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Published in: Current Neurology and Neuroscience Reports 9/2016

01-09-2016 | Critical Care (SA Mayer, Section Editor)

ICU Management of the Potential Organ Donor: State of the Art

Authors: Carolina B. Maciel, David M. Greer

Published in: Current Neurology and Neuroscience Reports | Issue 9/2016

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Abstract

End-organ failure is associated with high mortality and morbidity, in addition to increased health care costs. Organ transplantation is the only definitive treatment that can improve survival and quality of life in such patients; however, due to the persistent mismatch between organ supply and demand, waiting lists continue to grow across the world. Careful intensive care management of the potential organ donor with goal-directed therapy has the potential to optimize organ function and improve donation yield.
Literature
2.
go back to reference Wolfe RA et al. Comparison of mortality in all patients on dialysis, patients on dialysis awaiting transplantation, and recipients of a first cadaveric transplant. N Engl J Med. 1999;341(23):1725–30.CrossRefPubMed Wolfe RA et al. Comparison of mortality in all patients on dialysis, patients on dialysis awaiting transplantation, and recipients of a first cadaveric transplant. N Engl J Med. 1999;341(23):1725–30.CrossRefPubMed
4.
go back to reference Cleiren MP, Van Zoelen AA. Post-mortem organ donation and grief: a study of consent, refusal and well-being in bereavement. Death Stud. 2002;26(10):837–49.CrossRefPubMed Cleiren MP, Van Zoelen AA. Post-mortem organ donation and grief: a study of consent, refusal and well-being in bereavement. Death Stud. 2002;26(10):837–49.CrossRefPubMed
5.
go back to reference Merchant SJ et al. Exploring the psychological effects of deceased organ donation on the families of the organ donors. Clin Transplant. 2008;22(3):341–7.CrossRefPubMed Merchant SJ et al. Exploring the psychological effects of deceased organ donation on the families of the organ donors. Clin Transplant. 2008;22(3):341–7.CrossRefPubMed
6.
go back to reference Angel LFLF. Impact of a lung transplantation donor-management protocol on lung donation and recipient outcomes. Am J Respir Crit Care Med. 2006;174(6):710–6.CrossRefPubMed Angel LFLF. Impact of a lung transplantation donor-management protocol on lung donation and recipient outcomes. Am J Respir Crit Care Med. 2006;174(6):710–6.CrossRefPubMed
7.
go back to reference Salim AA. The effect of a protocol of aggressive donor management: implications for the national organ donor shortage. J Trauma: Inj Infect Crit Care. 2006;61(2):429–35.CrossRef Salim AA. The effect of a protocol of aggressive donor management: implications for the national organ donor shortage. J Trauma: Inj Infect Crit Care. 2006;61(2):429–35.CrossRef
8.
go back to reference Singbartl KK. Intensivist-led management of brain-dead donors is associated with an increase in organ recovery for transplantation. Am J Transplant. 2011;11(7):1517–21.CrossRefPubMed Singbartl KK. Intensivist-led management of brain-dead donors is associated with an increase in organ recovery for transplantation. Am J Transplant. 2011;11(7):1517–21.CrossRefPubMed
9.
go back to reference Malinoski DJ et al. The impact of meeting donor management goals on the number of organs transplanted per donor: results from the United Network for Organ Sharing Region 5 prospective donor management goals study. Crit Care Med. 2012;40(10):2773–80.CrossRefPubMed Malinoski DJ et al. The impact of meeting donor management goals on the number of organs transplanted per donor: results from the United Network for Organ Sharing Region 5 prospective donor management goals study. Crit Care Med. 2012;40(10):2773–80.CrossRefPubMed
10.
go back to reference Callahan DS et al. Trends in organ donor management: 2002 to 2012. J Am Coll Surg. 2014;219(4):752–6.CrossRefPubMed Callahan DS et al. Trends in organ donor management: 2002 to 2012. J Am Coll Surg. 2014;219(4):752–6.CrossRefPubMed
11.
go back to reference Abuanzeh RR. Early donor management increases the retrieval rate of hearts for transplantation in marginal donors. Eur J Cardiothorac Surg. 2015;47(1):72–7.CrossRefPubMed Abuanzeh RR. Early donor management increases the retrieval rate of hearts for transplantation in marginal donors. Eur J Cardiothorac Surg. 2015;47(1):72–7.CrossRefPubMed
12.
go back to reference Patel MS et al. The impact of meeting donor management goals on the number of organs transplanted per expanded criteria donor: a prospective study from the UNOS Region 5 Donor Management Goals Workgroup. JAMA Surg. 2014;149(9):969–75.CrossRefPubMed Patel MS et al. The impact of meeting donor management goals on the number of organs transplanted per expanded criteria donor: a prospective study from the UNOS Region 5 Donor Management Goals Workgroup. JAMA Surg. 2014;149(9):969–75.CrossRefPubMed
13.
go back to reference Healthcare, E.D.f.t.Q.o.M. International figures on donation and transplantation 2014. 2014. Healthcare, E.D.f.t.Q.o.M. International figures on donation and transplantation 2014. 2014.
