Skip to main content
Top
Published in: Current Urology Reports 4/2010

01-07-2010

Sexual Impact of Treatment of Lower Urinary Tract Symptoms Associated with Benign Prostatic Hyperplasia

Authors: Herbert J. Wiser, Tobias S. Köhler

Published in: Current Urology Reports | Issue 4/2010

Login to get access

Abstract

Lower urinary tract symptoms associated with benign prostatic hyperplasia (LUTS/BPH) and the treatment of these conditions are commonly associated with sexual dysfunction. The effects on sexual function of common medical and surgical therapies used in the treatment of LUTS/BPH are reviewed. Also discussed is the emerging use of phosphodiesterase inhibitors in the treatment of LUTS/BPH.
Literature
1.
go back to reference American Urological Association: AUA Guidelines on Management of Benign Prostatic Hyperplasia, 2003, revision 2006. Chapter 3. Available at http://www.auanet.org. Accessed February 2010. American Urological Association: AUA Guidelines on Management of Benign Prostatic Hyperplasia, 2003, revision 2006. Chapter 3. Available at http://​www.​auanet.​org. Accessed February 2010.
2.
go back to reference Price DT, Schwinn DA, Lomasney JW, et al.: Identification, quantification, and localization of mRNA for three distinct alpha 1 adrenergic receptor subtypes in human prostate. J Urol 1993, 150:546–551.PubMed Price DT, Schwinn DA, Lomasney JW, et al.: Identification, quantification, and localization of mRNA for three distinct alpha 1 adrenergic receptor subtypes in human prostate. J Urol 1993, 150:546–551.PubMed
3.
go back to reference Roehrborn CG: Efficacy of alpha-adrenergic receptor blockers in the treatment of male lower urinary tract symptoms. Rev Urol 2009, 11(Suppl 1):S1–S8.PubMed Roehrborn CG: Efficacy of alpha-adrenergic receptor blockers in the treatment of male lower urinary tract symptoms. Rev Urol 2009, 11(Suppl 1):S1–S8.PubMed
4.
go back to reference Hellstrom WJ, Sikka SC: Effects of acute treatment with tamsulosin versus alfuzosin on ejaculatory function in normal volunteers. J Urol 2006, 176:1529–1533.CrossRefPubMed Hellstrom WJ, Sikka SC: Effects of acute treatment with tamsulosin versus alfuzosin on ejaculatory function in normal volunteers. J Urol 2006, 176:1529–1533.CrossRefPubMed
5.
go back to reference Nagai A, Hara R, Yokoyama T, et al.: Ejaculatory dysfunction caused by the new α-blocker silodosin: A preliminary study to analyze human ejaculation using color Doppler ultrasonography. Int J Urol 2008, 15:915–918.CrossRefPubMed Nagai A, Hara R, Yokoyama T, et al.: Ejaculatory dysfunction caused by the new α-blocker silodosin: A preliminary study to analyze human ejaculation using color Doppler ultrasonography. Int J Urol 2008, 15:915–918.CrossRefPubMed
6.
go back to reference Hisasue S, Furuya R, Itoh N, et al.: Ejaculatory disorder caused by α-1 adrenoceptor antagonists is not retrograde ejaculation but a loss of seminal emission. Int J Urol 2006, 13:1311–1316.CrossRefPubMed Hisasue S, Furuya R, Itoh N, et al.: Ejaculatory disorder caused by α-1 adrenoceptor antagonists is not retrograde ejaculation but a loss of seminal emission. Int J Urol 2006, 13:1311–1316.CrossRefPubMed
7.
go back to reference Kobayashi K, Masumori N, Hisasue S, et al.: Inhibition of seminal emission is the main cause of anejaculation induced by a new highly selective α1A-blocker in normal volunteers. J Sex Med 2008, 5:2185–2190.CrossRefPubMed Kobayashi K, Masumori N, Hisasue S, et al.: Inhibition of seminal emission is the main cause of anejaculation induced by a new highly selective α1A-blocker in normal volunteers. J Sex Med 2008, 5:2185–2190.CrossRefPubMed
8.
go back to reference Goldstein I: Oral phentolamine: an alpha-1, alpha-2 adrenergic antagonist for the treatment of erectile dysfunction. Int J Impot Res 2000, 12(Suppl 1):S75–S80.CrossRef Goldstein I: Oral phentolamine: an alpha-1, alpha-2 adrenergic antagonist for the treatment of erectile dysfunction. Int J Impot Res 2000, 12(Suppl 1):S75–S80.CrossRef
