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Published in: Current Pain and Headache Reports 4/2010

01-08-2010

Migraine and Epilepsy: A Focus on Overlapping Clinical, Pathophysiological, Molecular, and Therapeutic Aspects

Authors: Marino Muxfeldt Bianchin, Renata Gomes Londero, José Eduardo Lima, Marcelo Eduardo Bigal

Published in: Current Pain and Headache Reports | Issue 4/2010

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Abstract

The association of epilepsy and migraine has been long recognized. Migraine and epilepsy are both chronic disorders with episodic attacks. Furthermore, headache may be a premonitory or postdromic symptom of seizures, and migraine headaches may cause seizures per se (migralepsy). Migraine and epilepsy are comorbid, sharing pathophysiological mechanisms and common clinical features. Several recent studies identified common genetic and molecular substrates for migraine and epilepsy, including phenotypic-genotypic correlations with mutations in the CACNA1A, ATP1A2, and SCN1A genes, as well as in syndromes due to mutations in the SLC1A3, POLG, and C10orF2 genes. Herein, we review the relationship between migraine and epilepsy, focusing on clinical aspects and some recent pathophysiological and molecular studies.
Literature
1.
go back to reference •• Stovner LJ, Hagen K, Jensen R, et al.: The global burden of headache: a documentation of headache prevalence and disability worldwide. Cephalalgia 2007, 27:193–210. This article is a comprehensive review about the global impact of headache disorders according to headache type. CrossRefPubMed •• Stovner LJ, Hagen K, Jensen R, et al.: The global burden of headache: a documentation of headache prevalence and disability worldwide. Cephalalgia 2007, 27:193–210. This article is a comprehensive review about the global impact of headache disorders according to headache type. CrossRefPubMed
2.
go back to reference Lipton RB, Bigal ME: Migraine: epidemiology, impact, and risk factors for progression. Headache 2005, 45(Suppl 1):S3–S13.CrossRefPubMed Lipton RB, Bigal ME: Migraine: epidemiology, impact, and risk factors for progression. Headache 2005, 45(Suppl 1):S3–S13.CrossRefPubMed
3.
go back to reference Sander JW, Shorvon SD: Epidemiology of the epilepsies. J Neurol Neurosurg Psychiatry 1996, 61:433–443. (Published erratum appears in J Neurol Neurosurg Psychiatry 1997, 62:679.)CrossRefPubMed Sander JW, Shorvon SD: Epidemiology of the epilepsies. J Neurol Neurosurg Psychiatry 1996, 61:433–443. (Published erratum appears in J Neurol Neurosurg Psychiatry 1997, 62:679.)CrossRefPubMed
4.
go back to reference de Boer HM, Mula M, Sander JW: The global burden and stigma of epilepsy. Epilepsy Behav 2008, 12:540–546.CrossRefPubMed de Boer HM, Mula M, Sander JW: The global burden and stigma of epilepsy. Epilepsy Behav 2008, 12:540–546.CrossRefPubMed
5.
go back to reference Pace BP, Sullivan-Fowler M: JAMA 100 years ago: A slander on the medical profession. JAMA 1996, 276:1222b.CrossRefPubMed Pace BP, Sullivan-Fowler M: JAMA 100 years ago: A slander on the medical profession. JAMA 1996, 276:1222b.CrossRefPubMed
6.
go back to reference •• Haut SR, Bigal ME, Lipton RB: Chronic disorders with episodic manifestations: focus on epilepsy and migraine. Lancet Neurol 2006, 5:148–157. This excellent review examines similarities and contrasts between migraine and epilepsy. CrossRefPubMed •• Haut SR, Bigal ME, Lipton RB: Chronic disorders with episodic manifestations: focus on epilepsy and migraine. Lancet Neurol 2006, 5:148–157. This excellent review examines similarities and contrasts between migraine and epilepsy. CrossRefPubMed
7.
