Top

Published in:

01-04-2016 | Prostate Cancer (A Kibel, Section Editor)

Magnetic Resonance Imaging-Ultrasound Fusion-Guided Prostate Biopsy: Review of Technology, Techniques, and Outcomes

Authors: Michael Kongnyuy, Arvin K. George, Ardeshir R. Rastinehad, Peter A. Pinto

Published in: Current Urology Reports | Issue 4/2016

Abstract

Transrectal ultrasound (TRUS)-guided (12–14 core) systematic biopsy of the prostate is the recommended standard for patients with suspicion of prostate cancer (PCa). Advances in imaging have led to the application of magnetic resonance imaging (MRI) for the detection of PCa with subsequent development of software-based co-registration allowing for the integration of MRI with real-time TRUS during prostate biopsy. A number of fusion-guided methods and platforms are now commercially available with common elements in image and analysis and planning. Implementation of fusion-guided prostate biopsy has now been proven to improve the detection of clinically significant PCa in appropriately selected patients.

Serefoglu EC, Altinova S, Ugras NS, Akincioglu E, Asil E, Balbay MD. How reliable is 12-core prostate biopsy procedure in the detection of prostate cancer? Can Urol Assoc J. 2013;7(5–6):E293–e8.PubMedPubMedCentral

2.••

Siddiqui MM, Rais-Bahrami S, Turkbey B, George AK, Rothwax J, Shakir N, et al. Comparison of MR/ultrasound fusion-guided biopsy with ultrasound-guided biopsy for the diagnosis of prostate cancer. JAMA. 2015;313(4):390–7. This is a landmark study that elucidates the role of targeted fusion biopsy in detection of prostate cancer. The study shows that targeted biopsy detects more clinically significant cancer and fewer clinically insignificant cancer. CrossRefPubMedPubMedCentral

George AK, Pinto PA, Rais-Bahrami S. Multiparametric MRI in the PSA screening era. Biomed Res Int. 2014;2014:465816.CrossRefPubMedPubMedCentral

Turkbey B, Mani H, Shah V, Rastinehad AR, Bernardo M, Pohida T, et al. Multiparametric 3T prostate magnetic resonance imaging to detect cancer: histopathological correlation using prostatectomy specimens processed in customized magnetic resonance imaging based molds. J Urol. 2011;186(5):1818–24.CrossRefPubMed

Raskolnikov D, George AK, Rais-Bahrami S, Turkbey B, Shakir NA, Okoro C, et al. Multiparametric magnetic resonance imaging and image-guided biopsy to detect seminal vesicle invasion by prostate cancer. J Endourol. 2014;28(11):1283–9.CrossRefPubMedPubMedCentral

Raskolnikov D, George AK, Rais-Bahrami S, Turkbey B, Siddiqui MM, Shakir NA, et al. The role of magnetic resonance image guided prostate biopsy in stratifying men for risk of extracapsular extension at radical prostatectomy. J Urol. 2015;194(1):105–11.CrossRefPubMed

7.•

Fascelli M, Rais-Bahrami S, Sankineni S, Brown AM, George AK, Ho R, et al. Combined Biparametric prostate MRI and prostate specific antigen in the detection of prostate cancer: a validation study in a biopsy naïve patient population. Urology 2015. Study which demonstrates the possible use of MRI as a screening tool.

Turkbey B, Merino MJ, Gallardo EC, Shah V, Aras O, Bernardo M, et al. Comparison of endorectal coil and nonendorectal coil T2W and diffusion-weighted MRI at 3 Tesla for localizing prostate cancer: correlation with whole-mount histopathology. J Magn Reson Imaging. 2014;39(6):1443–8.CrossRefPubMedPubMedCentral

Robertson NL, Emberton M, Moore CM. MRI-targeted prostate biopsy: a review of technique and results. Nat Rev Urol. 2013;10:589–97.CrossRefPubMed

10.

Hoeks CM, Schouten MG, Bomers JG, Hoogendoorn SP, Hulsbergen-van de Kaa CA, Hambrock T, et al. Three-Tesla magnetic resonance-guided prostate biopsy in men with increased prostate-specific antigen and repeated, negative, random, systematic, transrectal ultrasound biopsies: detection of clinically significant prostate cancers. Eur Urol. 2012;62(5):902–9.CrossRefPubMed

11.

Kongnyuy M, Frye TP, George AK, et al. A case of in-bore transperineal MRI-guided prostate biopsy of a patient with ileal pouch-anal anastomosis. Case Rep Urol. 2015. doi:10.1155/2015/676930.

12.