14.
go back to reference E. Committee. Recommendations for nonheartbeating organ donation. A position paper by the Ethics Committee, American College of Critical Care Medicine, Society of Critical Care Medicine. Crit Care Med. 2001;29(9):1826–31.CrossRef E. Committee. Recommendations for nonheartbeating organ donation. A position paper by the Ethics Committee, American College of Critical Care Medicine, Society of Critical Care Medicine. Crit Care Med. 2001;29(9):1826–31.CrossRef
16.
go back to reference M. Consultants. Guidelines for the determination of death. Report of the medical consultants on the diagnosis of death to the President’s Commission for the Study of Ethical Problems in Medicine and Biomedical and Behavioral Research. JAMA. 1981;246(19):2184–6.CrossRef M. Consultants. Guidelines for the determination of death. Report of the medical consultants on the diagnosis of death to the President’s Commission for the Study of Ethical Problems in Medicine and Biomedical and Behavioral Research. JAMA. 1981;246(19):2184–6.CrossRef
17.
18.•
go back to reference Shemie SD et al. International guideline development for the determination of death. Intensive Care Med. 2014;40(6):788–97. Of importance: First international initiative deriving international standards for death determination. CrossRefPubMedPubMedCentral Shemie SD et al. International guideline development for the determination of death. Intensive Care Med. 2014;40(6):788–97. Of importance: First international initiative deriving international standards for death determination. CrossRefPubMedPubMedCentral
19.
go back to reference Bernat JLJL. The circulatory-respiratory determination of death in organ donation. Crit Care Med. 2010;38(3):963–70.CrossRefPubMed Bernat JLJL. The circulatory-respiratory determination of death in organ donation. Crit Care Med. 2010;38(3):963–70.CrossRefPubMed
20.
go back to reference Munshi L, Keshavjee S, Cypel M. Donor management and lung preservation for lung transplantation. Lancet Respir Med. 2013;1(4):318–28.CrossRefPubMed Munshi L, Keshavjee S, Cypel M. Donor management and lung preservation for lung transplantation. Lancet Respir Med. 2013;1(4):318–28.CrossRefPubMed
21.
go back to reference Bendorf A et al. An international comparison of the effect of policy shifts to organ donation following cardiocirculatory death (DCD) on donation rates after brain death (DBD) and transplantation rates. PLoS One. 2013;8(5), e62010.CrossRefPubMedPubMedCentral Bendorf A et al. An international comparison of the effect of policy shifts to organ donation following cardiocirculatory death (DCD) on donation rates after brain death (DBD) and transplantation rates. PLoS One. 2013;8(5), e62010.CrossRefPubMedPubMedCentral
22.
go back to reference Blackstock MJ, Ray DC. Organ donation after circulatory death: an update. Eur J Emerg Med. 2014;21(5):324–9.CrossRefPubMed Blackstock MJ, Ray DC. Organ donation after circulatory death: an update. Eur J Emerg Med. 2014;21(5):324–9.CrossRefPubMed
23.
go back to reference Kootstra GG. Categories of non-heart-beating donors. Transplant Proc. 1995;27(5):2893.PubMed Kootstra GG. Categories of non-heart-beating donors. Transplant Proc. 1995;27(5):2893.PubMed
25.
go back to reference Fugate JE et al. Variability in donation after cardiac death protocols: a national survey. Transplantation. 2011;91(4):386–9.PubMed Fugate JE et al. Variability in donation after cardiac death protocols: a national survey. Transplantation. 2011;91(4):386–9.PubMed
26.
go back to reference Medicine, I.o., Non-heart-beating organ transplantation: medical and ethical issues in procurement, in non-heart-beating organ transplantation: medical and ethical issues in procurement. 1997, 1997 by the National Academy of Sciences: Washington, DC. Medicine, I.o., Non-heart-beating organ transplantation: medical and ethical issues in procurement, in non-heart-beating organ transplantation: medical and ethical issues in procurement. 1997, 1997 by the National Academy of Sciences: Washington, DC.
