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Current Rheumatology Reports
Published in: Current Rheumatology Reports 6/2017

Open Access 01-06-2017 | Biosimilars (E Mysler, Section Editor)

Switching Between Reference Biologics and Biosimilars for the Treatment of Rheumatology, Gastroenterology, and Dermatology Inflammatory Conditions: Considerations for the Clinician

Authors: Robert Moots, Valderilio Azevedo, Javier L. Coindreau, Thomas Dörner, Ehab Mahgoub, Eduardo Mysler, Morton Scheinberg, Lisa Marshall

Published in: Current Rheumatology Reports | Issue 6/2017

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Abstract

Purpose of Review

Biosimilars of the reference biologic therapeutics infliximab, etanercept, adalimumab, and rituximab are entering the market. Clinical and real-world data on the effects of reference → biosimilar switching are limited. This review was carried out to assess the current body of switching data.

Recent Findings

Fifty-three switching studies were identified. Infliximab publications covered CT-P13 (25 studies), SB2 (1), infliximab NK (1), and unspecified infliximab biosimilars (2). Etanercept publications covered SB4 (2) and GP2015 (2). Adalimumab publications covered ABP 501 (2) and SB5 (1). Rituximab publications covered CT-P10 (1). Efficacy and safety data generally showed no differences between patients who switched treatments versus those who did not. No differences were seen pre- and post-switch. Immunogenicity data were presented in 19/37 (51%) studies.

Summary

Additional data from switching studies of these therapies are still required, as is continuing pharma-covigilance. Switching should remain a case-by-case clinical decision made by the physician and patient on an individual basis supported by scientific evidence.
Appendix
Available only for authorised users
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Metadata
Title
Switching Between Reference Biologics and Biosimilars for the Treatment of Rheumatology, Gastroenterology, and Dermatology Inflammatory Conditions: Considerations for the Clinician
Authors
Robert Moots
Valderilio Azevedo
Javier L. Coindreau
Thomas Dörner
Ehab Mahgoub
Eduardo Mysler
Morton Scheinberg
Lisa Marshall
Publication date
01-06-2017
Publisher
Springer US
Published in
Current Rheumatology Reports / Issue 6/2017
Print ISSN: 1523-3774
Electronic ISSN: 1534-6307
DOI
https://doi.org/10.1007/s11926-017-0658-4

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