Skip to main content
Top
Published in: Current Neurology and Neuroscience Reports 5/2022

01-05-2022 | Stroke | Stroke (B. Ovbiagele, Section Editor)

Utilizing Implementation Science to Bridge Cerebrovascular Health Disparities: a Local to Global Perspective

Authors: Fred Stephen Sarfo, Bruce Ovbiagele

Published in: Current Neurology and Neuroscience Reports | Issue 5/2022

Login to get access

Abstract

Purpose of Review

Stroke is a prime example of a medical disorder whose incidence, prevalence, and outcomes are strongly characterized by health disparities across the globe. This scoping literature review seeks to depict how implementation science could be utilized to advance health equity in the prevention, acute treatment, and post-acute management of stroke in the underserved regions of high-income countries as well as in all low-income countries.

Recent Findings

A major reason for the persisting and widening cerebrovascular disease disparities is that evidence-based stroke prevention and treatment interventions have been differentially translated (if at all) to various populations and settings. The field of implementation science is endowed with frameworks, theories, methodological approaches, and outcome measures, including equity indices, which could be harnessed to facilitate the translation of evidence-based interventions into clinical practice for underserved and vulnerable communities.

Summary

Encouragingly, there are several novel frameworks, which eminently merge implementation science constructs with health equity determinants, thereby opening up key opportunities to bridge burgeoning worldwide gaps in cerebrovascular health equity.
Literature
3.
go back to reference Whitehead M. The concepts and principles of equity and health. Int J Health Serv. 1992;22:42945.CrossRef Whitehead M. The concepts and principles of equity and health. Int J Health Serv. 1992;22:42945.CrossRef
4.
go back to reference Marmot M, Allen J, Bell R, Bloomer E, Goldblatt P. WHO European review of social determinants of health and the health divide. Lancet. 2012;380:101129.CrossRef Marmot M, Allen J, Bell R, Bloomer E, Goldblatt P. WHO European review of social determinants of health and the health divide. Lancet. 2012;380:101129.CrossRef
5.
go back to reference Rid A, Johansson MA, Leung G, Valantine H, Burchard EG, Oh SS, et al. Towards equity in health research: researchers take stock. PLoS Med. 2016;13:e1002186.PubMedPubMedCentralCrossRef Rid A, Johansson MA, Leung G, Valantine H, Burchard EG, Oh SS, et al. Towards equity in health research: researchers take stock. PLoS Med. 2016;13:e1002186.PubMedPubMedCentralCrossRef
6.
go back to reference Mensah GA, Mokdad AH, Ford ES, Greenlund KJ, Croft JB. State of disparities in cardiovascular health in the United States. Circulation. 2005;111:1233–41.PubMedCrossRef Mensah GA, Mokdad AH, Ford ES, Greenlund KJ, Croft JB. State of disparities in cardiovascular health in the United States. Circulation. 2005;111:1233–41.PubMedCrossRef
7.
go back to reference Mensah GA, Cooper RS, Siega-Riz AM, Cooper LA, Smith JD, Brown CH, et al. Reducing cardiovascular disparities through community-engaged implementation research: a National Heart, Lung, and Blood Institute workshop report. Circ Res. 2018;122:213–30.PubMedPubMedCentralCrossRef Mensah GA, Cooper RS, Siega-Riz AM, Cooper LA, Smith JD, Brown CH, et al. Reducing cardiovascular disparities through community-engaged implementation research: a National Heart, Lung, and Blood Institute workshop report. Circ Res. 2018;122:213–30.PubMedPubMedCentralCrossRef
8.
9.
go back to reference Engelgau MM, Narayan KMV, Ezzati M, Salicrup LA, Belis D, Aron LY, et al. Implementation research to address the United States health disadvantage: report of a National Heart, Lung, and Blood Institute workshop. Glob Heart. 2018;13:65–72.PubMedCrossRef Engelgau MM, Narayan KMV, Ezzati M, Salicrup LA, Belis D, Aron LY, et al. Implementation research to address the United States health disadvantage: report of a National Heart, Lung, and Blood Institute workshop. Glob Heart. 2018;13:65–72.PubMedCrossRef
11.
go back to reference McGruder HF, Malarcher AM, Antoine TL, Greenlund KJ, Croft JB. Racial and ethnic disparities in cardiovascular risk factors among stroke survivors: United States 1999 to 2001. Stroke. 2004;35:1557–61.PubMedCrossRef McGruder HF, Malarcher AM, Antoine TL, Greenlund KJ, Croft JB. Racial and ethnic disparities in cardiovascular risk factors among stroke survivors: United States 1999 to 2001. Stroke. 2004;35:1557–61.PubMedCrossRef
12.
go back to reference Feng W, Hendry RM, Adams RJ. Risk of recurrent stroke, myocardial infarction, or death in hospitalized stroke patients. Neurology. 2010;74:588–93.PubMedCrossRef Feng W, Hendry RM, Adams RJ. Risk of recurrent stroke, myocardial infarction, or death in hospitalized stroke patients. Neurology. 2010;74:588–93.PubMedCrossRef
13.
go back to reference Centers for Disease C, Prevention. State-specific mortality from stroke & distribution of place of death—United States, 1999. MMWR Morb Mortal Wkly Rep. 2002;51:429–433. Centers for Disease C, Prevention. State-specific mortality from stroke & distribution of place of death—United States, 1999. MMWR Morb Mortal Wkly Rep. 2002;51:429–433.
