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Current Neurology and Neuroscience Reports
Published in: Current Neurology and Neuroscience Reports 4/2010

01-07-2010

Immunotherapy Approaches for Malignant Glioma From 2007 to 2009

Authors: Laura A. Johnson, John H. Sampson

Published in: Current Neurology and Neuroscience Reports | Issue 4/2010

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Abstract

Malignant glioma is a deadly disease for which there have been few therapeutic advances over the past century. Although previous treatments were largely unsuccessful, glioma may be an ideal target for immune-based therapy. Recently, translational research led to several clinical trials based on tumor immunotherapy to treat patients with malignant glioma. Here we review 17 recent glioma immunotherapy clinical trials, published over the past 3 years. Various approaches were used, including passive transfer of naked and radiolabeled antibodies, tumor antigen-specific peptide immunization, and the use of patient tumor cells with or without dendritic cells as vaccines. We compare and discuss the current state of the art of clinical immunotherapy treatment, as well as its limited successes, pitfalls, and future potential.
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Metadata
Title
Immunotherapy Approaches for Malignant Glioma From 2007 to 2009
Authors
Laura A. Johnson
John H. Sampson
Publication date
01-07-2010
Publisher
Current Science Inc.
Published in
Current Neurology and Neuroscience Reports / Issue 4/2010
Print ISSN: 1528-4042
Electronic ISSN: 1534-6293
DOI
https://doi.org/10.1007/s11910-010-0111-9

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