27.
go back to reference Sheth KN et al. Autoresuscitation after asystole in patients being considered for organ donation. Crit Care Med. 2012;40(1):158–61.CrossRefPubMed Sheth KN et al. Autoresuscitation after asystole in patients being considered for organ donation. Crit Care Med. 2012;40(1):158–61.CrossRefPubMed
28.
go back to reference Bernat JL et al. Report of a National Conference on Donation after cardiac death. Am J Transplant. 2006;6(2):281–91.CrossRefPubMed Bernat JL et al. Report of a National Conference on Donation after cardiac death. Am J Transplant. 2006;6(2):281–91.CrossRefPubMed
29.
go back to reference Lewis J et al. Development of the University of Wisconsin donation After Cardiac Death Evaluation Tool. Prog Transplant. 2003;13(4):265–73.CrossRefPubMed Lewis J et al. Development of the University of Wisconsin donation After Cardiac Death Evaluation Tool. Prog Transplant. 2003;13(4):265–73.CrossRefPubMed
30.
go back to reference DeVita MA et al. Donors after cardiac death: validation of identification criteria (DVIC) study for predictors of rapid death. Am J Transplant. 2008;8(2):432–41.CrossRefPubMed DeVita MA et al. Donors after cardiac death: validation of identification criteria (DVIC) study for predictors of rapid death. Am J Transplant. 2008;8(2):432–41.CrossRefPubMed
31.
go back to reference Yee AH et al. Factors influencing time to death after withdrawal of life support in neurocritical patients. Neurology. 2010;74(17):1380–5.CrossRefPubMed Yee AH et al. Factors influencing time to death after withdrawal of life support in neurocritical patients. Neurology. 2010;74(17):1380–5.CrossRefPubMed
32.
go back to reference Rabinstein AA et al. Prediction of potential for organ donation after cardiac death in patients in neurocritical state: a prospective observational study. Lancet Neurol. 2012;11(5):414–9.CrossRefPubMed Rabinstein AA et al. Prediction of potential for organ donation after cardiac death in patients in neurocritical state: a prospective observational study. Lancet Neurol. 2012;11(5):414–9.CrossRefPubMed
33.
go back to reference de Groot YJ et al. External validation of a prognostic model predicting time of death after withdrawal of life support in neurocritical patients. Crit Care Med. 2012;40(1):233–8.CrossRefPubMed de Groot YJ et al. External validation of a prognostic model predicting time of death after withdrawal of life support in neurocritical patients. Crit Care Med. 2012;40(1):233–8.CrossRefPubMed
34.•
go back to reference He X et al. Nomogram for predicting time to death after withdrawal of life-sustaining treatment in patients with devastating neurological injury. Am J Transplant. 2015;15(8):2136–42. Of importance: First complete nomogram predicting time to death following withdrawal of life-sustaining therapies in neurocritically ill patients that included several neurologic variables. CrossRefPubMed He X et al. Nomogram for predicting time to death after withdrawal of life-sustaining treatment in patients with devastating neurological injury. Am J Transplant. 2015;15(8):2136–42. Of importance: First complete nomogram predicting time to death following withdrawal of life-sustaining therapies in neurocritically ill patients that included several neurologic variables. CrossRefPubMed
35.
go back to reference He X et al. The development and validation of a nomogram for identification of potential donation after cardiac death donors. 2015. Am J Transplant. He X et al. The development and validation of a nomogram for identification of potential donation after cardiac death donors. 2015. Am J Transplant.
36.
go back to reference Medicine, I.o., Non-heart-beating organ transplantation: practice and protocols, in non-heart-beating organ transplantation: practice and protocols. 2000, 2000 by the National Academy of Sciences: Washington, DC. Medicine, I.o., Non-heart-beating organ transplantation: practice and protocols, in non-heart-beating organ transplantation: practice and protocols. 2000, 2000 by the National Academy of Sciences: Washington, DC.
37.
go back to reference Reich DJ et al. ASTS recommended practice guidelines for controlled donation after cardiac death organ procurement and transplantation. Am J Transplant. 2009;9(9):2004–11.CrossRefPubMed Reich DJ et al. ASTS recommended practice guidelines for controlled donation after cardiac death organ procurement and transplantation. Am J Transplant. 2009;9(9):2004–11.CrossRefPubMed
38.
go back to reference Detry O et al. Categories of donation after cardiocirculatory death. Transplant Proc. 2012;44(5):1189–95.CrossRefPubMed Detry O et al. Categories of donation after cardiocirculatory death. Transplant Proc. 2012;44(5):1189–95.CrossRefPubMed
39.
go back to reference Society, B.T. National standards for organ retrieval from deceased donors. 2013. Society, B.T. National standards for organ retrieval from deceased donors. 2013.
40.
go back to reference Abt P et al. Liver transplantation from controlled non-heart-beating donors: an increased incidence of biliary complications. Transplantation. 2003;75(10):1659–63.CrossRefPubMed Abt P et al. Liver transplantation from controlled non-heart-beating donors: an increased incidence of biliary complications. Transplantation. 2003;75(10):1659–63.CrossRefPubMed
41.
