Skip to main content
Top
Published in: Current Pain and Headache Reports 2/2017

01-02-2017 | Other Pain (N Vadivelu and A Kaye, Section Editors)

Atypical Facial Pain: a Comprehensive, Evidence-Based Review

Authors: Austin L. Weiss, Ken P. Ehrhardt, Reda Tolba

Published in: Current Pain and Headache Reports | Issue 2/2017

Login to get access

Abstract

Purpose of Review

The purpose of this article is to focus on an excruciating disorder of the face, named atypical facial pain or persistent idiopathic facial pain (PIFP). It is considered an underdiagnosed condition with limited treatment options. Facial pain can be a debilitating disorder that affects patients’ quality of life. Up to 26% of the general population has suffered from facial pain at some point in their lives. It is important to highlight the different types of facial pain to be able to properly manage this condition accordingly.

Recent Findings

Newer interventional modalities such as pulsed radiofrequency ablation (PFR) of the sphenopalatine ganglion, peripheral nerve field stimulators (PNFS), and botulinum toxin injections have promising results. In summary, more prospective studies such as randomized controlled trials are necessary to explore the possibility of their more widespread use as viable procedures for the treatment of PIFP.

Summary

In this review article, we describe the workup and diagnosis of PIFP and highlight recent literature regarding the pathophysiology and treatment of PIFP. PIFP is an excruciating disorder of the face often misdiagnosed as trigeminal neuralgia (TN) However, unlike TN symptoms, the pain is persistent rather than intermittent, usually unilateral, and without autonomic signs or symptoms. When a clinician encounters a patient with neuropathic facial pain whose symptoms are incongruent with the more common etiologies, the diagnosis of atypical facial pain must be entertained. Treatment of PIFP is multidisciplinary. Unfortunately, few randomized controlled trials for the treatment of PIFP exist. However, there are a select number of pharmacological, non-pharmacological, and interventional treatment options that have proven to be moderately effective.
Literature
1.
go back to reference Macfarlane TV, Blinkhorn AS, Davies RM, et al. Oro-facial pain in the community: prevalence and associated impact. Community Dent Oral Epidemiol. 2002;30(1):52–60.CrossRefPubMed Macfarlane TV, Blinkhorn AS, Davies RM, et al. Oro-facial pain in the community: prevalence and associated impact. Community Dent Oral Epidemiol. 2002;30(1):52–60.CrossRefPubMed
2.
go back to reference Obermann M, Holle D, Katsarava Z. Trigeminal neuralgia and persistent idiopathic facial pain. Expert review of neurotherapeutics. 2011;11(11):1619–29.CrossRefPubMed Obermann M, Holle D, Katsarava Z. Trigeminal neuralgia and persistent idiopathic facial pain. Expert review of neurotherapeutics. 2011;11(11):1619–29.CrossRefPubMed
3.
go back to reference Mueller D, Obermann M, Yoon MS, et al. Prevalence of trigeminal neuralgia and persistent idiopathic facial pain: a population-based study. Cephalalgia. 2011;31(15):1542–8.CrossRefPubMed Mueller D, Obermann M, Yoon MS, et al. Prevalence of trigeminal neuralgia and persistent idiopathic facial pain: a population-based study. Cephalalgia. 2011;31(15):1542–8.CrossRefPubMed
4.
go back to reference Headache Classification Committee of the International Headache Society (IHS). The International Classification of Headache Disorders, 3rd edition (beta version). Cephalalgia. 2013;33(9):629–808.CrossRef Headache Classification Committee of the International Headache Society (IHS). The International Classification of Headache Disorders, 3rd edition (beta version). Cephalalgia. 2013;33(9):629–808.CrossRef
5.
