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01-08-2014 | Sarcomas (SR Patel, Section Editor)

Advances in Therapy for Pediatric Sarcomas

Authors: Aaron Weiss, Jonathan Gill, John Goldberg, Joanne Lagmay, Holly Spraker-Perlman, Rajkumar Venkatramani, Damon Reed

Published in: Current Oncology Reports | Issue 8/2014

Abstract

Pediatric sarcomas are relatively rare malignancies individually. As a group they are typically approached with combination chemotherapies in addition to local control. Fortunately, these malignancies have been approached through careful clinical trial collaboration to define risk groups and appropriately deliver local control measures and systemic therapies. Although local disease is typically approached with curative intent, therapy typically lasts over 6 months and has significant associated morbidities. It is more difficult to cure metastatic disease or induce sustained remissions. In this article, we discuss recent advances in the understanding of the disease process and highlight recent and future cooperative group trials in osteosarcoma, Ewing sarcoma, rhabdomyosarcoma, nonrhabdomyosarcoma soft tissue sarcomas, and desmoid tumor as well as discuss promising therapeutic approaches such as epigenetics and immunotherapy.

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Title: Advances in Therapy for Pediatric Sarcomas
Authors: Aaron Weiss
Jonathan Gill
John Goldberg
Joanne Lagmay
Holly Spraker-Perlman
Rajkumar Venkatramani
Damon Reed
Publication date: 01-08-2014
Publisher: Springer US
Published in: Current Oncology Reports / Issue 8/2014
Print ISSN: 1523-3790
Electronic ISSN: 1534-6269
DOI: https://doi.org/10.1007/s11912-014-0395-z

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Springer Medicine

Abstract

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Other articles of this Issue 8/2014

Imaging Mimics of Primary Malignant Tumors of the Central Nervous System (CNS)

Cardiotoxicity of Antineoplastic Agents: What Is the Present and Future Role for Imaging?

Advances in the Management of Low-Grade Gliomas

Post-Treatment Imaging Changes in Primary Brain Tumors

Revisiting Oxaliplatin-based Regimens for Advanced Hepatocellular Carcinoma

Keynote webinar | Spotlight on antibody–drug conjugates in cancer