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Published in: Current Pain and Headache Reports 3/2020

01-03-2020 | Osteoporosis | Other Pain (AD Kaye and N Vadivelu, Section Editors)

Sacral Insufficiency Fractures: a Review of Risk Factors, Clinical Presentation, and Management

Authors: Ivan Urits, Vwaire Orhurhu, Jessica Callan, Nishita V. Maganty, Sara Pousti, Thomas Simopoulos, Cyrus Yazdi, Rachel J. Kaye, Lauren K. Eng, Alan D. Kaye, Laxmaiah Manchikanti, Omar Viswanath

Published in: Current Pain and Headache Reports | Issue 3/2020

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Abstract

Purpose of the Review

Sacral insufficiency fractures (SIF) are a common and often underdiagnosed source of low back pain. In patients with SIF, there is both a compromised sacroiliac joint and weakened sacrum, resulting in decreased resistance to torsional stress, leading to fracture. While conservative medical management is a safe option, minimally invasive intervention may provide improved short and long-term relief of low back pain in patients presenting with SIF. This comprehensive review is undertaken to provide an update to the current understanding of SIF with description of risk factors, clinical presentation, and management.

Recent Findings

Sacroplasty is a minimally invasive procedure in which polymethylmethacrylate (PMMA) cement is inserted into bone to improve its structural integrity and alleviate symptoms. Balloon sacroplasty (BSP) has also been successful in alleviating pain with minimal cement leakage in SIF patients. Various other interventional techniques, including navigation-assisted screw fixation have been used to address SIF and have shown improvement in pain with minimal side effects.

Summary

This review included various modalities of treatments available to manage SIF. This review shows that in comparison with nonsurgical management, sacroplasty has been shown to have greater pain reduction and improved mobility.
Literature
1.
go back to reference Dieleman JL, Baral R, Birger M, Bui AL, Bulchis A, Chapin A, et al. US spending on personal health care and public health, 1996-2013. JAMA. 2016;316:2627–46.PubMedPubMedCentral Dieleman JL, Baral R, Birger M, Bui AL, Bulchis A, Chapin A, et al. US spending on personal health care and public health, 1996-2013. JAMA. 2016;316:2627–46.PubMedPubMedCentral
2.
go back to reference Dieleman JL, Squires E, Bui AL, Campbell M, Chapin A, Hamavid H, et al. Factors associated with increase in US health care spending, 1996-2013. JAMA. 2017;318:1668–78.PubMedPubMedCentral Dieleman JL, Squires E, Bui AL, Campbell M, Chapin A, Hamavid H, et al. Factors associated with increase in US health care spending, 1996-2013. JAMA. 2017;318:1668–78.PubMedPubMedCentral
3.
go back to reference Manchikanti L, Kaye AM, Knezevic NN, McAnally H, Trescot AM, Blank S, et al. Responsible, safe, and effective prescription of opioids for chronic non-cancer pain: American Society of Interventional Pain Physicians (ASIPP) guidelines. Pain Physician. 2017;20:S3–S92.PubMed Manchikanti L, Kaye AM, Knezevic NN, McAnally H, Trescot AM, Blank S, et al. Responsible, safe, and effective prescription of opioids for chronic non-cancer pain: American Society of Interventional Pain Physicians (ASIPP) guidelines. Pain Physician. 2017;20:S3–S92.PubMed
4.
go back to reference Sanger N, Bhatt M, Singhal N, Ramsden K, Baptist-Mohseni N, Panesar B, et al. Adverse outcomes associated with prescription opioids for acute low back pain: a systematic review and meta-analysis. Pain Physician. 2019;22:119–38.PubMed Sanger N, Bhatt M, Singhal N, Ramsden K, Baptist-Mohseni N, Panesar B, et al. Adverse outcomes associated with prescription opioids for acute low back pain: a systematic review and meta-analysis. Pain Physician. 2019;22:119–38.PubMed
6.
go back to reference Manchikanti L, Sanapati J, Benyamin RM, Atluri S, Kaye AD, Hirsch JA. Reframing the prevention strategies of the opioid crisis: focusing on prescription opioids, fentanyl, and heroin epidemic. Pain Physician. 2018;21:309–26.PubMed Manchikanti L, Sanapati J, Benyamin RM, Atluri S, Kaye AD, Hirsch JA. Reframing the prevention strategies of the opioid crisis: focusing on prescription opioids, fentanyl, and heroin epidemic. Pain Physician. 2018;21:309–26.PubMed
7.
go back to reference • Manchikanti L, Soin A, Mann DP, Bakshi S, Pampati V, Hirsch JA. Reversal of growth of utilization of interventional techniques in managing chronic pain in Medicare population post affordable care act. Pain Physician. 2017;20:551–67. This is the latest manuscript describing the utilization of interventional techniques in managing chronic pain in the Medicare population. This updated analysis details various categories of procedures and their patterns of utilization. PubMed • Manchikanti L, Soin A, Mann DP, Bakshi S, Pampati V, Hirsch JA. Reversal of growth of utilization of interventional techniques in managing chronic pain in Medicare population post affordable care act. Pain Physician. 2017;20:551–67. This is the latest manuscript describing the utilization of interventional techniques in managing chronic pain in the Medicare population. This updated analysis details various categories of procedures and their patterns of utilization. PubMed
8.
