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Current Urology Reports
Published in: Current Urology Reports 4/2013

01-08-2013 | Pediatric Urology (M Castellan and R Gosalbez, Section Editors)

Oncology: The Role of Partial Nephrectomy in Wilms Tumor

Authors: Miriam Harel, John H. Makari, Fernando A. Ferrer Jr.

Published in: Current Urology Reports | Issue 4/2013

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Abstract

Wilms tumor represents the most common pediatric renal malignancy and the fourth most common childhood cancer overall. Overall survival from Wilms tumor has increased to over 90 % secondary to multidisciplinary therapy and multi-institutional cooperative group trials. Recent therapeutic focus has shifted to reduction in treatment morbidity and renal preservation while maintaining the high survival rates. Partial nephrectomy is an integral component of the multimodal treatment protocols for Wilms tumor patients with bilateral disease, solitary kidney, or predisposing syndromes. Recent consideration has been given to utilization of nephron sparing surgery (NSS) in carefully selected patients with nonsyndromic unilateral Wilms tumor. While long-term, prospective data in this subgroup of patients is not yet available, case series demonstrate comparable oncologic outcomes after partial versus radical nephrectomy. The relative rarity of Wilms tumor, especially those amenable to upfront partial nephrectomy, presents a challenge to conducting controlled trials.
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Metadata
Title
Oncology: The Role of Partial Nephrectomy in Wilms Tumor
Authors
Miriam Harel
John H. Makari
Fernando A. Ferrer Jr.
Publication date
01-08-2013
Publisher
Springer US
Published in
Current Urology Reports / Issue 4/2013
Print ISSN: 1527-2737
Electronic ISSN: 1534-6285
DOI
https://doi.org/10.1007/s11934-013-0330-0

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