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Current Neurology and Neuroscience Reports
Published in: Current Neurology and Neuroscience Reports 5/2015

01-05-2015 | Pediatric Neurology (P Pearl, Section Editor)

Glutamate and GABA Imbalance Following Traumatic Brain Injury

Authors: Réjean M. Guerriero, Christopher C. Giza, Alexander Rotenberg

Published in: Current Neurology and Neuroscience Reports | Issue 5/2015

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Abstract

Traumatic brain injury (TBI) leads to multiple short- and long-term changes in neuronal circuits that ultimately conclude with an imbalance of cortical excitation and inhibition. Changes in neurotransmitter concentrations, receptor populations, and specific cell survival are important contributing factors. Many of these changes occur gradually, which may explain the vulnerability of the brain to multiple mild impacts, alterations in neuroplasticity, and delays in the presentation of posttraumatic epilepsy. In this review, we provide an overview of normal glutamate and GABA homeostasis and describe acute, subacute, and chronic changes that follow injury. We conclude by highlighting opportunities for therapeutic interventions in this paradigm.
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Metadata
Title
Glutamate and GABA Imbalance Following Traumatic Brain Injury
Authors
Réjean M. Guerriero
Christopher C. Giza
Alexander Rotenberg
Publication date
01-05-2015
Publisher
Springer US
Published in
Current Neurology and Neuroscience Reports / Issue 5/2015
Print ISSN: 1528-4042
Electronic ISSN: 1534-6293
DOI
https://doi.org/10.1007/s11910-015-0545-1

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