14.
go back to reference Kissela B, Schneider A, Kleindorfer D, Khoury J, Miller R, Alwell K, et al. Stroke in a biracial population: the excess burden of stroke among blacks. Stroke. 2004;35:426–31.PubMedCrossRef Kissela B, Schneider A, Kleindorfer D, Khoury J, Miller R, Alwell K, et al. Stroke in a biracial population: the excess burden of stroke among blacks. Stroke. 2004;35:426–31.PubMedCrossRef
15.
go back to reference Howard VJ, Kleindorfer DO, Judd SE, McClure LA, Safford MM, et al. Disparities in stroke incidence contributing to disparities in stroke mortality. Ann Neurol. 2011;69:619–27.PubMedPubMedCentralCrossRef Howard VJ, Kleindorfer DO, Judd SE, McClure LA, Safford MM, et al. Disparities in stroke incidence contributing to disparities in stroke mortality. Ann Neurol. 2011;69:619–27.PubMedPubMedCentralCrossRef
16.
go back to reference Kleindorfer DO, Khoury J, Moomaw CJ, Alwell K, Woo D, Flaherty ML, et al. Stroke incidence is decreasing in whites but not in blacks: a population-based estimate of temporal trends in stroke incidence from the Greater Cincinnati/Northern Kentucky Stroke Study. Stroke. 2010;41:1326–31.PubMedPubMedCentralCrossRef Kleindorfer DO, Khoury J, Moomaw CJ, Alwell K, Woo D, Flaherty ML, et al. Stroke incidence is decreasing in whites but not in blacks: a population-based estimate of temporal trends in stroke incidence from the Greater Cincinnati/Northern Kentucky Stroke Study. Stroke. 2010;41:1326–31.PubMedPubMedCentralCrossRef
17.
go back to reference Ovbiagele B, Goldstein LB, Higashida RT, Howard VJ, Johnston SC, Khavjou OA, et al. American Heart Association Advocacy Coordinating C, Stroke C. Forecasting the future of stroke in the United States: a policy statement from the American Heart Association & American Stroke Association. Stroke. 2013;44:2361–2375. Ovbiagele B, Goldstein LB, Higashida RT, Howard VJ, Johnston SC, Khavjou OA, et al. American Heart Association Advocacy Coordinating C, Stroke C. Forecasting the future of stroke in the United States: a policy statement from the American Heart Association & American Stroke Association. Stroke. 2013;44:2361–2375.
18.
go back to reference Benjamin EJ, Blaha MJ, Chiuve SE, Cushman M, Das SR, Deo R, et al. American Heart Association Statistics C, Stroke Statistics S. Heart disease & stroke statistics-2017 update: a report from the American Heart Association. Circulation. 2017;135:e146–e603. Benjamin EJ, Blaha MJ, Chiuve SE, Cushman M, Das SR, Deo R, et al. American Heart Association Statistics C, Stroke Statistics S. Heart disease & stroke statistics-2017 update: a report from the American Heart Association. Circulation. 2017;135:e146–e603.
19.
go back to reference Carnethon MR, Pu J, Howard G, Albert MA, &erson CAM, Bertoni AG, et al. American Heart Association Council on E, Prevention, Council on Cardiovascular Disease in the Y, Council on C, Stroke N, Council on Clinical C, Council on Functional G, Translational B, Stroke C. Cardiovascular health in African Americans: a scientific statement from the American Heart Association. Circulation. 2017. Carnethon MR, Pu J, Howard G, Albert MA, &erson CAM, Bertoni AG, et al. American Heart Association Council on E, Prevention, Council on Cardiovascular Disease in the Y, Council on C, Stroke N, Council on Clinical C, Council on Functional G, Translational B, Stroke C. Cardiovascular health in African Americans: a scientific statement from the American Heart Association. Circulation. 2017.
20.
go back to reference Cruz-Flores S, Rabinstein A, Biller J, Elkind MS, Griffith P, Gorelick PB, et al. Racial-ethnic disparities in stroke care: the American experience: a statement for healthcare professionals from the American Heart Association/American Stroke Association. Stroke. 2011;42:2091–116.PubMedCrossRef Cruz-Flores S, Rabinstein A, Biller J, Elkind MS, Griffith P, Gorelick PB, et al. Racial-ethnic disparities in stroke care: the American experience: a statement for healthcare professionals from the American Heart Association/American Stroke Association. Stroke. 2011;42:2091–116.PubMedCrossRef
21.
23.
go back to reference Howard G, Lackland DT, Kleindorfer DO, Kissela BM, Moy CS, Judd SE, et al. Racial differences in the impact of elevated systolic blood pressure on stroke risk. JAMA Intern Med. 2013;173:46–51.PubMedPubMedCentralCrossRef Howard G, Lackland DT, Kleindorfer DO, Kissela BM, Moy CS, Judd SE, et al. Racial differences in the impact of elevated systolic blood pressure on stroke risk. JAMA Intern Med. 2013;173:46–51.PubMedPubMedCentralCrossRef
24.
go back to reference Howard VJ, Cushman M, Pulley L, Gomez CR, Go RC, Prineas RJ, et al. The reasons for geographic & racial differences in stroke study: objectives & design. Neuroepidemiology. 2005;25:135–43.PubMedCrossRef Howard VJ, Cushman M, Pulley L, Gomez CR, Go RC, Prineas RJ, et al. The reasons for geographic & racial differences in stroke study: objectives & design. Neuroepidemiology. 2005;25:135–43.PubMedCrossRef
25.
go back to reference Howard G, Cushman M, Kissela BM, Kleindorfer DO, McClure LA, Safford MM, et al. Racial Differences in Stroke I. Traditional risk factors as the underlying cause of racial disparities in stroke: lessons from the half-full (empty?) glass. Stroke. 2011;42:3369–3375. Howard G, Cushman M, Kissela BM, Kleindorfer DO, McClure LA, Safford MM, et al. Racial Differences in Stroke I. Traditional risk factors as the underlying cause of racial disparities in stroke: lessons from the half-full (empty?) glass. Stroke. 2011;42:3369–3375.
