Skip to main content
Top
Published in: Current Neurology and Neuroscience Reports 5/2016

01-05-2016 | Demyelinating Disorders (DN Bourdette and M Cameron, Section Editors)

Sleep Disorders in Multiple Sclerosis

Authors: Tiffany J. Braley, Eilis Ann Boudreau

Published in: Current Neurology and Neuroscience Reports | Issue 5/2016

Login to get access

Abstract

Recent studies suggest that individuals with multiple sclerosis (MS) are at increased risk for sleep disturbances and that sleep disturbances contribute to fatigue and other chronic symptoms in MS. Although fatigue occurs commonly in people with MS, this symptom is often attributed to MS-specific pathology. Consequently, sleep disorders are often unrecognized and untreated in this population. Timely diagnosis and treatment of sleep problems in MS offer a new opportunity to ameliorate some of the daytime fatigue experienced by patients with MS. To increase this opportunity, the practitioner should be comfortable performing basic screening for common sleep complaints among patients with MS. The objectives of this review are to summarize the latest relevant data on sleep disorders in MS and offer a helpful approach to the identification and workup of the most common sleep problems in this population. Unexplored research avenues and opportunities to address important questions at the interface of sleep and MS are also discussed.
Literature
3.
go back to reference Winkelman JW, Finn L, Young T. Prevalence and correlates of restless legs syndrome symptoms in the Wisconsin Sleep Cohort. Sleep Med. 2006;7:545–52.CrossRefPubMed Winkelman JW, Finn L, Young T. Prevalence and correlates of restless legs syndrome symptoms in the Wisconsin Sleep Cohort. Sleep Med. 2006;7:545–52.CrossRefPubMed
4.
go back to reference Merlino G, Fratticci L, Lenchig C, Valente M, Cargnelutti D, Picello M, et al. Prevalence of ‘poor sleep’ among patients with multiple sclerosis: an independent predictor of mental and physical status. Sleep Med. 2009;10:26–34.CrossRefPubMed Merlino G, Fratticci L, Lenchig C, Valente M, Cargnelutti D, Picello M, et al. Prevalence of ‘poor sleep’ among patients with multiple sclerosis: an independent predictor of mental and physical status. Sleep Med. 2009;10:26–34.CrossRefPubMed
5.•
go back to reference Braley TJ, Segal BM, Chervin RD. Obstructive sleep apnea and fatigue in patients with multiple sclerosis. J Clin Sleep Med. 2014;10:155–62. This study is of importance because it suggested that OSA is common in individuals with MS, especially when complaints of fatigue are present, and that OSA is under-recognized in this population. Braley TJ, Segal BM, Chervin RD. Obstructive sleep apnea and fatigue in patients with multiple sclerosis. J Clin Sleep Med. 2014;10:155–62. This study is of importance because it suggested that OSA is common in individuals with MS, especially when complaints of fatigue are present, and that OSA is under-recognized in this population.
6.
go back to reference Italian REMS Study Group, Manconi M, Ferini-Strambi L, Filippi M, Bonanni E, Iudice A, et al. Multicenter case–control study on restless legs syndrome in multiple sclerosis: the REMS study. Sleep. 2008;31:944–52. Italian REMS Study Group, Manconi M, Ferini-Strambi L, Filippi M, Bonanni E, Iudice A, et al. Multicenter case–control study on restless legs syndrome in multiple sclerosis: the REMS study. Sleep. 2008;31:944–52.
7.
go back to reference Brass SD, Li CS, Auerbach S. The underdiagnosis of sleep disorders in patients with multiple sclerosis. J Clin Sleep Med. 2014;10:1025–31.PubMedPubMedCentral Brass SD, Li CS, Auerbach S. The underdiagnosis of sleep disorders in patients with multiple sclerosis. J Clin Sleep Med. 2014;10:1025–31.PubMedPubMedCentral
8.••
