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01-11-2013 | OSTEOARTHRITIS (MB GOLDRING, SECTION EDITOR)

Homeostatic Mechanisms in Articular Cartilage and Role of Inflammation in Osteoarthritis

Authors: Xavier Houard, Mary B. Goldring, Francis Berenbaum

Published in: Current Rheumatology Reports | Issue 11/2013

Abstract

Osteoarthritis (OA) is a whole joint disease, in which thinning and disappearance of cartilage is a critical determinant in OA progression. The rupture of cartilage homeostasis whatever its cause (aging, genetic predisposition, trauma or metabolic disorder) induces profound phenotypic modifications of chondrocytes, which then promote the synthesis of a subset of factors that induce cartilage damage and target other joint tissues. Interestingly, among these factors are numerous components of the inflammatory pathways. Chondrocytes produce cytokines, chemokines, alarmins, prostanoids, and adipokines and express numerous cell surface receptors for cytokines and chemokines, as well as Toll-like receptors. These receptors activate intracellular signaling pathways involved in inflammatory and stress responses of chondrocytes in OA joints. This review focuses on mechanisms responsible for the maintenance of cartilage homeostasis and highlights the role of inflammatory processes in OA progression.

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Title: Homeostatic Mechanisms in Articular Cartilage and Role of Inflammation in Osteoarthritis
Authors: Xavier Houard
Mary B. Goldring
Francis Berenbaum
Publication date: 01-11-2013
Publisher: Springer US
Published in: Current Rheumatology Reports / Issue 11/2013
Print ISSN: 1523-3774
Electronic ISSN: 1534-6307
DOI: https://doi.org/10.1007/s11926-013-0375-6

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