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Current Neurology and Neuroscience Reports

Published in:

01-04-2011

Paraneoplastic Neurologic Disorders in Children

Authors: Elizabeth M. Wells, Josep Dalmau

Published in: Current Neurology and Neuroscience Reports | Issue 2/2011

Abstract

Paraneoplastic neurologic syndromes are rare disorders that have potentially devastating effects on the developing brain. Recently, there has been increased interest in possible immunotherapy for these disorders. Recognition of paraneoplastic syndromes in children may lead to early detection and treatment of the pediatric cancer and may diminish the neurologic damage that is the major source of morbidity in children with successfully treated tumors. This article reviews the presenting symptoms, immunology, long-term sequelae, and management options for paraneoplastic neurologic syndromes, focusing on those most commonly reported in children: opsoclonus-myoclonus ataxia, limbic encephalitis, and anti-NMDAR encephalitis. The child neurologist plays an important role in recognizing these disorders, initiating a tumor search, and directing ongoing treatment and management of neurologic symptoms after oncologic treatment is complete. Given the rarity of these conditions, multisite collaborative efforts are needed to develop standardized approaches to characterization and treatment.

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Title: Paraneoplastic Neurologic Disorders in Children
Authors: Elizabeth M. Wells
Josep Dalmau
Publication date: 01-04-2011
Publisher: Current Science Inc.
Published in: Current Neurology and Neuroscience Reports / Issue 2/2011
Print ISSN: 1528-4042
Electronic ISSN: 1534-6293
DOI: https://doi.org/10.1007/s11910-010-0169-4

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Paraneoplastic Neurologic Disorders in Children

Abstract

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