrossRef
17.
go back to reference Suskind AM, Quanstrom K, Zhao S, Bridge M, Walter LC, Neuhaus J, et al. Overactive bladder is strongly associated with frailty in older individuals. Urology. 2017;106:26–31.CrossRefPubMedPubMedCentral Suskind AM, Quanstrom K, Zhao S, Bridge M, Walter LC, Neuhaus J, et al. Overactive bladder is strongly associated with frailty in older individuals. Urology. 2017;106:26–31.CrossRefPubMedPubMedCentral
18.
go back to reference Jensen J, Lundin-Olsson L, Nyberg L, et al. Falls among frail older people in residential care. Scand J Public Health. 2002;30(1):54–61.CrossRefPubMed Jensen J, Lundin-Olsson L, Nyberg L, et al. Falls among frail older people in residential care. Scand J Public Health. 2002;30(1):54–61.CrossRefPubMed
19.
go back to reference Plassman BL, Langa KM, Fisher GG, Heeringa SG, Weir DR, Ofstedal MB, et al. Prevalence of dementia in the United States: the aging, demographics, and memory study. Neuroepidemiology. 2007;29(1–2):125–32.CrossRefPubMedPubMedCentral Plassman BL, Langa KM, Fisher GG, Heeringa SG, Weir DR, Ofstedal MB, et al. Prevalence of dementia in the United States: the aging, demographics, and memory study. Neuroepidemiology. 2007;29(1–2):125–32.CrossRefPubMedPubMedCentral
20.
go back to reference Jekel K, Damian M, Wattmo C, et al. Mild cognitive impairment and deficits in instrumental activities of daily living: a systematic review. Alzheimers Res Ther. 2015:7–17. Jekel K, Damian M, Wattmo C, et al. Mild cognitive impairment and deficits in instrumental activities of daily living: a systematic review. Alzheimers Res Ther. 2015:7–17.
21.
go back to reference Gold D. An examination of instrumental activities of daily living assessment in older adults and mild cognitive impairment. J Clin Exp Neuropsychol. 2012;34(1):11–34.CrossRefPubMed Gold D. An examination of instrumental activities of daily living assessment in older adults and mild cognitive impairment. J Clin Exp Neuropsychol. 2012;34(1):11–34.CrossRefPubMed
22.
go back to reference Ouslander JG, Shih YT, Malone-Lee J, Luber K. Overactive bladder: special considerations in the geriatric population. Am J Manag Care. 2000;6(11 Suppl):S599–606. Review PubMed Ouslander JG, Shih YT, Malone-Lee J, Luber K. Overactive bladder: special considerations in the geriatric population. Am J Manag Care. 2000;6(11 Suppl):S599–606. Review PubMed
23.
go back to reference Fayyad A, Hill S, Jones G. Prevalence and risk factors for bothersome lower urinary tract symptoms in women with diabetes mellitus from hospital-based diabetes clinic. Int Urogynecol J. 2009;20:1339–44.CrossRef Fayyad A, Hill S, Jones G. Prevalence and risk factors for bothersome lower urinary tract symptoms in women with diabetes mellitus from hospital-based diabetes clinic. Int Urogynecol J. 2009;20:1339–44.CrossRef
24.
25.
go back to reference Boudreau D, Yu O, Gray S, et al. Concomitant use of cholinesterase inhibitors and anticholingerics: prevalence and outcomes. J Am Geriatr Soc. 2011;59:2069–76.CrossRefPubMed Boudreau D, Yu O, Gray S, et al. Concomitant use of cholinesterase inhibitors and anticholingerics: prevalence and outcomes. J Am Geriatr Soc. 2011;59:2069–76.CrossRefPubMed
26.
go back to reference Maeda T, Tomita M, Nakazawa A, et al. Female functional constipation is associated with overactive bladder symptoms and urinary incontinence. Biomed Res Int. 2017;2138073 Maeda T, Tomita M, Nakazawa A, et al. Female functional constipation is associated with overactive bladder symptoms and urinary incontinence. Biomed Res Int. 2017;2138073
27.
go back to reference Morin L, Johnell K, Laroche ML, Fastbom J, Wastesson JW. The epidemiology of polypharmacy in older adults: register-based prospective cohort study. Clin Epidemiol. 2018;10:289–98.CrossRefPubMedPubMedCentral Morin L, Johnell K, Laroche ML, Fastbom J, Wastesson JW. The epidemiology of polypharmacy in older adults: register-based prospective cohort study. Clin Epidemiol. 2018;10:289–98.CrossRefPubMedPubMedCentral
