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Current Pain and Headache Reports
Published in: Current Pain and Headache Reports 3/2010

01-06-2010

Migraine and Olfactory Stimuli

Authors: Christina Sjöstrand, Ivanka Savic, Eva Laudon-Meyer, Lena Hillert, Karin Lodin, Elisabet Waldenlind

Published in: Current Pain and Headache Reports | Issue 3/2010

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Abstract

Migraine patients often report intolerance to odours. Migraineurs report odours may trigger attacks, that they experience osmophobia during attacks, and olfactory hypersensitivity between attacks. In this paper we discuss olfactory mechanisms in migraine. We also present data from a pilot questionnaire study in a group of young women diagnosed with migraine. The study results confirm that hypersensitivity to odour is a common feature in women with migraine. Migraine pathophysiology likely explains this particular vulnerability. We discuss these pathophysiologic mechanisms and hypotheses relating odour intolerances and migraine.
Literature
1.
Dahlof C, Linde M: One-year prevalence of migraine in Sweden: a population-based study in adults. Cephalalgia. 2001;21:664–71.CrossRefPubMed
2.
The International Classification of Headache Disorders. Cephalalgia 2004;24:1–160.
3.
Rasmussen BK, Olesen J: Migraine with aura and migraine without aura: an epidemiological study. Cephalalgia. 1992;12:221–8; discussion 186.CrossRefPubMed
4.
Savic I, Gulyas B, Larsson M, Roland P: Olfactory functions are mediated by parallel and hierarchical processing. Neuron. 2000;26:735–45.CrossRefPubMed
5.
Zatorre RJ, Jones-Gotman M, Evans AC, Meyer E: Functional localization and lateralization of human olfactory cortex. Nature. 1992;360:339–40.CrossRefPubMed
6.
Sobel N, Prabhakaran V, Desmond JE, et al.: Sniffing and smelling: separate subsystems in the human olfactory cortex. Nature. 1998;392:282–6.CrossRefPubMed
7.
Zald DH, Pardo JV: Functional neuroimaging of the olfactory system in humans. Int J Psychophysiol. 2000;36:165–81.CrossRefPubMed
8.
Savic I, Gulyas B: PET shows that odors are processed both ipsilaterally and contralaterally to the stimulated nostril. Neuroreport. 2000;11:2861–6.CrossRefPubMed
9.
Savic I, Berglund H: Passive perception of odors and semantic circuits. Hum Brain Mapp. 2004;21:271–8.CrossRefPubMed
10.
Savic I, Berglund H, Gulyas B, Roland P: Smelling of odorous sex hormone-like compounds causes sex-differentiated hypothalamic activations in humans. Neuron. 2001;31:661–8.CrossRefPubMed
11.
Svensson DA, Larsson B, Waldenlind E, Pedersen NL: Shared rearing environment in migraine: results from twins reared apart and twins reared together. Headache. 2003;43:235–44. (Published erratum appears in Headache 2003, 43:833.)CrossRefPubMed
12.
Lauritzen M: Pathophysiology of the migraine aura. The spreading depression theory. Brain. 1994;117 ( Pt 1):199–210.CrossRefPubMed
13.
May A, Goadsby PJ: The trigeminovascular system in humans: pathophysiologic implications for primary headache syndromes of the neural influences on the cerebral circulation. J Cereb Blood Flow Metab. 1999;19:115–27.CrossRefPubMed
14.
Welch KM: Contemporary concepts of migraine pathogenesis. Neurology. 2003;61:S2–8.PubMed
15.
Ambrosini A, de Noordhout AM, Sandor PS, Schoenen J: Electrophysiological studies in migraine: a comprehensive review of their interest and limitations. Cephalalgia. 2003;23 Suppl 1:13–31.CrossRefPubMed
16.
Vingen JV, Pareja JA, Stovner LJ: Quantitative evaluation of photophobia and phonophobia in cluster headache. Cephalalgia. 1998;18:250–6.CrossRefPubMed
17.
Vanagaite J, Pareja JA, Storen O, et al.: Light-induced discomfort and pain in migraine. Cephalalgia. 1997;17:733–41.CrossRefPubMed
18.
Zanchin G, Dainese F, Trucco M, et al.: Osmophobia in migraine and tension-type headache and its clinical features in patients with migraine. Cephalalgia. 2007;27:1061–8.CrossRefPubMed
19.
Chakravarty A: How triggers trigger acute migraine attacks: A hypothesis. Med Hypotheses. 2009.
20.
Tekle Haimanot R, Seraw B, Forsgren L, et al.: Migraine, chronic tension-type headache, and cluster headache in an Ethiopian rural community. Cephalalgia. 1995;15:482–8.CrossRefPubMed