go back to reference Zakrzewska JM. Differential diagnosis of facial pain and guidelines for management. Br J Anaesth. 2013;111(1):95–104.CrossRefPubMed Zakrzewska JM. Differential diagnosis of facial pain and guidelines for management. Br J Anaesth. 2013;111(1):95–104.CrossRefPubMed
6.
go back to reference Vadivelu N, Vadivelu A, Kaye AD. Orofacial pain: a clinician’s guide. Switzerland: Springer; 2014.CrossRef Vadivelu N, Vadivelu A, Kaye AD. Orofacial pain: a clinician’s guide. Switzerland: Springer; 2014.CrossRef
7.
go back to reference Slade GD. Epidemiology of dental pain and dental caries among children and adolescents. Community Dent Health. 2001;18(4):219–27.PubMed Slade GD. Epidemiology of dental pain and dental caries among children and adolescents. Community Dent Health. 2001;18(4):219–27.PubMed
8.
go back to reference Brennan DS, Spencer AJ, Roberts-Thomson KF. Quality of life and disability weights associated with periodontal disease. J Dent Res. 2007;86(8):713–7.CrossRefPubMed Brennan DS, Spencer AJ, Roberts-Thomson KF. Quality of life and disability weights associated with periodontal disease. J Dent Res. 2007;86(8):713–7.CrossRefPubMed
9.
go back to reference Manzoni GC, Torelli P. Epidemiology of typical and atypical craniofacial neuralgias. Neurol Sci. 2005;26 Suppl 2:s65–7.CrossRefPubMed Manzoni GC, Torelli P. Epidemiology of typical and atypical craniofacial neuralgias. Neurol Sci. 2005;26 Suppl 2:s65–7.CrossRefPubMed
10.
go back to reference Suzuki N, Mashu S, Toyoda M, et al. Oral burning sensation: prevalence and gender differences in a Japanese population. Pain Pract. 2010;10(4):306–11.CrossRefPubMed Suzuki N, Mashu S, Toyoda M, et al. Oral burning sensation: prevalence and gender differences in a Japanese population. Pain Pract. 2010;10(4):306–11.CrossRefPubMed
11.
go back to reference Bergdahl M, Bergdahl J. Burning mouth syndrome: prevalence and associated factors. J Oral Pathol Med. 1999;28(8):350–4.CrossRefPubMed Bergdahl M, Bergdahl J. Burning mouth syndrome: prevalence and associated factors. J Oral Pathol Med. 1999;28(8):350–4.CrossRefPubMed
12.
go back to reference Penna PP, Recupero M, Gil C. Influence of psychopathologies on craniomandibular disorders. Braz Dent J. 2009;20(3):226–30.CrossRefPubMed Penna PP, Recupero M, Gil C. Influence of psychopathologies on craniomandibular disorders. Braz Dent J. 2009;20(3):226–30.CrossRefPubMed
13.
go back to reference Abetz LM, Savage NW. Burning mouth syndrome and psychological disorders. Aust Dent J. 2009;54(2):84–93. quiz 173.CrossRefPubMed Abetz LM, Savage NW. Burning mouth syndrome and psychological disorders. Aust Dent J. 2009;54(2):84–93. quiz 173.CrossRefPubMed
14.
go back to reference Aggarwal VR, Macfarlane GJ, Farragher TM, et al. Risk factors for onset of chronic oro-facial pain-results of the North Cheshire oro-facial pain prospective population study. Pain. 2010;149(2):354–9.CrossRefPubMedPubMedCentral Aggarwal VR, Macfarlane GJ, Farragher TM, et al. Risk factors for onset of chronic oro-facial pain-results of the North Cheshire oro-facial pain prospective population study. Pain. 2010;149(2):354–9.CrossRefPubMedPubMedCentral
15.
go back to reference Mohan H, Tahlan A, Mundi I, et al. Non-neoplastic salivary gland lesions: a 15-year study. Eur Arch Otorhinolaryngol. 2010;268(8):1187–90.CrossRefPubMed Mohan H, Tahlan A, Mundi I, et al. Non-neoplastic salivary gland lesions: a 15-year study. Eur Arch Otorhinolaryngol. 2010;268(8):1187–90.CrossRefPubMed
16.
17.
go back to reference Melis M, Lobo SL, Ceneviz C, et al. Atyical odontalgia: a review of the literature. Headache. 2003;43(10):1060–74.CrossRefPubMed Melis M, Lobo SL, Ceneviz C, et al. Atyical odontalgia: a review of the literature. Headache. 2003;43(10):1060–74.CrossRefPubMed
18.
