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01-12-2015 | Genitourinary Cancers (DP Petrylak and JW Kim, Section Editors)

Targeting Signaling Transduction Pathways in Bladder Cancer

Authors: Phillip H. Abbosh, David J. McConkey, Elizabeth R. Plimack

Published in: Current Oncology Reports | Issue 12/2015

Abstract

Systemic therapy for urothelial carcinoma (UC) of the bladder has largely revolved around cytotoxic chemotherapy regimens. However, several recent clinical trials have explored the roles of targeted therapies which specifically inhibit signal transduction pathways. Simultaneously, a rationale for such therapies has come to the forefront of management of this disease because an overabundance of signaling pathways are genetically deranged as a result of point mutation or copy number alteration (CNA) as identified by several recent next generation sequencing (NGS) studies. Importantly, these derangements are found in all stages of disease, and therefore targeted therapies hold promise as a next step in the evolution of the medical management of both localized and metastatic UCC. We review the rationale for and progress in studying inhibition of signal transduction as a means of treatment of UCC.

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Title: Targeting Signaling Transduction Pathways in Bladder Cancer
Authors: Phillip H. Abbosh
David J. McConkey
Elizabeth R. Plimack
Publication date: 01-12-2015
Publisher: Springer US
Published in: Current Oncology Reports / Issue 12/2015
Print ISSN: 1523-3790
Electronic ISSN: 1534-6269
DOI: https://doi.org/10.1007/s11912-015-0477-6

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