9.
go back to reference Kirby RS, Roehrborn C, Boyle P, et al.: Efficacy and tolerability of doxazosin and finasteride, alone or in combination, in treatment of symptomatic benign prostatic hyperplasia: the Prospective European Doxazosin and Combination Therapy (PREDICT) trial. Urology 2003, 61:119–126.CrossRefPubMed Kirby RS, Roehrborn C, Boyle P, et al.: Efficacy and tolerability of doxazosin and finasteride, alone or in combination, in treatment of symptomatic benign prostatic hyperplasia: the Prospective European Doxazosin and Combination Therapy (PREDICT) trial. Urology 2003, 61:119–126.CrossRefPubMed
10.
go back to reference Lepor H, Williford WO, Barry MJ, et al.: The efficacy of terazosin, finasteride, or both in benign prostatic hyperplasia Veterans Affairs Cooperative Studies Benign Prostatic Hyperplasia Study Group. N Engl J Med 1996, 335:533–539.CrossRefPubMed Lepor H, Williford WO, Barry MJ, et al.: The efficacy of terazosin, finasteride, or both in benign prostatic hyperplasia Veterans Affairs Cooperative Studies Benign Prostatic Hyperplasia Study Group. N Engl J Med 1996, 335:533–539.CrossRefPubMed
11.
go back to reference van Kerrebroeck P, Jardin A, Laval KU, van Cangh P: Efficacy and safety of a new prolonged release formulation of alfuzosin 10 mg once daily versus alfuzosin 2.5 mg thrice daily and placebo in patients with symptomatic benign prostatic hyperplasia. ALFORTI Study Group. Eur Urol 2000, 37:306–313.CrossRefPubMed van Kerrebroeck P, Jardin A, Laval KU, van Cangh P: Efficacy and safety of a new prolonged release formulation of alfuzosin 10 mg once daily versus alfuzosin 2.5 mg thrice daily and placebo in patients with symptomatic benign prostatic hyperplasia. ALFORTI Study Group. Eur Urol 2000, 37:306–313.CrossRefPubMed
12.
go back to reference Van Kerrebroeck P, Jardin A, van Cangh P, et al.: Long-term safety and efficacy of a once-daily formulation of alfuzosin 10 mg in patients with symptomatic benign prostatic hyperplasia: Open-label extension study. Eur Urol 2002, 41:54–60.CrossRef Van Kerrebroeck P, Jardin A, van Cangh P, et al.: Long-term safety and efficacy of a once-daily formulation of alfuzosin 10 mg in patients with symptomatic benign prostatic hyperplasia: Open-label extension study. Eur Urol 2002, 41:54–60.CrossRef
13.
go back to reference Elhilali M, Emberton M, Matzkin H, et al.: Long-term efficacy and safety of alfuzosin 10 mg once-daily: A 2-year experience in “real-life” practice. BJU Int 2006, 97:513–519.CrossRefPubMed Elhilali M, Emberton M, Matzkin H, et al.: Long-term efficacy and safety of alfuzosin 10 mg once-daily: A 2-year experience in “real-life” practice. BJU Int 2006, 97:513–519.CrossRefPubMed
14.
go back to reference Narayan P, Tewari A: A second phase III multicenter placebo controlled study of 2 dosages of modified release tamsulosin in patients with symptoms of benign prostatic hyperplasia. United States 93-01 Study Group. J Urol 1998, 160:1701–1706.CrossRefPubMed Narayan P, Tewari A: A second phase III multicenter placebo controlled study of 2 dosages of modified release tamsulosin in patients with symptoms of benign prostatic hyperplasia. United States 93-01 Study Group. J Urol 1998, 160:1701–1706.CrossRefPubMed
15.
go back to reference Narayan P, Lepor H: Long-term, open-label, phase III multicenter study of tamsulosin in benign prostatic hyperplasia. Urology 2001, 57:466–470.CrossRefPubMed Narayan P, Lepor H: Long-term, open-label, phase III multicenter study of tamsulosin in benign prostatic hyperplasia. Urology 2001, 57:466–470.CrossRefPubMed
16.
go back to reference Höfner K, Claes H, De Reijke TM, et al.: Tamsulosin 0.4 mg once daily: effect on sexual function in patients with lower urinary tract symptoms suggestive of benign prostatic obstruction. Eur Urol 1999, 36:335–341.CrossRefPubMed Höfner K, Claes H, De Reijke TM, et al.: Tamsulosin 0.4 mg once daily: effect on sexual function in patients with lower urinary tract symptoms suggestive of benign prostatic obstruction. Eur Urol 1999, 36:335–341.CrossRefPubMed