go back to reference Andermann F, Andermann E: Migraine and epilepsy, with special reference to the benign epilepsies of childhood. Epilepsy Res Suppl 1992, 6:207–214.PubMed Andermann F, Andermann E: Migraine and epilepsy, with special reference to the benign epilepsies of childhood. Epilepsy Res Suppl 1992, 6:207–214.PubMed
8.
go back to reference Ottman R, Lipton RB: Comorbidity of migraine and epilepsy. Neurology 1994, 44:2105–2110.PubMed Ottman R, Lipton RB: Comorbidity of migraine and epilepsy. Neurology 1994, 44:2105–2110.PubMed
9.
go back to reference Ottman R, Lipton RB: Is the comorbidity of epilepsy and migraine due to a shared genetic susceptibility? Neurology 1996, 47:918–924.PubMed Ottman R, Lipton RB: Is the comorbidity of epilepsy and migraine due to a shared genetic susceptibility? Neurology 1996, 47:918–924.PubMed
10.
go back to reference Di Clemente L, Coppola G, Magis D, et al.: Interictal habituation deficit of the nociceptive blink reflex: an endophenotypic marker for presymptomatic migraine? Brain 2007, 130:765–770.CrossRefPubMed Di Clemente L, Coppola G, Magis D, et al.: Interictal habituation deficit of the nociceptive blink reflex: an endophenotypic marker for presymptomatic migraine? Brain 2007, 130:765–770.CrossRefPubMed
11.
go back to reference Leniger T, von den Driesch S, Isbruch K, et al.: Clinical characteristics of patients with comorbidity of migraine and epilepsy. Headache 2003, 43:672–677.CrossRefPubMed Leniger T, von den Driesch S, Isbruch K, et al.: Clinical characteristics of patients with comorbidity of migraine and epilepsy. Headache 2003, 43:672–677.CrossRefPubMed
12.
go back to reference Headache Classification Subcommittee of the International Headache Society: The International Classification of Headache Disorders: 2nd edition. Cephalalgia 2004, 24 (Suppl 1):9–160. Headache Classification Subcommittee of the International Headache Society: The International Classification of Headache Disorders: 2nd edition. Cephalalgia 2004, 24 (Suppl 1):9–160.
13.
go back to reference Bernasconi A, Andermann F, Bernasconi N, et al.: Lateralizing value of peri-ictal headache: A study of 100 patients with partial epilepsy. Neurology 2001, 56:130–132.PubMed Bernasconi A, Andermann F, Bernasconi N, et al.: Lateralizing value of peri-ictal headache: A study of 100 patients with partial epilepsy. Neurology 2001, 56:130–132.PubMed
14.
go back to reference Yankovsky AE, Andermann F, Bernasconi A: Characteristics of headache associated with intractable partial epilepsy. Epilepsia 2005, 46:1241–1245.CrossRefPubMed Yankovsky AE, Andermann F, Bernasconi A: Characteristics of headache associated with intractable partial epilepsy. Epilepsia 2005, 46:1241–1245.CrossRefPubMed
15.
go back to reference Cai S, Hamiwka LD, Wirrell EC: Peri-ictal headache in children: prevalence and character. Pediatr Neurol 2008, 39:91–96.CrossRefPubMed Cai S, Hamiwka LD, Wirrell EC: Peri-ictal headache in children: prevalence and character. Pediatr Neurol 2008, 39:91–96.CrossRefPubMed
16.
go back to reference Yankovsky AE, Andermann F, Mercho S, et al.: Preictal headache in partial epilepsy. Neurology 2005, 65:1979–1981.CrossRefPubMed Yankovsky AE, Andermann F, Mercho S, et al.: Preictal headache in partial epilepsy. Neurology 2005, 65:1979–1981.CrossRefPubMed
17.
go back to reference Laplante P, Saint-Hilaire JM, Bouvier G: Headache as an epileptic manifestation. Neurology 1983, 33:1493–1495.PubMed Laplante P, Saint-Hilaire JM, Bouvier G: Headache as an epileptic manifestation. Neurology 1983, 33:1493–1495.PubMed
18.