go back to reference Forssell H, Jaaskelainen S, List T, Svensson P, Baad-Hansen L. An update on pathophysiological mechanisms related to idiopathic oro-facial pain conditions with implications for management. J Oral Rehabil. 2015;42(4):300–22.CrossRefPubMed Forssell H, Jaaskelainen S, List T, Svensson P, Baad-Hansen L. An update on pathophysiological mechanisms related to idiopathic oro-facial pain conditions with implications for management. J Oral Rehabil. 2015;42(4):300–22.CrossRefPubMed
19.
go back to reference Jääskeläinen SK, Forssell H, Tenovuo O. Electrophysiological testing of the trigeminofacial system: aid in the diagnosis of atypical facial pain. Pain. 1999;80(1):191–200.CrossRefPubMed Jääskeläinen SK, Forssell H, Tenovuo O. Electrophysiological testing of the trigeminofacial system: aid in the diagnosis of atypical facial pain. Pain. 1999;80(1):191–200.CrossRefPubMed
20.
go back to reference Lang E, Kaltenhäuser M, Seidler S, Mattenklodt P, Neundörfer B. Persistent idiopathic facial pain exists independent of somatosensory input from the painful region: findings from quantitative sensory functions and somatotopy of the primary somatosensory cortex. Pain. 2005;118(1):80–91.CrossRefPubMed Lang E, Kaltenhäuser M, Seidler S, Mattenklodt P, Neundörfer B. Persistent idiopathic facial pain exists independent of somatosensory input from the painful region: findings from quantitative sensory functions and somatotopy of the primary somatosensory cortex. Pain. 2005;118(1):80–91.CrossRefPubMed
21.
go back to reference Jääskeläinen SK, Rinne JO, Forssell H, et al. Role of the dopaminergic system in chronic pain—a fluorodopa-PET study. Pain. 2001;90(3):257–60.CrossRefPubMed Jääskeläinen SK, Rinne JO, Forssell H, et al. Role of the dopaminergic system in chronic pain—a fluorodopa-PET study. Pain. 2001;90(3):257–60.CrossRefPubMed
22.
go back to reference Hagelberg N, Forssell H, Aalto S, et al. Altered dopamine D2 receptor binding in atypical facial pain. Pain. 2003;106(1):43–8.CrossRefPubMed Hagelberg N, Forssell H, Aalto S, et al. Altered dopamine D2 receptor binding in atypical facial pain. Pain. 2003;106(1):43–8.CrossRefPubMed
23.
go back to reference Hagelberg N, Forssell H, Rinne JO, et al. Striatal dopamine D1 and D2 receptors in burning mouth syndrome. Pain. 2003;101(1):149–54.CrossRefPubMed Hagelberg N, Forssell H, Rinne JO, et al. Striatal dopamine D1 and D2 receptors in burning mouth syndrome. Pain. 2003;101(1):149–54.CrossRefPubMed
24.
go back to reference Wood PB. Role of central dopamine in pain and analgesia. Expert review of neurotherapeutics. 2008;8(5):781–97.CrossRefPubMed Wood PB. Role of central dopamine in pain and analgesia. Expert review of neurotherapeutics. 2008;8(5):781–97.CrossRefPubMed
25.
go back to reference Taiminen T, Kuusalo L, Lehtinen L, et al. Psychiatric (axis I) and personality (axis II) disorders in patients with burning mouth syndrome or atypical facial pain. Scandinavian Journal of Pain. 2011;2(4):155–60.CrossRef Taiminen T, Kuusalo L, Lehtinen L, et al. Psychiatric (axis I) and personality (axis II) disorders in patients with burning mouth syndrome or atypical facial pain. Scandinavian Journal of Pain. 2011;2(4):155–60.CrossRef
26.
go back to reference Zakrzewska JM, Hamlyn PJ. Facial pain. In: Crombie IK, editor. Epidemiology of pain. Seattle: IASP Press; 1999. p. 171–202. Zakrzewska JM, Hamlyn PJ. Facial pain. In: Crombie IK, editor. Epidemiology of pain. Seattle: IASP Press; 1999. p. 171–202.
27.
go back to reference Cornelissen P, van Kleef M, Mekhail N, Day M, van Zundert J. Evidence-based interventional pain medicine according to clinical diagnoses. 3. Persistent idiopathic facial pain. Pain Pract. 2009;9(6):443–8.CrossRefPubMed Cornelissen P, van Kleef M, Mekhail N, Day M, van Zundert J. Evidence-based interventional pain medicine according to clinical diagnoses. 3. Persistent idiopathic facial pain. Pain Pract. 2009;9(6):443–8.CrossRefPubMed
