Skip to main content
Top
Published in: Current Psychiatry Reports 5/2011

01-10-2011

Update on Environmental Risk Factors for Attention-Deficit/Hyperactivity Disorder

Authors: Tanya E. Froehlich, Julia S. Anixt, Irene M. Loe, Vilawan Chirdkiatgumchai, Lisa Kuan, Richard C. Gilman

Published in: Current Psychiatry Reports | Issue 5/2011

Login to get access

Abstract

Attention-deficit/hyperactivity disorder (ADHD) is a prevalent neurobehavioral disorder affecting 5% to 10% of children. Although considered to be a highly familial disorder, ADHD heritability estimates of 60% to 80% highlight the considerable role that environmental factors may still play in disorder susceptibility. Proposed ADHD environmental risk factors include prenatal substance exposures, heavy metal and chemical exposures, nutritional factors, and lifestyle/psychosocial factors. This paper reviews the literature published in 2010 investigating the association between environmental risk factors and ADHD or related symptomatology. Sources of risk factor exposure and the proposed mechanism by which each exposure is linked to ADHD-related neurobehavioral changes are also reported. Methodologic limitations of the current literature are discussed, and guidelines for future study are proposed. An improved understanding of the role that environmental factors play in ADHD etiology is critical to future ADHD prevention efforts.
Literature
1.
go back to reference Barkley RA. Major life activity and health outcomes associated with attention-deficit/hyperactivity disorder. J Clin Psychiatry. 2002;63 Suppl 12:10–5.PubMed Barkley RA. Major life activity and health outcomes associated with attention-deficit/hyperactivity disorder. J Clin Psychiatry. 2002;63 Suppl 12:10–5.PubMed
2.
go back to reference Nigg JT. What causes ADHD? Understanding what goes wrong and why. New York: The Guilford Press; 2006. Nigg JT. What causes ADHD? Understanding what goes wrong and why. New York: The Guilford Press; 2006.
3.
go back to reference Lindblad F, Hjern A. ADHD after fetal exposure to maternal smoking. Nicotine Tob Res. 2010;12:408–15.PubMedCrossRef Lindblad F, Hjern A. ADHD after fetal exposure to maternal smoking. Nicotine Tob Res. 2010;12:408–15.PubMedCrossRef
4.
go back to reference Nomura Y, Marks DJ, Halperin JM. Prenatal exposure to maternal and paternal smoking on attention deficit hyperactivity disorders symptoms and diagnosis in offspring. J Nerv Ment Dis. 2010;198:672–8.PubMedCrossRef Nomura Y, Marks DJ, Halperin JM. Prenatal exposure to maternal and paternal smoking on attention deficit hyperactivity disorders symptoms and diagnosis in offspring. J Nerv Ment Dis. 2010;198:672–8.PubMedCrossRef
5.
go back to reference Motlagh MG, Katsovich L, Thompson N, et al. Severe psychosocial stress and heavy cigarette smoking during pregnancy: an examination of the pre- and perinatal risk factors associated with ADHD and Tourette syndrome. Eur Child Adolesc Psychiatry. 2010;19:755–64.PubMedCrossRef Motlagh MG, Katsovich L, Thompson N, et al. Severe psychosocial stress and heavy cigarette smoking during pregnancy: an examination of the pre- and perinatal risk factors associated with ADHD and Tourette syndrome. Eur Child Adolesc Psychiatry. 2010;19:755–64.PubMedCrossRef
6.
go back to reference Bos-Veneman NGP, Kuin A, Minderaa RB, Hoekstra PJ. Role of perinatal adversities on tic severity and symptoms of attention deficit/hyperactivity disorder in children and adolescents with a tic disorder. J Dev Behav Pediatr. 2010;31:100–6.PubMedCrossRef Bos-Veneman NGP, Kuin A, Minderaa RB, Hoekstra PJ. Role of perinatal adversities on tic severity and symptoms of attention deficit/hyperactivity disorder in children and adolescents with a tic disorder. J Dev Behav Pediatr. 2010;31:100–6.PubMedCrossRef
7.
go back to reference Thapar A, Rice F, Hay D, et al. Prenatal smoking might not cause attention-deficit/hyperactivity disorder: evidence from a novel design. Biol Psychiatry. 2009;66:722–7.PubMedCrossRef Thapar A, Rice F, Hay D, et al. Prenatal smoking might not cause attention-deficit/hyperactivity disorder: evidence from a novel design. Biol Psychiatry. 2009;66:722–7.PubMedCrossRef
8.
go back to reference •• Nigg J, Nikolas M, Burt SA: Measured gene-by-environment interaction in relation to attention-deficit/hyperactivity disorder. Journal of the American Academy of Child & Adolescent Psychiatry. 2010, 49:863–873. This article provides a summary and evaluation of the current state of knowledge regarding gene–environment interactions in relation to ADHD. PubMedCrossRef •• Nigg J, Nikolas M, Burt SA: Measured gene-by-environment interaction in relation to attention-deficit/hyperactivity disorder. Journal of the American Academy of Child & Adolescent Psychiatry. 2010, 49:863–873. This article provides a summary and evaluation of the current state of knowledge regarding gene–environment interactions in relation to ADHD. PubMedCrossRef
9.
go back to reference Wermter A-K, Laucht M, Schimmelmann BG, et al. From nature versus nurture, via nature and nurture, to gene x environment interaction in mental disorders. Eur Child Adolesc Psychiatry. 2010;19:199–210.PubMedCrossRef Wermter A-K, Laucht M, Schimmelmann BG, et al. From nature versus nurture, via nature and nurture, to gene x environment interaction in mental disorders. Eur Child Adolesc Psychiatry. 2010;19:199–210.PubMedCrossRef
10.