go back to reference Moskowitz MA: Genes, proteases, cortical spreading depression and migraine: impact on pathophysiology and treatment. Funct Neurol 2007, 22:133–136.PubMed Moskowitz MA: Genes, proteases, cortical spreading depression and migraine: impact on pathophysiology and treatment. Funct Neurol 2007, 22:133–136.PubMed
19.
go back to reference Marks DA, Ehrenberg BL: Migraine-related seizures in adults with epilepsy, with EEG correlation. Neurology 1993, 43:2476–2483.PubMed Marks DA, Ehrenberg BL: Migraine-related seizures in adults with epilepsy, with EEG correlation. Neurology 1993, 43:2476–2483.PubMed
20.
go back to reference Leniger T, Isbruch K, von den Driesch S, et al.: Seizure-associated headache in epilepsy. Epilepsia 2001, 42:1176–1179.CrossRefPubMed Leniger T, Isbruch K, von den Driesch S, et al.: Seizure-associated headache in epilepsy. Epilepsia 2001, 42:1176–1179.CrossRefPubMed
21.
go back to reference Piccioli M, Parisi P, Tisei P, et al.: Ictal headache and visual sensitivity. Cephalalgia 2009, 29:194–203.CrossRefPubMed Piccioli M, Parisi P, Tisei P, et al.: Ictal headache and visual sensitivity. Cephalalgia 2009, 29:194–203.CrossRefPubMed
22.
go back to reference Isler H, Wirsen ML, Elli N: Hemicrania epileptica: synchronous ipsilateral ictal headache with migraine features. In Migraine and Epilepsy. Edited by Andermann F, Lugaresi E. Boston: Butterworths; 1987:246–263. Isler H, Wirsen ML, Elli N: Hemicrania epileptica: synchronous ipsilateral ictal headache with migraine features. In Migraine and Epilepsy. Edited by Andermann F, Lugaresi E. Boston: Butterworths; 1987:246–263.
23.
go back to reference Guerrini R, Genton P: Epileptic syndromes and visually induced seizures. Epilepsia 2004, 45(Suppl 1):14–18.CrossRefPubMed Guerrini R, Genton P: Epileptic syndromes and visually induced seizures. Epilepsia 2004, 45(Suppl 1):14–18.CrossRefPubMed
24.
go back to reference Ito M, Adachi N, Nakamura F, et al.: Characteristics of postictal headache in patients with partial epilepsy. Cephalalgia 2004, 24:23–28.CrossRefPubMed Ito M, Adachi N, Nakamura F, et al.: Characteristics of postictal headache in patients with partial epilepsy. Cephalalgia 2004, 24:23–28.CrossRefPubMed
25.
go back to reference Ogunyemi A, Adams D: Migraine-like symptoms triggered by occipital lobe seizures: response to sumatriptan. Can J Neurol Sci 1998, 25:151–153.PubMed Ogunyemi A, Adams D: Migraine-like symptoms triggered by occipital lobe seizures: response to sumatriptan. Can J Neurol Sci 1998, 25:151–153.PubMed
26.
go back to reference Caraballo RH, Cersósimo RO, Fejerman N: Childhood occipital epilepsy of Gastaut: a study of 33 patients. Epilepsia 2008, 49:288–297.CrossRefPubMed Caraballo RH, Cersósimo RO, Fejerman N: Childhood occipital epilepsy of Gastaut: a study of 33 patients. Epilepsia 2008, 49:288–297.CrossRefPubMed
27.
go back to reference • Taylor I, Berkovic SF, Kivity S, Scheffer IE: Benign occipital epilepsies of childhood: clinical features and genetics. Brain 2008, 131:2287–2294. The authors examine early and late benign occipital epilepsies of childhood as two discrete electroclinical syndromes, exploring clinical features and clinical genetics of these two syndromes.CrossRefPubMed • Taylor I, Berkovic SF, Kivity S, Scheffer IE: Benign occipital epilepsies of childhood: clinical features and genetics. Brain 2008, 131:2287–2294. The authors examine early and late benign occipital epilepsies of childhood as two discrete electroclinical syndromes, exploring clinical features and clinical genetics of these two syndromes.CrossRefPubMed
28.