go back to reference Manchikanti L, Soin A, Mann DP, Bakshi S, Pampati V, Kaye AD, et al. Utilization patterns of facet joint interventions in managing spinal pain: a retrospective cohort study in the US fee-for-service Medicare population. Curr Pain Headache Rep. 2019;23:73.PubMed Manchikanti L, Soin A, Mann DP, Bakshi S, Pampati V, Kaye AD, et al. Utilization patterns of facet joint interventions in managing spinal pain: a retrospective cohort study in the US fee-for-service Medicare population. Curr Pain Headache Rep. 2019;23:73.PubMed
9.
go back to reference Manchikanti L, Soin A, Mann DP, Bakshi S, Pampati V, Hirsch JA. Comparative analysis of utilization of epidural procedures in managing chronic pain in the Medicare population: pre and post affordable care act. Spine (Phila Pa 1976). 2019;44:220–32. Manchikanti L, Soin A, Mann DP, Bakshi S, Pampati V, Hirsch JA. Comparative analysis of utilization of epidural procedures in managing chronic pain in the Medicare population: pre and post affordable care act. Spine (Phila Pa 1976). 2019;44:220–32.
10.
go back to reference • Manchikanti MV, Manchikanti L, Kaye AD, Pampati V, Hirsch JA. Usage patterns of sacroiliac joint injections - a comparative evaluation of pre and post Affordable Care Act in Medicare population. IPM Reports. 2018;2:157–66. This manuscript describes the utility of sacroiliac joint injections which increased from 2009 to 2016. • Manchikanti MV, Manchikanti L, Kaye AD, Pampati V, Hirsch JA. Usage patterns of sacroiliac joint injections - a comparative evaluation of pre and post Affordable Care Act in Medicare population. IPM Reports. 2018;2:157–66. This manuscript describes the utility of sacroiliac joint injections which increased from 2009 to 2016.
11.
go back to reference Manchikanti L, Pampati V, Benyamin RM, Hirsch JA. Cost calculation methodology exacerbates site-of-service differentials by 10- to 18-fold for soft tissue and joint injections in hospital outpatient departments. IPM Reports. 2017;1:183–9. Manchikanti L, Pampati V, Benyamin RM, Hirsch JA. Cost calculation methodology exacerbates site-of-service differentials by 10- to 18-fold for soft tissue and joint injections in hospital outpatient departments. IPM Reports. 2017;1:183–9.
12.
go back to reference Lee JH, Shin KS, Park SJ, Lee GJ, Lee CH, Kim DH, et al. Comparison of clinical efficacy between transforaminal and interlaminar epidural injections in lumbosacral disc herniation: a systematic review and meta-analysis. Pain Physician. 2018;21:433–48.PubMed Lee JH, Shin KS, Park SJ, Lee GJ, Lee CH, Kim DH, et al. Comparison of clinical efficacy between transforaminal and interlaminar epidural injections in lumbosacral disc herniation: a systematic review and meta-analysis. Pain Physician. 2018;21:433–48.PubMed
13.
go back to reference Lee JH, Kim DH, Kim DH, Shin KS, Park SJ, Lee GJ, et al. Comparison of clinical efficacy of epidural injection with or without steroid in lumbosacral disc herniation: a systematic review and meta-analysis. Pain Physician. 2018;21:449–68.PubMed Lee JH, Kim DH, Kim DH, Shin KS, Park SJ, Lee GJ, et al. Comparison of clinical efficacy of epidural injection with or without steroid in lumbosacral disc herniation: a systematic review and meta-analysis. Pain Physician. 2018;21:449–68.PubMed
14.
go back to reference Sanapati J, Manchikanti L, Atluri S, Jordan S, Albers SL, Pappolla MA, et al. Do regenerative medicine therapies provide long-term relief in chronic low back pain: a systematic review and metaanalysis. Pain Physician. 2018;21:515–40.PubMed Sanapati J, Manchikanti L, Atluri S, Jordan S, Albers SL, Pappolla MA, et al. Do regenerative medicine therapies provide long-term relief in chronic low back pain: a systematic review and metaanalysis. Pain Physician. 2018;21:515–40.PubMed
15.
go back to reference Tran ZV, Ivashchenko A, Brooks L. Sacroiliac joint fusion methodology - minimally invasive compared to screw-type surgeries: a systematic review and meta-analysis. Pain Physician. 2019;22:29–40.PubMed Tran ZV, Ivashchenko A, Brooks L. Sacroiliac joint fusion methodology - minimally invasive compared to screw-type surgeries: a systematic review and meta-analysis. Pain Physician. 2019;22:29–40.PubMed
16.
go back to reference Shen J, Xu S, Xu S, Ye S, Hao J. Fusion or not for degenerative lumbar spinal stenosis: a meta-analysis and systematic review. Pain Physician. 2018;21:1–8.PubMed Shen J, Xu S, Xu S, Ye S, Hao J. Fusion or not for degenerative lumbar spinal stenosis: a meta-analysis and systematic review. Pain Physician. 2018;21:1–8.PubMed
17.
go back to reference Coulter ID, Crawford C, Vernon H, Hurwitz EL, Khorsan R, Booth MS, et al. Manipulation and mobilization for treating chronic nonspecific neck pain: a systematic review and meta-analysis for an appropriateness panel. Pain Physician. 2019;22:E55–70.PubMedPubMedCentral Coulter ID, Crawford C, Vernon H, Hurwitz EL, Khorsan R, Booth MS, et al. Manipulation and mobilization for treating chronic nonspecific neck pain: a systematic review and meta-analysis for an appropriateness panel. Pain Physician. 2019;22:E55–70.PubMedPubMedCentral
18.