Kwak JT, Hong CW, Pinto PA, Williams M, Xu S, Kruecker J, et al. Is visual registration equivalent to semiautomated registration in prostate biopsy? Biomed Res Int. 2015;2015:394742.CrossRefPubMedPubMedCentral

13.

Wysock JS, Rosenkrantz AB, Huang WC, Stifelman MD, Lepor H, Deng FM, et al. A prospective, blinded comparison of magnetic resonance (MR) imaging-ultrasound fusion and visual estimation in the performance of MR-targeted prostate biopsy: the PROFUS trial. Eur Urol. 2014;66(2):343–51.CrossRefPubMed

14.

Haffner J, Lemaitre L, Puech P, et al. Role of magnetic resonance imaging before initial biopsy: comparison of magnetic resonance imaging-targeted and systematic biopsy for significant prostate cancer detection. BJU Int. 2011;108, E171.CrossRefPubMed

15.

Raskolnikov D, Rais-Bahrami S, George AK, Turkbey B, Shakir NA, Okoro C, et al. The role of image guided biopsy targeting in patients with atypical small acinar proliferation. J Urol. 2015;193(2):473–8.CrossRefPubMed

16.

Fascelli M, George AK, Frye T, Turkbey B, Choyke PL, Pinto PA. The role of MRI in active surveillance for prostate cancer. Curr Urol Rep. 2015;16(6):42.CrossRefPubMed

17.

Sonn GA, Filson CP, Chang E, Natarajan S, Margolis DJ, Macairan M, et al. Initial experience with electronic tracking of specific tumor sites in men undergoing active surveillance of prostate cancer. Urol Oncol. 2014;32(7):952–7.CrossRefPubMedPubMedCentral

18.

Muller BG, Kaushal A, Sankineni S, Lita E, Hoang AN, George AK, et al. Multiparametric magnetic resonance imaging-transrectal ultrasound fusion-assisted biopsy for the diagnosis of local recurrence after radical prostatectomy. Urol Oncol. 2015;33(10):425.e1–6.CrossRef

19.

Sankineni S, George AK, Brown AM, Rais-Bahrami S, Wood BJ, Merino MJ, et al. Posterior subcapsular prostate cancer: identification with mpMRI and MRI/TRUS fusion-guided biopsy. Abdom Imaging. 2015;40(7):2557–65.CrossRefPubMed

20.

Manfredi M, Costa Moretti TB, Emberton M, Villers A, Valerio M. MRI/TRUS fusion software-based targeted biopsy: the new standard of care? Minerva Urol Nefrol = Ital J Urol Nephrol. 2015;67(3):233–46.

21.

Valerio M, Donaldson I, Emberton M, Ehdaie B, Hadaschik BA, Marks LS, et al. Detection of clinically significant prostate cancer using magnetic resonance imaging-ultrasound fusion targeted biopsy: a systematic review. Eur Urol. 2015;68(1):8–19.CrossRefPubMed

22.

Vourganti S, Rastinehad A, Yerram NK, Nix J, Volkin D, Hoang A, et al. Multiparametric magnetic resonance imaging and ultrasound fusion biopsy detect prostate cancer in patients with prior negative transrectal ultrasound biopsies. J Urol. 2012;188(6):2152–7.CrossRefPubMedPubMedCentral

23.•

Salami SS, Ben-Levi E, Yaskiv O, Ryniker L, Turkbey B, Kavoussi LR, et al. In patients with a previous negative prostate biopsy and a suspicious lesion on magnetic resonance imaging, is a 12-core biopsy still necessary in addition to a targeted biopsy? BJU Int. 2015;115(4):562–70. Study which demonstrates the value of fusion-guided prostate biopsy in the evaluation of patients with a prior negative prostate biopsy.

24.

Eggener SE, Badani K, Barocas DA, Barrisford GW, Cheng JS, Chin AI, et al. Gleason 6 prostate cancer: translating biology into population health. J Urol. 2015;194(3):626–34.CrossRefPubMedPubMedCentral

25.

Okoro C, George AK, Siddiqui MM, Rais-Bahrami S, Walton-Diaz A, Shakir NA, et al. Magnetic resonance imaging/Transrectal ultrasonography fusion prostate biopsy significantly outperforms systematic 12-core biopsy for prediction of total magnetic resonance imaging tumor volume in active surveillance patients. J Endourol. 2015;29(10):1115–21.CrossRefPubMed

26.

George AK, Pinto PA. Editorial comment re: multiparametric magnetic resonance imaging enhances detection of significant tumor in patients on active surveillance for prostate cancer. Urology. 2015;85(2):429.CrossRefPubMed

27.