go back to reference Panayiotopoulos CP, Michael M, Sanders S, et al.: Benign childhood focal epilepsies: assessment of established and newly recognized syndromes. Brain 2008, 131:2264–2286.CrossRefPubMed Panayiotopoulos CP, Michael M, Sanders S, et al.: Benign childhood focal epilepsies: assessment of established and newly recognized syndromes. Brain 2008, 131:2264–2286.CrossRefPubMed
29.
go back to reference Caraballo R, Koutroumanidis M, Panayiotopoulos CP, Fejerman N: Idiopathic childhood occipital epilepsy of Gastaut: a review and differentiation from migraine and other epilepsies. J Child Neurol 2009, 24:1536–1542.CrossRefPubMed Caraballo R, Koutroumanidis M, Panayiotopoulos CP, Fejerman N: Idiopathic childhood occipital epilepsy of Gastaut: a review and differentiation from migraine and other epilepsies. J Child Neurol 2009, 24:1536–1542.CrossRefPubMed
30.
go back to reference Wirrell EC, Hamiwka LD: Do children with benign rolandic epilepsy have a higher prevalence of migraine than those with other partial epilepsies or nonepilepsy controls? Epilepsia 2006, 47:1674–1681.CrossRefPubMed Wirrell EC, Hamiwka LD: Do children with benign rolandic epilepsy have a higher prevalence of migraine than those with other partial epilepsies or nonepilepsy controls? Epilepsia 2006, 47:1674–1681.CrossRefPubMed
31.
go back to reference Clarke T, Baskurt Z, Strug LJ, Pal DK: Evidence of shared genetic risk factors for migraine and rolandic epilepsy. Epilepsia 2009, 50:2428–2433.CrossRefPubMed Clarke T, Baskurt Z, Strug LJ, Pal DK: Evidence of shared genetic risk factors for migraine and rolandic epilepsy. Epilepsia 2009, 50:2428–2433.CrossRefPubMed
32.
go back to reference Deprez L, Peeters K, Van Paesschen W, et al.: Familial occipitotemporal lobe epilepsy and migraine with visual aura: linkage to chromosome 9q. Neurology 2007, 68:1995–2002.CrossRefPubMed Deprez L, Peeters K, Van Paesschen W, et al.: Familial occipitotemporal lobe epilepsy and migraine with visual aura: linkage to chromosome 9q. Neurology 2007, 68:1995–2002.CrossRefPubMed
33.
go back to reference Deprez L, Weckhuysen S, Peeters K, et al.: Epilepsy as part of the phenotype associated with ATP1A2 mutations. Epilepsia 2008, 49:500–508.CrossRefPubMed Deprez L, Weckhuysen S, Peeters K, et al.: Epilepsy as part of the phenotype associated with ATP1A2 mutations. Epilepsia 2008, 49:500–508.CrossRefPubMed
34.
go back to reference • Barrett CF, van den Maagdenberg AM, Frants RR, Ferrari MD: Familial hemiplegic migraine. Adv Genet 2008, 63:57–83. The authors review clinical features of migraine and discuss the continuing highway of migraine gene discovery.CrossRefPubMed • Barrett CF, van den Maagdenberg AM, Frants RR, Ferrari MD: Familial hemiplegic migraine. Adv Genet 2008, 63:57–83. The authors review clinical features of migraine and discuss the continuing highway of migraine gene discovery.CrossRefPubMed
35.
go back to reference Lipton RB, Stewart WF, Diamond S, et al.: Prevalence and burden of migraine in the United States: data from the American Migraine Study II. Headache 2001, 41:646–657.CrossRefPubMed Lipton RB, Stewart WF, Diamond S, et al.: Prevalence and burden of migraine in the United States: data from the American Migraine Study II. Headache 2001, 41:646–657.CrossRefPubMed
36.