go back to reference Banerjee TD, Middleton F, Faraone SV. Environmental risk factors for attention-deficit hyperactivity disorder. Acta Paediatr. 2007;96:1269–74.PubMedCrossRef Banerjee TD, Middleton F, Faraone SV. Environmental risk factors for attention-deficit hyperactivity disorder. Acta Paediatr. 2007;96:1269–74.PubMedCrossRef
11.
go back to reference Eriksson M, Jonsson B, Steneroth G, Zetterstrom R. Amphetamine abuse during pregnancy: environmental factors and outcome after 14–15 years. Scand J Public Health. 2000;28:154–7.PubMed Eriksson M, Jonsson B, Steneroth G, Zetterstrom R. Amphetamine abuse during pregnancy: environmental factors and outcome after 14–15 years. Scand J Public Health. 2000;28:154–7.PubMed
12.
go back to reference Linares TJ, Singer LT, Kirchner HL, et al. Mental health outcomes of cocaine-exposed children at 6 years of age. J Pediatr Psychol. 2006;31:85–97.PubMedCrossRef Linares TJ, Singer LT, Kirchner HL, et al. Mental health outcomes of cocaine-exposed children at 6 years of age. J Pediatr Psychol. 2006;31:85–97.PubMedCrossRef
13.
go back to reference Ornoy A, Michailevskaya V, Lukashov I, Bar-Hamburger R, Harel S. The developmental outcome of children born to heroin-dependent mothers, raised at home or adopted. Child Abuse Negl. 1996;20:385–96.PubMedCrossRef Ornoy A, Michailevskaya V, Lukashov I, Bar-Hamburger R, Harel S. The developmental outcome of children born to heroin-dependent mothers, raised at home or adopted. Child Abuse Negl. 1996;20:385–96.PubMedCrossRef
14.
go back to reference Williams JH, Ross L. Consequences of prenatal toxin exposure for mental health in children and adolescents: a systematic review. Eur Child Adolesc Psychiatry. 2007;16:243–53.PubMedCrossRef Williams JH, Ross L. Consequences of prenatal toxin exposure for mental health in children and adolescents: a systematic review. Eur Child Adolesc Psychiatry. 2007;16:243–53.PubMedCrossRef
15.
go back to reference Ornoy A, Daka L, Goldzweig G, et al. Neurodevelopmental and psychological assessment of adolescents born to drug-addicted parents: effects of SES and adoption. Child Abuse Negl. 2010;34:354–68.PubMedCrossRef Ornoy A, Daka L, Goldzweig G, et al. Neurodevelopmental and psychological assessment of adolescents born to drug-addicted parents: effects of SES and adoption. Child Abuse Negl. 2010;34:354–68.PubMedCrossRef
16.
go back to reference Bekkhus M, Skjothaug T, Nordhagen R, Borge AI. Intrauterine exposure to caffeine and inattention/overactivity in children. Acta Paediatr. 2010;99:925–8.PubMedCrossRef Bekkhus M, Skjothaug T, Nordhagen R, Borge AI. Intrauterine exposure to caffeine and inattention/overactivity in children. Acta Paediatr. 2010;99:925–8.PubMedCrossRef
17.
go back to reference Linnet KM, Wisborg K, Secher NJ, et al. Coffee consumption during pregnancy and the risk of hyperkinetic disorder and ADHD: a prospective cohort study. Acta Paediatr. 2009;98:173–9.PubMedCrossRef Linnet KM, Wisborg K, Secher NJ, et al. Coffee consumption during pregnancy and the risk of hyperkinetic disorder and ADHD: a prospective cohort study. Acta Paediatr. 2009;98:173–9.PubMedCrossRef
18.
go back to reference Barr H, Streissguth A. Caffeine use during pregnancy and child outcome: a 7-year prospective study. Neurotoxicol Teratol. 1991;13:441–8.PubMedCrossRef Barr H, Streissguth A. Caffeine use during pregnancy and child outcome: a 7-year prospective study. Neurotoxicol Teratol. 1991;13:441–8.PubMedCrossRef
19.
go back to reference Pasker-de Jong PC, Zielhuis GA, van Gelder MM, et al. Antihypertensive treatment during pregnancy and functional development at primary school age in a historical cohort study. BJOG-Int J Obstet Gynaecol. 2010;117:1080–6.CrossRef Pasker-de Jong PC, Zielhuis GA, van Gelder MM, et al. Antihypertensive treatment during pregnancy and functional development at primary school age in a historical cohort study. BJOG-Int J Obstet Gynaecol. 2010;117:1080–6.CrossRef
20.
go back to reference Figueroa RMDP. Use of antidepressants during pregnancy and risk of attention-deficit/hyperactivity disorder in the offspring. [article]. J Dev Behav Pediatr. 2010;31:641–8.PubMedCrossRef Figueroa RMDP. Use of antidepressants during pregnancy and risk of attention-deficit/hyperactivity disorder in the offspring. [article]. J Dev Behav Pediatr. 2010;31:641–8.PubMedCrossRef
21.
go back to reference Nulman I, Rovet J, Stewart DE, et al. Child development following exposure to tricyclic antidepressants or fluoxetine throughout fetal life: a prospective, controlled study. Am J Psychiatry. 1989;159:1889–95.CrossRef Nulman I, Rovet J, Stewart DE, et al. Child development following exposure to tricyclic antidepressants or fluoxetine throughout fetal life: a prospective, controlled study. Am J Psychiatry. 1989;159:1889–95.CrossRef
22.