go back to reference Navani A, Manchikanti L, Albers SL, Latchaw RE, Sanapati J, Kaye AD, et al. Responsible, safe, and effective use of biologics in the management of low back pain: American Society of Interventional Pain Physicians (ASIPP) guidelines. Pain Physician. 2019;22:S1–74.PubMed Navani A, Manchikanti L, Albers SL, Latchaw RE, Sanapati J, Kaye AD, et al. Responsible, safe, and effective use of biologics in the management of low back pain: American Society of Interventional Pain Physicians (ASIPP) guidelines. Pain Physician. 2019;22:S1–74.PubMed
19.
go back to reference Zhiyong C, Yun T, Hui F, Zhongwei Y, Zhaorui L. Unilateral versus bilateral balloon kyphoplasty for osteoporotic vertebral compression fractures: a systematic review of overlapping meta-analyses. Pain Physician. 2019;22:15–28.PubMed Zhiyong C, Yun T, Hui F, Zhongwei Y, Zhaorui L. Unilateral versus bilateral balloon kyphoplasty for osteoporotic vertebral compression fractures: a systematic review of overlapping meta-analyses. Pain Physician. 2019;22:15–28.PubMed
20.
go back to reference Manchikanti L, Pampati V, Benyamin RM, Hirsch JA. Declining utilization of percutaneous epidural adhesiolysis in Medicare population: evidence-based or over-regulated? IPM Rep. 2018;2:9–18. Manchikanti L, Pampati V, Benyamin RM, Hirsch JA. Declining utilization of percutaneous epidural adhesiolysis in Medicare population: evidence-based or over-regulated? IPM Rep. 2018;2:9–18.
21.
go back to reference Chen X, Guo W, Li Q, Ou Z, Lao Z, Liu Y, et al. Is unilateral percutaneous kyphoplasty superior to bilateral percutaneous kyphoplasty for osteoporotic vertebral compression fractures? Evidence from a systematic review of discordant meta-analyses. Pain Physician. 2018;21:327–36.PubMed Chen X, Guo W, Li Q, Ou Z, Lao Z, Liu Y, et al. Is unilateral percutaneous kyphoplasty superior to bilateral percutaneous kyphoplasty for osteoporotic vertebral compression fractures? Evidence from a systematic review of discordant meta-analyses. Pain Physician. 2018;21:327–36.PubMed
22.
go back to reference Manchikanti L, Sanapati J, Pampati V, Kaye AD, Hirsch JA. Utilization of vertebral augmentation procedures in the United States: a comparative analysis in Medicare fee-for-service population pre- and post-2009 trials. Curr Pain Headache Rep. 2019;23:73.PubMed Manchikanti L, Sanapati J, Pampati V, Kaye AD, Hirsch JA. Utilization of vertebral augmentation procedures in the United States: a comparative analysis in Medicare fee-for-service population pre- and post-2009 trials. Curr Pain Headache Rep. 2019;23:73.PubMed
23.
go back to reference Xiang GH, Tong MJ, Lou C, Zhu SP, Guo WJ, Ke CR. The role of unilateral balloon kyphoplasty for the treatment of patients with OVCFS: a systematic review and meta-analysis. Pain Physician. 2018;21:209–18.PubMed Xiang GH, Tong MJ, Lou C, Zhu SP, Guo WJ, Ke CR. The role of unilateral balloon kyphoplasty for the treatment of patients with OVCFS: a systematic review and meta-analysis. Pain Physician. 2018;21:209–18.PubMed
24.
go back to reference Zadro JR, Shirley D, Ferreira M, Carvalho Silva AP, Lamb SE, Cooper C, et al. Is vitamin D supplementation effective for low back pain? A systematic review and meta-analysis. Pain Physician. 2018;21:121–45.PubMed Zadro JR, Shirley D, Ferreira M, Carvalho Silva AP, Lamb SE, Cooper C, et al. Is vitamin D supplementation effective for low back pain? A systematic review and meta-analysis. Pain Physician. 2018;21:121–45.PubMed
25.
go back to reference Sun H, Lu PP, Liu YJ, Yang X, Zhou PH, Shen XF, et al. Can unilateral kyphoplasty replace bilateral kyphoplasty in treatment of osteoporotic vertebral compression fractures? A systematic review and meta-analysis. Pain Physician. 2016;19:551–63.PubMed Sun H, Lu PP, Liu YJ, Yang X, Zhou PH, Shen XF, et al. Can unilateral kyphoplasty replace bilateral kyphoplasty in treatment of osteoporotic vertebral compression fractures? A systematic review and meta-analysis. Pain Physician. 2016;19:551–63.PubMed
26.
go back to reference Kortman K, Ortiz O, Miller T, Brook A, Tutton S, Mathis J, et al. Multicenter study to assess the efficacy and safety of sacroplasty in patients with osteoporotic sacral insufficiency fractures or pathologic sacral lesions. J Neurointerv Surg. 2013;5:461–6.PubMed Kortman K, Ortiz O, Miller T, Brook A, Tutton S, Mathis J, et al. Multicenter study to assess the efficacy and safety of sacroplasty in patients with osteoporotic sacral insufficiency fractures or pathologic sacral lesions. J Neurointerv Surg. 2013;5:461–6.PubMed
27.
