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01-12-2011 | Epidemiology and Pathophysiology (Mone Zaidi and Jeffrey I. Mechanick, Section Editors)

Events in Articular Chondrocytes with Aging

Authors: Daniel J. Leong, Hui B. Sun

Published in: Current Osteoporosis Reports | Issue 4/2011

Abstract

It is well accepted that aging is one of the most prominent risk factors for the initiation and progression of osteoarthritis. One of the most pronounced age-related changes in chondrocytes is the exhibition of a senescent phenotype, which is the result of several factors including the accumulation of reactive oxygen species and advanced glycation end products. Compared with a normal chondrocyte, senescent chondrocytes exhibit an impaired ability to respond to many mechanical and inflammatory insults to the articular cartilage. Furthermore, protein secretion is altered in aging chondrocytes, demonstrated by a decrease in anabolic activity and increased production of proinflammatory cytokines and matrix-degrading enzymes. Together, these events may make the articular cartilage matrix more susceptible to damage and lead to the onset of osteoarthritis. A better understanding of the mechanisms underlying age-related chondrocyte pathophysiology may be critical for the development of novel therapeutic interventions for progressive joint diseases.

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Title: Events in Articular Chondrocytes with Aging
Authors: Daniel J. Leong
Hui B. Sun
Publication date: 01-12-2011
Publisher: Current Science Inc.
Published in: Current Osteoporosis Reports / Issue 4/2011
Print ISSN: 1544-1873
Electronic ISSN: 1544-2241
DOI: https://doi.org/10.1007/s11914-011-0070-3

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Events in Articular Chondrocytes with Aging

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