17.
go back to reference Marks LS, Gittelman MC, Hill LA, et al.: Rapid efficacy of the highly selective alpha1A-adrenoceptor antagonist silodosin in men with signs and symptoms of benign prostatic hyperplasia: pooled results of 2 phase 3 studies.. J Urol 2009, 181:2634–2640.CrossRefPubMed Marks LS, Gittelman MC, Hill LA, et al.: Rapid efficacy of the highly selective alpha1A-adrenoceptor antagonist silodosin in men with signs and symptoms of benign prostatic hyperplasia: pooled results of 2 phase 3 studies.. J Urol 2009, 181:2634–2640.CrossRefPubMed
18.
go back to reference Kawabe K, Yoshida M, Homma Y: Silodosin, a new alpha1A-adrenoceptor-selective antagonist for treating benign prostatic hyperplasia: results of a phase III randomized, placebo-controlled, double-blind study in Japanese men. BJU Int 2006, 98:1019–1024.CrossRefPubMed Kawabe K, Yoshida M, Homma Y: Silodosin, a new alpha1A-adrenoceptor-selective antagonist for treating benign prostatic hyperplasia: results of a phase III randomized, placebo-controlled, double-blind study in Japanese men. BJU Int 2006, 98:1019–1024.CrossRefPubMed
19.
go back to reference Andriole G, Bruchovsky N, Chung LW, et al.: Dihydrotestosterone and the prostate: the scientific rationale for 5alpha-reductase inhibitors in the treatment of benign prostatic hyperplasia. J Urol 2004, 172:1399–1403.CrossRefPubMed Andriole G, Bruchovsky N, Chung LW, et al.: Dihydrotestosterone and the prostate: the scientific rationale for 5alpha-reductase inhibitors in the treatment of benign prostatic hyperplasia. J Urol 2004, 172:1399–1403.CrossRefPubMed
20.
go back to reference Marberger MJ: Long-term effects of finasteride in patients with benign prostatic hyperplasia: a double-blind, placebo-controlled, multicenter study. PROWESS Study Group. Urology 1998, 51:677–686. Marberger MJ: Long-term effects of finasteride in patients with benign prostatic hyperplasia: a double-blind, placebo-controlled, multicenter study. PROWESS Study Group. Urology 1998, 51:677–686.
21.
go back to reference Roehrborn CG, Boyle P, Nickel JC, et al.: Efficacy and safety of a dual inhibitor of 5-alpha-reductase types 1 and 2 (dutasteride) in men with benign prostatic hyperplasia. Urology 2002, 60:431–441.CrossRef Roehrborn CG, Boyle P, Nickel JC, et al.: Efficacy and safety of a dual inhibitor of 5-alpha-reductase types 1 and 2 (dutasteride) in men with benign prostatic hyperplasia. Urology 2002, 60:431–441.CrossRef
22.
go back to reference Roehrborn CG, Marks LS, Fenter T, et al.: Efficacy and safety of dutasteride in the four-year treatment of men with benign prostatic hyperplasia. Urology 2004, 63:709–715.CrossRefPubMed Roehrborn CG, Marks LS, Fenter T, et al.: Efficacy and safety of dutasteride in the four-year treatment of men with benign prostatic hyperplasia. Urology 2004, 63:709–715.CrossRefPubMed
23.
go back to reference McVary KT, Roehrborn CG, Kaminetsky JC, et al.: Tadalafil relieves lower urinary tract symptoms secondary to benign prostatic hyperplasia. Urology 2007, 177:1401–1407.CrossRef McVary KT, Roehrborn CG, Kaminetsky JC, et al.: Tadalafil relieves lower urinary tract symptoms secondary to benign prostatic hyperplasia. Urology 2007, 177:1401–1407.CrossRef
24.
go back to reference • Roehrborn CG, McVary KT, Elion-Mboussa A, Viktrup L: Tadalafil administered once daily for lower urinary tract symptoms secondary to benign prostatic hyperplasia: a dose finding study. J Urol 2008, 180:1228–1234. This excellent follow-up study to McVary et al. 2007 redemonstrates the efficacy of PDE5Is over placebo and provides useful clinical information regarding appropriate dosing.CrossRefPubMed • Roehrborn CG, McVary KT, Elion-Mboussa A, Viktrup L: Tadalafil administered once daily for lower urinary tract symptoms secondary to benign prostatic hyperplasia: a dose finding study. J Urol 2008, 180:1228–1234. This excellent follow-up study to McVary et al. 2007 redemonstrates the efficacy of PDE5Is over placebo and provides useful clinical information regarding appropriate dosing.CrossRefPubMed