go back to reference • Park JW, Park SM, Lee HJ, Lee CK, Chang BS, Kim H. Mortality following benign sacral insufficiency fracture and associated risk factors. Arch Osteoporos. 2017;12:100. An important manuscript describing mortality following benign sacral insufficiency fractures and associated risk factors. Appropriate management will reduce mortality, as well as morbidity. PubMed • Park JW, Park SM, Lee HJ, Lee CK, Chang BS, Kim H. Mortality following benign sacral insufficiency fracture and associated risk factors. Arch Osteoporos. 2017;12:100. An important manuscript describing mortality following benign sacral insufficiency fractures and associated risk factors. Appropriate management will reduce mortality, as well as morbidity. PubMed
28.
go back to reference • Frey ME, Warner C, Thomas SM, Johar K, Singh H, Mohammad MS, et al. Sacroplasty: a ten-year analysis of prospective patients treated with percutaneous sacroplasty: literature review and technical considerations. Pain Physician. 2017;20:E1063–72. This manuscript is one of the early manuscripts describing a 10 year analysis of percutaneous sacroplasty and includes a literature review. PubMed • Frey ME, Warner C, Thomas SM, Johar K, Singh H, Mohammad MS, et al. Sacroplasty: a ten-year analysis of prospective patients treated with percutaneous sacroplasty: literature review and technical considerations. Pain Physician. 2017;20:E1063–72. This manuscript is one of the early manuscripts describing a 10 year analysis of percutaneous sacroplasty and includes a literature review. PubMed
29.
go back to reference Lourie H. Spontaneous osteoporotic fracture of the sacrum. An unrecognized syndrome of the elderly. JAMA. 1982;248:715–7.PubMed Lourie H. Spontaneous osteoporotic fracture of the sacrum. An unrecognized syndrome of the elderly. JAMA. 1982;248:715–7.PubMed
30.
go back to reference Rawlings CE 3rd, Wilkins RH, Martinez S, Wilkinson RH Jr. Osteoporotic sacral fractures: a clinical study. Neurosurgery. 1988;22:72–6.PubMed Rawlings CE 3rd, Wilkins RH, Martinez S, Wilkinson RH Jr. Osteoporotic sacral fractures: a clinical study. Neurosurgery. 1988;22:72–6.PubMed
31.
go back to reference Sudhir G, LK K, Acharya S, Chahal R. Sacral insufficiency fractures mimicking lumbar spine pathology. Asian Spine J. 2016;10:558–64.PubMedPubMedCentral Sudhir G, LK K, Acharya S, Chahal R. Sacral insufficiency fractures mimicking lumbar spine pathology. Asian Spine J. 2016;10:558–64.PubMedPubMedCentral
32.
go back to reference Grasland A. Sacral insufficiency fractures. Arch Intern Med. 2011;156:668–74. Grasland A. Sacral insufficiency fractures. Arch Intern Med. 2011;156:668–74.
33.
go back to reference Tamaki Y, Nagamachi A, Inoue K, Takeuchi M, Sugiura K, Omichi Y, et al. Incidence and clinical features of sacral insufficiency fracture in the emergency department. Am J Emerg Med. 2017;35:1314–6.PubMed Tamaki Y, Nagamachi A, Inoue K, Takeuchi M, Sugiura K, Omichi Y, et al. Incidence and clinical features of sacral insufficiency fracture in the emergency department. Am J Emerg Med. 2017;35:1314–6.PubMed
34.
go back to reference Vleeming A, Schuenke MD, Masi AT, Carreiro JE, Danneels L, Willard FH. The sacroiliac joint: an overview of its anatomy, function and potential clinical implications. J Anat. 2012;221:537–67.PubMedPubMedCentral Vleeming A, Schuenke MD, Masi AT, Carreiro JE, Danneels L, Willard FH. The sacroiliac joint: an overview of its anatomy, function and potential clinical implications. J Anat. 2012;221:537–67.PubMedPubMedCentral
35.
go back to reference Poiliot AJ, Zwirner J, Doyle T, Hammer N. A systematic review of the normal sacroiliac joint anatomy and adjacent tissues for pain physicians. Pain Physician. 2019;22:E247–74. Poiliot AJ, Zwirner J, Doyle T, Hammer N. A systematic review of the normal sacroiliac joint anatomy and adjacent tissues for pain physicians. Pain Physician. 2019;22:E247–74.
36.
go back to reference Sakaguchi M, Maebayashi T, Aizawa T, Ishibashi N. Risk factors for sacral insufficiency fractures in cervical cancer after whole pelvic radiation therapy. Anticancer Res. 2019;39:361–7.PubMed Sakaguchi M, Maebayashi T, Aizawa T, Ishibashi N. Risk factors for sacral insufficiency fractures in cervical cancer after whole pelvic radiation therapy. Anticancer Res. 2019;39:361–7.PubMed
37.
go back to reference Zhang L, He Q, Jiang M, Zhang B, Zhong X, Zhang R. Diagnosis of insufficiency fracture after radiotherapy in patients with cervical cancer: contribution of technetium Tc 99m-labeled methylene diphosphonate single-photon emission computed tomography/computed tomography. Int J Gynecol Cancer. 2018;28:1369–76.PubMed Zhang L, He Q, Jiang M, Zhang B, Zhong X, Zhang R. Diagnosis of insufficiency fracture after radiotherapy in patients with cervical cancer: contribution of technetium Tc 99m-labeled methylene diphosphonate single-photon emission computed tomography/computed tomography. Int J Gynecol Cancer. 2018;28:1369–76.PubMed
38.
go back to reference Bostel T, Nicolay NH, Welzel T, Bruckner T, Mattke M, Akbaba S, et al. Sacral insufficiency fractures after high-dose carbon-ion based radiotherapy of sacral chordomas. Radiat Oncol. 2018;13:1–7. Bostel T, Nicolay NH, Welzel T, Bruckner T, Mattke M, Akbaba S, et al. Sacral insufficiency fractures after high-dose carbon-ion based radiotherapy of sacral chordomas. Radiat Oncol. 2018;13:1–7.