42.
go back to reference Lee KW et al. Factors affecting graft survival after liver transplantation from donation after cardiac death donors. Transplantation. 2006;82(12):1683–8.CrossRef Lee KW et al. Factors affecting graft survival after liver transplantation from donation after cardiac death donors. Transplantation. 2006;82(12):1683–8.CrossRef
43.
go back to reference Locke JE et al. Outcomes of kidneys from donors after cardiac death: implications for allocation and preservation. Am J Transplant. 2007;7(7):1797–807.CrossRefPubMed Locke JE et al. Outcomes of kidneys from donors after cardiac death: implications for allocation and preservation. Am J Transplant. 2007;7(7):1797–807.CrossRefPubMed
44.
go back to reference Phua J et al. Pro/con debate: in patients who are potential candidates for organ donation after cardiac death, starting medications and/or interventions for the sole purpose of making the organs more viable is an acceptable practice. Crit Care. 2007;11(2):211.CrossRefPubMedPubMedCentral Phua J et al. Pro/con debate: in patients who are potential candidates for organ donation after cardiac death, starting medications and/or interventions for the sole purpose of making the organs more viable is an acceptable practice. Crit Care. 2007;11(2):211.CrossRefPubMedPubMedCentral
45.
go back to reference Mateos-Rodríguez AA. Kidney transplant function using organs from non-heart-beating donors maintained by mechanical chest compressions. Resuscitation. 2010;81(7):904–7.CrossRefPubMed Mateos-Rodríguez AA. Kidney transplant function using organs from non-heart-beating donors maintained by mechanical chest compressions. Resuscitation. 2010;81(7):904–7.CrossRefPubMed
47.
go back to reference Wilkinson D, Savulescu J. Should we allow organ donation euthanasia? Alternatives for maximizing the number and quality of organs for transplantation. Bioethics. 2012;26(1):32–48.CrossRefPubMedPubMedCentral Wilkinson D, Savulescu J. Should we allow organ donation euthanasia? Alternatives for maximizing the number and quality of organs for transplantation. Bioethics. 2012;26(1):32–48.CrossRefPubMedPubMedCentral
48.
go back to reference Mollaret P, Goulon M. [The depassed coma (preliminary memoir)]. Rev Neurol (Paris). 1959;101:3–15. Mollaret P, Goulon M. [The depassed coma (preliminary memoir)]. Rev Neurol (Paris). 1959;101:3–15.
49.
go back to reference Wertheimer P, Jouvet M, Descotes J. Diagnosis of death of the nervous system in comas with respiratory arrest treated by artificial respiration. Presse Med. 1959;67(3):87–8.PubMed Wertheimer P, Jouvet M, Descotes J. Diagnosis of death of the nervous system in comas with respiratory arrest treated by artificial respiration. Presse Med. 1959;67(3):87–8.PubMed
51.
go back to reference A.H. Committee. A definition of irreversible coma. Report of the Ad Hoc Committee of the Harvard Medical School to Examine the Definition of Brain Death. JAMA. 1968;205(6):337–40.CrossRef A.H. Committee. A definition of irreversible coma. Report of the Ad Hoc Committee of the Harvard Medical School to Examine the Definition of Brain Death. JAMA. 1968;205(6):337–40.CrossRef
52.
go back to reference Wijdicks EF et al. Evidence-based guideline update: determining brain death in adults: report of the Quality Standards Subcommittee of the American Academy of Neurology. Neurology. 2010;74(23):1911–8.CrossRefPubMed Wijdicks EF et al. Evidence-based guideline update: determining brain death in adults: report of the Quality Standards Subcommittee of the American Academy of Neurology. Neurology. 2010;74(23):1911–8.CrossRefPubMed
53.
go back to reference Transplant., N.B.a. Transplant activity in the UK. Activity report 2014/15. 2014. Transplant., N.B.a. Transplant activity in the UK. Activity report 2014/15. 2014.
54.
go back to reference OPTN/UNOS OPTN/UNOS OPO Committee Report. 2008. OPTN/UNOS OPTN/UNOS OPO Committee Report. 2008.
55.
go back to reference de Groot YJ et al. Imminent brain death: point of departure for potential heart-beating organ donor recognition. Intensive Care Med. 2010;36(9):1488–94.CrossRefPubMedPubMedCentral de Groot YJ et al. Imminent brain death: point of departure for potential heart-beating organ donor recognition. Intensive Care Med. 2010;36(9):1488–94.CrossRefPubMedPubMedCentral
56.
go back to reference Wijdicks, E.F.M.E.F., Determining brain death. Continuum (Minneapolis, Minn.), 2015. 21(5 neurocritical care): pp. 1411-1424. Wijdicks, E.F.M.E.F., Determining brain death. Continuum (Minneapolis, Minn.), 2015. 21(5 neurocritical care): pp. 1411-1424.