28.
go back to reference Schneidinger CS, Umek W, Böhmdorfer B. The problem of polypharmacy in female patients with overactive bladders - cross-sectional study in a specialist outpatient department. Geburtshilfe Frauenheilkd. 2016 Dec;76(12).CrossRefPubMedPubMedCentral Schneidinger CS, Umek W, Böhmdorfer B. The problem of polypharmacy in female patients with overactive bladders - cross-sectional study in a specialist outpatient department. Geburtshilfe Frauenheilkd. 2016 Dec;76(12).CrossRefPubMedPubMedCentral
29.
go back to reference By the American Geriatrics Society 2015 Beers Criteria Update Expert Panel. American Geriatrics Society 2015 updated Beers Criteria for potentially inappropriate medication use in older adults. J Am Geriatr Soc. 2015;63(11):2227–46. By the American Geriatrics Society 2015 Beers Criteria Update Expert Panel. American Geriatrics Society 2015 updated Beers Criteria for potentially inappropriate medication use in older adults. J Am Geriatr Soc. 2015;63(11):2227–46.
30.
go back to reference Iosif C, Bekassy Z. Prevalence of genitourinary symptoms in the late menopause. Acta Obstet Gynaecol Scan. 1984;63:257–60.CrossRef Iosif C, Bekassy Z. Prevalence of genitourinary symptoms in the late menopause. Acta Obstet Gynaecol Scan. 1984;63:257–60.CrossRef
31.
go back to reference Batra S, Andersson K. Estrogen-induced changes in muscarinic receptor density and contractile responses in the female rat urinary bladder. Acta Physiol Scand. 1989;137:135–41.CrossRefPubMed Batra S, Andersson K. Estrogen-induced changes in muscarinic receptor density and contractile responses in the female rat urinary bladder. Acta Physiol Scand. 1989;137:135–41.CrossRefPubMed
32.
go back to reference Shenfield O, Blackmore P, Morgan C, et al. Rapid effects of estriol and progesterone on tone and spontaneous rhythmic contractions of the rabbit bladder. Neurourol Urodyn. 1998;17:408–9. Shenfield O, Blackmore P, Morgan C, et al. Rapid effects of estriol and progesterone on tone and spontaneous rhythmic contractions of the rabbit bladder. Neurourol Urodyn. 1998;17:408–9.
33.
go back to reference Griebling TL, Liao Z, Smith PG. Systemic and topical hormone therapies reduce vaginal innervations density in postmenopausal women. Menopause. 2010;19:630–5.CrossRef Griebling TL, Liao Z, Smith PG. Systemic and topical hormone therapies reduce vaginal innervations density in postmenopausal women. Menopause. 2010;19:630–5.CrossRef
34.
go back to reference Tandir Y, Ercan F, Tarcan T. Exogenous testosterone and estrogen affect bladder tissue contractility and histomorphology differently in rat ovariectomy model. J Sex Med. 2011;8:1626–37.CrossRef Tandir Y, Ercan F, Tarcan T. Exogenous testosterone and estrogen affect bladder tissue contractility and histomorphology differently in rat ovariectomy model. J Sex Med. 2011;8:1626–37.CrossRef
35.
go back to reference Benness C, Wise BG, Cutner A, et al. Does low dose vaginal oestradiol improve frequency and urgency in postmenopausal women. Int Urogynaecol J. 1992;3:281. Benness C, Wise BG, Cutner A, et al. Does low dose vaginal oestradiol improve frequency and urgency in postmenopausal women. Int Urogynaecol J. 1992;3:281.
36.
go back to reference Eriksen PS, Rasmussen H. Low dose 17b-oestradiol vaginal tablets in the treatment of atrophic vaginitis: a double-blind placebo controlled study. Eur J Obstet Gynaecol Reprod Biol. 1992;44:137–44.CrossRef Eriksen PS, Rasmussen H. Low dose 17b-oestradiol vaginal tablets in the treatment of atrophic vaginitis: a double-blind placebo controlled study. Eur J Obstet Gynaecol Reprod Biol. 1992;44:137–44.CrossRef
37.