go back to reference Veauthier C, Gaede G, Radbruch H, Gottschalk S, Wernecke KD, Paul F. Treatment of sleep disorders may improve fatigue in multiple sclerosis. Clin Neurol Neurosurg. 2013;115:1826–30. This study was of major importance because it demonstrated that treatment of sleep disorders in individuals with MS, could decrease fatigue, one of the most frequent and disabling symptoms associated with MS. Veauthier C, Gaede G, Radbruch H, Gottschalk S, Wernecke KD, Paul F. Treatment of sleep disorders may improve fatigue in multiple sclerosis. Clin Neurol Neurosurg. 2013;115:1826–30. This study was of major importance because it demonstrated that treatment of sleep disorders in individuals with MS, could decrease fatigue, one of the most frequent and disabling symptoms associated with MS.
9.
go back to reference Young T, Shahar E, Nieto FJ, Redline S, Newman AB, Gottlieb DJ, et al. Predictors of sleep-disordered breathing in community-dwelling adults: the Sleep Heart Health Study. Arch Intern Med. 2002;162:893–900.CrossRefPubMed Young T, Shahar E, Nieto FJ, Redline S, Newman AB, Gottlieb DJ, et al. Predictors of sleep-disordered breathing in community-dwelling adults: the Sleep Heart Health Study. Arch Intern Med. 2002;162:893–900.CrossRefPubMed
11.
go back to reference Brown DL, McDermott M, Mowla A, De Lott L, Morgenstern LB, Kerber KA, et al. Brainstem infarction and sleep-disordered breathing in the BASIC sleep apnea study. Sleep Med. 2014;15:887–91.CrossRefPubMedPubMedCentral Brown DL, McDermott M, Mowla A, De Lott L, Morgenstern LB, Kerber KA, et al. Brainstem infarction and sleep-disordered breathing in the BASIC sleep apnea study. Sleep Med. 2014;15:887–91.CrossRefPubMedPubMedCentral
12.
go back to reference Losurdo A, Dittoni S, Testani E, Di Blasi C, Scarano E, Mariotti P, et al. Sleep disordered breathing in children and adolescents with Chiari malformation type I. J Clin Sleep Med. 2013;9:371–7.PubMedPubMedCentral Losurdo A, Dittoni S, Testani E, Di Blasi C, Scarano E, Mariotti P, et al. Sleep disordered breathing in children and adolescents with Chiari malformation type I. J Clin Sleep Med. 2013;9:371–7.PubMedPubMedCentral
13.
go back to reference Gabbay IE, Lavie P. Age- and gender-related characteristics of obstructive sleep apnea. Sleep Breath. 2012;16:453–60.CrossRefPubMed Gabbay IE, Lavie P. Age- and gender-related characteristics of obstructive sleep apnea. Sleep Breath. 2012;16:453–60.CrossRefPubMed
15.
go back to reference Peppard PE. Is obstructive sleep apnea a risk factor for hypertension?—differences between the Wisconsin Sleep Cohort and the Sleep Heart Health Study. J Clin Sleep Med. 2009;5:404–5.PubMedPubMedCentral Peppard PE. Is obstructive sleep apnea a risk factor for hypertension?—differences between the Wisconsin Sleep Cohort and the Sleep Heart Health Study. J Clin Sleep Med. 2009;5:404–5.PubMedPubMedCentral
16.
go back to reference Gottlieb DJ, Yenokyan G, Newman AB, O’Connor GT, Punjabi NM, Quan SF, et al. Prospective study of obstructive sleep apnea and incident coronary heart disease and heart failure: the sleep heart health study. Circulation. 2010;122:352–60.CrossRefPubMedPubMedCentral Gottlieb DJ, Yenokyan G, Newman AB, O’Connor GT, Punjabi NM, Quan SF, et al. Prospective study of obstructive sleep apnea and incident coronary heart disease and heart failure: the sleep heart health study. Circulation. 2010;122:352–60.CrossRefPubMedPubMedCentral
17.
go back to reference Yaggi HK, Concato J, Kernan WN, Lichtman JH, Brass LM, Mohsenin V. Obstructive sleep apnea as a risk factor for stroke and death. N Engl J Med. 2005;353:2034–41.CrossRefPubMed Yaggi HK, Concato J, Kernan WN, Lichtman JH, Brass LM, Mohsenin V. Obstructive sleep apnea as a risk factor for stroke and death. N Engl J Med. 2005;353:2034–41.CrossRefPubMed
18.
go back to reference Epstein LJ, Kristo D, Strollo Jr PJ, Friedman N, Malhotra A, Patil SP, et al. Clinical guideline for the evaluation, management and long-term care of obstructive sleep apnea in adults. J Clin Sleep Med. 2009;5:263–76.PubMed Epstein LJ, Kristo D, Strollo Jr PJ, Friedman N, Malhotra A, Patil SP, et al. Clinical guideline for the evaluation, management and long-term care of obstructive sleep apnea in adults. J Clin Sleep Med. 2009;5:263–76.PubMed
19.