go back to reference Oberlander TF, Reebye P, Misri S, et al. Externalizing and attentional behaviors in children of depressed mothers treated with a selective serotonin reuptake inhibitor antidepressant during pregnancy. Arch Pediatr Adolesc Med. 2007;161:22–9.PubMedCrossRef Oberlander TF, Reebye P, Misri S, et al. Externalizing and attentional behaviors in children of depressed mothers treated with a selective serotonin reuptake inhibitor antidepressant during pregnancy. Arch Pediatr Adolesc Med. 2007;161:22–9.PubMedCrossRef
23.
go back to reference Cho SC, Kim BN, Hong YC, et al. Effect of environmental exposure to lead and tobacco smoke on inattentive and hyperactive symptoms and neurocognitive performance in children. J Child Psychol Psychiatry. 2010;51:1050–7.PubMedCrossRef Cho SC, Kim BN, Hong YC, et al. Effect of environmental exposure to lead and tobacco smoke on inattentive and hyperactive symptoms and neurocognitive performance in children. J Child Psychol Psychiatry. 2010;51:1050–7.PubMedCrossRef
24.
go back to reference Nicolescu R, Petcu C, Cordeanu A, et al. Environmental exposure to lead, but not other neurotoxic metals, relates to core elements of ADHD in Romanian children: performance and questionnaire data. Environ Res. 2010;110:476–83.PubMedCrossRef Nicolescu R, Petcu C, Cordeanu A, et al. Environmental exposure to lead, but not other neurotoxic metals, relates to core elements of ADHD in Romanian children: performance and questionnaire data. Environ Res. 2010;110:476–83.PubMedCrossRef
25.
go back to reference Nigg JT, Nikolas M, Mark Knottnerus G, Cavanagh K, Friderici K. Confirmation and extension of association of blood lead with attention-deficit/hyperactivity disorder (ADHD) and ADHD symptom domains at population-typical exposure levels. J Child Psychol Psychiatry. 2010;51:58–65.PubMedCrossRef Nigg JT, Nikolas M, Mark Knottnerus G, Cavanagh K, Friderici K. Confirmation and extension of association of blood lead with attention-deficit/hyperactivity disorder (ADHD) and ADHD symptom domains at population-typical exposure levels. J Child Psychol Psychiatry. 2010;51:58–65.PubMedCrossRef
26.
go back to reference Farias AC, Cunha A, Benko CR, et al. Manganese in children with attention-deficit/hyperactivity disorder: relationship with methylphenidate exposure. J Child Adolesc Psychopharmacol. 2010;20:113–8.PubMedCrossRef Farias AC, Cunha A, Benko CR, et al. Manganese in children with attention-deficit/hyperactivity disorder: relationship with methylphenidate exposure. J Child Adolesc Psychopharmacol. 2010;20:113–8.PubMedCrossRef
27.
go back to reference Menezes-Filho JA, Bouchard M, Sarcinelli Pde N, Moreira JC. Manganese exposure and the neuropsychological effect on children and adolescents: a review. Rev Panam Salud Publica. 2009;26:541–8.PubMedCrossRef Menezes-Filho JA, Bouchard M, Sarcinelli Pde N, Moreira JC. Manganese exposure and the neuropsychological effect on children and adolescents: a review. Rev Panam Salud Publica. 2009;26:541–8.PubMedCrossRef
28.
go back to reference Schober SE, Sinks TH, Jones RL, et al. Blood mercury levels in US children and women of childbearing age, 1999–2000. JAMA. 2003;289:1667–74.PubMedCrossRef Schober SE, Sinks TH, Jones RL, et al. Blood mercury levels in US children and women of childbearing age, 1999–2000. JAMA. 2003;289:1667–74.PubMedCrossRef
29.
go back to reference Ha M, Kwon HJ, Lim MH, et al. Low blood levels of lead and mercury and symptoms of attention deficit hyperactivity in children: a report of the Children's Health and Environment Research (CHEER). Neurotoxicology. 2009;30:31–6.PubMedCrossRef Ha M, Kwon HJ, Lim MH, et al. Low blood levels of lead and mercury and symptoms of attention deficit hyperactivity in children: a report of the Children's Health and Environment Research (CHEER). Neurotoxicology. 2009;30:31–6.PubMedCrossRef
30.
go back to reference Heron J, Golding J. Thimerosal exposure in infants and developmental disorders: a prospective cohort study in the United kingdom does not support a causal association. Pediatrics. 2004;114:577–83.PubMedCrossRef Heron J, Golding J. Thimerosal exposure in infants and developmental disorders: a prospective cohort study in the United kingdom does not support a causal association. Pediatrics. 2004;114:577–83.PubMedCrossRef
31.
go back to reference Sagiv SK, Thurston SW, Bellinger DC, et al. Prenatal organochlorine exposure and behaviors associated with attention deficit hyperactivity disorder in school-aged children. Am J Epidemiol. 2010;171:593–601.PubMedCrossRef Sagiv SK, Thurston SW, Bellinger DC, et al. Prenatal organochlorine exposure and behaviors associated with attention deficit hyperactivity disorder in school-aged children. Am J Epidemiol. 2010;171:593–601.PubMedCrossRef
32.
go back to reference •• Eubig PA, Aguiar A, Schantz SL: Lead and PCBs as risk factors for attention deficit/hyperactivity disorder. Environ Health Perspect. 2010, 118:1654–1667. This article provides an overview on the effects of lead and PCBs on ADHD-related neurobehavioral functions. PubMedCrossRef •• Eubig PA, Aguiar A, Schantz SL: Lead and PCBs as risk factors for attention deficit/hyperactivity disorder. Environ Health Perspect. 2010, 118:1654–1667. This article provides an overview on the effects of lead and PCBs on ADHD-related neurobehavioral functions. PubMedCrossRef
33.