26.
go back to reference Romanelli RJ, Schiro TA, Jukes T, Wong KS, Ishisaka DY. Disparities in blood pressure control within a community-based provider network: an exploratory analysis. Ann Pharmacother. 2011;45:1473–82.PubMedCrossRef Romanelli RJ, Schiro TA, Jukes T, Wong KS, Ishisaka DY. Disparities in blood pressure control within a community-based provider network: an exploratory analysis. Ann Pharmacother. 2011;45:1473–82.PubMedCrossRef
27.
go back to reference Joseph JJ, Echouffo-Tcheugui JB, Kalyani RR, Yeh HS, Bertoni AG, Effoe VS, et al. Aldosterone, renin, cardiovascular events, and all-cause mortality among African Americans. The Jackson Heart Study. J Am Coll Cardiol HF. 2017;5:642–651. Joseph JJ, Echouffo-Tcheugui JB, Kalyani RR, Yeh HS, Bertoni AG, Effoe VS, et al. Aldosterone, renin, cardiovascular events, and all-cause mortality among African Americans. The Jackson Heart Study. J Am Coll Cardiol HF. 2017;5:642–651.
28.
go back to reference Boden-Albala, Sacco RL, Lee H-S, et al. Metabolic syndrome and ischemic stroke risk Northern Manhattan Study. Stroke J Cereb Circ. 2008;39(1):30. Boden-Albala, Sacco RL, Lee H-S, et al. Metabolic syndrome and ischemic stroke risk Northern Manhattan Study. Stroke J Cereb Circ. 2008;39(1):30.
29.
go back to reference Mitchell BD, Stern MP, Haffner SM, Hazuda HP, Patterson JK. Risk factors for cardiovascular mortality in Mexican Americans and non-Hispanic Whites. Am J Epidemiol. 1990;131(3):423–33.PubMedCrossRef Mitchell BD, Stern MP, Haffner SM, Hazuda HP, Patterson JK. Risk factors for cardiovascular mortality in Mexican Americans and non-Hispanic Whites. Am J Epidemiol. 1990;131(3):423–33.PubMedCrossRef
30.
go back to reference Mueller M, Purnell TS, Mensah GA, Cooper LA. Reducing racial and ethnic disparities in hypertension prevention and control: what will it take to translate research into practice and policy? Am J Hypertens. 2015;28:699–716.PubMedCrossRef Mueller M, Purnell TS, Mensah GA, Cooper LA. Reducing racial and ethnic disparities in hypertension prevention and control: what will it take to translate research into practice and policy? Am J Hypertens. 2015;28:699–716.PubMedCrossRef
31.
go back to reference Ellis C, Egede LE. Racial/ethnic differences in stroke awareness among veterans. Ethn Dis. 2008;18(2):198–203.PubMed Ellis C, Egede LE. Racial/ethnic differences in stroke awareness among veterans. Ethn Dis. 2008;18(2):198–203.PubMed
33.
go back to reference Martinez M, Prabhakar N, Drake K, et al. Identification of barriers to stroke awareness and risk factor management unique to Hispanics. Int J Environ Res Public Health. 2016;13(1). Martinez M, Prabhakar N, Drake K, et al. Identification of barriers to stroke awareness and risk factor management unique to Hispanics. Int J Environ Res Public Health. 2016;13(1).
34.
go back to reference Charles E, Egede LE. Ethnic disparities in stroke recognition in individuals with prior stroke. Public Health Rep. 2008;123(4):514–22.PubMedCentralCrossRef Charles E, Egede LE. Ethnic disparities in stroke recognition in individuals with prior stroke. Public Health Rep. 2008;123(4):514–22.PubMedCentralCrossRef
35.
go back to reference DuBard CA, Garrett J, Gizlice Z. Effect of language on heart attack and stroke awareness among US Hispanics. Am J Prev Med. 2006;30(3):189–96.PubMedCrossRef DuBard CA, Garrett J, Gizlice Z. Effect of language on heart attack and stroke awareness among US Hispanics. Am J Prev Med. 2006;30(3):189–96.PubMedCrossRef
36.
go back to reference Mochari-Greenberger H, Xian Y, Hellkamp AS, et al. Racial/ethnic and sex differences in emergency medical services transport among hospitalized US stroke patients: analysis of the National Get With The Guideline-Stroke Registry. J Am Heart Assoc. 2015;4(8):e002099.PubMedPubMedCentralCrossRef Mochari-Greenberger H, Xian Y, Hellkamp AS, et al. Racial/ethnic and sex differences in emergency medical services transport among hospitalized US stroke patients: analysis of the National Get With The Guideline-Stroke Registry. J Am Heart Assoc. 2015;4(8):e002099.PubMedPubMedCentralCrossRef
37.
go back to reference Chen FM, Fryer GE, Phillips RL, Wilson E, Pathman DE. Patients’ beliefs about racism, preferences for physician race, and satisfaction with care. Ann Fam Med. 2005;3(2):138–43.PubMedPubMedCentralCrossRef Chen FM, Fryer GE, Phillips RL, Wilson E, Pathman DE. Patients’ beliefs about racism, preferences for physician race, and satisfaction with care. Ann Fam Med. 2005;3(2):138–43.PubMedPubMedCentralCrossRef
38.
go back to reference Karve SJ, Balkrishnan R, Mohammad YM, Levine DA. Racial/ethnic disparities in emergency department waiting time for stroke patients in the United States. J Stroke Cerebrovasc Dis. 2011;20(1):30–40.PubMedCrossRef Karve SJ, Balkrishnan R, Mohammad YM, Levine DA. Racial/ethnic disparities in emergency department waiting time for stroke patients in the United States. J Stroke Cerebrovasc Dis. 2011;20(1):30–40.PubMedCrossRef
39.