Hu JC, Chang E, Natarajan S, Margolis DJ, Macairan M, Lieu P, et al. Targeted prostate biopsy in select men for active surveillance: do the Epstein criteria still apply? J Urol. 2014;192(2):385–90.CrossRefPubMedPubMedCentral

28.

Walton Diaz A, Shakir NA, George AK, Rais-Bahrami S, Turkbey B, Rothwax JT, et al. Use of serial multiparametric magnetic resonance imaging in the management of patients with prostate cancer on active surveillance. Urol Oncol. 2015;33(5):202.e1–7.CrossRef

29.

Wang S, Burtt K, Turkbey B, Choyke P, Summers RM. Computer aided-diagnosis of prostate cancer on multiparametric MRI: a technical review of current research. Biomed Res Int. 2014;2014:789561.PubMedPubMedCentral

30.

Logan JK, Rais-Bahrami S, Turkbey B, Gomella A, Amalou H, Choyke PL, et al. Current status of magnetic resonance imaging (MRI) and ultrasonography fusion software platforms for guidance of prostate biopsies. BJU Int. 2014;114(5):641–52.CrossRefPubMedPubMedCentral

31.

Ewertsen C, Nielsen KR, Nielsen MB. Freehand biopsy guided by electromagnetic needle tracking: a phantom study. Ultraschall Med. 2011;32(6):614–8.CrossRefPubMed

32.

Ewertsen C, Saftoiu A, Gruionu LG, Karstrup S, Nielsen MB. Real-time image fusion involving diagnostic ultrasound. AJR Am J Roentgenol. 2013;200(3):W249–55.CrossRefPubMed

33.

Hakime A, Deschamps F, De Carvalho EG, Barah A, Auperin A, De Baere T. Electromagnetic-tracked biopsy under ultrasound guidance: preliminary results. Cardiovasc Intervent Radiol. 2012;35(4):898–905.CrossRefPubMed

34.

Sonn GA, Margolis DJ, Marks LS. Target detection: magnetic resonance imaging-ultrasound fusion-guided prostate biopsy. Urol Oncol. 2014;32(6):903–11.

35.

Hadaschik BA, Kuru TH, Tulea C, Rieker P, Popeneciu IV, Simpfendorfer T, et al. A novel stereotactic prostate biopsy system integrating pre-interventional magnetic resonance imaging and live ultrasound fusion. J Urol. 2011;186(6):2214–20.CrossRefPubMed

36.

Kuru TH, Roethke M, Popeneciu V, Teber D, Pahernik S, Zogal P, et al. Phantom study of a novel stereotactic prostate biopsy system integrating preinterventional magnetic resonance imaging and live ultrasonography fusion. J Endourol. 2012;26(7):807–13.CrossRefPubMed

37.

Rothwax JT, George AK, Wood BJ, Pinto PA. Multiparametric MRI in biopsy guidance for prostate cancer: fusion-guided. Biomed Res Int. 2014;2014:439171.CrossRefPubMedPubMedCentral

38.

Baumann M, Mozer P, Daanen V, Troccaz J. Prostate biopsy tracking with deformation estimation. Med Image Anal. 2012;16(3):562–76.CrossRefPubMed

39.

Martin S, Troccaz J, Daanenc V. Automated segmentation of the prostate in 3D MR images using a probabilistic atlas and a spatially constrained deformable model. Med Phys. 2010;37(4):1579–90.CrossRefPubMed

40.

Carignan A, Roussy JF, Lapointe V, Valiquette L, Sabbagh R, Pepin J. Increasing risk of infectious complications after transrectal ultrasound-guided prostate biopsies: time to reassess antimicrobial prophylaxis? Eur Urol. 2012;62(3):453–9.CrossRefPubMed

41.

Loeb S, Vellekoop A, Ahmed HU, Catto J, Emberton M, Nam R, et al. Systematic review of complications of prostate biopsy. Eur Urol. 2013;64(6):876–92.CrossRefPubMed

42.

Grummet JP, Weerakoon M, Huang S, Lawrentschuk N, Frydenberg M, Moon DA, et al. Sepsis and ‘superbugs’: should we favour the transperineal over the transrectal approach for prostate biopsy? BJU Int. 2014;114(3):384–8.PubMed

43.

Roberts MJ, Williamson DA, Hadway P, Doi SA, Gardiner RA, Paterson DL. Baseline prevalence of antimicrobial resistance and subsequent infection following prostate biopsy using empirical or altered prophylaxis: a bias-adjusted meta-analysis. Int J Antimicrob Agents. 2014;43(4):301–9.CrossRefPubMed

44.