go back to reference Lee DH, Jacobs DR, Porta M. Association of serum concentrations of persistent organic pollutants with the prevalence of learning disability and attention deficit disorder. J Epidemiol Community Health. 2007;61:591–6.PubMedCrossRef Lee DH, Jacobs DR, Porta M. Association of serum concentrations of persistent organic pollutants with the prevalence of learning disability and attention deficit disorder. J Epidemiol Community Health. 2007;61:591–6.PubMedCrossRef
34.
go back to reference •• Marks AR, Harley K, Bradman A, et al.: Organophosphate pesticide exposure and attention in young Mexican-American children: the CHAMACOS study. Environ Health Perspect. 2010, 118:1768–1774. This study is among the first to document an association between organophosphate pesticide exposure and ADHD-related symptomatology. Key features of the study include assessment of both prenatal and childhood organophosphate pesticide exposure levels; evaluation of outcomes using maternal report, psychometrician observation, and direct assessment; and the observation that the adverse effects of organophosphate exposure were stronger in boys than girls. PubMedCrossRef •• Marks AR, Harley K, Bradman A, et al.: Organophosphate pesticide exposure and attention in young Mexican-American children: the CHAMACOS study. Environ Health Perspect. 2010, 118:1768–1774. This study is among the first to document an association between organophosphate pesticide exposure and ADHD-related symptomatology. Key features of the study include assessment of both prenatal and childhood organophosphate pesticide exposure levels; evaluation of outcomes using maternal report, psychometrician observation, and direct assessment; and the observation that the adverse effects of organophosphate exposure were stronger in boys than girls. PubMedCrossRef
35.
go back to reference Bouchard MF, Bellinger DC, Wright RO, Weisskopf MG. Attention-deficit/hyperactivity disorder and urinary metabolites of organophosphate pesticides. Pediatrics. 2010;125:e1270–7.PubMedCrossRef Bouchard MF, Bellinger DC, Wright RO, Weisskopf MG. Attention-deficit/hyperactivity disorder and urinary metabolites of organophosphate pesticides. Pediatrics. 2010;125:e1270–7.PubMedCrossRef
36.
go back to reference Eskenazi B, Marks AR, Bradman A, et al. Organophosphate pesticide exposure and neurodevelopment in young Mexican-American children. Environ Health Perspect. 2007;115:792–8.PubMedCrossRef Eskenazi B, Marks AR, Bradman A, et al. Organophosphate pesticide exposure and neurodevelopment in young Mexican-American children. Environ Health Perspect. 2007;115:792–8.PubMedCrossRef
37.
go back to reference Rauh VA, Garfinkel R, Perera FP, et al. Impact of prenatal chlorpyrifos exposure on neurodevelopment in the first 3 years of life among inner-city children. Pediatrics. 2006;118:e1845–59.PubMedCrossRef Rauh VA, Garfinkel R, Perera FP, et al. Impact of prenatal chlorpyrifos exposure on neurodevelopment in the first 3 years of life among inner-city children. Pediatrics. 2006;118:e1845–59.PubMedCrossRef
38.
go back to reference Kim BN, Cho SC, Kim Y, et al. Phthalates exposure and attention-deficit/hyperactivity disorder in school-age children. Biol Psychiatry. 2009;66:958–63.PubMedCrossRef Kim BN, Cho SC, Kim Y, et al. Phthalates exposure and attention-deficit/hyperactivity disorder in school-age children. Biol Psychiatry. 2009;66:958–63.PubMedCrossRef
39.
go back to reference Hoffman K, Webster TF, Weisskopf MG, Weinberg J, Vieira VM. Exposure to polyfluoroalkyl chemicals and attention deficit/hyperactivity disorder in U.S. children 12–15 years of age. Environ Health Perspect. 2010;118:1762–7.PubMedCrossRef Hoffman K, Webster TF, Weisskopf MG, Weinberg J, Vieira VM. Exposure to polyfluoroalkyl chemicals and attention deficit/hyperactivity disorder in U.S. children 12–15 years of age. Environ Health Perspect. 2010;118:1762–7.PubMedCrossRef
40.
go back to reference Johansson N, Fredriksson A, Eriksson P. Neonatal exposure to perfluorooctane sulfonate (PFOS) and perfluorooctanoic acid (PFOA) causes neurobehavioural defects in adult mice. Neurotoxicology. 2008;29:160–9.PubMedCrossRef Johansson N, Fredriksson A, Eriksson P. Neonatal exposure to perfluorooctane sulfonate (PFOS) and perfluorooctanoic acid (PFOA) causes neurobehavioural defects in adult mice. Neurotoxicology. 2008;29:160–9.PubMedCrossRef
41.
go back to reference Fei C, McLaughlin JK, Lipworth L, Olsen J. Prenatal exposure to perfluorooctanoate (PFOA) and perfluorooctanesulfonate (PFOS) and maternally reported developmental milestones in infancy. Environ Health Perspect. 2008;116:1391–5.PubMedCrossRef Fei C, McLaughlin JK, Lipworth L, Olsen J. Prenatal exposure to perfluorooctanoate (PFOA) and perfluorooctanesulfonate (PFOS) and maternally reported developmental milestones in infancy. Environ Health Perspect. 2008;116:1391–5.PubMedCrossRef
42.
go back to reference Schlotz W, Jones A, Phillips DI, et al. Lower maternal folate status in early pregnancy is associated with childhood hyperactivity and peer problems in offspring. J Child Psychol Psychiatr Allied Disc. 2010;51:594–602.CrossRef Schlotz W, Jones A, Phillips DI, et al. Lower maternal folate status in early pregnancy is associated with childhood hyperactivity and peer problems in offspring. J Child Psychol Psychiatr Allied Disc. 2010;51:594–602.CrossRef
43.
go back to reference Rodriguez A. Maternal pre-pregnancy obesity and risk for inattention and negative emotionality in children. J Child Psychol Psychiatr Allied Disc. 2010;51:134–43.CrossRef Rodriguez A. Maternal pre-pregnancy obesity and risk for inattention and negative emotionality in children. J Child Psychol Psychiatr Allied Disc. 2010;51:134–43.CrossRef
44.