39.
go back to reference Kawamoto T, Ito K, Furuya T, Sasai K, Karasawa K. Sacral insufficiency fracture after stereotactic body radiation therapy for sacral metastasis. Clin Case Rep. 2018;6:2293–4.PubMedPubMedCentral Kawamoto T, Ito K, Furuya T, Sasai K, Karasawa K. Sacral insufficiency fracture after stereotactic body radiation therapy for sacral metastasis. Clin Case Rep. 2018;6:2293–4.PubMedPubMedCentral
40.
go back to reference Speziali A, Tei MM, Placella G, Chillemi M, Cerulli G. Postpartum sacral stress fracture: an atypical case report. Case Rep Orthop. 2015;2015:704393.PubMedPubMedCentral Speziali A, Tei MM, Placella G, Chillemi M, Cerulli G. Postpartum sacral stress fracture: an atypical case report. Case Rep Orthop. 2015;2015:704393.PubMedPubMedCentral
41.
go back to reference Hmida B, Boudokhane S, Migaou H, Kalai A, Jellad A, Salah ZB. Postpartum sacral stress fracture associated with mechanical sacroiliac joint disease: a case report. Medicine (Baltimore). 2018;97:e11735. Hmida B, Boudokhane S, Migaou H, Kalai A, Jellad A, Salah ZB. Postpartum sacral stress fracture associated with mechanical sacroiliac joint disease: a case report. Medicine (Baltimore). 2018;97:e11735.
42.
go back to reference Kinoshita H, Miyakoshi N, Kobayashi T, Abe T, Kikuchi K, Shimada Y. Comparison of patients with diagnosed and suspected sacral insufficiency fractures. J Orthop Sci. 2019;24:702–7.PubMed Kinoshita H, Miyakoshi N, Kobayashi T, Abe T, Kikuchi K, Shimada Y. Comparison of patients with diagnosed and suspected sacral insufficiency fractures. J Orthop Sci. 2019;24:702–7.PubMed
43.
go back to reference Yoo JI, Ha YC, Ryu HJ, Chang GW, Lee YK, Yoo MJ, et al. Teriparatide treatment in elderly patients with sacral insufficiency fracture. J Clin Endocrinol Metab. 2017;102:560–5.PubMed Yoo JI, Ha YC, Ryu HJ, Chang GW, Lee YK, Yoo MJ, et al. Teriparatide treatment in elderly patients with sacral insufficiency fracture. J Clin Endocrinol Metab. 2017;102:560–5.PubMed
44.
go back to reference Kim YY, Chung BM, Kim WT. Lumbar spine MRI versus non-lumbar imaging modalities in the diagnosis of sacral insufficiency fracture: a retrospective observational study. BMC Musculoskelet Disord. 2018;19:257.PubMedPubMedCentral Kim YY, Chung BM, Kim WT. Lumbar spine MRI versus non-lumbar imaging modalities in the diagnosis of sacral insufficiency fracture: a retrospective observational study. BMC Musculoskelet Disord. 2018;19:257.PubMedPubMedCentral
45.
go back to reference Expert Panel on Musculoskeletal Imaging, Bencardino JT, Stone TJ, Roberts CC, Appel M, Baccei SJ, et al. ACR appropriateness criteria® stress (fatigue/insufficiency) fracture, including sacrum, excluding other vertebrae. J Am Coll Radiol. 2017;14:S293–306. Expert Panel on Musculoskeletal Imaging, Bencardino JT, Stone TJ, Roberts CC, Appel M, Baccei SJ, et al. ACR appropriateness criteria® stress (fatigue/insufficiency) fracture, including sacrum, excluding other vertebrae. J Am Coll Radiol. 2017;14:S293–306.
46.
go back to reference Yang SC, Tsai TT, Chen HS, Fang CJ, Kao YH, Tu YK. Comparison of sacroplasty with or without balloon assistance for the treatment of sacral insufficiency fractures. J Orthop Surg (Hong Kong). 2018;26:230949901878257. Yang SC, Tsai TT, Chen HS, Fang CJ, Kao YH, Tu YK. Comparison of sacroplasty with or without balloon assistance for the treatment of sacral insufficiency fractures. J Orthop Surg (Hong Kong). 2018;26:230949901878257.
47.
go back to reference Parry SM, Puthucheary ZA. The impact of extended bed rest on the musculoskeletal system in the critical care environment. Extreme Physiol Med. 2015;4:16. Parry SM, Puthucheary ZA. The impact of extended bed rest on the musculoskeletal system in the critical care environment. Extreme Physiol Med. 2015;4:16.
48.
go back to reference Lin JT, Lane JM. Sacral stress fractures. J Women’s Health. 2003;12:879–88. Lin JT, Lane JM. Sacral stress fractures. J Women’s Health. 2003;12:879–88.