go back to reference Engel J Jr; International League Against Epilepsy (ILAE): A proposed diagnostic scheme for people with epileptic seizures and with epilepsy: report of the ILAE Task Force on Classification and Terminology. Epilepsia 2001, 42:796–803.CrossRefPubMed Engel J Jr; International League Against Epilepsy (ILAE): A proposed diagnostic scheme for people with epileptic seizures and with epilepsy: report of the ILAE Task Force on Classification and Terminology. Epilepsia 2001, 42:796–803.CrossRefPubMed
37.
go back to reference • Crompton DE, Berkovic SF: The borderland of epilepsy: clinical and molecular features of phenomena that mimic epileptic seizures. Lancet Neurol 2009, 8:370–381. The authors present an interesting discussion about clinical and molecular similarities and differences of epileptic seizures from other paroxysmal disorders.CrossRefPubMed • Crompton DE, Berkovic SF: The borderland of epilepsy: clinical and molecular features of phenomena that mimic epileptic seizures. Lancet Neurol 2009, 8:370–381. The authors present an interesting discussion about clinical and molecular similarities and differences of epileptic seizures from other paroxysmal disorders.CrossRefPubMed
38.
go back to reference Wild E: Deja vu in neurology. J Neurol 2005, 252:1–7. Wild E: Deja vu in neurology. J Neurol 2005, 252:1–7.
39.
go back to reference Gaitatzis A, Sander JW: The mortality of epilepsy revisited. Epileptic Disord 2004, 6:3–13.PubMed Gaitatzis A, Sander JW: The mortality of epilepsy revisited. Epileptic Disord 2004, 6:3–13.PubMed
40.
go back to reference Goadsby PJ, Hoskin KL: Inhibition of trigeminal neurons by intravenous administration of the serotonin (5HT)1B/D receptor agonist zolmitriptan (311C90): are brain stem sites therapeutic target in migraine? Pain 1996, 67:355–359.CrossRefPubMed Goadsby PJ, Hoskin KL: Inhibition of trigeminal neurons by intravenous administration of the serotonin (5HT)1B/D receptor agonist zolmitriptan (311C90): are brain stem sites therapeutic target in migraine? Pain 1996, 67:355–359.CrossRefPubMed
42.
go back to reference •• de Vries B, Frants RR, Ferrari MD, van den Maagdenberg AM: Molecular genetics of migraine. Hum Genet 2009, 126:115–132. This is an excellent and comprehensive review about molecular aspects of migraine.CrossRefPubMed •• de Vries B, Frants RR, Ferrari MD, van den Maagdenberg AM: Molecular genetics of migraine. Hum Genet 2009, 126:115–132. This is an excellent and comprehensive review about molecular aspects of migraine.CrossRefPubMed
43.
go back to reference Bahra A, Matharu MS, Buchel C, et al.: Brainstem activation specific to migraine headache. Lancet 2001, 357:1016–1017.CrossRefPubMed Bahra A, Matharu MS, Buchel C, et al.: Brainstem activation specific to migraine headache. Lancet 2001, 357:1016–1017.CrossRefPubMed
44.
go back to reference Goadsby PJ: Neurovascular headache and a midbrain vascular malformation: evidence for a role of the brainstem in chronic migraine. Cephalalgia 2002, 22:107–111.CrossRefPubMed Goadsby PJ: Neurovascular headache and a midbrain vascular malformation: evidence for a role of the brainstem in chronic migraine. Cephalalgia 2002, 22:107–111.CrossRefPubMed
45.
go back to reference Lauritzen M: Pathophysiology of the migraine aura. The spreading depression theory. Brain 1994, 117:199–210. Lauritzen M: Pathophysiology of the migraine aura. The spreading depression theory. Brain 1994, 117:199–210.