28.
go back to reference Forssell H, Tasmuth T, Tenovuo O, Hampf G, Kalso E. Venlafaxine in the treatment of atypical facial pain: a randomized controlled trial. J Orofac Pain. 2004;18(2):131–7.PubMed Forssell H, Tasmuth T, Tenovuo O, Hampf G, Kalso E. Venlafaxine in the treatment of atypical facial pain: a randomized controlled trial. J Orofac Pain. 2004;18(2):131–7.PubMed
31.
go back to reference Harrison S, Glover L, Maslin L, Feinmann C, Pearce S, Harris M. A comparison of antidepressant medication alone and in conjunction with cognitive behavioural therapy for chronic idiopathic facial pain. In: Jensen G, Turner JA, Weisenfeld-Hallin Z, editors. Proceedings of the 8th World Congress on Pain: progress in pain research and management, vol. 8. Seattle: IASP Press; 1997. p. 663–72. Harrison S, Glover L, Maslin L, Feinmann C, Pearce S, Harris M. A comparison of antidepressant medication alone and in conjunction with cognitive behavioural therapy for chronic idiopathic facial pain. In: Jensen G, Turner JA, Weisenfeld-Hallin Z, editors. Proceedings of the 8th World Congress on Pain: progress in pain research and management, vol. 8. Seattle: IASP Press; 1997. p. 663–72.
32.
go back to reference Abrahamsen R, Baad-Hansen L, Svensson P. Hypnosis in the management of persistent idiopathic orofacial pain—clinical and psychosocial findings. Pain. 2008;136(1–2):44–52.CrossRefPubMed Abrahamsen R, Baad-Hansen L, Svensson P. Hypnosis in the management of persistent idiopathic orofacial pain—clinical and psychosocial findings. Pain. 2008;136(1–2):44–52.CrossRefPubMed
33.
go back to reference • Zakrzewska JM. Chronic/persistent idiopathic facial pain. Neurosurg Clin N Am. 2016;27(3):345–51. Stress coping strategies and treatment of underlying psychological disorders is a key factor for multimodal management of patients with PIFP.CrossRefPubMed • Zakrzewska JM. Chronic/persistent idiopathic facial pain. Neurosurg Clin N Am. 2016;27(3):345–51. Stress coping strategies and treatment of underlying psychological disorders is a key factor for multimodal management of patients with PIFP.CrossRefPubMed
34.
go back to reference • McDonough P, McKenna JP, McCreary C, Downer EJ. Neuropathic orofacial pain: cannabinoids as a therapeutic avenue. Int J Biochem Cell Biol. 2014;55:72–8. Cannabinoids treatment has been a hot topic of interest for treatment of chronic painful conditions, including PIFP.CrossRefPubMed • McDonough P, McKenna JP, McCreary C, Downer EJ. Neuropathic orofacial pain: cannabinoids as a therapeutic avenue. Int J Biochem Cell Biol. 2014;55:72–8. Cannabinoids treatment has been a hot topic of interest for treatment of chronic painful conditions, including PIFP.CrossRefPubMed
35.
go back to reference Dalton VS, Zavitsanou K. Differential treatment regimen-related effects of cannabinoids on D1 and D2 receptors in adolescent and adult rat brain. J Chem Neuroanat. 2010;40(4):272–80.CrossRefPubMed Dalton VS, Zavitsanou K. Differential treatment regimen-related effects of cannabinoids on D1 and D2 receptors in adolescent and adult rat brain. J Chem Neuroanat. 2010;40(4):272–80.CrossRefPubMed
36.
go back to reference Bayer E, Racz GB, Miles D, Heavner J. Sphenopalatine ganglion pulsed radiofrequency treatment in 30 patients suffering from chronic face and head pain. Pain Practice. 2005;5(3):223–7.CrossRefPubMed Bayer E, Racz GB, Miles D, Heavner J. Sphenopalatine ganglion pulsed radiofrequency treatment in 30 patients suffering from chronic face and head pain. Pain Practice. 2005;5(3):223–7.CrossRefPubMed
37.