go back to reference Rodriguez A, Miettunen J, Henriksen TB, et al. Maternal adiposity prior to pregnancy is associated with ADHD symptoms in offspring: evidence from three prospective pregnancy cohorts. Int J Obes. 2008;32:550–7.CrossRef Rodriguez A, Miettunen J, Henriksen TB, et al. Maternal adiposity prior to pregnancy is associated with ADHD symptoms in offspring: evidence from three prospective pregnancy cohorts. Int J Obes. 2008;32:550–7.CrossRef
45.
go back to reference Juneja M, Jain R, Singh V, Mallika V. Iron deficiency in Indian children with attention deficit hyperactivity disorder. Indian Pediatr. 2010;47:955–8.PubMedCrossRef Juneja M, Jain R, Singh V, Mallika V. Iron deficiency in Indian children with attention deficit hyperactivity disorder. Indian Pediatr. 2010;47:955–8.PubMedCrossRef
46.
go back to reference Corapci F, Calatroni A, Kaciroti N, Jimenez E, Lozoff B. Longitudinal evaluation of externalizing and internalizing behavior problems following iron deficiency in infancy. J Pediatr Psychol. 2010;35:296–305.PubMedCrossRef Corapci F, Calatroni A, Kaciroti N, Jimenez E, Lozoff B. Longitudinal evaluation of externalizing and internalizing behavior problems following iron deficiency in infancy. J Pediatr Psychol. 2010;35:296–305.PubMedCrossRef
47.
go back to reference Menegassi M, Mello ED, Guimaraes LR, et al. Food intake and serum levels of iron in children and adolescents with attention-deficit/hyperactivity disorder. Rev Bras Psiquiatr. 2010;32:132–8.PubMedCrossRef Menegassi M, Mello ED, Guimaraes LR, et al. Food intake and serum levels of iron in children and adolescents with attention-deficit/hyperactivity disorder. Rev Bras Psiquiatr. 2010;32:132–8.PubMedCrossRef
48.
go back to reference Kiddie JY, Weiss MD, Kitts DD, Levy-Milne R, Wasdell MB. Nutritional status of children with attention deficit hyperactivity disorder: a pilot study. Int J Pediatr. 2010;2010:767318.PubMed Kiddie JY, Weiss MD, Kitts DD, Levy-Milne R, Wasdell MB. Nutritional status of children with attention deficit hyperactivity disorder: a pilot study. Int J Pediatr. 2010;2010:767318.PubMed
49.
go back to reference Konofal E, Lecendreux M, Arnulf I, Mouren MC. Iron deficiency in children with attention-deficit/hyperactivity disorder. Arch Pediatr Adolesc Med. 2004;158:1113–5.PubMedCrossRef Konofal E, Lecendreux M, Arnulf I, Mouren MC. Iron deficiency in children with attention-deficit/hyperactivity disorder. Arch Pediatr Adolesc Med. 2004;158:1113–5.PubMedCrossRef
50.
go back to reference Otero GA, Pliego-Rivero FB, Contreras G, Ricardo J, Fernandez T. Iron supplementation brings up a lacking P300 in iron deficient children. Clin Neurophysiol. 2004;115:2259–66.PubMedCrossRef Otero GA, Pliego-Rivero FB, Contreras G, Ricardo J, Fernandez T. Iron supplementation brings up a lacking P300 in iron deficient children. Clin Neurophysiol. 2004;115:2259–66.PubMedCrossRef
51.
go back to reference Chen JR, Hsu SF, Hsu CD, Hwang LH, Yang SC. Dietary patterns and blood fatty acid composition in children with attention-deficit hyperactivity disorder in Taiwan. J Nutr Biochem. 2004;15:467–72.PubMedCrossRef Chen JR, Hsu SF, Hsu CD, Hwang LH, Yang SC. Dietary patterns and blood fatty acid composition in children with attention-deficit hyperactivity disorder in Taiwan. J Nutr Biochem. 2004;15:467–72.PubMedCrossRef
52.
go back to reference Millichap JG, Yee MM, Davidson SI. Serum ferritin in children with attention-deficit hyperactivity disorder. Pediatr Neurol. 2006;34:200–3.PubMedCrossRef Millichap JG, Yee MM, Davidson SI. Serum ferritin in children with attention-deficit hyperactivity disorder. Pediatr Neurol. 2006;34:200–3.PubMedCrossRef
53.
go back to reference Sinn N. Nutritional and dietary influences on attention deficit hyperactivity disorder. Nutr Rev. 2008;66:558–68.PubMedCrossRef Sinn N. Nutritional and dietary influences on attention deficit hyperactivity disorder. Nutr Rev. 2008;66:558–68.PubMedCrossRef
54.
go back to reference Arnold LE, DiSilvestro RA. Zinc in attention-deficit/hyperactivity disorder. J Child Adolesc Psychopharmacol. 2005;15:619–27.PubMedCrossRef Arnold LE, DiSilvestro RA. Zinc in attention-deficit/hyperactivity disorder. J Child Adolesc Psychopharmacol. 2005;15:619–27.PubMedCrossRef
55.
go back to reference Starobrat-Hermelin B. The effect of deficiency of selected bioelements on hyperactivity in children with certain specified mental disorders. Ann Acad Med Stetin. 1998;44:297–314.PubMed Starobrat-Hermelin B. The effect of deficiency of selected bioelements on hyperactivity in children with certain specified mental disorders. Ann Acad Med Stetin. 1998;44:297–314.PubMed
56.