go back to reference Reed SD, Cramer SC, Blough DK, Meyer K, Jarvik JG. Treatment with tissue plasminogen activator and inpatient mortality rates for patients with ischemic stroke treated in community hospitals. Stroke. 2001;32(8):1832–40.PubMedCrossRef Reed SD, Cramer SC, Blough DK, Meyer K, Jarvik JG. Treatment with tissue plasminogen activator and inpatient mortality rates for patients with ischemic stroke treated in community hospitals. Stroke. 2001;32(8):1832–40.PubMedCrossRef
40.
go back to reference Johnston SC, Fung LH, Gillum LA, et al. Utilization of intravenous tissue-type plasminogen activator for ischemic stroke at academic medical centers: the influence of ethnicity. Stroke. 2001;32(5):1061–8.PubMedCrossRef Johnston SC, Fung LH, Gillum LA, et al. Utilization of intravenous tissue-type plasminogen activator for ischemic stroke at academic medical centers: the influence of ethnicity. Stroke. 2001;32(5):1061–8.PubMedCrossRef
41.
go back to reference Mendelson SJ, Aggarwal NT, Richards C, O’Neill K, Holl JL, Prabhakaran S. Racial disparities in refusal of stroke thrombolysis in Chicago. Neurology. 2018;90(5):e359–64.PubMedCrossRef Mendelson SJ, Aggarwal NT, Richards C, O’Neill K, Holl JL, Prabhakaran S. Racial disparities in refusal of stroke thrombolysis in Chicago. Neurology. 2018;90(5):e359–64.PubMedCrossRef
42.
go back to reference Saver JL, Goyal M, van der Lugt A, Menon BK, Majoe CB, Dippel DW, et al. Time to treatment with endovascular thrombectomy and outcomes from ischemic stroke: a meta-analysis. JAMA. 2016;316:1279–88.PubMedCrossRef Saver JL, Goyal M, van der Lugt A, Menon BK, Majoe CB, Dippel DW, et al. Time to treatment with endovascular thrombectomy and outcomes from ischemic stroke: a meta-analysis. JAMA. 2016;316:1279–88.PubMedCrossRef
43.
go back to reference Tatlisumak T. Implication of the recent positive endovascular intervention trials for organizing acute stroke care: European perspective. Stroke. 2015;46:1468–73.PubMedCrossRef Tatlisumak T. Implication of the recent positive endovascular intervention trials for organizing acute stroke care: European perspective. Stroke. 2015;46:1468–73.PubMedCrossRef
44.
go back to reference Rinaldo L, Rabinstein AA, Cloft H, Knudsen J, Castilla LR, Brinkikji W. Racial and ethnic disparities in the utilization of thrombectomy for acute stroke. Stroke. 2019;50(9):2428–32.PubMedCrossRef Rinaldo L, Rabinstein AA, Cloft H, Knudsen J, Castilla LR, Brinkikji W. Racial and ethnic disparities in the utilization of thrombectomy for acute stroke. Stroke. 2019;50(9):2428–32.PubMedCrossRef
45.
go back to reference Esenwa C, Lekoubou A, Bishu KG, Small K, Liberman A, Ovbiagele B. Racial differences in mechanical thrombectomy utilization for ischemic stroke in the United States. Ethn Dis. 2020;30(1):91–96. Compared with non-Hispanic Whites (NHWs), racial-ethnic minorities bear a disproportionate burden of stroke but receive fewer evidence-based stroke care processes and treatments. This study highlights profound disparity among African Americans who are 33% less likely to receive mechanical thrombectomy compared with NHWs. Esenwa C, Lekoubou A, Bishu KG, Small K, Liberman A, Ovbiagele B. Racial differences in mechanical thrombectomy utilization for ischemic stroke in the United States. Ethn Dis. 2020;30(1):91–96. Compared with non-Hispanic Whites (NHWs), racial-ethnic minorities bear a disproportionate burden of stroke but receive fewer evidence-based stroke care processes and treatments. This study highlights profound disparity among African Americans who are 33% less likely to receive mechanical thrombectomy compared with NHWs.
46.
go back to reference Levine DA, Galecki AT, Langa KM, Unverzagt FW, Kabeto MU, Giordani B, et al. Trajectory of cognitive decline after incident stroke. JAMA. 2015;314:41–51. Levine DA, Galecki AT, Langa KM, Unverzagt FW, Kabeto MU, Giordani B, et al. Trajectory of cognitive decline after incident stroke. JAMA. 2015;314:41–51.
47.
go back to reference Walker R, Whiting D, Unwin N, Mugusi F, Swai M, Aris E, et al. Stroke incidence in rural & urban Tanzania: a prospective, community-based study. Lancet Neurol. 2010;9:786–92.PubMedCrossRef Walker R, Whiting D, Unwin N, Mugusi F, Swai M, Aris E, et al. Stroke incidence in rural & urban Tanzania: a prospective, community-based study. Lancet Neurol. 2010;9:786–92.PubMedCrossRef
48.
go back to reference Ezejimofor MC, Uthman OA, Maduka O, Ezeabasili AC, Onwuchekwa AC, Ezejimofor BC, et al. Stroke survivors in Nigeria: a door-to-door prevalence survey from the Niger Delta region. J Neurol Sci. 2017;372:262–9.PubMedCrossRef Ezejimofor MC, Uthman OA, Maduka O, Ezeabasili AC, Onwuchekwa AC, Ezejimofor BC, et al. Stroke survivors in Nigeria: a door-to-door prevalence survey from the Niger Delta region. J Neurol Sci. 2017;372:262–9.PubMedCrossRef
49.
go back to reference Sarfo FS, Akassi J, Awuah D, Adamu S, Nkyi C, Owolabi M, Ovbiagele B. Trends in stroke admission and mortality rates from 1983 to 2013 in central Ghana. J Neurol Sci. 2015;357(1–2):240–5.PubMedCrossRef Sarfo FS, Akassi J, Awuah D, Adamu S, Nkyi C, Owolabi M, Ovbiagele B. Trends in stroke admission and mortality rates from 1983 to 2013 in central Ghana. J Neurol Sci. 2015;357(1–2):240–5.PubMedCrossRef
50.