57.
go back to reference Hwang DY, Gilmore EJ, Greer DM. Assessment of brain death in the neurocritical care unit. Neurosurg Clin N Am. 2013;24(3):469–82.CrossRefPubMed Hwang DY, Gilmore EJ, Greer DM. Assessment of brain death in the neurocritical care unit. Neurosurg Clin N Am. 2013;24(3):469–82.CrossRefPubMed
58.
go back to reference Saposnik G et al. Problems associated with the apnea test in the diagnosis of brain death. Neurol India. 2004;52(3):342–5.PubMed Saposnik G et al. Problems associated with the apnea test in the diagnosis of brain death. Neurol India. 2004;52(3):342–5.PubMed
59.
go back to reference Denny JT et al. A new technique for avoiding barotrauma-induced complications in apnea testing for brain death. J Clin Neurosci. 2015;22(6):1021–4.CrossRefPubMed Denny JT et al. A new technique for avoiding barotrauma-induced complications in apnea testing for brain death. J Clin Neurosci. 2015;22(6):1021–4.CrossRefPubMed
61.
go back to reference Solek-Pastuszka J et al. Evolution of apnoea test in brain death diagnostics. Anaesth Intensive Ther. 2015;47(4):363–7.CrossRef Solek-Pastuszka J et al. Evolution of apnoea test in brain death diagnostics. Anaesth Intensive Ther. 2015;47(4):363–7.CrossRef
62.
go back to reference Wieczorek A, Gaszynski T. Boussignac CPAP system for brain death confirmation with apneic test in case of acute lung injury/adult respiratory distress syndrome—series of cases. Ther Clin Risk Manag. 2015;11:961–5.PubMedPubMedCentral Wieczorek A, Gaszynski T. Boussignac CPAP system for brain death confirmation with apneic test in case of acute lung injury/adult respiratory distress syndrome—series of cases. Ther Clin Risk Manag. 2015;11:961–5.PubMedPubMedCentral
63.
go back to reference Giani, M.M., Apnea test during brain death assessment in mechanically ventilated and ECMO patients. Intensive Care Med. 2015. Giani, M.M., Apnea test during brain death assessment in mechanically ventilated and ECMO patients. Intensive Care Med. 2015.
64.
go back to reference Anthony DC et al. The systemic response to brain injury and disease. Brain Behav Immun. 2012;26(4):534–40.CrossRefPubMed Anthony DC et al. The systemic response to brain injury and disease. Brain Behav Immun. 2012;26(4):534–40.CrossRefPubMed
65.
go back to reference Watts RPRP. Inflammatory signalling associated with brain dead organ donation: from brain injury to brain stem death and posttransplant ischaemia reperfusion injury. J Transplant. 2013;2013(2):1–19.CrossRef Watts RPRP. Inflammatory signalling associated with brain dead organ donation: from brain injury to brain stem death and posttransplant ischaemia reperfusion injury. J Transplant. 2013;2013(2):1–19.CrossRef
66.
go back to reference Lee ST et al. Cholinergic anti-inflammatory pathway in intracerebral hemorrhage. Brain Res. 2010;1309:164–71.CrossRefPubMed Lee ST et al. Cholinergic anti-inflammatory pathway in intracerebral hemorrhage. Brain Res. 2010;1309:164–71.CrossRefPubMed
67.
go back to reference Adrie C et al. Immune status and apoptosis activation during brain death. Shock. 2010;33(4):353–62.CrossRefPubMed Adrie C et al. Immune status and apoptosis activation during brain death. Shock. 2010;33(4):353–62.CrossRefPubMed
68.
go back to reference Hoeger S et al. Modulation of brain dead induced inflammation by vagus nerve stimulation. Am J Transplant. 2010;10(3):477–89.CrossRefPubMed Hoeger S et al. Modulation of brain dead induced inflammation by vagus nerve stimulation. Am J Transplant. 2010;10(3):477–89.CrossRefPubMed
69.
go back to reference Skrabal CA et al. Organ-specific regulation of pro-inflammatory molecules in heart, lung, and kidney following brain death. J Surg Res. 2005;123(1):118–25.CrossRefPubMed Skrabal CA et al. Organ-specific regulation of pro-inflammatory molecules in heart, lung, and kidney following brain death. J Surg Res. 2005;123(1):118–25.CrossRefPubMed
70.
go back to reference Schrader H, Hall C, Zwetnow NN. Effects of prolonged supratentorial mass expansion on regional blood flow and cardiovascular parameters during the Cushing response. Acta Neurol Scand. 1985;72(3):283–94.CrossRefPubMed Schrader H, Hall C, Zwetnow NN. Effects of prolonged supratentorial mass expansion on regional blood flow and cardiovascular parameters during the Cushing response. Acta Neurol Scand. 1985;72(3):283–94.CrossRefPubMed
72.
go back to reference Berman M et al. Is stress cardiomyopathy the underlying cause of ventricular dysfunction associated with brain death? J Heart Lung Transplant. 2010;29(9):957–65.CrossRefPubMed Berman M et al. Is stress cardiomyopathy the underlying cause of ventricular dysfunction associated with brain death? J Heart Lung Transplant. 2010;29(9):957–65.CrossRefPubMed
73.