go back to reference Tseng LH, Wang AC, Chang YL, Soong YK, Lloyd LK, Ko YJ. Randomized comparison of tolterodine with vaginal estrogen cream versus tolterodine alone for the treatment of postmenopausal women with overactive bladder syndrome. Neurourol Urodyn. 2009;28:47–51.CrossRefPubMed Tseng LH, Wang AC, Chang YL, Soong YK, Lloyd LK, Ko YJ. Randomized comparison of tolterodine with vaginal estrogen cream versus tolterodine alone for the treatment of postmenopausal women with overactive bladder syndrome. Neurourol Urodyn. 2009;28:47–51.CrossRefPubMed
38.
go back to reference Serati M, Salvatore S, Uccella S, Cardozo L, Bolis P. Is there a synergistic effect of topical estrogens when administered with antimuscarinics in the treatment of symptomatic detrusor overactivity? Eur Urol. 2009;55:713–9.CrossRefPubMed Serati M, Salvatore S, Uccella S, Cardozo L, Bolis P. Is there a synergistic effect of topical estrogens when administered with antimuscarinics in the treatment of symptomatic detrusor overactivity? Eur Urol. 2009;55:713–9.CrossRefPubMed
39.
go back to reference Nelken RS, Ozel BZ, Leegant AR, et al. Randomised trial of oestradiol vaginal ring versus oral oxybutynin for the treatment of overactive bladder. Menopause. 2011;18:962–6.CrossRefPubMed Nelken RS, Ozel BZ, Leegant AR, et al. Randomised trial of oestradiol vaginal ring versus oral oxybutynin for the treatment of overactive bladder. Menopause. 2011;18:962–6.CrossRefPubMed
40.
go back to reference Cody JD, Richardson K, Moehrer B, et al. Estrogen therapy for urinary incontinence in postmenopausal women. Cochrane Database Syst Rev 2009; Issue 4. Art. No: CD001405. Cody JD, Richardson K, Moehrer B, et al. Estrogen therapy for urinary incontinence in postmenopausal women. Cochrane Database Syst Rev 2009; Issue 4. Art. No: CD001405.
41.
go back to reference Health, United States, 2016: with chartbook on long-term trends in health. Centers for disease control and prevention. National center for health statistics. 2017. Health, United States, 2016: with chartbook on long-term trends in health. Centers for disease control and prevention. National center for health statistics. 2017.
42.
go back to reference Vinsnes AG, Helbostad JL, Nyronning S, et al. Effect of physical training on urinary incontinence: a randomized parallel group trial in nursing homes. Clin Interv Aging. 2012;7:45–50.CrossRefPubMedPubMedCentral Vinsnes AG, Helbostad JL, Nyronning S, et al. Effect of physical training on urinary incontinence: a randomized parallel group trial in nursing homes. Clin Interv Aging. 2012;7:45–50.CrossRefPubMedPubMedCentral
43.
go back to reference Tak EC, van Hespen A, van Dommelen P, et al. Does improved functional performance help to reduce urinary incontinence in institutionalized older women? A multicenter randomized clinical trial. BMC Geriatr. 2012;12:51.CrossRefPubMedPubMedCentral Tak EC, van Hespen A, van Dommelen P, et al. Does improved functional performance help to reduce urinary incontinence in institutionalized older women? A multicenter randomized clinical trial. BMC Geriatr. 2012;12:51.CrossRefPubMedPubMedCentral
44.
go back to reference Ouslander JG, Griffiths PC, McConnell E, Riolo L, Kutner M, Schnelle J. Functional incidental training: a randomized, controlled, crossover trial in Veterans Affairs nursing homes. J Am Geriatr Soc. 2005;53:1091–100.CrossRefPubMed Ouslander JG, Griffiths PC, McConnell E, Riolo L, Kutner M, Schnelle J. Functional incidental training: a randomized, controlled, crossover trial in Veterans Affairs nursing homes. J Am Geriatr Soc. 2005;53:1091–100.CrossRefPubMed
45.
go back to reference Schnelle JF, MacRae PG, Ouslander JG, et al. Functional incidental training, mobility performance, and incontinence care with nursing home residents. J Am Geriatr Soc. 1995;43:1356–62.CrossRefPubMed Schnelle JF, MacRae PG, Ouslander JG, et al. Functional incidental training, mobility performance, and incontinence care with nursing home residents. J Am Geriatr Soc. 1995;43:1356–62.CrossRefPubMed
46.