go back to reference Ramar K, Dort LC, Katz SG, Lettieri CJ, Harrod CG, Thomas SM, et al. Clinical practice guideline for the treatment of obstructive sleep apnea and snoring with oral appliance therapy: an update for 2015. J Clin Sleep Med. 2015;11:773–827.PubMedPubMedCentral Ramar K, Dort LC, Katz SG, Lettieri CJ, Harrod CG, Thomas SM, et al. Clinical practice guideline for the treatment of obstructive sleep apnea and snoring with oral appliance therapy: an update for 2015. J Clin Sleep Med. 2015;11:773–827.PubMedPubMedCentral
20.
go back to reference American Academy of Sleep Medicine. International Classification of Sleep Disorders (ICSD-3): diagnostic and coding manual, 3rd ed. American Academy of Sleep Medicine, 2014. American Academy of Sleep Medicine. International Classification of Sleep Disorders (ICSD-3): diagnostic and coding manual, 3rd ed. American Academy of Sleep Medicine, 2014.
21.
go back to reference Zaslavsky O, LaCroix AZ, Hale L, Tindle H, Shochat T. Longitudinal changes in insomnia status and incidence of physical, emotional, or mixed impairment in postmenopausal women participating in the Women’s Health Initiative (WHI) study. Sleep Med. 2015;16:364–71.CrossRefPubMed Zaslavsky O, LaCroix AZ, Hale L, Tindle H, Shochat T. Longitudinal changes in insomnia status and incidence of physical, emotional, or mixed impairment in postmenopausal women participating in the Women’s Health Initiative (WHI) study. Sleep Med. 2015;16:364–71.CrossRefPubMed
22.
go back to reference Taylor DJ, Mallory LJ, Lichstein KL, Durrence HH, Riedel BW, Bush AJ. Comorbidity of chronic insomnia with medical problems. Sleep. 2007;30:213–8.PubMed Taylor DJ, Mallory LJ, Lichstein KL, Durrence HH, Riedel BW, Bush AJ. Comorbidity of chronic insomnia with medical problems. Sleep. 2007;30:213–8.PubMed
23.
go back to reference Hurwitz BJ, Jeffery D, Arnason B, Bigley K, Coyle P, Goodin D, et al. Tolerability and safety profile of 12- to 28-week treatment with interferon beta-1b 250 and 500 microg QOD in patients with relapsing-remitting multiple sclerosis: a multicenter, randomized, double-blind, parallel-group pilot study. Clin Ther. 2008;30:1102–12.CrossRefPubMed Hurwitz BJ, Jeffery D, Arnason B, Bigley K, Coyle P, Goodin D, et al. Tolerability and safety profile of 12- to 28-week treatment with interferon beta-1b 250 and 500 microg QOD in patients with relapsing-remitting multiple sclerosis: a multicenter, randomized, double-blind, parallel-group pilot study. Clin Ther. 2008;30:1102–12.CrossRefPubMed
24.
go back to reference Byerley WF, Reimherr FW, Wood DR, Grosser BI. Fluoxetine, a selective serotonin uptake inhibitor, for the treatment of outpatients with major depression. J Clin Psychopharmacol. 1988;8:112–5.CrossRefPubMed Byerley WF, Reimherr FW, Wood DR, Grosser BI. Fluoxetine, a selective serotonin uptake inhibitor, for the treatment of outpatients with major depression. J Clin Psychopharmacol. 1988;8:112–5.CrossRefPubMed
26.
go back to reference Mendozzi L, Tronci F, Garegnani M, Pugnetti L. Sleep disturbance and fatigue in mild relapsing remitting multiple sclerosis patients on chronic immunomodulant therapy: an actigraphic study. Mult Scler. 2010;16:238–47.CrossRefPubMed Mendozzi L, Tronci F, Garegnani M, Pugnetti L. Sleep disturbance and fatigue in mild relapsing remitting multiple sclerosis patients on chronic immunomodulant therapy: an actigraphic study. Mult Scler. 2010;16:238–47.CrossRefPubMed
27.
go back to reference Edinger JD, Wohlgemuth WK, Radtke RA, Marsh GR, Quillian RE. Cognitive behavioral therapy for treatment of chronic primary insomnia: a randomized controlled trial. JAMA. 2001;285:1856–64.CrossRefPubMed Edinger JD, Wohlgemuth WK, Radtke RA, Marsh GR, Quillian RE. Cognitive behavioral therapy for treatment of chronic primary insomnia: a randomized controlled trial. JAMA. 2001;285:1856–64.CrossRefPubMed
28.
go back to reference Morin CM, Vallieres A, Guay B, Ivers H, Savard J, Merette C, et al. Cognitive behavioral therapy, singly and combined with medication, for persistent insomnia: a randomized controlled trial. JAMA. 2009;301:2005–15.CrossRefPubMedPubMedCentral Morin CM, Vallieres A, Guay B, Ivers H, Savard J, Merette C, et al. Cognitive behavioral therapy, singly and combined with medication, for persistent insomnia: a randomized controlled trial. JAMA. 2009;301:2005–15.CrossRefPubMedPubMedCentral
