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01-06-2012 | ANXIETY DISORDERS (DJ STEIN, SECTION EDITOR)

Systematic Review of Proinflammatory Cytokines in Obsessive-Compulsive Disorder

Authors: Simon M. Gray, Michael H. Bloch

Published in: Current Psychiatry Reports | Issue 3/2012

Abstract

Several studies have examined levels of proinflammatory cytokines, such as tumor necrosis factor (TNF)-α, interleukin (IL)-1β, and IL-6. This meta-analysis was conducted to examine the association between obsessive-compulsive disorder (OCD) and plasma serum levels of proinflammatory cytokines. Twelve studies met inclusion criteria. The meta-analysis demonstrated a significant reduction in IL-1β levels in OCD. No significant difference in plasma levels of IL-6 or TNF-α was demonstrated. Stratified subgroup analysis revealed possible moderating effects of age and medication use on IL-6 levels. Studies including children on psychotropic medication had lower plasma IL-6 levels. Stratified subgroup analysis revealed a moderating effect of comorbid depression on TNF-α levels. Elevated TNF-α levels were reported in studies that included individuals with comorbid depression. Future studies examining immune function in OCD should adjust for potential confounding due to medication use and comorbid depression. Further studies assessing cerebrospinal fluid cytokine levels in OCD are also needed.

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Title: Systematic Review of Proinflammatory Cytokines in Obsessive-Compulsive Disorder
Authors: Simon M. Gray
Michael H. Bloch
Publication date: 01-06-2012
Publisher: Current Science Inc.
Published in: Current Psychiatry Reports / Issue 3/2012
Print ISSN: 1523-3812
Electronic ISSN: 1535-1645
DOI: https://doi.org/10.1007/s11920-012-0272-0

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Systematic Review of Proinflammatory Cytokines in Obsessive-Compulsive Disorder

Abstract

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

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