go back to reference Salim AA. Complications of brain death: frequency and impact on organ retrieval. Am Surg. 2006;72(5):377.PubMed Salim AA. Complications of brain death: frequency and impact on organ retrieval. Am Surg. 2006;72(5):377.PubMed
74.
go back to reference Smith M. Physiologic changes during brain stem death—lessons for management of the organ donor. J Heart Lung Transplant. 2004;23(9 Suppl):S217–22.CrossRefPubMed Smith M. Physiologic changes during brain stem death—lessons for management of the organ donor. J Heart Lung Transplant. 2004;23(9 Suppl):S217–22.CrossRefPubMed
75.
go back to reference Avlonitis VS et al. The hemodynamic mechanisms of lung injury and systemic inflammatory response following brain death in the transplant donor. Am J Transplant. 2005;5(4 Pt 1):684–93.CrossRefPubMed Avlonitis VS et al. The hemodynamic mechanisms of lung injury and systemic inflammatory response following brain death in the transplant donor. Am J Transplant. 2005;5(4 Pt 1):684–93.CrossRefPubMed
76.
go back to reference Chen EP et al. Hormonal and hemodynamic changes in a validated animal model of brain death. Crit Care Med. 1996;24(8):1352–9.CrossRefPubMed Chen EP et al. Hormonal and hemodynamic changes in a validated animal model of brain death. Crit Care Med. 1996;24(8):1352–9.CrossRefPubMed
77.
go back to reference Klein AS et al. Organ donation and utilization in the United States, 1999–2008. Am J Transplant. 2010;10(4 Pt 2):973–86.CrossRefPubMed Klein AS et al. Organ donation and utilization in the United States, 1999–2008. Am J Transplant. 2010;10(4 Pt 2):973–86.CrossRefPubMed
78.
go back to reference Westendorp WH, Leuvenink HG, Ploeg RJ. Brain death induced renal injury. Curr Opin Organ Transplant. 2011;16(2):151–6.CrossRefPubMed Westendorp WH, Leuvenink HG, Ploeg RJ. Brain death induced renal injury. Curr Opin Organ Transplant. 2011;16(2):151–6.CrossRefPubMed
79.
go back to reference Ramjug S, Hussain N, Yonan N. Prolonged time between donor brain death and organ retrieval results in an increased risk of mortality in cardiac transplant recipients. Interact Cardiovasc Thorac Surg. 2011;12(6):938–42.CrossRefPubMed Ramjug S, Hussain N, Yonan N. Prolonged time between donor brain death and organ retrieval results in an increased risk of mortality in cardiac transplant recipients. Interact Cardiovasc Thorac Surg. 2011;12(6):938–42.CrossRefPubMed
80.
go back to reference Dikdan GS, Mora-Esteves C, Koneru B. Review of randomized clinical trials of donor management and organ preservation in deceased donors: opportunities and issues. Transplantation. 2012;94(5):425–41.CrossRefPubMed Dikdan GS, Mora-Esteves C, Koneru B. Review of randomized clinical trials of donor management and organ preservation in deceased donors: opportunities and issues. Transplantation. 2012;94(5):425–41.CrossRefPubMed
81.
go back to reference Macdonald PS et al. A systematic review and meta-analysis of clinical trials of thyroid hormone administration to brain dead potential organ donors. Crit Care Med. 2012;40(5):1635–44.CrossRefPubMed Macdonald PS et al. A systematic review and meta-analysis of clinical trials of thyroid hormone administration to brain dead potential organ donors. Crit Care Med. 2012;40(5):1635–44.CrossRefPubMed
82.
go back to reference Sharpe MDMD. Oral and intravenous thyroxine (T4) achieve comparable serum levels for hormonal resuscitation protocol in organ donors: a randomized double-blinded study. Can J Anesth. 2013;60(10):998–1002.CrossRefPubMed Sharpe MDMD. Oral and intravenous thyroxine (T4) achieve comparable serum levels for hormonal resuscitation protocol in organ donors: a randomized double-blinded study. Can J Anesth. 2013;60(10):998–1002.CrossRefPubMed
83.
go back to reference Pinsard M et al. Interest of low-dose hydrocortisone therapy during brain-dead organ donor resuscitation: the CORTICOME study. Crit Care. 2014;18(4):R158.CrossRefPubMedPubMedCentral Pinsard M et al. Interest of low-dose hydrocortisone therapy during brain-dead organ donor resuscitation: the CORTICOME study. Crit Care. 2014;18(4):R158.CrossRefPubMedPubMedCentral
84.••
go back to reference Kotloff RM et al. Management of the potential organ donor in the ICU: Society of Critical Care Medicine/American College of Chest Physicians/Association of Organ Procurement Organizations Consensus Statement. Crit Care Med. 2015;43(6):1291–325. First guidelines for the critical care management of the potential organ donor. CrossRefPubMed Kotloff RM et al. Management of the potential organ donor in the ICU: Society of Critical Care Medicine/American College of Chest Physicians/Association of Organ Procurement Organizations Consensus Statement. Crit Care Med. 2015;43(6):1291–325. First guidelines for the critical care management of the potential organ donor. CrossRefPubMed
85.