29.
go back to reference Pigeon WR, Bishop TM, Marcus JA. Advances in the management of insomnia. F1000Prime Rep 2014;6:48,48. eCollection 2014. Pigeon WR, Bishop TM, Marcus JA. Advances in the management of insomnia. F1000Prime Rep 2014;6:48,48. eCollection 2014.
30.
go back to reference Rothdach AJ, Trenkwalder C, Haberstock J, Keil U, Berger K. Prevalence and risk factors of RLS in an elderly population: the MEMO study. Memory and Morbidity in Augsburg Elderly. Neurology. 2000;54:1064–8.CrossRefPubMed Rothdach AJ, Trenkwalder C, Haberstock J, Keil U, Berger K. Prevalence and risk factors of RLS in an elderly population: the MEMO study. Memory and Morbidity in Augsburg Elderly. Neurology. 2000;54:1064–8.CrossRefPubMed
31.
go back to reference Li Y, Munger KL, Batool-Anwar S, De Vito K, Ascherio A, Gao X. Association of multiple sclerosis with restless legs syndrome and other sleep disorders in women. Neurology. 2012;78:1500–6.CrossRefPubMedPubMedCentral Li Y, Munger KL, Batool-Anwar S, De Vito K, Ascherio A, Gao X. Association of multiple sclerosis with restless legs syndrome and other sleep disorders in women. Neurology. 2012;78:1500–6.CrossRefPubMedPubMedCentral
32.
go back to reference Auger C, Montplaisir J, Duquette P. Increased frequency of restless legs syndrome in a French-Canadian population with multiple sclerosis. Neurology. 2005;65:1652–3.CrossRefPubMed Auger C, Montplaisir J, Duquette P. Increased frequency of restless legs syndrome in a French-Canadian population with multiple sclerosis. Neurology. 2005;65:1652–3.CrossRefPubMed
33.
go back to reference Lutz EG. Restless legs, anxiety and caffeinism. J Clin Psychiatry. 1978;39:693–8.PubMed Lutz EG. Restless legs, anxiety and caffeinism. J Clin Psychiatry. 1978;39:693–8.PubMed
34.
go back to reference Aldrich MS, Shipley JE. Alcohol use and periodic limb movements of sleep. Alcohol Clin Exp Res. 1993;17:192–6.CrossRefPubMed Aldrich MS, Shipley JE. Alcohol use and periodic limb movements of sleep. Alcohol Clin Exp Res. 1993;17:192–6.CrossRefPubMed
35.
go back to reference Ohayon MM, Roth T. Prevalence of restless legs syndrome and periodic limb movement disorder in the general population. J Psychosom Res. 2002;53:547–54.CrossRefPubMed Ohayon MM, Roth T. Prevalence of restless legs syndrome and periodic limb movement disorder in the general population. J Psychosom Res. 2002;53:547–54.CrossRefPubMed
36.
go back to reference Pigeon WR, Yurcheshen M. Behavioral sleep medicine interventions for restless legs syndrome and periodic limb movement disorder. Sleep Med Clin. 2009;4:487–94.CrossRefPubMedPubMedCentral Pigeon WR, Yurcheshen M. Behavioral sleep medicine interventions for restless legs syndrome and periodic limb movement disorder. Sleep Med Clin. 2009;4:487–94.CrossRefPubMedPubMedCentral
37.
go back to reference Hoque R, Chesson Jr AL. Pharmacologically induced/exacerbated restless legs syndrome, periodic limb movements of sleep, and REM behavior disorder/REM sleep without atonia: literature review, qualitative scoring, and comparative analysis. J Clin Sleep Med. 2010;6:79–83.PubMedPubMedCentral Hoque R, Chesson Jr AL. Pharmacologically induced/exacerbated restless legs syndrome, periodic limb movements of sleep, and REM behavior disorder/REM sleep without atonia: literature review, qualitative scoring, and comparative analysis. J Clin Sleep Med. 2010;6:79–83.PubMedPubMedCentral
38.
go back to reference Littner MR, Kushida C, Anderson WM, Bailey D, Berry RB, Hirshkowitz M, et al. Practice parameters for the dopaminergic treatment of restless legs syndrome and periodic limb movement disorder. Sleep. 2004;27:557–9.PubMed Littner MR, Kushida C, Anderson WM, Bailey D, Berry RB, Hirshkowitz M, et al. Practice parameters for the dopaminergic treatment of restless legs syndrome and periodic limb movement disorder. Sleep. 2004;27:557–9.PubMed