go back to reference Talley KC, Wyman JF, Bronas U, et al. Defeating urinary incontinence with exercise training: results of a pilot study in frail older women. J Am Geriatr Soc. 2017;65(6):1321–7.CrossRefPubMedPubMedCentral Talley KC, Wyman JF, Bronas U, et al. Defeating urinary incontinence with exercise training: results of a pilot study in frail older women. J Am Geriatr Soc. 2017;65(6):1321–7.CrossRefPubMedPubMedCentral
47.
go back to reference Burgio KL, Goode PS, Locher JL, Umlauf MG, Roth DL, Richter HE, et al. Behavioral training with and without biofeedback in the treatment of urge incontinence in older women: a randomized controlled trial. JAMA. 2002 Nov 13;288(18):2293–9.CrossRefPubMed Burgio KL, Goode PS, Locher JL, Umlauf MG, Roth DL, Richter HE, et al. Behavioral training with and without biofeedback in the treatment of urge incontinence in older women: a randomized controlled trial. JAMA. 2002 Nov 13;288(18):2293–9.CrossRefPubMed
48.
go back to reference Griffiths D, Clarkson B, Tadic SD, Resnick NM. Brain mechanisms underlying urge incontinence and its response to pelvic floor muscle training. J Urol. 2015;194(3):708–15.CrossRefPubMedPubMedCentral Griffiths D, Clarkson B, Tadic SD, Resnick NM. Brain mechanisms underlying urge incontinence and its response to pelvic floor muscle training. J Urol. 2015;194(3):708–15.CrossRefPubMedPubMedCentral
49.
go back to reference Hooper L, Abdelhamid A, Attreed NJ, et al. Clinical symptoms, signs and tests for identification of impending and current water-loss dehydration in older people. Cochrane Database Syst Rev. 2015;4:CD009647. Hooper L, Abdelhamid A, Attreed NJ, et al. Clinical symptoms, signs and tests for identification of impending and current water-loss dehydration in older people. Cochrane Database Syst Rev. 2015;4:CD009647.
50.
go back to reference Wagg A. Antimuscarinic treatment in overactive bladder: special considerations in elderly patients. Drugs Aging. 2012;29(7):539–48.CrossRefPubMed Wagg A. Antimuscarinic treatment in overactive bladder: special considerations in elderly patients. Drugs Aging. 2012;29(7):539–48.CrossRefPubMed
51.
go back to reference Carriere I, Fourrier-Reglat A, Dartigues J, et al. Drugs with anticholinergic properties, cognitive decline, and dementia in an elderly general population: the 3-city study. Arch Intern Med. 2009;169(14):1317–24.CrossRefPubMedPubMedCentral Carriere I, Fourrier-Reglat A, Dartigues J, et al. Drugs with anticholinergic properties, cognitive decline, and dementia in an elderly general population: the 3-city study. Arch Intern Med. 2009;169(14):1317–24.CrossRefPubMedPubMedCentral
52.
go back to reference Fox C, Richardson K, Maidman I, et al. Anticholinergic medication and use and cognitive impairment in the older population: the medical research council cognitive function and aging study. J Am Geriatr Soc. 2011;59(8):1477–83.CrossRefPubMed Fox C, Richardson K, Maidman I, et al. Anticholinergic medication and use and cognitive impairment in the older population: the medical research council cognitive function and aging study. J Am Geriatr Soc. 2011;59(8):1477–83.CrossRefPubMed
53.
go back to reference McFerren S, Gomelsky A. Treatment of overactive bladder in the elderly female: the case for trospium, oxybutynin, fesoterodine and darifenacin. Drugs Aging. 2015;32:809–19.CrossRefPubMed McFerren S, Gomelsky A. Treatment of overactive bladder in the elderly female: the case for trospium, oxybutynin, fesoterodine and darifenacin. Drugs Aging. 2015;32:809–19.CrossRefPubMed
54.
go back to reference Salahudeen MS, Duffull SB, Nishtala PS. Anticholinergic burden quantified by anticholinergic risk scales and adverse outcomes in older people: a systematic review. BMC Geriatr. 2015 Mar 25;15:31.CrossRefPubMedPubMedCentral Salahudeen MS, Duffull SB, Nishtala PS. Anticholinergic burden quantified by anticholinergic risk scales and adverse outcomes in older people: a systematic review. BMC Geriatr. 2015 Mar 25;15:31.CrossRefPubMedPubMedCentral