go back to reference Narouze SN. Interventional management of head and face pain: nerve blocks and beyond. New York: Springer; 2014.CrossRef Narouze SN. Interventional management of head and face pain: nerve blocks and beyond. New York: Springer; 2014.CrossRef
38.
go back to reference •• Akbas M, Gunduz E, Sanli S, Yegin A. Sphenopalatine ganglion pulsed radiofrequency treatment in patients suffering from chronic face and head pain. Braz J Anesthesiol. 2016;66(1):50–4. Novel techniques such as pulsed radiofrequency ablation of the sphenopalatine ganglion have been studied and used for treatment of PIFP as well as other forms of facial pain.CrossRefPubMed •• Akbas M, Gunduz E, Sanli S, Yegin A. Sphenopalatine ganglion pulsed radiofrequency treatment in patients suffering from chronic face and head pain. Braz J Anesthesiol. 2016;66(1):50–4. Novel techniques such as pulsed radiofrequency ablation of the sphenopalatine ganglion have been studied and used for treatment of PIFP as well as other forms of facial pain.CrossRefPubMed
39.
go back to reference •• Klein J, Sandi-Gahun S, Schackert G, Juratli TA. Peripheral nerve field stimulation for trigeminal neuralgia, trigeminal neuropathic pain, and persistent idiopathic facial pain. Cephalalgia. 2016;36(5):445–53. Emerging technologies in the field of neuromodulation such as peripheral nerve stimulation are promising options for patients suffering from IPFP.CrossRefPubMed •• Klein J, Sandi-Gahun S, Schackert G, Juratli TA. Peripheral nerve field stimulation for trigeminal neuralgia, trigeminal neuropathic pain, and persistent idiopathic facial pain. Cephalalgia. 2016;36(5):445–53. Emerging technologies in the field of neuromodulation such as peripheral nerve stimulation are promising options for patients suffering from IPFP.CrossRefPubMed
40.
go back to reference •• Cuadrado ML, Garcia-Moreno H, Arias JA, Pareja JA. Botulinum neurotoxin type-A for the treatment of atypical odontalgia. Pain Med. 2016. Injection of neurotoxins such as botulinum toxins could be a promising treatment option for patients suffering from facial pain. •• Cuadrado ML, Garcia-Moreno H, Arias JA, Pareja JA. Botulinum neurotoxin type-A for the treatment of atypical odontalgia. Pain Med. 2016. Injection of neurotoxins such as botulinum toxins could be a promising treatment option for patients suffering from facial pain.
41.
go back to reference Pessoa BL, Escudeiro G, Nascimento OJ. Emerging treatments for neuropathic pain. Curr Pain Headache Rep. 2015;19(12):1–9.CrossRef Pessoa BL, Escudeiro G, Nascimento OJ. Emerging treatments for neuropathic pain. Curr Pain Headache Rep. 2015;19(12):1–9.CrossRef
42.
go back to reference •• Mittal SO, Safarpour D, Jabbari B. Botulinum toxin treatment of neuropathic pain. Seminars in Neurology. 2016;36(01):073–83. Injection of neurotoxins such as botulinum toxins could be a promising treatment option for patients suffering from facial pain.CrossRef •• Mittal SO, Safarpour D, Jabbari B. Botulinum toxin treatment of neuropathic pain. Seminars in Neurology. 2016;36(01):073–83. Injection of neurotoxins such as botulinum toxins could be a promising treatment option for patients suffering from facial pain.CrossRef
Metadata
Title
Atypical Facial Pain: a Comprehensive, Evidence-Based Review
Authors
Austin L. Weiss
Ken P. Ehrhardt
Reda Tolba
Publication date
01-02-2017
Publisher
Springer US
Published in
Current Pain and Headache Reports / Issue 2/2017
Print ISSN: 1531-3433
Electronic ISSN: 1534-3081
DOI
https://doi.org/10.1007/s11916-017-0609-9

Other articles of this Issue 2/2017

Current Pain and Headache Reports 2/2017 Go to the issue

Other Pain (N Vadivelu and A Kaye, Section Editors)

New Cancer Pain Treatment Options

Other Pain (N Vadivelu and A Kaye, Section Editors)

Pain Management of Patients with Substance Abuse in the Ambulatory Setting