39.
go back to reference Wilt TJ, MacDonald R, Ouellette J, Khawaja IS, Rutks I, Butler M, et al. Pharmacologic therapy for primary restless legs syndrome: a systematic review and meta-analysis. JAMA Int Med. 2013;173:496–505.CrossRef Wilt TJ, MacDonald R, Ouellette J, Khawaja IS, Rutks I, Butler M, et al. Pharmacologic therapy for primary restless legs syndrome: a systematic review and meta-analysis. JAMA Int Med. 2013;173:496–505.CrossRef
40.
go back to reference Allen RP, Chen C, Garcia-Borreguero D, Polo O, DuBrava S, Miceli J, et al. Comparison of pregabalin with pramipexole for restless legs syndrome. N Engl J Med. 2014;370:621–31.CrossRefPubMed Allen RP, Chen C, Garcia-Borreguero D, Polo O, DuBrava S, Miceli J, et al. Comparison of pregabalin with pramipexole for restless legs syndrome. N Engl J Med. 2014;370:621–31.CrossRefPubMed
41.
go back to reference Krupp L. Fatigue is intrinsic to multiple sclerosis (MS) and is the most commonly reported symptom of the disease. Mult Scler. 2006;12:367–8.CrossRefPubMed Krupp L. Fatigue is intrinsic to multiple sclerosis (MS) and is the most commonly reported symptom of the disease. Mult Scler. 2006;12:367–8.CrossRefPubMed
42.
go back to reference Krupp LB, Alvarez LA, LaRocca NG, Scheinberg LC. Fatigue in multiple sclerosis. Arch Neurol. 1988;45:435–7.CrossRefPubMed Krupp LB, Alvarez LA, LaRocca NG, Scheinberg LC. Fatigue in multiple sclerosis. Arch Neurol. 1988;45:435–7.CrossRefPubMed
43.
go back to reference Lerdal A, Celius EG, Krupp L, Dahl AA. A prospective study of patterns of fatigue in multiple sclerosis. Eur J Neurol. 2007;14:1338–43.CrossRefPubMed Lerdal A, Celius EG, Krupp L, Dahl AA. A prospective study of patterns of fatigue in multiple sclerosis. Eur J Neurol. 2007;14:1338–43.CrossRefPubMed
44.
go back to reference Janardhan V, Bakshi R. Quality of life in patients with multiple sclerosis: the impact of fatigue and depression. J Neurol Sci. 2002;205:51–8.CrossRefPubMed Janardhan V, Bakshi R. Quality of life in patients with multiple sclerosis: the impact of fatigue and depression. J Neurol Sci. 2002;205:51–8.CrossRefPubMed
45.
go back to reference Roelcke U, Kappos L, Lechner-Scott J, Brunnschweiler H, Huber S, Ammann W, et al. Reduced glucose metabolism in the frontal cortex and basal ganglia of multiple sclerosis patients with fatigue: a 18F-fluorodeoxyglucose positron emission tomography study. Neurology. 1997;48:1566–71.CrossRefPubMed Roelcke U, Kappos L, Lechner-Scott J, Brunnschweiler H, Huber S, Ammann W, et al. Reduced glucose metabolism in the frontal cortex and basal ganglia of multiple sclerosis patients with fatigue: a 18F-fluorodeoxyglucose positron emission tomography study. Neurology. 1997;48:1566–71.CrossRefPubMed
46.
go back to reference Flachenecker P, Bihler I, Weber F, Gottschalk M, Toyka KV, Rieckmann P. Cytokine mRNA expression in patients with multiple sclerosis and fatigue. Mult Scler. 2004;10:165–9.CrossRefPubMed Flachenecker P, Bihler I, Weber F, Gottschalk M, Toyka KV, Rieckmann P. Cytokine mRNA expression in patients with multiple sclerosis and fatigue. Mult Scler. 2004;10:165–9.CrossRefPubMed
47.
go back to reference Tartaglia MC, Narayanan S, Francis SJ, Santos AC, De Stefano N, Lapierre Y, et al. The relationship between diffuse axonal damage and fatigue in multiple sclerosis. Arch Neurol. 2004;61:201–7.CrossRefPubMed Tartaglia MC, Narayanan S, Francis SJ, Santos AC, De Stefano N, Lapierre Y, et al. The relationship between diffuse axonal damage and fatigue in multiple sclerosis. Arch Neurol. 2004;61:201–7.CrossRefPubMed
48.
go back to reference Veauthier C, Radbruch H, Gaede G, Pfueller CF, Dorr J, Bellmann-Strobl J, et al. Fatigue in multiple sclerosis is closely related to sleep disorders: a polysomnographic cross-sectional study. Mult Scler. 2011;17:613–22.CrossRefPubMed Veauthier C, Radbruch H, Gaede G, Pfueller CF, Dorr J, Bellmann-Strobl J, et al. Fatigue in multiple sclerosis is closely related to sleep disorders: a polysomnographic cross-sectional study. Mult Scler. 2011;17:613–22.CrossRefPubMed
49.