21.
Fukui PT, Goncalves TR, Strabelli CG, et al.: Trigger factors in migraine patients. Arq Neuropsiquiatr. 2008;66:494–9.PubMed
22.
Kelman L: The triggers or precipitants of the acute migraine attack. Cephalalgia. 2007;27:394–402.CrossRefPubMed
23.
Theeler BJ, Kenney K, Prokhorenko OA, et al.: Headache Triggers in the US Military. Headache. 2009.
24.
Chakravarty A, Mukherjee A, Roy D: Trigger factors in childhood migraine: a clinic-based study from eastern India. J Headache Pain. 2009;10:375–80.CrossRefPubMed
25.
26.
Vingen JV, Sand T, Stovner LJ: Sensitivity to various stimuli in primary headaches: a questionnaire study. Headache. 1999;39:552–8.CrossRefPubMed
27.
Morillo LE, Alarcon F, Aranaga N, et al.: Clinical characteristics and patterns of medication use of migraneurs in Latin America from 12 cities in 6 countries. Headache. 2005;45:118–26.CrossRefPubMed
28.
Raieli V, Pandolfi E, La Vecchia M, et al.: The prevalence of allodynia, osmophobia and red ear syndrome in the juvenile headache: preliminary data. J Headache Pain. 2005;6:271–3.CrossRefPubMed
29.
Corletto E, Dal Zotto L, Resos A, et al.: Osmophobia in juvenile primary headaches. Cephalalgia. 2008;28:825–31.CrossRefPubMed
30.
Demarquay G, Royet JP, Giraud P, et al.: Rating of olfactory judgements in migraine patients. Cephalalgia. 2006;26:1123–30.CrossRefPubMed
31.
32.
33.
Grosser K, Oelkers R, Hummel T, et al.: Olfactory and trigeminal event-related potentials in migraine. Cephalalgia. 2000;20:621–31.PubMed
34.
Demarquay G, Royet JP, Mick G, Ryvlin P: Olfactory hypersensitivity in migraineurs: a H(2)(15)O-PET study. Cephalalgia. 2008;28:1069–80.CrossRefPubMed
35.
Hillert L, Musabasic V, Berglund H, et al.: Odor processing in multiple chemical sensitivity. Hum Brain Mapp. 2007;28:172–82.CrossRefPubMed
36.
Spierings EL, Ranke AH, Honkoop PC: Precipitating and aggravating factors of migraine versus tension-type headache. Headache. 2001;41:554–8.CrossRefPubMed
37.
Multiple chemical sensitivity: a 1999 consensus. Arch Environ Health. 1999;54:147–9.
38.
Evers S, Voss H, Bauer B, et al.: Peripheral autonomic potentials in primary headache and drug-induced headache. Cephalalgia. 1998;18:216–21.CrossRefPubMed
39.
Haumann K, Kiesswetter E, van Thriel C, et al.: Breathing and heart rate during experimental solvent exposure of young adults with self-reported multiple chemical sensitivity (sMCS). Neurotoxicology. 2003;24:179–86.CrossRefPubMed
40.
Kowacs PA, Piovesan EJ, Werneck LC, et al.: Influence of intense light stimulation on trigeminal and cervical pain perception thresholds. Cephalalgia. 2001;21:184–8.CrossRefPubMed
41.
Drummond PD: Motion sickness and migraine: optokinetic stimulation increases scalp tenderness, pain sensitivity in the fingers and photophobia. Cephalalgia. 2002;22:117–24.CrossRefPubMed
42.
Villeneuve PJ, Szyszkowicz M, Stieb D, Bourque DA: Weather and emergency room visits for migraine headaches in Ottawa, Canada. Headache. 2006;46:64–72.CrossRefPubMed
43.
Jansen SC, van Dusseldorp M, Bottema KC, Dubois AE: Intolerance to dietary biogenic amines: a review. Ann Allergy Asthma Immunol. 2003;91:233-40; quiz 41-2, 96.CrossRefPubMed
44.
Johansson A, Bramerson A, Millqvist E, et al.: Prevalence and risk factors for self-reported odour intolerance: the Skovde population-based study. Int Arch Occup Environ Health. 2005;78:559–64.CrossRefPubMed
45.
Bengtsson S, Berglund H, Gulyas B, et al.: Brain activation during odor perception in males and females. Neuroreport. 2001;12:2027–33.CrossRefPubMed
46.
Munck A, Guyre PM, Holbrook NJ: Physiological functions of glucocorticoids in stress and their relation to pharmacological actions. Endocr Rev. 1984;5:25–44.CrossRefPubMed
Metadata
Title
Migraine and Olfactory Stimuli
Authors
Christina Sjöstrand
Ivanka Savic
Eva Laudon-Meyer
Lena Hillert
Karin Lodin
Elisabet Waldenlind
Publication date
01-06-2010
Publisher
Current Science Inc.
Published in
Current Pain and Headache Reports / Issue 3/2010
Print ISSN: 1531-3433
Electronic ISSN: 1534-3081
DOI
https://doi.org/10.1007/s11916-010-0109-7

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