46.
go back to reference Bolay H, Reuter U, Dunn AK, et al.: Intrinsic brain activity triggers trigeminal meningeal afferents in a migraine model. Nat Med 2002, 8:136–142.CrossRefPubMed Bolay H, Reuter U, Dunn AK, et al.: Intrinsic brain activity triggers trigeminal meningeal afferents in a migraine model. Nat Med 2002, 8:136–142.CrossRefPubMed
47.
go back to reference Ayata C, Jin H, Kudo C, et al.: Suppression of cortical spreading depression in migraine prophylaxis. Ann Neurol 2006, 59:652–661.CrossRefPubMed Ayata C, Jin H, Kudo C, et al.: Suppression of cortical spreading depression in migraine prophylaxis. Ann Neurol 2006, 59:652–661.CrossRefPubMed
48.
go back to reference Aurora SK: Is chronic migraine one end of a spectrum of migraine or a separate entity? Cephalalgia 2009, 29:597–605.CrossRefPubMed Aurora SK: Is chronic migraine one end of a spectrum of migraine or a separate entity? Cephalalgia 2009, 29:597–605.CrossRefPubMed
49.
go back to reference Ophoff RA, Terwindt GM, Vergouwe MN, et al.: Familial hemiplegic migraine and episodic ataxia type-2 are caused by mutations in the Ca2+ channel gene CACNL1A4. Cell 1996, 87:543–552.CrossRefPubMed Ophoff RA, Terwindt GM, Vergouwe MN, et al.: Familial hemiplegic migraine and episodic ataxia type-2 are caused by mutations in the Ca2+ channel gene CACNL1A4. Cell 1996, 87:543–552.CrossRefPubMed
50.
go back to reference Tottene A, Conti R, Fabbro A, et al.: Enhanced excitatory transmission at cortical synapses as the basis for facilitated spreading depression in Ca(v)2.1 knockin migraine mice. Neuron 2009, 61:762–773.CrossRefPubMed Tottene A, Conti R, Fabbro A, et al.: Enhanced excitatory transmission at cortical synapses as the basis for facilitated spreading depression in Ca(v)2.1 knockin migraine mice. Neuron 2009, 61:762–773.CrossRefPubMed
51.
go back to reference Gargus JJ: Genetic calcium signaling abnormalities in the central nervous system: seizures, migraine, and autism. Ann N Y Acad Sci 2009, 1151:133–156.CrossRefPubMed Gargus JJ: Genetic calcium signaling abnormalities in the central nervous system: seizures, migraine, and autism. Ann N Y Acad Sci 2009, 1151:133–156.CrossRefPubMed
52.
go back to reference De Fusco M, Marconi R, Silvestri L, et al.: Haploinsufficiency of ATP1A2 encoding the Na+/K+ pump alpha2 subunit associated with familial hemiplegic migraine type 2. Nat Genet 2003, 33:192–196.CrossRefPubMed De Fusco M, Marconi R, Silvestri L, et al.: Haploinsufficiency of ATP1A2 encoding the Na+/K+ pump alpha2 subunit associated with familial hemiplegic migraine type 2. Nat Genet 2003, 33:192–196.CrossRefPubMed
53.
go back to reference Castro MJ, Stam AH, Lemos C, et al.: Recurrent ATP1A2 mutations in Portuguese families with familial hemiplegic migraine. J Hum Genet 2007, 52:990–998.CrossRefPubMed Castro MJ, Stam AH, Lemos C, et al.: Recurrent ATP1A2 mutations in Portuguese families with familial hemiplegic migraine. J Hum Genet 2007, 52:990–998.CrossRefPubMed
54.
go back to reference Dichgans M, Freilinger T, Eckstein G, et al.: Mutation in the neuronal voltage-gated sodium channel SCN1A in familial hemiplegic migraine. Lancet 2005, 366:371–377.CrossRefPubMed Dichgans M, Freilinger T, Eckstein G, et al.: Mutation in the neuronal voltage-gated sodium channel SCN1A in familial hemiplegic migraine. Lancet 2005, 366:371–377.CrossRefPubMed
55.
go back to reference Gambardella A, Marini C: Clinical spectrum of SCN1A mutations. Epilepsia 2009, 50(Suppl 5):20–23.CrossRefPubMed Gambardella A, Marini C: Clinical spectrum of SCN1A mutations. Epilepsia 2009, 50(Suppl 5):20–23.CrossRefPubMed
56.