go back to reference Kaminska M, Kimoff R, Benedetti A, Robinson A, Bar-Or A, Lapierre Y, et al. Obstructive sleep apnea is associated with fatigue in multiple sclerosis. Mult Scler. 2012;18:1159–69.CrossRefPubMed Kaminska M, Kimoff R, Benedetti A, Robinson A, Bar-Or A, Lapierre Y, et al. Obstructive sleep apnea is associated with fatigue in multiple sclerosis. Mult Scler. 2012;18:1159–69.CrossRefPubMed
50.••
go back to reference Cote I, Trojan DA, Kaminska M, Cardoso M, Benedetti A, Weiss D, et al. Impact of sleep disorder treatment on fatigue in multiple sclerosis. Mult Scler. 2013;19:480–9. This study was of significant importance because the authors demonstrated that the standard treatment of obstructive sleep apnea in patients with MS resulted in improvement in their symptoms of fatigue and sleep quality. Because symptoms of fatigue are so common in patients with MS, this study supports the screening for and treating sleep apnea in this population. Cote I, Trojan DA, Kaminska M, Cardoso M, Benedetti A, Weiss D, et al. Impact of sleep disorder treatment on fatigue in multiple sclerosis. Mult Scler. 2013;19:480–9. This study was of significant importance because the authors demonstrated that the standard treatment of obstructive sleep apnea in patients with MS resulted in improvement in their symptoms of fatigue and sleep quality. Because symptoms of fatigue are so common in patients with MS, this study supports the screening for and treating sleep apnea in this population.
51.
go back to reference Braley TJ, Segal BM, Chervin RD. Hypnotic use and fatigue in multiple sclerosis. Sleep Med. 2015;16:131–7.CrossRefPubMed Braley TJ, Segal BM, Chervin RD. Hypnotic use and fatigue in multiple sclerosis. Sleep Med. 2015;16:131–7.CrossRefPubMed
52.
go back to reference Neau JP, Paquereau J, Auche V, Mathis S, Godeneche G, Ciron J, et al. Sleep disorders and multiple sclerosis: a clinical and polysomnography study. Eur Neurol. 2012;68:8–15.CrossRefPubMed Neau JP, Paquereau J, Auche V, Mathis S, Godeneche G, Ciron J, et al. Sleep disorders and multiple sclerosis: a clinical and polysomnography study. Eur Neurol. 2012;68:8–15.CrossRefPubMed
53.
go back to reference Trojan DA, Kaminska M, Bar-Or A, Benedetti A, Lapierre Y, Da Costa D, et al. Polysomnographic measures of disturbed sleep are associated with reduced quality of life in multiple sclerosis. J Neurol Sci. 2012;316:158–63.CrossRefPubMed Trojan DA, Kaminska M, Bar-Or A, Benedetti A, Lapierre Y, Da Costa D, et al. Polysomnographic measures of disturbed sleep are associated with reduced quality of life in multiple sclerosis. J Neurol Sci. 2012;316:158–63.CrossRefPubMed
54.
55.
go back to reference Amtmann D, Askew RL, Kim J, Chung H, Ehde DM, Bombardier CH, et al. Pain affects depression through anxiety, fatigue, and sleep in multiple sclerosis. Rehabil Psychol. 2015;60:81–90.CrossRefPubMedPubMedCentral Amtmann D, Askew RL, Kim J, Chung H, Ehde DM, Bombardier CH, et al. Pain affects depression through anxiety, fatigue, and sleep in multiple sclerosis. Rehabil Psychol. 2015;60:81–90.CrossRefPubMedPubMedCentral
56.
go back to reference Braley TJ, Kratz AL, Kaplish N, Chervin RD. Cognitive dysfunction in multiple sclerosis is associated with obstructive sleep apnea. Assoc Profess Sleep Soc, SLEEP, 2014. Braley TJ, Kratz AL, Kaplish N, Chervin RD. Cognitive dysfunction in multiple sclerosis is associated with obstructive sleep apnea. Assoc Profess Sleep Soc, SLEEP, 2014.
57.
go back to reference Braley TJ, Kratz AL. Polysomnographic predictors of visuospatial functioning in multiple sclerosis. Assoc Profess Sleep Societies, SLEEP, 2015. Braley TJ, Kratz AL. Polysomnographic predictors of visuospatial functioning in multiple sclerosis. Assoc Profess Sleep Societies, SLEEP, 2015.
58.
go back to reference Chung F, Subramanyam R, Liao P, Sasaki E, Shapiro C, Sun Y. High STOP-Bang score indicates a high probability of obstructive sleep apnoea. Br J Anaesth. 2012;108:768–75.CrossRefPubMedPubMedCentral Chung F, Subramanyam R, Liao P, Sasaki E, Shapiro C, Sun Y. High STOP-Bang score indicates a high probability of obstructive sleep apnoea. Br J Anaesth. 2012;108:768–75.CrossRefPubMedPubMedCentral