go back to reference Walker RW, Jusabani A, Aris E, et al. Post-stroke case fatality within an incident population in rural Tanzania. J Neurol Neurosurg Psychiatry. 2011;82(9):1001–5.PubMedCrossRef Walker RW, Jusabani A, Aris E, et al. Post-stroke case fatality within an incident population in rural Tanzania. J Neurol Neurosurg Psychiatry. 2011;82(9):1001–5.PubMedCrossRef
51.
go back to reference Owolabi MO, Akarolo-Anthony S, Akinyemi R, Arnett D, Gebregziabher M, Jenkins C, et al. The burden of stroke in Africa: a glance at the present & a glimpse into the future. Cardiovasc J Afr. 2015;26:S27-38.PubMedPubMedCentralCrossRef Owolabi MO, Akarolo-Anthony S, Akinyemi R, Arnett D, Gebregziabher M, Jenkins C, et al. The burden of stroke in Africa: a glance at the present & a glimpse into the future. Cardiovasc J Afr. 2015;26:S27-38.PubMedPubMedCentralCrossRef
52.
go back to reference Ojagbemi A, Akpa O, Elugbadebo F, Owolabi M, Ovbiagele B. Depression after stroke in sub-Saharan Africa: a systematic review & meta-analysis. Behav Neurol. 2017;2017:4160259.PubMedPubMedCentral Ojagbemi A, Akpa O, Elugbadebo F, Owolabi M, Ovbiagele B. Depression after stroke in sub-Saharan Africa: a systematic review & meta-analysis. Behav Neurol. 2017;2017:4160259.PubMedPubMedCentral
53.
go back to reference Sarfo FS, Akassi J, Adamu S, Obese V, Ovbiagele B. Burden & predictors of poststroke cognitive impairment in a sample of Ghanaian stroke survivors. J Stroke Cerebrovasc Dis. 2017;26:2553–62.PubMedPubMedCentralCrossRef Sarfo FS, Akassi J, Adamu S, Obese V, Ovbiagele B. Burden & predictors of poststroke cognitive impairment in a sample of Ghanaian stroke survivors. J Stroke Cerebrovasc Dis. 2017;26:2553–62.PubMedPubMedCentralCrossRef
54.
go back to reference Owolabi M, Sarfo F, Howard VJ, Irvin MR, Gebregziabher M, Akinyemi R, et al. Stroke in indigenous Africans, African Americans, & European Americans: interplay of racial & geographic factors. Stroke. 2017;48:1169–75.PubMedPubMedCentralCrossRef Owolabi M, Sarfo F, Howard VJ, Irvin MR, Gebregziabher M, Akinyemi R, et al. Stroke in indigenous Africans, African Americans, & European Americans: interplay of racial & geographic factors. Stroke. 2017;48:1169–75.PubMedPubMedCentralCrossRef
55.
go back to reference Owolabi MO, Sarfo FS, Akinyemi R, Gebregziabher M, Akpa O, Akpalu A, et al. Dominant modifiable risk factors for stroke in Ghana and Nigeria (SIREN): a case-control study. Lancet Glob Health. 2018;6(4):e436–46.PubMedPubMedCentralCrossRef Owolabi MO, Sarfo FS, Akinyemi R, Gebregziabher M, Akpa O, Akpalu A, et al. Dominant modifiable risk factors for stroke in Ghana and Nigeria (SIREN): a case-control study. Lancet Glob Health. 2018;6(4):e436–46.PubMedPubMedCentralCrossRef
56.
go back to reference Sarfo FS, Ovbiagele B, Gebregziabher M, Akpa O, Akpalu A, Wahab K, et al. SIREN. Unravelling the risk factors for spontaneous intracerebral hemorrhage among West Africans. Neurology. 2020;94(10):e998–e1012. Sarfo FS, Ovbiagele B, Gebregziabher M, Akpa O, Akpalu A, Wahab K, et al. SIREN. Unravelling the risk factors for spontaneous intracerebral hemorrhage among West Africans. Neurology. 2020;94(10):e998–e1012.
57.
go back to reference Sarfo FS, Ovbiagele B, Gebregziabher M, Wahab K, Akinyemi R, Akpalu A, et al. Stroke among young West Africans: evidence from the SIREN (Stroke Investigative Research and Educational Network) large multisite case-control study. Stroke. 2018;49(5):1116–22.PubMedPubMedCentralCrossRef Sarfo FS, Ovbiagele B, Gebregziabher M, Wahab K, Akinyemi R, Akpalu A, et al. Stroke among young West Africans: evidence from the SIREN (Stroke Investigative Research and Educational Network) large multisite case-control study. Stroke. 2018;49(5):1116–22.PubMedPubMedCentralCrossRef
58.
go back to reference Sarfo FS, Akpa O, Ovbiagele B, Akpalu A, Wahab K, Komolafe M, et al. SIREN. Influence of age on links between major modifiable risk factors and stroke occurrence in West Africans. J Neurol Sci. 2021;428:117573. Sarfo FS, Akpa O, Ovbiagele B, Akpalu A, Wahab K, Komolafe M, et al. SIREN. Influence of age on links between major modifiable risk factors and stroke occurrence in West Africans. J Neurol Sci. 2021;428:117573.
59.
go back to reference Woodward EN, Matthieu MM, Uchendu US, Rogal S, Kirchner JE. The health equity implementation framework: proposal and preliminary study of hepatitis C virus treatment. Implement Sci. 2019; 14:1–18. The HEIF demonstrates a useful approach to modifying an implementation framework to better evaluate health equity determinants with potential implications for cerebrovascular disorders. Woodward EN, Matthieu MM, Uchendu US, Rogal S, Kirchner JE. The health equity implementation framework: proposal and preliminary study of hepatitis C virus treatment. Implement Sci. 2019; 14:1–18. The HEIF demonstrates a useful approach to modifying an implementation framework to better evaluate health equity determinants with potential implications for cerebrovascular disorders.