55.
go back to reference Boustani M, Campbell N, Munger S, Maidment I, Fox C. Impact of anticholinergics on the aging brain: a review and practical application. Aging Health. 2008;4(3):311–20.CrossRef Boustani M, Campbell N, Munger S, Maidment I, Fox C. Impact of anticholinergics on the aging brain: a review and practical application. Aging Health. 2008;4(3):311–20.CrossRef
56.
go back to reference DuBeau C, Kraus S, Griebling T, et al. Effect of fesoterodine in vulunerable elderly subjects with urgency incontinence: a double-blind, placebo-controlled trial. J Uro. 2014;191:395–404.CrossRef DuBeau C, Kraus S, Griebling T, et al. Effect of fesoterodine in vulunerable elderly subjects with urgency incontinence: a double-blind, placebo-controlled trial. J Uro. 2014;191:395–404.CrossRef
57.
go back to reference Wagg A, Khullar V, Marschall-Kehrel D, Michel MC, Oelke M, Darekar A, et al. Flexible-dose fesoterodine in elderly adults with overactive bladder: results of the randomized, double-blind, placebo-controlled study of fesoterodine in an aging population. J Am Geriatr Soc. 2013;61:185–93.CrossRefPubMed Wagg A, Khullar V, Marschall-Kehrel D, Michel MC, Oelke M, Darekar A, et al. Flexible-dose fesoterodine in elderly adults with overactive bladder: results of the randomized, double-blind, placebo-controlled study of fesoterodine in an aging population. J Am Geriatr Soc. 2013;61:185–93.CrossRefPubMed
58.
go back to reference • Geller EJ, Dumond JB, Bowling JM et al. Effect of trospium chloride on cognitive function in women aged 50 and older: a randomized trial. Female Pelvic Med Reconstr Surg. 2017;23(2):118–123 Randomized double-blind placebo-controlled trial aimed to investigate the effect of trospium chloride on cognitive function in postmenopausal women treated for OAB with no changes in cognitive function found between those taking trospium and placebo. CrossRef • Geller EJ, Dumond JB, Bowling JM et al. Effect of trospium chloride on cognitive function in women aged 50 and older: a randomized trial. Female Pelvic Med Reconstr Surg. 2017;23(2):118–123 Randomized double-blind placebo-controlled trial aimed to investigate the effect of trospium chloride on cognitive function in postmenopausal women treated for OAB with no changes in cognitive function found between those taking trospium and placebo. CrossRef
59.
go back to reference Rosa G, Ferrero S, Nitti V, et al. Cardiovascular safety of B3-adrenoceptor agonists for the treatment of patients with overactive bladder. Eur Urol. 2016;69:311–23.CrossRefPubMed Rosa G, Ferrero S, Nitti V, et al. Cardiovascular safety of B3-adrenoceptor agonists for the treatment of patients with overactive bladder. Eur Urol. 2016;69:311–23.CrossRefPubMed
60.
go back to reference Yamaguchi O, Chapple CR. Beta3-adrenoceptors in urinary bladder. Neurourol Urodyn. 2007;26(6):752–6.CrossRefPubMed Yamaguchi O, Chapple CR. Beta3-adrenoceptors in urinary bladder. Neurourol Urodyn. 2007;26(6):752–6.CrossRefPubMed
61.
go back to reference Burton C, Sajja A, Latthe PM. Effectiveness of percutaneous posterior tibial nerve stimulation for overactive bladder: a systematic review and meta-analysis. Neurourol Urodyn. 2012;31(8):1206–16.CrossRefPubMed Burton C, Sajja A, Latthe PM. Effectiveness of percutaneous posterior tibial nerve stimulation for overactive bladder: a systematic review and meta-analysis. Neurourol Urodyn. 2012;31(8):1206–16.CrossRefPubMed
62.
go back to reference Amundsen CL, Webster GD. Sacral neuromodulation in an older, urge incontinent population. Am J Obstet Gynecol. 2002;187(6):1462–5.CrossRefPubMed Amundsen CL, Webster GD. Sacral neuromodulation in an older, urge incontinent population. Am J Obstet Gynecol. 2002;187(6):1462–5.CrossRefPubMed
63.