25.
go back to reference Bechara A, Romano S, Casabé A, et al.: Comparative efficacy assessment of tamsulosin vs. tamsulosin plus tadalafil in the treatment of LUTS/BPH. Pilot study. J Sex Med 2008, 5:2170–2178.CrossRefPubMed Bechara A, Romano S, Casabé A, et al.: Comparative efficacy assessment of tamsulosin vs. tamsulosin plus tadalafil in the treatment of LUTS/BPH. Pilot study. J Sex Med 2008, 5:2170–2178.CrossRefPubMed
26.
go back to reference Liguori G, Trombetta C, De Giorgi G, et al.: Efficacy and safety of combined oral therapy with tadalafil and alfuzosin: an integrated approach to the management of patients with lower urinary tract symptoms and erectile dysfunction. Preliminary report. J Sex Med 2009, 6:544–552.CrossRefPubMed Liguori G, Trombetta C, De Giorgi G, et al.: Efficacy and safety of combined oral therapy with tadalafil and alfuzosin: an integrated approach to the management of patients with lower urinary tract symptoms and erectile dysfunction. Preliminary report. J Sex Med 2009, 6:544–552.CrossRefPubMed
27.
go back to reference Kaplan SA, Roehrborn CG, Rovner ES, et al.: Tolterodine and tamsulosin for treatment of men with lower urinary tract symptoms and overactive bladder. JAMA 2006, 296:2319–2328. (Published erratums appear in JAMA 2007, 297:1195 and JAMA 2007, 298:1864.)CrossRefPubMed Kaplan SA, Roehrborn CG, Rovner ES, et al.: Tolterodine and tamsulosin for treatment of men with lower urinary tract symptoms and overactive bladder. JAMA 2006, 296:2319–2328. (Published erratums appear in JAMA 2007, 297:1195 and JAMA 2007, 298:1864.)CrossRefPubMed
28.
go back to reference Bent S, Kane C, Shinohara K, et al.: Saw palmetto for benign prostatic hyperplasia. N Engl J Med 2006, 354:557–566.CrossRefPubMed Bent S, Kane C, Shinohara K, et al.: Saw palmetto for benign prostatic hyperplasia. N Engl J Med 2006, 354:557–566.CrossRefPubMed
29.
go back to reference Debruyne F, Koch G, Boyle P, et al.: Comparison of a phytotherapeutic agent (Permixon) with an alpha-blocker (Tamsulosin) in the treatment of benign prostatic hyperplasia: a 1-year randomized international study.. European Urology 2002, 41:497–506.CrossRefPubMed Debruyne F, Koch G, Boyle P, et al.: Comparison of a phytotherapeutic agent (Permixon) with an alpha-blocker (Tamsulosin) in the treatment of benign prostatic hyperplasia: a 1-year randomized international study.. European Urology 2002, 41:497–506.CrossRefPubMed
30.
go back to reference Muntener M, Aellig S, Kuettel R, et al.: Sexual function after transurethral resection of the prostate (TURP): results of an independent prospective multicentre assessment of outcome. Eur Urol 2007, 52:510–515. (Published erratum appears in Eur Urol 2008, 53:456.)CrossRefPubMed Muntener M, Aellig S, Kuettel R, et al.: Sexual function after transurethral resection of the prostate (TURP): results of an independent prospective multicentre assessment of outcome. Eur Urol 2007, 52:510–515. (Published erratum appears in Eur Urol 2008, 53:456.)CrossRefPubMed
31.
go back to reference Poulakis V, Ferakis N, Witzsch U, et al.: Erectile dysfunction after transurethral prostatectomy for lower urinary tract symptoms: results from a center with over 500 patients. Asian J Androl 2006, 8:69–74.CrossRefPubMed Poulakis V, Ferakis N, Witzsch U, et al.: Erectile dysfunction after transurethral prostatectomy for lower urinary tract symptoms: results from a center with over 500 patients. Asian J Androl 2006, 8:69–74.CrossRefPubMed
32.
go back to reference • Jaidane M, Arfa NB, Hmida W, et al.: Effect of transurethral resection of the prostate on erectile function: a prospective comparative study. Int J Impot Res 2010, 22:146–151. This unusual and useful study used TURBT as a sham study for comparison with TURP and its effects on erectile function.CrossRefPubMed • Jaidane M, Arfa NB, Hmida W, et al.: Effect of transurethral resection of the prostate on erectile function: a prospective comparative study. Int J Impot Res 2010, 22:146–151. This unusual and useful study used TURBT as a sham study for comparison with TURP and its effects on erectile function.CrossRefPubMed