Womble PR, Linsell SM, Gao Y, Ye Z, Montie JE, Gandhi TN, et al. A statewide intervention to reduce hospitalizations after prostate biopsy. J Urol. 2015;194(2):403–9.CrossRefPubMed

45.

Kubo T, Kanemori K, Kusumoto R, Kawai T, Sueyoshi K, Naito T, et al. Simple and effective label-free capillary electrophoretic analysis of sugars by complexation using quinoline boronic acids. Anal Chem. 2015;87(10):5068–73.CrossRefPubMed

46.

Trobaugh JW, Trobaugh DJ, Richard WD. Three-dimensional imaging with stereotactic ultrasonography. Comput Med Imaging Graph: Off J Comput Med Imaging Soc. 1994;18(5):315–23.CrossRef

47.

Singh AK, Kruecker J, Xu S, Glossop N, Guion P, Ullman K, et al. Initial clinical experience with real-time transrectal ultrasonography-magnetic resonance imaging fusion-guided prostate biopsy. BJU Int. 2008;101(7):841–5.CrossRefPubMedPubMedCentral

48.

Hong CW, Rais-Bahrami S, Walton-Diaz A, Shakir N, Su D, George AK, et al. Comparison of magnetic resonance imaging and ultrasound (MRI-US) fusion-guided prostate biopsies obtained from axial and sagittal approaches. BJU Int. 2015;115(5):772–9.CrossRefPubMed

49.

Xu S, Kruecker J, Turkbey B, Glossop N, Singh AK, Choyke P, et al. Real-time MRI-TRUS fusion for guidance of targeted prostate biopsies. Comput Aided Surg: Off J Int Soc Comput Aided Surg. 2008;13(5):255–64.CrossRef

50.

Rastinehad AR, Turkbey B, Salami SS, Yaskiv O, George AK, Fakhoury M, et al. Improving detection of clinically significant prostate cancer: magnetic resonance imaging/transrectal ultrasound fusion guided prostate biopsy. J Urol. 2014;191(6):1749–54.CrossRefPubMed

51.

Zogal P, Sakas G, Rösch W, Baltas D. Physics contributions on: BiopSee®—transperineal stereotactic navigated prostate biopsy. J Contemp Brachytherapy. 2011;3(2):91–5.CrossRef

52.

Di Mauro E, Solbiati M, De Beni S, Forzoni L, D’Onofrio S, Solbiati L. Virtual navigator real-time ultrasound fusion imaging with positron emission tomography for liver interventions. Conf Proc: Annua Int Conf IEEE Eng Med Biol Soc IEEE Eng Med Biol Soc Annua Conf. 2013;2013:1406–9.

53.

Miyagawa T, Ishikawa S, Kimura T, Suetomi T, Tsutsumi M, Irie T, et al. Real-time virtual sonography for navigation during targeted prostate biopsy using magnetic resonance imaging data. Int J Urol: Off J Jpn Urol Assoc. 2010;17(10):855–60.CrossRef

54.

Puech P, Rouviere O, Renard-Penna R, Villers A, Devos P, Colombel M, et al. Prostate cancer diagnosis: multiparametric MR-targeted biopsy with cognitive and transrectal US-MR fusion guidance versus systematic biopsy--prospective multicenter study. Radiology. 2013;268(2):461–9.CrossRefPubMed

55.

Marks L, Young S, Natarajan S. MRI-ultrasound fusion for guidance of targeted prostate biopsy. Curr Opin Urol. 2013;23(1):43–50.CrossRefPubMedPubMedCentral

56.

Sonn GA, Natarajan S, Margolis DJ, MacAiran M, Lieu P, Huang J, et al. Targeted biopsy in the detection of prostate cancer using an office based magnetic resonance ultrasound fusion device. J Urol. 2013;189(1):86–91.CrossRefPubMedPubMedCentral

57.

Natarajan S, Marks LS, Margolis DJ, Huang J, Macairan ML, Lieu P, et al. Clinical application of a 3D ultrasound-guided prostate biopsy system. Urol Oncol. 2011;29(3):334–42.CrossRefPubMedPubMedCentral

58.

Paoletti G, Silvani M, Confalone D, Lodigiani L, Manzoli L, D’Onofrio S, et al. Latest Advancements in real-time fusion imaging for prostate. ECR 2015 Educational Exhibit.

59.

Kuru TH, Roethke MC, Seidenader J, Simpfendorfer T, Boxler S, Alammar K, et al. Critical evaluation of magnetic resonance imaging targeted, transrectal ultrasound guided transperineal fusion biopsy for detection of prostate cancer. J Urol. 2013;190(4):1380–6.CrossRefPubMed

60.