go back to reference Mi Z et al. The optimal hormonal replacement modality selection for multiple organ procurement from brain-dead organ donors. Clin Epidemiol. 2015;7:17–27.PubMed Mi Z et al. The optimal hormonal replacement modality selection for multiple organ procurement from brain-dead organ donors. Clin Epidemiol. 2015;7:17–27.PubMed
86.
go back to reference Hadian M et al. Cross-comparison of cardiac output trending accuracy of LiDCO, PiCCO, FloTrac and pulmonary artery catheters. Crit Care. 2010;14(6):R212.CrossRefPubMedPubMedCentral Hadian M et al. Cross-comparison of cardiac output trending accuracy of LiDCO, PiCCO, FloTrac and pulmonary artery catheters. Crit Care. 2010;14(6):R212.CrossRefPubMedPubMedCentral
87.
go back to reference Al-Khafaji A et al. Protocolized fluid therapy in brain-dead donors: the multicenter randomized MOnIToR trial. Intensive Care Med. 2015;41(3):418–26.CrossRefPubMedPubMedCentral Al-Khafaji A et al. Protocolized fluid therapy in brain-dead donors: the multicenter randomized MOnIToR trial. Intensive Care Med. 2015;41(3):418–26.CrossRefPubMedPubMedCentral
89.
go back to reference Schnuelle P et al. Effects of donor pretreatment with dopamine on graft function after kidney transplantation: a randomized controlled trial. JAMA. 2009;302(10):1067–75.CrossRefPubMed Schnuelle P et al. Effects of donor pretreatment with dopamine on graft function after kidney transplantation: a randomized controlled trial. JAMA. 2009;302(10):1067–75.CrossRefPubMed
90.
go back to reference Wang Z et al. Stimulation of dopamine D3 receptor attenuates renal ischemia-reperfusion injury via increased linkage with Galpha12. Transplantation. 2015;99(11):2274–84.CrossRefPubMed Wang Z et al. Stimulation of dopamine D3 receptor attenuates renal ischemia-reperfusion injury via increased linkage with Galpha12. Transplantation. 2015;99(11):2274–84.CrossRefPubMed
91.
go back to reference Mascia L et al. Effect of a lung protective strategy for organ donors on eligibility and availability of lungs for transplantation: a randomized controlled trial. JAMA. 2010;304(23):2620–7.CrossRefPubMed Mascia L et al. Effect of a lung protective strategy for organ donors on eligibility and availability of lungs for transplantation: a randomized controlled trial. JAMA. 2010;304(23):2620–7.CrossRefPubMed
92.
go back to reference Minambres E et al. Lung donor treatment protocol in brain dead-donors: a multicenter study. J Heart Lung Transplant. 2015;34(6):773–80.CrossRefPubMed Minambres E et al. Lung donor treatment protocol in brain dead-donors: a multicenter study. J Heart Lung Transplant. 2015;34(6):773–80.CrossRefPubMed
93.
go back to reference Minambres E et al. Impact of restrictive fluid balance focused to increase lung procurement on renal function after kidney transplantation. Nephrol Dial Transplant. 2010;25(7):2352–6.CrossRefPubMed Minambres E et al. Impact of restrictive fluid balance focused to increase lung procurement on renal function after kidney transplantation. Nephrol Dial Transplant. 2010;25(7):2352–6.CrossRefPubMed
94.
go back to reference Miñambres EE. Aggressive lung donor management increases graft procurement without increasing renal graft loss after transplantation. Clin Transpl. 2013;27(1):52–9.CrossRef Miñambres EE. Aggressive lung donor management increases graft procurement without increasing renal graft loss after transplantation. Clin Transpl. 2013;27(1):52–9.CrossRef
95.
go back to reference Prodhan P et al. Inhaled nitric oxide in neurogenic cardiopulmonary dysfunction: implications for organ donation. Transplant Proc. 2004;36(9):2570–2.CrossRefPubMed Prodhan P et al. Inhaled nitric oxide in neurogenic cardiopulmonary dysfunction: implications for organ donation. Transplant Proc. 2004;36(9):2570–2.CrossRefPubMed
96.
go back to reference Park ES et al. Inhaled nitric oxide for the brain dead donor with neurogenic pulmonary edema during anesthesia for organ donation: a case report. Korean J Anesthesiol. 2014;67(2):133–8.CrossRefPubMedPubMedCentral Park ES et al. Inhaled nitric oxide for the brain dead donor with neurogenic pulmonary edema during anesthesia for organ donation: a case report. Korean J Anesthesiol. 2014;67(2):133–8.CrossRefPubMedPubMedCentral
97.