49.
go back to reference • Su B, O’Connor JP. NSAID therapy effects on healing of bone, tendon, and the enthesis. J Appl Physiol. 2013;115:892–9. This study demonstrates no benefit of augmentation of sacroiliac screws with sacroplasty. PubMedPubMedCentral • Su B, O’Connor JP. NSAID therapy effects on healing of bone, tendon, and the enthesis. J Appl Physiol. 2013;115:892–9. This study demonstrates no benefit of augmentation of sacroiliac screws with sacroplasty. PubMedPubMedCentral
50.
go back to reference García-Martínez O, De Luna-Bertos E, Ramos-Torrecillas J, Manzano-Moreno FJ, Ruiz C. Repercussions of NSAIDS drugs on bone tissue: the osteoblast. Life Sci. 2015;123:72–7.PubMed García-Martínez O, De Luna-Bertos E, Ramos-Torrecillas J, Manzano-Moreno FJ, Ruiz C. Repercussions of NSAIDS drugs on bone tissue: the osteoblast. Life Sci. 2015;123:72–7.PubMed
51.
go back to reference Tang BM, Eslick GD, Nowson C, Smith C, Bensoussan A. Use of calcium or calcium in combination with vitamin D supplementation to prevent fractures and bone loss in people aged 50 years and older: a meta-analysis. Lancet. 2007;370:657–66.PubMed Tang BM, Eslick GD, Nowson C, Smith C, Bensoussan A. Use of calcium or calcium in combination with vitamin D supplementation to prevent fractures and bone loss in people aged 50 years and older: a meta-analysis. Lancet. 2007;370:657–66.PubMed
52.
go back to reference • Ma S, Goh EL, Jin A, Bhattacharya R, Boughton OR, Patel B, et al. Long-term effects of bisphosphonate therapy: perforations, microcracks and mechanical properties. Sci Rep. 2017;7:43399. A long-term follow up of patients treated with sacroplasty. PubMedPubMedCentral • Ma S, Goh EL, Jin A, Bhattacharya R, Boughton OR, Patel B, et al. Long-term effects of bisphosphonate therapy: perforations, microcracks and mechanical properties. Sci Rep. 2017;7:43399. A long-term follow up of patients treated with sacroplasty. PubMedPubMedCentral
53.
go back to reference Adler RA, El-Hajj Fuleihan G, Bauer DC, Camacho PM, Clarke BL, Clines GA, et al. Managing osteoporosis in patients on long-term bisphosphonate treatment: report of a task force of the American Society for Bone and Mineral Research. J Bone Miner Res. 2016;31:16–35.PubMedPubMedCentral Adler RA, El-Hajj Fuleihan G, Bauer DC, Camacho PM, Clarke BL, Clines GA, et al. Managing osteoporosis in patients on long-term bisphosphonate treatment: report of a task force of the American Society for Bone and Mineral Research. J Bone Miner Res. 2016;31:16–35.PubMedPubMedCentral
54.
go back to reference Aspenberg P, Genant HK, Johansson T, Nino AJ, See K, Krohn K, et al. Teriparatide for acceleration of fracture repair in humans: a prospective, randomized, double-blind study of 102 postmenopausal women with distal radial fractures. J Bone Miner Res. 2010;25:404–14.PubMed Aspenberg P, Genant HK, Johansson T, Nino AJ, See K, Krohn K, et al. Teriparatide for acceleration of fracture repair in humans: a prospective, randomized, double-blind study of 102 postmenopausal women with distal radial fractures. J Bone Miner Res. 2010;25:404–14.PubMed
55.
go back to reference Alkhiary Y, Gerstenfeld L, Krall E, Westmore M, Sato M, Mitlak BH, et al. Enhancement of experimental fracture-healing by systemic administration of recombinant human parathyroid hormone (PTH 1-34). J Bone Joint Surg Am. 2005;87:731–41.PubMed Alkhiary Y, Gerstenfeld L, Krall E, Westmore M, Sato M, Mitlak BH, et al. Enhancement of experimental fracture-healing by systemic administration of recombinant human parathyroid hormone (PTH 1-34). J Bone Joint Surg Am. 2005;87:731–41.PubMed
56.
go back to reference Carvalho N, Voss L, Almeida MO, Salgado CL, Bandeira F. Atypical femoral fractures during prolonged use of bisphosphonates: short-term responses to strontium ranelate and teriparatide. J Clin Endocrinol Metab. 2011;96:2675–80.PubMed Carvalho N, Voss L, Almeida MO, Salgado CL, Bandeira F. Atypical femoral fractures during prolonged use of bisphosphonates: short-term responses to strontium ranelate and teriparatide. J Clin Endocrinol Metab. 2011;96:2675–80.PubMed
57.
go back to reference Zhang D, Potty A, Vyas P, Lane J. The role of recombinant PTH in human fracture healing: a systematic review. J Orthop Trauma. 2014;28:57–62.PubMed Zhang D, Potty A, Vyas P, Lane J. The role of recombinant PTH in human fracture healing: a systematic review. J Orthop Trauma. 2014;28:57–62.PubMed
58.
go back to reference Baillieul S, Guinot M, Dubois C, Prunier A, Mahler F, Gaudin P. Set the pace of bone healing–treatment of a bilateral sacral stress fracture using teriparatide in a long-distance runner. Joint Bone Spine. 2017;84:499–500.PubMed Baillieul S, Guinot M, Dubois C, Prunier A, Mahler F, Gaudin P. Set the pace of bone healing–treatment of a bilateral sacral stress fracture using teriparatide in a long-distance runner. Joint Bone Spine. 2017;84:499–500.PubMed
59.