go back to reference Fujiwara T: Clinical spectrum of mutations in SCN1A gene: severe myoclonic epilepsy in infancy and related epilepsies. Epilepsy Res 2006, 70(Suppl 1):S223–S230.CrossRefPubMed Fujiwara T: Clinical spectrum of mutations in SCN1A gene: severe myoclonic epilepsy in infancy and related epilepsies. Epilepsy Res 2006, 70(Suppl 1):S223–S230.CrossRefPubMed
57.
go back to reference • Harkin LA, McMahon JM, Iona X, et al.: The spectrum of SCN1A-related infantile epileptic encephalopathies. Brain 2007, 130:843–852. The authors present an expanded spectrum of epileptic encephalopathies associated with SCN1A mutations.CrossRefPubMed • Harkin LA, McMahon JM, Iona X, et al.: The spectrum of SCN1A-related infantile epileptic encephalopathies. Brain 2007, 130:843–852. The authors present an expanded spectrum of epileptic encephalopathies associated with SCN1A mutations.CrossRefPubMed
58.
go back to reference Claes LR, Deprez L, Suls A, et al.: The SCN1A variant database: a novel research and diagnostic tool. Hum Mutat 2009, 30:E904–E920.CrossRefPubMed Claes LR, Deprez L, Suls A, et al.: The SCN1A variant database: a novel research and diagnostic tool. Hum Mutat 2009, 30:E904–E920.CrossRefPubMed
59.
go back to reference Jen JC, Wan J, Palos TP, et al.: Mutation in the glutamate transporter EAAT1 causes episodic ataxia, hemiplegia, and seizures. Neurology 2005, 65:529–534.CrossRefPubMed Jen JC, Wan J, Palos TP, et al.: Mutation in the glutamate transporter EAAT1 causes episodic ataxia, hemiplegia, and seizures. Neurology 2005, 65:529–534.CrossRefPubMed
60.
go back to reference Tzoulis C, Engelsen BA, Telstad W, et al.: The spectrum of clinical disease caused by the A467T and W748S POLG mutations: a study of 26 cases. Brain 2006, 129:1685–1692.CrossRefPubMed Tzoulis C, Engelsen BA, Telstad W, et al.: The spectrum of clinical disease caused by the A467T and W748S POLG mutations: a study of 26 cases. Brain 2006, 129:1685–1692.CrossRefPubMed
61.
go back to reference Lönnqvist T, Paetau A, Valanne L, Pihko H: Recessive twinkle mutations cause severe epileptic encephalopathy. Brain 2009, 132:1553–1562.CrossRefPubMed Lönnqvist T, Paetau A, Valanne L, Pihko H: Recessive twinkle mutations cause severe epileptic encephalopathy. Brain 2009, 132:1553–1562.CrossRefPubMed
63.
go back to reference Silberstein SD: Topiramate in migraine prevention: evidence-based medicine from clinical trials. Neurol Sci 2004, 25(Suppl 3):S244–S245.CrossRefPubMed Silberstein SD: Topiramate in migraine prevention: evidence-based medicine from clinical trials. Neurol Sci 2004, 25(Suppl 3):S244–S245.CrossRefPubMed
64.
go back to reference Rapoport AM, Bigal ME: Migraine preventive therapy: current and emerging treatment options. Neurol Sci 2005, 26(Suppl 2):s111–s120.CrossRefPubMed Rapoport AM, Bigal ME: Migraine preventive therapy: current and emerging treatment options. Neurol Sci 2005, 26(Suppl 2):s111–s120.CrossRefPubMed
Metadata
Title
Migraine and Epilepsy: A Focus on Overlapping Clinical, Pathophysiological, Molecular, and Therapeutic Aspects
Authors
Marino Muxfeldt Bianchin
Renata Gomes Londero
José Eduardo Lima
Marcelo Eduardo Bigal
Publication date
01-08-2010
Publisher
Current Science Inc.
Published in
Current Pain and Headache Reports / Issue 4/2010
Print ISSN: 1531-3433
Electronic ISSN: 1534-3081
DOI
https://doi.org/10.1007/s11916-010-0121-y

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