59.
go back to reference Buysse DJ. Reynolds CF,3rd, Monk TH, Berman SR, Kupfer DJ. The Pittsburgh Sleep Quality Index: a new instrument for psychiatric practice and research. Psychiatry Res. 1989;28:193–213.CrossRefPubMed Buysse DJ. Reynolds CF,3rd, Monk TH, Berman SR, Kupfer DJ. The Pittsburgh Sleep Quality Index: a new instrument for psychiatric practice and research. Psychiatry Res. 1989;28:193–213.CrossRefPubMed
60.
go back to reference Ferri R, Lanuzza B, Cosentino FI, Iero I, Tripodi M, Spada RS, et al. A single question for the rapid screening of restless legs syndrome in the neurological clinical practice. Eur J Neurol. 2007;14:1016–21.CrossRefPubMed Ferri R, Lanuzza B, Cosentino FI, Iero I, Tripodi M, Spada RS, et al. A single question for the rapid screening of restless legs syndrome in the neurological clinical practice. Eur J Neurol. 2007;14:1016–21.CrossRefPubMed
61.
go back to reference Benes H, Kohnen R. Validation of an algorithm for the diagnosis of restless legs syndrome: the Restless Legs Syndrome-Diagnostic Index (RLS-DI). Sleep Med. 2009;10:515–23.CrossRefPubMed Benes H, Kohnen R. Validation of an algorithm for the diagnosis of restless legs syndrome: the Restless Legs Syndrome-Diagnostic Index (RLS-DI). Sleep Med. 2009;10:515–23.CrossRefPubMed
62.
go back to reference Walters AS, LeBrocq C, Dhar A, Hening W, Rosen R, Allen RP, et al. Validation of the International Restless Legs Syndrome Study Group rating scale for restless legs syndrome. Sleep Med. 2003;4:121–32.CrossRefPubMed Walters AS, LeBrocq C, Dhar A, Hening W, Rosen R, Allen RP, et al. Validation of the International Restless Legs Syndrome Study Group rating scale for restless legs syndrome. Sleep Med. 2003;4:121–32.CrossRefPubMed
63.
go back to reference Krupp LB, LaRocca NG, Muir-Nash J, Steinberg AD. The fatigue severity scale. Application to patients with multiple sclerosis and systemic lupus erythematosus. Arch Neurol. 1989;46:1121–3.CrossRefPubMed Krupp LB, LaRocca NG, Muir-Nash J, Steinberg AD. The fatigue severity scale. Application to patients with multiple sclerosis and systemic lupus erythematosus. Arch Neurol. 1989;46:1121–3.CrossRefPubMed
64.
go back to reference Fisk JD, Ritvo PG, Ross L, Haase DA, Marrie TJ, Schlech WF. Measuring the functional impact of fatigue: initial validation of the fatigue impact scale. Clin Infect Dis. 1994;18 Suppl 1:S79–83.CrossRefPubMed Fisk JD, Ritvo PG, Ross L, Haase DA, Marrie TJ, Schlech WF. Measuring the functional impact of fatigue: initial validation of the fatigue impact scale. Clin Infect Dis. 1994;18 Suppl 1:S79–83.CrossRefPubMed
65.
go back to reference Tellez N, Rio J, Tintore M, Nos C, Galan I, Montalban X. Does the Modified Fatigue Impact Scale offer a more comprehensive assessment of fatigue in MS? Mult Scler. 2005;11:198–202.CrossRefPubMed Tellez N, Rio J, Tintore M, Nos C, Galan I, Montalban X. Does the Modified Fatigue Impact Scale offer a more comprehensive assessment of fatigue in MS? Mult Scler. 2005;11:198–202.CrossRefPubMed
66.
go back to reference Johns MW. A new method for measuring daytime sleepiness: the Epworth Sleepiness Scale. Sleep. 1991;14:540–5.PubMed Johns MW. A new method for measuring daytime sleepiness: the Epworth Sleepiness Scale. Sleep. 1991;14:540–5.PubMed
67.
go back to reference Hedstrom AK, Akerstedt T, Hillert J, Olsson T, Alfredsson L. Shift work at young age is associated with increased risk for multiple sclerosis. Ann Neurol. 2011;70:733–41.CrossRefPubMed Hedstrom AK, Akerstedt T, Hillert J, Olsson T, Alfredsson L. Shift work at young age is associated with increased risk for multiple sclerosis. Ann Neurol. 2011;70:733–41.CrossRefPubMed
68.
go back to reference Archibald CJ, McGrath PJ, Ritvo PG, Fisk JD, Bhan V, Maxner CE, et al. Pain prevalence, severity and impact in a clinic sample of multiple sclerosis patients. Pain. 1994;58:89–93.CrossRefPubMed Archibald CJ, McGrath PJ, Ritvo PG, Fisk JD, Bhan V, Maxner CE, et al. Pain prevalence, severity and impact in a clinic sample of multiple sclerosis patients. Pain. 1994;58:89–93.CrossRefPubMed
