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Current Osteoporosis Reports
Published in: Current Osteoporosis Reports 2/2010

01-06-2010

Mesenchymal Stem Cell Mechanobiology

Authors: Alesha B. Castillo, Christopher R. Jacobs

Published in: Current Osteoporosis Reports | Issue 2/2010

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Abstract

Bone marrow-derived multipotent stem and stromal cells (MSCs) are likely candidates for cell-based therapies for various conditions including skeletal disease. Advancement of these therapies will rely on an ability to identify, isolate, manipulate, and deliver stem cells in a safe and effective manner. Although it is clear that physical signals affect tissue morphogenesis, stem cell differentiation, and healing processes, integration of mechanically induced signaling events remain obscure. Mechanisms underlying sensation and interpretation of mechanical signals by stem cells are the focus of intense study. External mechanical signals have the ability to activate osteogenic signaling pathways in MSCs including Wnt, Ror2, and Runx2. It is also clear that intracellular tensile forces resulting from cell–extracellular matrix interactions play a critical role in MSC regulation. Further work is required to determine the precise role that mechanical forces play in stem cell function.
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Metadata
Title
Mesenchymal Stem Cell Mechanobiology
Authors
Alesha B. Castillo
Christopher R. Jacobs
Publication date
01-06-2010
Publisher
Current Science Inc.
Published in
Current Osteoporosis Reports / Issue 2/2010
Print ISSN: 1544-1873
Electronic ISSN: 1544-2241
DOI
https://doi.org/10.1007/s11914-010-0015-2

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