go back to reference • Faris A, Gill B, Pizarro-Berdichevsky J. Impact of age and comorbidities on use of sacral neuromodulation. J Urol.2017;198(1):161–166 This study challenges the existing literature regarding age and SNS outcomes, suggesting that age alone should not be considered a limiting factory in SNS and can be modestly protective against device revision. CrossRefPubMed • Faris A, Gill B, Pizarro-Berdichevsky J. Impact of age and comorbidities on use of sacral neuromodulation. J Urol.2017;198(1):161–166 This study challenges the existing literature regarding age and SNS outcomes, suggesting that age alone should not be considered a limiting factory in SNS and can be modestly protective against device revision. CrossRefPubMed
64.
go back to reference Miotla P, Cartwright R, Skorupska K, Bogusiewicz M, Markut-Miotla E, Futyma K, et al. Urinary retention in female OAB after intravesical Botox injection: who is really at risk. Int Urogynecol J. 2017;28(6):845–50.CrossRefPubMed Miotla P, Cartwright R, Skorupska K, Bogusiewicz M, Markut-Miotla E, Futyma K, et al. Urinary retention in female OAB after intravesical Botox injection: who is really at risk. Int Urogynecol J. 2017;28(6):845–50.CrossRefPubMed
65.
go back to reference • Komesu Y, Amundsen C, Richter H, et al. Refractory urgency urinary incontinence treatment in women: impact of age on outcomes and complications. Am J Obstet Gynecol.2018;218.e1–9 Interesting planned secondary analysis of a multicenter, randomized trial on treatment efficacy and adverse events in women treated with onabotulinumtoxinA or SNS and stratified by age. • Komesu Y, Amundsen C, Richter H, et al. Refractory urgency urinary incontinence treatment in women: impact of age on outcomes and complications. Am J Obstet Gynecol.2018;218.e1–9 Interesting planned secondary analysis of a multicenter, randomized trial on treatment efficacy and adverse events in women treated with onabotulinumtoxinA or SNS and stratified by age.
66.
go back to reference Liao C, Kuo H. Increased risk of large post-void residual urine and decreased long-term success rate after intravesical onabotulinumtoxinA injection for refractory idiopathic detrusor overactivity. J Urol. 2013;189:1804–10.CrossRefPubMed Liao C, Kuo H. Increased risk of large post-void residual urine and decreased long-term success rate after intravesical onabotulinumtoxinA injection for refractory idiopathic detrusor overactivity. J Urol. 2013;189:1804–10.CrossRefPubMed
67.
go back to reference Owen RK, Abrams KR, Mayne C, Slack M, Tincello DG. Patient factors associated with onabotulinum toxin A treatment outcome in women with detrusor overactivity. Neurourol Urodyn. 2017 Feb;36(2):426–31.CrossRefPubMed Owen RK, Abrams KR, Mayne C, Slack M, Tincello DG. Patient factors associated with onabotulinum toxin A treatment outcome in women with detrusor overactivity. Neurourol Urodyn. 2017 Feb;36(2):426–31.CrossRefPubMed
Metadata
Title
Management of Overactive Bladder in Older Women
Authors
Toya S. Pratt
Anne M. Suskind
Publication date
01-11-2018
Publisher
Springer US
Published in
Current Urology Reports / Issue 11/2018
Print ISSN: 1527-2737
Electronic ISSN: 1534-6285
DOI
https://doi.org/10.1007/s11934-018-0845-5

Other articles of this Issue 11/2018

Current Urology Reports 11/2018 Go to the issue

New Imaging Techniques (S Rais-Bahrami and K Porter, Section Editors)

Advanced Imaging for the Diagnosis and Treatment of Coexistent Renal and Müllerian Abnormalities

Lower Urinary Tract Symptoms & Voiding Dysfunction (J Sandhu, Section Editor)

Recurrent Urinary Tract Infections in Females and the Overlap with Overactive Bladder

Lower Urinary Tract Symptoms & Voiding Dysfunction (J Sandhu, Section Editor)

Complications of Botox and their Management

Lower Urinary Tract Symptoms & Voiding Dysfunction (J Sandhu, Section Editor)

Management of Chronic Prostatitis (CP)

New Imaging Techniques (S Rais-Bahrami and K Porter, Section Editors)

Use of MR Urography in Pediatric Patients