60.
go back to reference Galaviz KI, Breland JY, Sanders M, Breathett K, Cerezo A, Gil O, et al. Implementation science to address health disparities during the coronavirus pandemic. Health Equity. 2020;4:463–7.PubMedPubMedCentralCrossRef Galaviz KI, Breland JY, Sanders M, Breathett K, Cerezo A, Gil O, et al. Implementation science to address health disparities during the coronavirus pandemic. Health Equity. 2020;4:463–7.PubMedPubMedCentralCrossRef
61.
go back to reference McLeroy KR, Bibeau D, Steckler A, Glanz K. An ecological perspective on health promotion programs. Health Educ Q. 1988;15:351–77.PubMedCrossRef McLeroy KR, Bibeau D, Steckler A, Glanz K. An ecological perspective on health promotion programs. Health Educ Q. 1988;15:351–77.PubMedCrossRef
65.
go back to reference Magnani JW, Mujahid MS, Aronow HD, Cene CW, Dickson VV, Havranek E, et al. Health literacy and cardiovascular disease: fundamental relevance to primary and secondary prevention: a scientific statement from the American Heart Association. Circulation. 2018;138:e48–74.PubMedPubMedCentralCrossRef Magnani JW, Mujahid MS, Aronow HD, Cene CW, Dickson VV, Havranek E, et al. Health literacy and cardiovascular disease: fundamental relevance to primary and secondary prevention: a scientific statement from the American Heart Association. Circulation. 2018;138:e48–74.PubMedPubMedCentralCrossRef
66.
go back to reference Smolderen KG, Spertus JA, Tang F, Oetgen W, Borden WB, Ting HH, et al. Treatment differences by health insurance among outpatients with coronary artery disease: insights from the national cardiovascular data registry. J Am Coll Cardiol. 2013;61:1069–75.PubMedPubMedCentralCrossRef Smolderen KG, Spertus JA, Tang F, Oetgen W, Borden WB, Ting HH, et al. Treatment differences by health insurance among outpatients with coronary artery disease: insights from the national cardiovascular data registry. J Am Coll Cardiol. 2013;61:1069–75.PubMedPubMedCentralCrossRef
67.
go back to reference John-Baptiste A, Naglie G, Tomlinson G, Alibhai SM, Etchells E, Cheung A, et al. The effect of English language proficiency on length of stay and in-hospital mortality. J Gen Intern Med. 2004;19:221–8.PubMedPubMedCentralCrossRef John-Baptiste A, Naglie G, Tomlinson G, Alibhai SM, Etchells E, Cheung A, et al. The effect of English language proficiency on length of stay and in-hospital mortality. J Gen Intern Med. 2004;19:221–8.PubMedPubMedCentralCrossRef
68.
go back to reference Shah BR, Khan NA, O’Donnel MJ, Kapral MK. Impact of language barriers on stroke care and outcomes. Stroke. 2015;46:813–8.PubMedCrossRef Shah BR, Khan NA, O’Donnel MJ, Kapral MK. Impact of language barriers on stroke care and outcomes. Stroke. 2015;46:813–8.PubMedCrossRef
69.
go back to reference Panza GA, Puhl RM, Taylor BA, Zaleski AL, Livingston J, Pescatello LS. Links between discrimination and cardiovascular health among socially stigmatized groups: a systematic review. PLoS One. 2019;14(6):e0217623.PubMedPubMedCentralCrossRef Panza GA, Puhl RM, Taylor BA, Zaleski AL, Livingston J, Pescatello LS. Links between discrimination and cardiovascular health among socially stigmatized groups: a systematic review. PLoS One. 2019;14(6):e0217623.PubMedPubMedCentralCrossRef
70.
go back to reference Lewey J, Shrank WH, Bowry AD, Kilabuk E, Brennan TA, Choudhry NK. Gender and racial disparities in adherence to statin therapy: a meta-analysis. Am Heart J. 2013;165:665–78.PubMedCrossRef Lewey J, Shrank WH, Bowry AD, Kilabuk E, Brennan TA, Choudhry NK. Gender and racial disparities in adherence to statin therapy: a meta-analysis. Am Heart J. 2013;165:665–78.PubMedCrossRef
71.
go back to reference Roth GA, Johnson CO, Abate KH, Abd-Allah F, Ahmed M, Alam K, et al. The burden of cardiovascular diseases among US states, 1990–2016. JAMA Cardiol. 2018;3:375–89.PubMedPubMedCentralCrossRef Roth GA, Johnson CO, Abate KH, Abd-Allah F, Ahmed M, Alam K, et al. The burden of cardiovascular diseases among US states, 1990–2016. JAMA Cardiol. 2018;3:375–89.PubMedPubMedCentralCrossRef
72.
73.
go back to reference Lewis LM, Askie P, Randleman S, Shelton-Dunston B. Medication adherence beliefs of community-dwelling hypertensive African Americans. J Cardiovasc Nurs. 2010;25:199–206.PubMedCrossRef Lewis LM, Askie P, Randleman S, Shelton-Dunston B. Medication adherence beliefs of community-dwelling hypertensive African Americans. J Cardiovasc Nurs. 2010;25:199–206.PubMedCrossRef
74.
go back to reference Chan PS, Nichol G, Krumholz HM, Spertus JA, Jones PG, Peterson ED, et al. American Heart Association national registry of cardiopulmonary resuscitation (NRCPR) investigators. Racial differences in survival after in-hospital cardiac arrest. JAMA. 2009;302:1195–1201. Chan PS, Nichol G, Krumholz HM, Spertus JA, Jones PG, Peterson ED, et al. American Heart Association national registry of cardiopulmonary resuscitation (NRCPR) investigators. Racial differences in survival after in-hospital cardiac arrest. JAMA. 2009;302:1195–1201.