Shoji S, Hiraiwa S, Endo J, Hashida K, Tomonaga T, Nakano M, et al. Manually controlled targeted prostate biopsy with real-time fusion imaging of multiparametric magnetic resonance imaging and transrectal ultrasound: an early experience. Int J Urol: Off J Jpn Urol Assoc. 2015;22(2):173–8.CrossRef

61.

Tewes S, Hueper K, Hartung D, Imkamp F, Herrmann TR, Weidemann J, et al. Targeted MRI/TRUS fusion-guided biopsy in men with previous prostate biopsies using a novel registration software and multiparametric MRI PI-RADS scores: first results. World J Urol. 2015;33(11):1707–14.CrossRefPubMed

62.

Ukimura O, Desai MM, Palmer S, Valencerina S, Gross M, Abreu AL, et al. 3-Dimensional elastic registration system of prostate biopsy location by real-time 3-dimensional transrectal ultrasound guidance with magnetic resonance/transrectal ultrasound image fusion. J Urol. 2012;187(3):1080–6.CrossRefPubMed

63.

Rud E, Baco E, Eggesbo HB. MRI and ultrasound-guided prostate biopsy using soft image fusion. Anticancer Res. 2012;32(8):3383–9.PubMed

64.

Frye TP, Pinto PA, George AK. Optimizing patient population for MP-MRI and fusion biopsy for prostate cancer detection. Curr Urol Rep. 2015;16(7):50.CrossRefPubMed

65.

Shakir NA, George AK, Siddiqui MM, Rothwax JT, Rais-Bahrami S, Stamatakis L, et al. Identification of threshold prostate specific antigen levels to optimize the detection of clinically significant prostate cancer by magnetic resonance imaging/ultrasound fusion guided biopsy. J Urol. 2014;192(6):1642–8.CrossRefPubMedPubMedCentral

66.

Rastinehad AR, Waingankar N, Turkbey B, Yaskiv O, Sonstegard AM, Fakhoury M, et al. Comparison of multiparametric MRI scoring systems and the impact on cancer detection in patients undergoing MR US fusion guided prostate biopsies. PLoS One. 2015;10(11), e0143404.CrossRefPubMedPubMedCentral

67.

Muller BG, Shih JH, Sankineni S, Marko J, Rais-Bahrami S, George AK, et al. Prostate cancer: interobserver agreement and accuracy with the revised prostate imaging reporting and data system at multiparametric MR imaging. Radiology. 2015;277(3):741–50.CrossRefPubMed

68.

Mozer P, Roupret M, Le Cossec C, Granger B, Comperat E, de Gorski A, et al. First round of targeted biopsies using magnetic resonance imaging/ultrasonography fusion compared with conventional transrectal ultrasonography-guided biopsies for the diagnosis of localised prostate cancer. BJU Int. 2015;115(1):50–7.CrossRefPubMed

69.

Sonn GA, Chang E, Natarajan S, Margolis DJ, Macairan M, Lieu P, et al. Value of targeted prostate biopsy using magnetic resonance-ultrasound fusion in men with prior negative biopsy and elevated prostate-specific antigen. Eur Urol. 2014;65(4):809–15.CrossRefPubMedPubMedCentral

Title: Magnetic Resonance Imaging-Ultrasound Fusion-Guided Prostate Biopsy: Review of Technology, Techniques, and Outcomes
Authors: Michael Kongnyuy
Arvin K. George
Ardeshir R. Rastinehad
Peter A. Pinto
Publication date: 01-04-2016
Publisher: Springer US
Published in: Current Urology Reports / Issue 4/2016
Print ISSN: 1527-2737
Electronic ISSN: 1534-6285
DOI: https://doi.org/10.1007/s11934-016-0589-z

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Magnetic Resonance Imaging-Ultrasound Fusion-Guided Prostate Biopsy: Review of Technology, Techniques, and Outcomes

Abstract

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Please log in to get access to this content

Other articles of this Issue 4/2016

Prostate Cancer Prevention: Concepts and Clinical Trials

Female Sexual Dysfunction: Is It a Treatable Disease?

Minimally Invasive (“Mini”) Percutaneous Nephrolithotomy: Classification, Indications, and Outcomes

Novel Insights into Molecular Indicators of Response and Resistance to Modern Androgen-Axis Therapies in Prostate Cancer

Mesh Excision: Is Total Mesh Excision Necessary?

Female Bladder Outlet Obstruction