go back to reference Kirby A, Woodward A, Jackson S, Wang Y, Crawford MA. Childrens' learning and behaviour and the association with cheek cell polyunsaturated fatty acid levels. Res Dev Disabil. 2010;31:731–42.PubMedCrossRef Kirby A, Woodward A, Jackson S, Wang Y, Crawford MA. Childrens' learning and behaviour and the association with cheek cell polyunsaturated fatty acid levels. Res Dev Disabil. 2010;31:731–42.PubMedCrossRef
57.
go back to reference Raz R, Gabis L. Essential fatty acids and attention-deficit-hyperactivity disorder: a systematic review. Dev Med Child Neurol. 2009;51:580–92.PubMedCrossRef Raz R, Gabis L. Essential fatty acids and attention-deficit-hyperactivity disorder: a systematic review. Dev Med Child Neurol. 2009;51:580–92.PubMedCrossRef
58.
go back to reference Howard AL, Robinson M, Smith GJ, et al.: ADHD is associated with a 'Western' dietary pattern in adolescents. J Atten Disord. 2010. Howard AL, Robinson M, Smith GJ, et al.: ADHD is associated with a 'Western' dietary pattern in adolescents. J Atten Disord. 2010.
59.
go back to reference Stevenson J, Sonuga-Barke E, McCann D, et al. The role of histamine degradation gene polymorphisms in moderating the effects of food additives on children's ADHD symptoms. Am J Psychiatry. 2010;167:1108–15.PubMedCrossRef Stevenson J, Sonuga-Barke E, McCann D, et al. The role of histamine degradation gene polymorphisms in moderating the effects of food additives on children's ADHD symptoms. Am J Psychiatry. 2010;167:1108–15.PubMedCrossRef
60.
go back to reference Administration USFaD: Interim Toxicology Review Memorandum: Artificial Food Colors and ADHD in Childhood and Related Problem Behaviors. In F. A. Committee (ed). Washington, D.C.: Department of Health & Human Services, 2011. Administration USFaD: Interim Toxicology Review Memorandum: Artificial Food Colors and ADHD in Childhood and Related Problem Behaviors. In F. A. Committee (ed). Washington, D.C.: Department of Health & Human Services, 2011.
61.
go back to reference Cheng S, Maeda T, Yoichi S, et al. Early television exposure and children's behavioral and social outcomes at age 30 months. J Epidemiol. 2010;20 Suppl 2:S482–9.PubMedCrossRef Cheng S, Maeda T, Yoichi S, et al. Early television exposure and children's behavioral and social outcomes at age 30 months. J Epidemiol. 2010;20 Suppl 2:S482–9.PubMedCrossRef
62.
go back to reference Swing EL, Gentile DA, Anderson CA, Walsh DA. Television and video game exposure and the development of attention problems. Pediatrics. 2010;126:214–21.PubMedCrossRef Swing EL, Gentile DA, Anderson CA, Walsh DA. Television and video game exposure and the development of attention problems. Pediatrics. 2010;126:214–21.PubMedCrossRef
63.
go back to reference Christakis DA, Zimmerman FJ, DiGiuseppe DL, McCarty CA. Early television exposure and subsequent attentional problems in children. Pediatrics. 2004;113:708–13.PubMedCrossRef Christakis DA, Zimmerman FJ, DiGiuseppe DL, McCarty CA. Early television exposure and subsequent attentional problems in children. Pediatrics. 2004;113:708–13.PubMedCrossRef
64.
go back to reference Mistry KB, Minkovitz CS, Strobino DM, Borzekowski DL. Children's television exposure and behavioral and social outcomes at 5.5 years: does timing of exposure matter? Pediatrics. 2007;120:762–9.PubMedCrossRef Mistry KB, Minkovitz CS, Strobino DM, Borzekowski DL. Children's television exposure and behavioral and social outcomes at 5.5 years: does timing of exposure matter? Pediatrics. 2007;120:762–9.PubMedCrossRef
65.
go back to reference Stevens T, Mulsow M. There is no meaningful relationship between television exposure and symptoms of attention-deficit/hyperactivity disorder. Pediatrics. 2006;117:665–72.PubMedCrossRef Stevens T, Mulsow M. There is no meaningful relationship between television exposure and symptoms of attention-deficit/hyperactivity disorder. Pediatrics. 2006;117:665–72.PubMedCrossRef
66.
67.
go back to reference Li J, Olsen J, Vestergaard M, Obel C. Attention-deficit/hyperactivity disorder in the offspring following prenatal maternal bereavement: a nationwide follow-up study in Denmark. Eur Child Adolesc Psychiatry. 2010;19:747–53.PubMedCrossRef Li J, Olsen J, Vestergaard M, Obel C. Attention-deficit/hyperactivity disorder in the offspring following prenatal maternal bereavement: a nationwide follow-up study in Denmark. Eur Child Adolesc Psychiatry. 2010;19:747–53.PubMedCrossRef
68.
go back to reference Martini J, Knappe S, Beesdo-Baum K, Lieb R, Wittchen HU. Anxiety disorders before birth and self-perceived distress during pregnancy: associations with maternal depression and obstetric, neonatal and early childhood outcomes. Early Hum Dev. 2010;86:305–10.PubMedCrossRef Martini J, Knappe S, Beesdo-Baum K, Lieb R, Wittchen HU. Anxiety disorders before birth and self-perceived distress during pregnancy: associations with maternal depression and obstetric, neonatal and early childhood outcomes. Early Hum Dev. 2010;86:305–10.PubMedCrossRef
69.
go back to reference Linnet KM, Dalsgaard S, Obel C, et al. Maternal lifestyle factors in pregnancy risk of attention deficit hyperactivity disorder and associated behaviors: review of the current evidence. Am J Psychiatry. 2003;160:1028–40.PubMedCrossRef Linnet KM, Dalsgaard S, Obel C, et al. Maternal lifestyle factors in pregnancy risk of attention deficit hyperactivity disorder and associated behaviors: review of the current evidence. Am J Psychiatry. 2003;160:1028–40.PubMedCrossRef
70.