33.
go back to reference Arai Y, Aoki Y, Okubo K, et al.: Impact of interventional therapy for benign prostatic hypertrophy on quality of life and sexual function: a prospective study. J Urol 2000, 164:1206–1211.CrossRefPubMed Arai Y, Aoki Y, Okubo K, et al.: Impact of interventional therapy for benign prostatic hypertrophy on quality of life and sexual function: a prospective study. J Urol 2000, 164:1206–1211.CrossRefPubMed
34.
go back to reference Kavoussi PK, Hermans MR: Maintenance of erectile function after photoselective vaporization of the prostate for obstructive benign prostatic hypertrophy. J Sex Med 2008, 5:2669–2671.CrossRefPubMed Kavoussi PK, Hermans MR: Maintenance of erectile function after photoselective vaporization of the prostate for obstructive benign prostatic hypertrophy. J Sex Med 2008, 5:2669–2671.CrossRefPubMed
35.
go back to reference Paick JS, Um JM, Kim SW, Ku JH: Influence of high-power potassium-titanyl-phosphate photoselective vaporization of the prostate on erectile function: a short-term follow-up study. J Sex Med 2007, 4:1701–1707.CrossRefPubMed Paick JS, Um JM, Kim SW, Ku JH: Influence of high-power potassium-titanyl-phosphate photoselective vaporization of the prostate on erectile function: a short-term follow-up study. J Sex Med 2007, 4:1701–1707.CrossRefPubMed
36.
go back to reference Wilson LC, Gilling PJ, Williams A, et al.: A randomized trial comparing holmium laser enucleation versus transurethral resection in the treatment of prostates larger than 40 grams: results at 2 years. Eur Urol 2006, 50:569–573.CrossRefPubMed Wilson LC, Gilling PJ, Williams A, et al.: A randomized trial comparing holmium laser enucleation versus transurethral resection in the treatment of prostates larger than 40 grams: results at 2 years. Eur Urol 2006, 50:569–573.CrossRefPubMed
37.
go back to reference Briganti A, Naspro R, Gallina A, et al.: Impact on sexual function of holmium laser enucleation versus transurethral resection of the prostate: results of a prospective, 2-center, randomized trial. J Urol 2006, 175:1817–1821.CrossRefPubMed Briganti A, Naspro R, Gallina A, et al.: Impact on sexual function of holmium laser enucleation versus transurethral resection of the prostate: results of a prospective, 2-center, randomized trial. J Urol 2006, 175:1817–1821.CrossRefPubMed
38.
go back to reference Serretta V, Morgia G, Fondacaro L, et al.: Open prostatectomy for benign prostatic enlargement in southern Europe in the late 1990 s: A contemporary series of 1800 interventions. Urology 2002, 60:623–627.CrossRefPubMed Serretta V, Morgia G, Fondacaro L, et al.: Open prostatectomy for benign prostatic enlargement in southern Europe in the late 1990 s: A contemporary series of 1800 interventions. Urology 2002, 60:623–627.CrossRefPubMed
39.
go back to reference Gacci M, Bartoletti R, Figlioli S, et al.: Urinary symptoms, quality of life and sexual function in patients with benign prostatic hypertrophy before and after prostatectomy: a prospective study. BJU Int 2003, 91:196–200.CrossRefPubMed Gacci M, Bartoletti R, Figlioli S, et al.: Urinary symptoms, quality of life and sexual function in patients with benign prostatic hypertrophy before and after prostatectomy: a prospective study. BJU Int 2003, 91:196–200.CrossRefPubMed
Metadata
Title
Sexual Impact of Treatment of Lower Urinary Tract Symptoms Associated with Benign Prostatic Hyperplasia
Authors
Herbert J. Wiser
Tobias S. Köhler
Publication date
01-07-2010
Publisher
Current Science Inc.
Published in
Current Urology Reports / Issue 4/2010
Print ISSN: 1527-2737
Electronic ISSN: 1534-6285
DOI
https://doi.org/10.1007/s11934-010-0112-x

Other articles of this Issue 4/2010

Current Urology Reports 4/2010 Go to the issue