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Current Rheumatology Reports
Published in: Current Rheumatology Reports 1/2016

01-01-2016 | Scleroderma (J Varga, Section Editor)

Macrophage Involvement in Systemic Sclerosis: Do We Need More Evidence?

Authors: Giuseppina Stifano, Romy Beatriz Christmann

Published in: Current Rheumatology Reports | Issue 1/2016

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Abstract

The pathogenesis of systemic sclerosis is still unknown, although immune cells, mainly macrophages/monocytes, may have an important role in initiating and/or perpetuating the disease. Macrophages and monocytes are often classified as pro-inflammatory M1 phenotype or classic activation and pro-fibrotic/anti-inflammatory M2 phenotype or alternative activation. In this review, we highlighted the most relevant research regarding the involvement of macrophages/monocytes in the pathogenesis of this complex disease.
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Metadata
Title
Macrophage Involvement in Systemic Sclerosis: Do We Need More Evidence?
Authors
Giuseppina Stifano
Romy Beatriz Christmann
Publication date
01-01-2016
Publisher
Springer US
Published in
Current Rheumatology Reports / Issue 1/2016
Print ISSN: 1523-3774
Electronic ISSN: 1534-6307
DOI
https://doi.org/10.1007/s11926-015-0554-8

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