go back to reference Tsai JN, Uihlein AV, Burnett-Bowie SM, Neer RM, Derrico NP, Lee H, et al. Effects of two years of teriparatide, denosumab, or both on bone microarchitecture and strength (DATA-HRpQCT study). J Clin Endocrinol Metab. 2016;101:2023–30.PubMedPubMedCentral Tsai JN, Uihlein AV, Burnett-Bowie SM, Neer RM, Derrico NP, Lee H, et al. Effects of two years of teriparatide, denosumab, or both on bone microarchitecture and strength (DATA-HRpQCT study). J Clin Endocrinol Metab. 2016;101:2023–30.PubMedPubMedCentral
60.
go back to reference Choi KC, Shin SH, Lee DC, Shim HK, Park CK. Effects of percutaneous sacroplasty on pain and mobility in sacral insufficiency fracture. J Korean Neurosurg Soc. 2017;60:60–6.PubMed Choi KC, Shin SH, Lee DC, Shim HK, Park CK. Effects of percutaneous sacroplasty on pain and mobility in sacral insufficiency fracture. J Korean Neurosurg Soc. 2017;60:60–6.PubMed
61.
go back to reference Onen MR, Yuvruk E, Naderi S. Reliability and effectiveness of percutaneous sacroplasty in sacral insufficiency fractures. J Clin Neurosci. 2015;22:1601–8.PubMed Onen MR, Yuvruk E, Naderi S. Reliability and effectiveness of percutaneous sacroplasty in sacral insufficiency fractures. J Clin Neurosci. 2015;22:1601–8.PubMed
62.
go back to reference Andresen R, Radmer S, Wollny M, Andresen JR, Nissen U, Schober HC. CT-guided cement sacroplasty (CSP) as pain therapy in non-dislocated insufficiency fractures. Eur J Orthop Surg Traumatol. 2017;27:1045–50.PubMedPubMedCentral Andresen R, Radmer S, Wollny M, Andresen JR, Nissen U, Schober HC. CT-guided cement sacroplasty (CSP) as pain therapy in non-dislocated insufficiency fractures. Eur J Orthop Surg Traumatol. 2017;27:1045–50.PubMedPubMedCentral
63.
go back to reference Andresen R, Radmer S, Andresen JR, Schober HC. Comparison of the 18-month outcome after the treatment of osteoporotic insufficiency fractures by means of balloon sacroplasty (BSP) and radiofrequency sacroplasty (RFS) in comparison: a prospective randomised study. Eur Spine J. 2017;26:3235–40.PubMed Andresen R, Radmer S, Andresen JR, Schober HC. Comparison of the 18-month outcome after the treatment of osteoporotic insufficiency fractures by means of balloon sacroplasty (BSP) and radiofrequency sacroplasty (RFS) in comparison: a prospective randomised study. Eur Spine J. 2017;26:3235–40.PubMed
64.
go back to reference Sanders D, Fox J, Starr A, Sathy A, Chao J. Transsacral-transiliac screw stabilization. J Orthop Trauma. 2016;30:469–73.PubMed Sanders D, Fox J, Starr A, Sathy A, Chao J. Transsacral-transiliac screw stabilization. J Orthop Trauma. 2016;30:469–73.PubMed
65.
go back to reference Walker JB, Mitchell SM, Karr SD, Lowe JA, Jones CB. Percutaneous transiliac–transsacral screw fixation of sacral fragility fractures improves pain, ambulation, and rate of disposition to home. J Orthop Trauma. 2018;32:452–6.PubMed Walker JB, Mitchell SM, Karr SD, Lowe JA, Jones CB. Percutaneous transiliac–transsacral screw fixation of sacral fragility fractures improves pain, ambulation, and rate of disposition to home. J Orthop Trauma. 2018;32:452–6.PubMed
66.
go back to reference Mehling I, Hessmann MH, Rommens PM. Stabilization of fatigue fractures of the dorsal pelvis with a trans-sacral bar. Operative technique and outcome. Injury. 2012;43:446–51.PubMed Mehling I, Hessmann MH, Rommens PM. Stabilization of fatigue fractures of the dorsal pelvis with a trans-sacral bar. Operative technique and outcome. Injury. 2012;43:446–51.PubMed
67.
go back to reference Oberkircher L, Masaeli A, Bliemel C, Debus F, Ruchholtz S, Krüger A. Primary stability of three different iliosacral screw fixation techniques in osteoporotic cadaver specimens—a biomechanical investigation. Spine J. 2016;16:226–32.PubMed Oberkircher L, Masaeli A, Bliemel C, Debus F, Ruchholtz S, Krüger A. Primary stability of three different iliosacral screw fixation techniques in osteoporotic cadaver specimens—a biomechanical investigation. Spine J. 2016;16:226–32.PubMed
68.
go back to reference Maki S, Nakamura K, Yamauchi T, Suzuki T, Horii M, Kawamura K, et al. Lumbopelvic fixation for sacral insufficiency fracture presenting with sphincter dysfunction. Case Rep Orthop. 2019;2019:1–4. Maki S, Nakamura K, Yamauchi T, Suzuki T, Horii M, Kawamura K, et al. Lumbopelvic fixation for sacral insufficiency fracture presenting with sphincter dysfunction. Case Rep Orthop. 2019;2019:1–4.