98.
go back to reference Andres A et al. Lower rate of family refusal for organ donation in non-heart-beating versus brain-dead donors. Transplant Proc. 2009;41(6):2304–5.CrossRefPubMed Andres A et al. Lower rate of family refusal for organ donation in non-heart-beating versus brain-dead donors. Transplant Proc. 2009;41(6):2304–5.CrossRefPubMed
99.
go back to reference Volk ML et al. Attitudes of the American public toward organ donation after uncontrolled (sudden) cardiac death. Am J Transplant. 2010;10(3):675–80.CrossRefPubMed Volk ML et al. Attitudes of the American public toward organ donation after uncontrolled (sudden) cardiac death. Am J Transplant. 2010;10(3):675–80.CrossRefPubMed
100.
go back to reference Niemann CU et al. Therapeutic hypothermia in deceased organ donors and kidney-graft function. N Engl J Med. 2015;373(5):405–14.CrossRefPubMed Niemann CU et al. Therapeutic hypothermia in deceased organ donors and kidney-graft function. N Engl J Med. 2015;373(5):405–14.CrossRefPubMed
101.
go back to reference Evrard P. Belgian modified classification of Maastricht for donors after circulatory death. Transplant Proc. 2014;46(9):3138–42.CrossRefPubMed Evrard P. Belgian modified classification of Maastricht for donors after circulatory death. Transplant Proc. 2014;46(9):3138–42.CrossRefPubMed
102.
go back to reference Trasplantes, O.N.d. Donation after circulatory death in Spain: current situation and recommendations. National Consensus Document. 2012. Trasplantes, O.N.d. Donation after circulatory death in Spain: current situation and recommendations. National Consensus Document. 2012.
103.
go back to reference Dujardin KS et al. Myocardial dysfunction associated with brain death: clinical, echocardiographic, and pathologic features. J Heart Lung Transplant. 2001;20(3):350–7.CrossRefPubMed Dujardin KS et al. Myocardial dysfunction associated with brain death: clinical, echocardiographic, and pathologic features. J Heart Lung Transplant. 2001;20(3):350–7.CrossRefPubMed
104.
105.
go back to reference Wind JJ. Preservation of kidneys from controlled donors after cardiac death. Br J Surg. 2011;98(9):1260–6.CrossRefPubMed Wind JJ. Preservation of kidneys from controlled donors after cardiac death. Br J Surg. 2011;98(9):1260–6.CrossRefPubMed
106.
go back to reference Reznik ON et al. Uncontrolled donors with controlled reperfusion after sixty minutes of asystole: a novel reliable resource for kidney transplantation. PLoS One. 2013;8(5), e64209.CrossRefPubMedPubMedCentral Reznik ON et al. Uncontrolled donors with controlled reperfusion after sixty minutes of asystole: a novel reliable resource for kidney transplantation. PLoS One. 2013;8(5), e64209.CrossRefPubMedPubMedCentral
107.
go back to reference Barlow AD, Hosgood SA, Nicholson ML. Current state of pancreas preservation and implications for DCD pancreas transplantation. Transplantation. 2013;95(12):1419–24.CrossRefPubMed Barlow AD, Hosgood SA, Nicholson ML. Current state of pancreas preservation and implications for DCD pancreas transplantation. Transplantation. 2013;95(12):1419–24.CrossRefPubMed
108.
go back to reference Morrissey PE, Monaco AP. Donation after circulatory death: current practices, ongoing challenges, and potential improvements. Transplantation. 2014;97(3):258–64.CrossRefPubMed Morrissey PE, Monaco AP. Donation after circulatory death: current practices, ongoing challenges, and potential improvements. Transplantation. 2014;97(3):258–64.CrossRefPubMed
110.
go back to reference Dhital KK et al. Adult heart transplantation with distant procurement and ex-vivo preservation of donor hearts after circulatory death: a case series. Lancet. 2015;385(9987):2585–91.CrossRefPubMed Dhital KK et al. Adult heart transplantation with distant procurement and ex-vivo preservation of donor hearts after circulatory death: a case series. Lancet. 2015;385(9987):2585–91.CrossRefPubMed
111.
go back to reference Chaumont M et al. Delayed graft function in kidney transplants: time evolution, role of acute rejection, risk factors, and impact on patient and graft outcome. J Transplant. 2015;2015:163757.CrossRefPubMedPubMedCentral Chaumont M et al. Delayed graft function in kidney transplants: time evolution, role of acute rejection, risk factors, and impact on patient and graft outcome. J Transplant. 2015;2015:163757.CrossRefPubMedPubMedCentral
Metadata
Title
ICU Management of the Potential Organ Donor: State of the Art
Authors
Carolina B. Maciel
David M. Greer
Publication date
01-09-2016
Publisher
Springer US
Published in
Current Neurology and Neuroscience Reports / Issue 9/2016
Print ISSN: 1528-4042
Electronic ISSN: 1534-6293
DOI
https://doi.org/10.1007/s11910-016-0682-1

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