go back to reference Merz EC, McCall RB. Behavior problems in children adopted from psychosocially depriving institutions. J Abnorm Child Psychol. 2010;38:459–70.PubMedCrossRef Merz EC, McCall RB. Behavior problems in children adopted from psychosocially depriving institutions. J Abnorm Child Psychol. 2010;38:459–70.PubMedCrossRef
71.
go back to reference McLaughlin KA, Fox NA, Zeanah CH, et al. Delayed maturation in brain electrical activity partially explains the association between early environmental deprivation and symptoms of attention-deficit/hyperactivity disorder. Biol Psychiatry. 2010;68:329–36.PubMedCrossRef McLaughlin KA, Fox NA, Zeanah CH, et al. Delayed maturation in brain electrical activity partially explains the association between early environmental deprivation and symptoms of attention-deficit/hyperactivity disorder. Biol Psychiatry. 2010;68:329–36.PubMedCrossRef
72.
go back to reference Kreppner JM, O'Connor TG, Rutter M. Can inattention/overactivity be an institutional deprivation syndrome? J Abnorm Child Psychol. 2001;29:513–28.PubMedCrossRef Kreppner JM, O'Connor TG, Rutter M. Can inattention/overactivity be an institutional deprivation syndrome? J Abnorm Child Psychol. 2001;29:513–28.PubMedCrossRef
73.
go back to reference Briggs-Gowan MJ, Carter AS, Clark R, et al. Exposure to potentially traumatic events in early childhood: differential links to emergent psychopathology. J Child Psychol Psychiatry. 2010;51:1132–40.PubMedCrossRef Briggs-Gowan MJ, Carter AS, Clark R, et al. Exposure to potentially traumatic events in early childhood: differential links to emergent psychopathology. J Child Psychol Psychiatry. 2010;51:1132–40.PubMedCrossRef
74.
go back to reference Ford JD, Racusin R, Daviss WB, et al. Trauma exposure among children with oppositional defiant disorder and attention deficit-hyperactivity disorder. J Consult Clin Psychol. 1999;67:786–9.PubMedCrossRef Ford JD, Racusin R, Daviss WB, et al. Trauma exposure among children with oppositional defiant disorder and attention deficit-hyperactivity disorder. J Consult Clin Psychol. 1999;67:786–9.PubMedCrossRef
75.
go back to reference Winders Davis D, Williams PG. Attention deficit/hyperactivity disorder in preschool-age children: issues and concerns. Clin Pediatr. 2011;50:144–52.CrossRef Winders Davis D, Williams PG. Attention deficit/hyperactivity disorder in preschool-age children: issues and concerns. Clin Pediatr. 2011;50:144–52.CrossRef
77.
go back to reference Schlotz W, Jones A, Phillips DI, et al. Lower maternal folate status in early pregnancy is associated with childhood hyperactivity and peer problems in offspring. J Child Psychol Psychiatry. 2010;51:594–602.PubMedCrossRef Schlotz W, Jones A, Phillips DI, et al. Lower maternal folate status in early pregnancy is associated with childhood hyperactivity and peer problems in offspring. J Child Psychol Psychiatry. 2010;51:594–602.PubMedCrossRef
78.
go back to reference Chen Q, Huang NN, Huang JT, et al. Sodium benzoate exposure downregulates the expression of tyrosine hydroxylase and dopamine transporter in dopaminergic neurons in developing zebrafish. Birth Defects Res B Dev Reprod Toxicol. 2009;86:85–91.PubMedCrossRef Chen Q, Huang NN, Huang JT, et al. Sodium benzoate exposure downregulates the expression of tyrosine hydroxylase and dopamine transporter in dopaminergic neurons in developing zebrafish. Birth Defects Res B Dev Reprod Toxicol. 2009;86:85–91.PubMedCrossRef
79.
go back to reference Kantor MA, Trout JR, Lachance PA. Food dyes produce minimal effects on locomotor activity and vitamin B-6 levels in postweanling rats. J Nutr. 1984;114:1402–12.PubMed Kantor MA, Trout JR, Lachance PA. Food dyes produce minimal effects on locomotor activity and vitamin B-6 levels in postweanling rats. J Nutr. 1984;114:1402–12.PubMed
80.
go back to reference Sheridan M, Drury S, McLaughlin K, Almas A. Early institutionalization: neurobiological consequences and genetic modifiers. Neuropsychol Rev. 2010;20:414–29.PubMedCrossRef Sheridan M, Drury S, McLaughlin K, Almas A. Early institutionalization: neurobiological consequences and genetic modifiers. Neuropsychol Rev. 2010;20:414–29.PubMedCrossRef
81.
go back to reference Wigle DT. Child health and the environment. New York: Oxford University Press; 2003. Wigle DT. Child health and the environment. New York: Oxford University Press; 2003.