69.
go back to reference Collinge CA, Crist BD. Combined percutaneous iliosacral screw fixation with sacroplasty using resorbable calcium phosphate cement for osteoporotic pelvic fractures requiring surgery. J Orthop Trauma. 2016;30:e217–22.PubMed Collinge CA, Crist BD. Combined percutaneous iliosacral screw fixation with sacroplasty using resorbable calcium phosphate cement for osteoporotic pelvic fractures requiring surgery. J Orthop Trauma. 2016;30:e217–22.PubMed
70.
go back to reference Dmytriw AA, Talla K, Smith R. Percutaneous sacroplasty for the management of painful pathologic fracture in a multiple myeloma patient: case report and review of the literature. Neuroradiol J. 2017;30:80–3.PubMed Dmytriw AA, Talla K, Smith R. Percutaneous sacroplasty for the management of painful pathologic fracture in a multiple myeloma patient: case report and review of the literature. Neuroradiol J. 2017;30:80–3.PubMed
71.
go back to reference Yoong J, Chandra RV, William L, Franco M, Goldschlager T, Runacres F, et al. Percutaneous sacroplasty for painful bone metastases: a case report. Pain Pract. 2017;17:945–51.PubMed Yoong J, Chandra RV, William L, Franco M, Goldschlager T, Runacres F, et al. Percutaneous sacroplasty for painful bone metastases: a case report. Pain Pract. 2017;17:945–51.PubMed
72.
go back to reference Moussazadeh N, Laufer I, Werner T, Krol G, Boland P, Bilsky MH, et al. Sacroplasty for cancer-associated insufficiency fractures. Neurosurgery. 2015;76:446–50.PubMed Moussazadeh N, Laufer I, Werner T, Krol G, Boland P, Bilsky MH, et al. Sacroplasty for cancer-associated insufficiency fractures. Neurosurgery. 2015;76:446–50.PubMed
73.
go back to reference Hutson N, Hung JC, Puttanniah V, Lis E, Laufer I, Gulati A. Interventional pain management for sacroiliac tumors in the oncologic population: a case series and paradigm approach. Pain Med. 2017;18:959–68.PubMed Hutson N, Hung JC, Puttanniah V, Lis E, Laufer I, Gulati A. Interventional pain management for sacroiliac tumors in the oncologic population: a case series and paradigm approach. Pain Med. 2017;18:959–68.PubMed
74.
go back to reference Andresen R, Radmer S, Lüdtke C, Kamusella P, Wissgott C, Schober H. Balloon sacroplasty as a palliative pain treatment in patients with metastasis-induced bone destruction and pathological fractures. RoFo. 2014;186:881–6.PubMed Andresen R, Radmer S, Lüdtke C, Kamusella P, Wissgott C, Schober H. Balloon sacroplasty as a palliative pain treatment in patients with metastasis-induced bone destruction and pathological fractures. RoFo. 2014;186:881–6.PubMed
75.
go back to reference Gupta AC, Chandra RV, Yoo AJ, Leslie-Mazwi TM, Bell DL, Mehta BP, et al. Safety and effectiveness of sacroplasty: a large single-center experience. AJNR Am J Neuroradiol. 2014;35:2202–6.PubMed Gupta AC, Chandra RV, Yoo AJ, Leslie-Mazwi TM, Bell DL, Mehta BP, et al. Safety and effectiveness of sacroplasty: a large single-center experience. AJNR Am J Neuroradiol. 2014;35:2202–6.PubMed
76.
go back to reference Pereira LP, Clarençon F, Cormier É, Rose M, Jean B, Le Jean L, et al. Safety and effectiveness of percutaneous sacroplasty: a single-Centre experience in 58 consecutive patients with tumours or osteoporotic insufficient fractures treated under fluoroscopic guidance. Eur Radiol. 2013;23:2764–72.PubMed Pereira LP, Clarençon F, Cormier É, Rose M, Jean B, Le Jean L, et al. Safety and effectiveness of percutaneous sacroplasty: a single-Centre experience in 58 consecutive patients with tumours or osteoporotic insufficient fractures treated under fluoroscopic guidance. Eur Radiol. 2013;23:2764–72.PubMed
77.
go back to reference Soo Park H, Cho S, Yeon Kim D, Hyo Kim C, Kyung Chung R, Youn Jin Kim A. Percutaneous sacroplasty under fluoroscopic guidance combined with epidurogram for sacral insufficiency fracture resulting from metastatic tumor and osteoporosis. Pain Physician. 2016;19:473–80. Soo Park H, Cho S, Yeon Kim D, Hyo Kim C, Kyung Chung R, Youn Jin Kim A. Percutaneous sacroplasty under fluoroscopic guidance combined with epidurogram for sacral insufficiency fracture resulting from metastatic tumor and osteoporosis. Pain Physician. 2016;19:473–80.
78.
go back to reference Worts PR, Chandler GS III. Office-based kyphoplasty: a viable option using local anesthesia with oral sedation. Pain Physician. 2019;22:177–85.PubMed Worts PR, Chandler GS III. Office-based kyphoplasty: a viable option using local anesthesia with oral sedation. Pain Physician. 2019;22:177–85.PubMed
Metadata
Title
Sacral Insufficiency Fractures: a Review of Risk Factors, Clinical Presentation, and Management
Authors
Ivan Urits
Vwaire Orhurhu
Jessica Callan
Nishita V. Maganty
Sara Pousti
Thomas Simopoulos
Cyrus Yazdi
Rachel J. Kaye
Lauren K. Eng
Alan D. Kaye
Laxmaiah Manchikanti
Omar Viswanath
Publication date
01-03-2020
Publisher
Springer US
Published in
Current Pain and Headache Reports / Issue 3/2020
Print ISSN: 1531-3433
Electronic ISSN: 1534-3081
DOI
https://doi.org/10.1007/s11916-020-0848-z

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