75.
go back to reference Cené CW, Roter D, Carson KA, Miller ER 3rd, Cooper LA. The effect of patient race and blood pressure control on patient-physician communication. J Gen Intern Med. 2009;24:1057–64.PubMedPubMedCentralCrossRef Cené CW, Roter D, Carson KA, Miller ER 3rd, Cooper LA. The effect of patient race and blood pressure control on patient-physician communication. J Gen Intern Med. 2009;24:1057–64.PubMedPubMedCentralCrossRef
76.
go back to reference Benjamins MR. Race/ethnic discrimination and preventive service utilization in a sample of whites, blacks, Mexicans, and Puerto Ricans. Med Care. 2012;50:870–6.PubMedCrossRef Benjamins MR. Race/ethnic discrimination and preventive service utilization in a sample of whites, blacks, Mexicans, and Puerto Ricans. Med Care. 2012;50:870–6.PubMedCrossRef
77.
go back to reference Karve AM, Ou FS, Lytle BL, Peterson ED. Potential unintended financial consequences of pay-for-performance on the quality of care for minority patients. Am Heart J. 2008;155:571–6.PubMedCrossRef Karve AM, Ou FS, Lytle BL, Peterson ED. Potential unintended financial consequences of pay-for-performance on the quality of care for minority patients. Am Heart J. 2008;155:571–6.PubMedCrossRef
78.
go back to reference Lee JT, Netuveli G, Majeed A, Millett C. The effects of pay for performance on disparities in stroke, hypertension, and coronary heart disease management: interrupted time series study. PLoS One. 2011;6:e27236.PubMedPubMedCentralCrossRef Lee JT, Netuveli G, Majeed A, Millett C. The effects of pay for performance on disparities in stroke, hypertension, and coronary heart disease management: interrupted time series study. PLoS One. 2011;6:e27236.PubMedPubMedCentralCrossRef
79.
go back to reference Mueller M, Purnell TS, Mensah GA, Cooper LA. Reducing racial and ethnic disparities in hypertension prevention and control: what will it take to translate research into practice and policy? Am J Hypertens. 2015;28:699–716.PubMedCrossRef Mueller M, Purnell TS, Mensah GA, Cooper LA. Reducing racial and ethnic disparities in hypertension prevention and control: what will it take to translate research into practice and policy? Am J Hypertens. 2015;28:699–716.PubMedCrossRef
80.
go back to reference Damschroder LJ, Aron DC, Keith RE, Kirsh SR, Alexander JA, Lowery JC. Fostering implementation of health services research findings into practice: a consolidated framework for advancing implementation science. Implement Sci. 2009;4:50.PubMedPubMedCentralCrossRef Damschroder LJ, Aron DC, Keith RE, Kirsh SR, Alexander JA, Lowery JC. Fostering implementation of health services research findings into practice: a consolidated framework for advancing implementation science. Implement Sci. 2009;4:50.PubMedPubMedCentralCrossRef
81.
go back to reference Glasgow RE, Vogt TM, Boles SM. Evaluating the public health impact of health promotion interventions: the RE-AIM framework. Am J Public Health. 1999;89:1322–7.PubMedPubMedCentralCrossRef Glasgow RE, Vogt TM, Boles SM. Evaluating the public health impact of health promotion interventions: the RE-AIM framework. Am J Public Health. 1999;89:1322–7.PubMedPubMedCentralCrossRef
82.
go back to reference Kitson AL, Rycroft-Malone J, Harvey G, McCormack B, Seers K, Titchen A. Evaluating the successful implementation of evidence into practice using the PARiHS framework: theoretical and practical challenges. Implement Sci. 2008;3:1.PubMedPubMedCentralCrossRef Kitson AL, Rycroft-Malone J, Harvey G, McCormack B, Seers K, Titchen A. Evaluating the successful implementation of evidence into practice using the PARiHS framework: theoretical and practical challenges. Implement Sci. 2008;3:1.PubMedPubMedCentralCrossRef
83.
go back to reference Eslava-Schmalbach J, Garzón-Orjuela N, Elias V, Reveiz L, Tran N, Langlois EV. Conceptual framework of equity-focused implementation research for health programs (EquIR). Int J Equity Health. 2019;18:80.PubMedPubMedCentralCrossRef Eslava-Schmalbach J, Garzón-Orjuela N, Elias V, Reveiz L, Tran N, Langlois EV. Conceptual framework of equity-focused implementation research for health programs (EquIR). Int J Equity Health. 2019;18:80.PubMedPubMedCentralCrossRef
84.
go back to reference Curran GM, Bauer M, Mittman B, Pyne JM, Stetler C. Effectiveness-implementation hybrid designs: combining elements of clinical effectiveness and implementation research to enhance public health impact. Med Care. 2012;50:217–26.PubMedPubMedCentralCrossRef Curran GM, Bauer M, Mittman B, Pyne JM, Stetler C. Effectiveness-implementation hybrid designs: combining elements of clinical effectiveness and implementation research to enhance public health impact. Med Care. 2012;50:217–26.PubMedPubMedCentralCrossRef
85.
go back to reference Lyon AR, Koerner K. User-centered design for psychosocial intervention development and implementation. Clin Psychol (New York). 2016;23:180–200.PubMedPubMedCentral Lyon AR, Koerner K. User-centered design for psychosocial intervention development and implementation. Clin Psychol (New York). 2016;23:180–200.PubMedPubMedCentral
86.
go back to reference Israel BA, Schulz AJ, Parker EA, Becker AB. Review of community-based re-search: assessing partnership approaches to improve public health. Annu Rev Public Health. 1998;19:173–202.PubMedCrossRef Israel BA, Schulz AJ, Parker EA, Becker AB. Review of community-based re-search: assessing partnership approaches to improve public health. Annu Rev Public Health. 1998;19:173–202.PubMedCrossRef
87.
go back to reference Mensah GA, Engelgau M, Stoney C, Mishoe H, Kaufmann P, Freemer M, Fine L; Trans-NHLBI T4 Translation Research Work Groups. News from NIH: a center for translation research and implementation science. Transl Behav Med. 2015;5:127–130. Mensah GA, Engelgau M, Stoney C, Mishoe H, Kaufmann P, Freemer M, Fine L; Trans-NHLBI T4 Translation Research Work Groups. News from NIH: a center for translation research and implementation science. Transl Behav Med. 2015;5:127–130.