82.
go back to reference Bourdineaud JP, Fujimura M, Laclau M, Sawada M, Yasutake A. Deleterious effects in mice of fish-associated methylmercury contained in a diet mimicking the Western populations’ average fish consumption. Environ Int. 2011;37:303–13.PubMedCrossRef Bourdineaud JP, Fujimura M, Laclau M, Sawada M, Yasutake A. Deleterious effects in mice of fish-associated methylmercury contained in a diet mimicking the Western populations’ average fish consumption. Environ Int. 2011;37:303–13.PubMedCrossRef
83.
go back to reference Udagawa J, Hatta T, Hashimoto R, Otani H. Roles of leptin in prenatal and perinatal brain development. Congenit Anom (Kyoto). 2007;47:77–83.CrossRef Udagawa J, Hatta T, Hashimoto R, Otani H. Roles of leptin in prenatal and perinatal brain development. Congenit Anom (Kyoto). 2007;47:77–83.CrossRef
84.
go back to reference Rodriguez A. Maternal pre-pregnancy obesity and risk for inattention and negative emotionality in children. J Child Psychol Psychiatry. 2010;51:134–43.PubMedCrossRef Rodriguez A. Maternal pre-pregnancy obesity and risk for inattention and negative emotionality in children. J Child Psychol Psychiatry. 2010;51:134–43.PubMedCrossRef
85.
go back to reference McNamara RK, Carlson SE. Role of omega-3 fatty acids in brain development and function: potential implications for the pathogenesis and prevention of psychopathology. Prostaglandins Leukot Essent Fatty Acids. 2006;75:329–49.PubMedCrossRef McNamara RK, Carlson SE. Role of omega-3 fatty acids in brain development and function: potential implications for the pathogenesis and prevention of psychopathology. Prostaglandins Leukot Essent Fatty Acids. 2006;75:329–49.PubMedCrossRef
86.
go back to reference Chen T, Yang W, Li Y, Chen X, Xu S. Mono-(2-ethylhexyl) phthalate impairs neurodevelopment: inhibition of proliferation and promotion of differentiation in PC12 cells. Toxicol Lett. 2011;201:34–41.PubMedCrossRef Chen T, Yang W, Li Y, Chen X, Xu S. Mono-(2-ethylhexyl) phthalate impairs neurodevelopment: inhibition of proliferation and promotion of differentiation in PC12 cells. Toxicol Lett. 2011;201:34–41.PubMedCrossRef
87.
go back to reference Johansson N, Eriksson P, Viberg H. Neonatal exposure to PFOS and PFOA in mice results in changes in proteins which are important for neuronal growth and synaptogenesis in the developing brain. Toxicol Sci. 2009;108:412–8.PubMedCrossRef Johansson N, Eriksson P, Viberg H. Neonatal exposure to PFOS and PFOA in mice results in changes in proteins which are important for neuronal growth and synaptogenesis in the developing brain. Toxicol Sci. 2009;108:412–8.PubMedCrossRef
88.
go back to reference Goodlett CR, Horn KH. Mechanisms of alcohol-induced damage to the developing nervous system. Alcohol Res Health. 2001;25:175–84.PubMed Goodlett CR, Horn KH. Mechanisms of alcohol-induced damage to the developing nervous system. Alcohol Res Health. 2001;25:175–84.PubMed
89.
go back to reference Wang J, Haj-Dahmane S, Shen RY. Effects of prenatal ethanol exposure on the excitability of ventral tegmental area dopamine neurons in vitro. J Pharmacol Exp Ther. 2006;319:857–63.PubMedCrossRef Wang J, Haj-Dahmane S, Shen RY. Effects of prenatal ethanol exposure on the excitability of ventral tegmental area dopamine neurons in vitro. J Pharmacol Exp Ther. 2006;319:857–63.PubMedCrossRef
90.
go back to reference Hu S, Sheng WS, Lokensgard JR, Peterson PK. Morphine induces apoptosis of human microglia and neurons. Neuropharmacology. 2002;42:829–36.PubMedCrossRef Hu S, Sheng WS, Lokensgard JR, Peterson PK. Morphine induces apoptosis of human microglia and neurons. Neuropharmacology. 2002;42:829–36.PubMedCrossRef
91.
go back to reference Vathy I. Prenatal opiate exposure: long-term CNS consequences in the stress system of the offspring. Psychoneuroendocrinology. 2002;27:273–83.PubMedCrossRef Vathy I. Prenatal opiate exposure: long-term CNS consequences in the stress system of the offspring. Psychoneuroendocrinology. 2002;27:273–83.PubMedCrossRef
92.
go back to reference Pauly JR, Slotkin TA. Maternal tobacco smoking, nicotine replacement and neurobehavioural development. Acta Paediatr. 2008;97:1331–7.PubMedCrossRef Pauly JR, Slotkin TA. Maternal tobacco smoking, nicotine replacement and neurobehavioural development. Acta Paediatr. 2008;97:1331–7.PubMedCrossRef
93.
go back to reference Viltart O, Mairesse J, Darnaudery M, et al. Prenatal stress alters Fos protein expression in hippocampus and locus coeruleus stress-related brain structures. Psychoneuroendocrinology. 2006;31:769–80.PubMedCrossRef Viltart O, Mairesse J, Darnaudery M, et al. Prenatal stress alters Fos protein expression in hippocampus and locus coeruleus stress-related brain structures. Psychoneuroendocrinology. 2006;31:769–80.PubMedCrossRef
94.
go back to reference Lepping P, Huber M. Role of zinc in the pathogenesis of attention-deficit hyperactivity disorder: implications for research and treatment. CNS Drugs. 2010;24:721–8.PubMed Lepping P, Huber M. Role of zinc in the pathogenesis of attention-deficit hyperactivity disorder: implications for research and treatment. CNS Drugs. 2010;24:721–8.PubMed
Metadata
Title
Update on Environmental Risk Factors for Attention-Deficit/Hyperactivity Disorder
Authors
Tanya E. Froehlich
Julia S. Anixt
Irene M. Loe
Vilawan Chirdkiatgumchai
Lisa Kuan
Richard C. Gilman
Publication date
01-10-2011
Publisher
Current Science Inc.
Published in
Current Psychiatry Reports / Issue 5/2011
Print ISSN: 1523-3812
Electronic ISSN: 1535-1645
DOI
https://doi.org/10.1007/s11920-011-0221-3

Other articles of this Issue 5/2011

Current Psychiatry Reports 5/2011 Go to the issue