69.
go back to reference Ehde DM, Osborne TL, Hanley MA, Jensen MP, Kraft GH. The scope and nature of pain in persons with multiple sclerosis. Mult Scler. 2006;12:629–38.CrossRefPubMed Ehde DM, Osborne TL, Hanley MA, Jensen MP, Kraft GH. The scope and nature of pain in persons with multiple sclerosis. Mult Scler. 2006;12:629–38.CrossRefPubMed
70.
go back to reference Stanton BR, Barnes F, Silber E. Sleep and fatigue in multiple sclerosis. Mult Scler. 2006;12:481–6.CrossRefPubMed Stanton BR, Barnes F, Silber E. Sleep and fatigue in multiple sclerosis. Mult Scler. 2006;12:481–6.CrossRefPubMed
71.
go back to reference Newland PK, Naismith RT, Ullione M. The impact of pain and other symptoms on quality of life in women with relapsing-remitting multiple sclerosis. J Neurosci Nurs. 2009;41:322–8.CrossRefPubMedPubMedCentral Newland PK, Naismith RT, Ullione M. The impact of pain and other symptoms on quality of life in women with relapsing-remitting multiple sclerosis. J Neurosci Nurs. 2009;41:322–8.CrossRefPubMedPubMedCentral
73.
go back to reference Ehde DM, Gibbons LE, Chwastiak L, Bombardier CH, Sullivan MD, Kraft GH. Chronic pain in a large community sample of persons with multiple sclerosis. Mult Scler. 2003;9:605–11.CrossRefPubMed Ehde DM, Gibbons LE, Chwastiak L, Bombardier CH, Sullivan MD, Kraft GH. Chronic pain in a large community sample of persons with multiple sclerosis. Mult Scler. 2003;9:605–11.CrossRefPubMed
74.
go back to reference O’Connor AB, Schwid SR, Herrmann DN, Markman JD, Dworkin RH. Pain associated with multiple sclerosis: systematic review and proposed classification. Pain. 2008;137:96–111.CrossRefPubMed O’Connor AB, Schwid SR, Herrmann DN, Markman JD, Dworkin RH. Pain associated with multiple sclerosis: systematic review and proposed classification. Pain. 2008;137:96–111.CrossRefPubMed
75.
go back to reference Buysse DJ, Yu L, Moul DE, Germain A, Stover A, Dodds NE, et al. Development and validation of patient-reported outcome measures for sleep disturbance and sleep-related impairments. Sleep. 2010;33:781–92.PubMedPubMedCentral Buysse DJ, Yu L, Moul DE, Germain A, Stover A, Dodds NE, et al. Development and validation of patient-reported outcome measures for sleep disturbance and sleep-related impairments. Sleep. 2010;33:781–92.PubMedPubMedCentral
77.
go back to reference Mullaney DJ, Kripke DF, Messin S. Wrist-actigraphic estimation of sleep time. Sleep. 1980;3:83–92.PubMed Mullaney DJ, Kripke DF, Messin S. Wrist-actigraphic estimation of sleep time. Sleep. 1980;3:83–92.PubMed
78.
go back to reference Jean-Louis G, Kripke DF, Cole RJ, Assmus JD, Langer RD. Sleep detection with an accelerometer actigraph: comparisons with polysomnography. Physiol Behav. 2001;72:21–8.CrossRefPubMed Jean-Louis G, Kripke DF, Cole RJ, Assmus JD, Langer RD. Sleep detection with an accelerometer actigraph: comparisons with polysomnography. Physiol Behav. 2001;72:21–8.CrossRefPubMed
79.
go back to reference Buysse DJ, Ancoli-Israel S, Edinger JD, Lichstein KL, Morin CM. Recommendations for a standard research assessment of insomnia. Sleep. 2006;29:1155–73.PubMed Buysse DJ, Ancoli-Israel S, Edinger JD, Lichstein KL, Morin CM. Recommendations for a standard research assessment of insomnia. Sleep. 2006;29:1155–73.PubMed
Metadata
Title
Sleep Disorders in Multiple Sclerosis
Authors
Tiffany J. Braley
Eilis Ann Boudreau
Publication date
01-05-2016
Publisher
Springer US
Published in
Current Neurology and Neuroscience Reports / Issue 5/2016
Print ISSN: 1528-4042
Electronic ISSN: 1534-6293
DOI
https://doi.org/10.1007/s11910-016-0649-2

Other articles of this Issue 5/2016

Current Neurology and Neuroscience Reports 5/2016 Go to the issue

Movement Disorders (S Fox, Section Editor)

Neuropsychiatric Issues in Parkinson’s Disease

Neurotrauma (M Kumar, Section Editor)

Mapping the Connectome Following Traumatic Brain Injury

Infection (J Halperin, Section Editor)

The Clinical Approach to Encephalitis