88.
go back to reference Curran GM, Bauer M, Mittman B, Pyne JM, Stetler C. Effectiveness-implementation hybrid designs: combining elements of clinical effectiveness and implementation research to enhance public health impact. Med Care. 2012;50:217–26.PubMedPubMedCentralCrossRef Curran GM, Bauer M, Mittman B, Pyne JM, Stetler C. Effectiveness-implementation hybrid designs: combining elements of clinical effectiveness and implementation research to enhance public health impact. Med Care. 2012;50:217–26.PubMedPubMedCentralCrossRef
90.
go back to reference Powell BJ, Waltz TJ, Chinman MJ, Damschroder L, Smith JL, Matthieu MM, et al. A refined compilation of implementation strategies: results from the Expert Recommendations for Implementing Change (ERIC) project. Implement Sci. 2015;10:21.PubMedPubMedCentralCrossRef Powell BJ, Waltz TJ, Chinman MJ, Damschroder L, Smith JL, Matthieu MM, et al. A refined compilation of implementation strategies: results from the Expert Recommendations for Implementing Change (ERIC) project. Implement Sci. 2015;10:21.PubMedPubMedCentralCrossRef
91.
go back to reference Dover DC, Belon AP. The health equity framework: a comprehensive model to measure social inequities in health. Int J Equity Health. 2019; 18:36. The HEMF merges constructs from the social determinants of health for measuring health equity indicators which may be applicable for addressing cerebrovascular disease inequities. Dover DC, Belon AP. The health equity framework: a comprehensive model to measure social inequities in health. Int J Equity Health. 2019; 18:36. The HEMF merges constructs from the social determinants of health for measuring health equity indicators which may be applicable for addressing cerebrovascular disease inequities.
92.
go back to reference Sarfo F, Treiber F, Gebregziabher M, Adamu S, Patel S, Nichols M, et al. PINGS (phone-based intervention under nurse guidance after stroke): results of a pilot randomized controlled trial. Stroke. 2018;49(1):236–9.PubMedCrossRef Sarfo F, Treiber F, Gebregziabher M, Adamu S, Patel S, Nichols M, et al. PINGS (phone-based intervention under nurse guidance after stroke): results of a pilot randomized controlled trial. Stroke. 2018;49(1):236–9.PubMedCrossRef
93.
go back to reference Sarfo FS, Treiber F, Gebregziabher M, Adamu S, Nichols M, Singh A, et al. Phone-based intervention for blood pressure control among Ghanaian stroke survivors: a pilot randomized controlled trial. Int J Stroke. 2019;14(6):630–8.PubMedCrossRef Sarfo FS, Treiber F, Gebregziabher M, Adamu S, Nichols M, Singh A, et al. Phone-based intervention for blood pressure control among Ghanaian stroke survivors: a pilot randomized controlled trial. Int J Stroke. 2019;14(6):630–8.PubMedCrossRef
94.
go back to reference Nichols M, Sarfo FS, Singh A, Qanungo S, Treiber F, Ovbiagele B, Saulson R, et al. Assessing mobile health capacity and task shifting strategies to improve hypertension among Ghanaian stroke survivors. Am J Med Sci. 2017;354(6):573–80.PubMedPubMedCentralCrossRef Nichols M, Sarfo FS, Singh A, Qanungo S, Treiber F, Ovbiagele B, Saulson R, et al. Assessing mobile health capacity and task shifting strategies to improve hypertension among Ghanaian stroke survivors. Am J Med Sci. 2017;354(6):573–80.PubMedPubMedCentralCrossRef
95.
go back to reference Sarfo FS, Akpalu A, Bockarie A, Appiah L, Nguah SB, Ayisi-Boateng NK, et al. Phone-based intervention under nurse guidance after stroke (PINGS II) study: protocol for a phase III randomized clinical trial. J Stroke Cerebrovasc Dis. 2021; 30(8):105888. One of the few on-going clinical trials in Africa with a hybrid design to measure implementation outcomes. Sarfo FS, Akpalu A, Bockarie A, Appiah L, Nguah SB, Ayisi-Boateng NK, et al. Phone-based intervention under nurse guidance after stroke (PINGS II) study: protocol for a phase III randomized clinical trial. J Stroke Cerebrovasc Dis. 2021; 30(8):105888. One of the few on-going clinical trials in Africa with a hybrid design to measure implementation outcomes.
96.
go back to reference Hunter RM, Davie C, Rudd A, et al. Impact on clinical and cost outcomes of a centralized approach to acute stroke care in London: a comparative effectiveness before and after model. PLoS One. 2013;8(8). Hunter RM, Davie C, Rudd A, et al. Impact on clinical and cost outcomes of a centralized approach to acute stroke care in London: a comparative effectiveness before and after model. PLoS One. 2013;8(8).
Metadata
Title
Utilizing Implementation Science to Bridge Cerebrovascular Health Disparities: a Local to Global Perspective
Authors
Fred Stephen Sarfo
Bruce Ovbiagele
Publication date
01-05-2022
Publisher
Springer US
Keyword
Stroke
Published in
Current Neurology and Neuroscience Reports / Issue 5/2022
Print ISSN: 1528-4042
Electronic ISSN: 1534-6293
DOI
https://doi.org/10.1007/s11910-022-01193-8